Published in N Engl J Med on March 28, 1996
Effects of Growth Hormone on Exercise Capacity | NCT00501514
Protein kinase cascades in the regulation of cardiac hypertrophy. J Clin Invest (2005) 4.31
Death begets failure in the heart. J Clin Invest (2005) 2.72
Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery. Circulation (2013) 2.19
New developments in the treatment of cardiac failure. Arch Dis Child (1999) 1.38
Insulin-like growth factor 1 prevents diastolic and systolic dysfunction associated with cardiomyopathy and preserves adrenergic sensitivity. Acta Physiol (Oxf) (2015) 1.38
Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction. Proc Natl Acad Sci U S A (2010) 1.27
Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest (1996) 1.20
Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease. J Am Coll Cardiol (2010) 1.17
Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol (2005) 1.12
Ghrelin: integrative neuroendocrine peptide in health and disease. Ann Surg (2004) 1.06
Chronic treatment with insulin-like growth factor I enhances myocyte contraction by upregulation of Akt-SERCA2a signaling pathway. Am J Physiol Heart Circ Physiol (2008) 1.05
Thyroid hormone improves function and Ca2+ handling in pressure overload hypertrophy. Association with increased sarcoplasmic reticulum Ca2+-ATPase and alpha-myosin heavy chain in rat hearts. J Clin Invest (1997) 1.01
Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocr Rev (2012) 1.01
Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. Am J Pathol (1999) 0.95
"AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation. Trends Cardiovasc Med (2007) 0.94
Ghrelin and cardiovascular diseases. Curr Cardiol Rev (2010) 0.93
The insulin-like growth factor system: towards clinical applications. Clin Biochem Rev (2004) 0.89
GH and the cardiovascular system: an update on a topic at heart. Endocrine (2014) 0.84
The GH/IGF-1 Axis and Heart Failure. Curr Cardiol Rev (2009) 0.84
Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol (2000) 0.80
Dilated cardiomyopathy in childhood. Images Paediatr Cardiol (2000) 0.78
Muscle wasting and cachexia in heart failure: mechanisms and therapies. Nat Rev Cardiol (2017) 0.78
Growth hormone in the treatment of dilated cardiomyopathy. N Engl J Med (1996) 0.77
Growth hormone for heart failure--cause for cautious optimism. N Engl J Med (1996) 0.76
Growth hormone therapy in dilated cardiomyopathy monitored with MRI. MAGMA (1998) 0.75
Hormonal Profile in Patients With Dilated Cardiomyopathy. Res Cardiovasc Med (2015) 0.75
Sarcopenia in heart failure: mechanisms and therapeutic strategies. J Geriatr Cardiol (2016) 0.75
Growth hormone in the treatment of dilated cardiomyopathy. N Engl J Med (1996) 0.75
Growth hormone-releasing hormone agonists reduce myocardial infarct scar in swine with subacute ischemic cardiomyopathy. J Am Heart Assoc (2015) 0.75
The potential for growth hormone in the management of heart failure. Heart (1997) 0.75
Advanced Strategies for End-Stage Heart Failure: Combining Regenerative Approaches with LVAD, a New Horizon? Front Surg (2015) 0.75
Six-months of recombinant human GH therapy in patients with ischemic cardiac failure. Int J Cardiovasc Imaging (2004) 0.75
Korean Guidelines for Diagnosis and Management of Chronic Heart Failure. Korean Circ J (2017) 0.75
Dissociation of mammalian polyribosomes into subunits by puromycin. Proc Natl Acad Sci U S A (1971) 6.77
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science (1992) 6.40
Recruitment of p300/CBP in p53-dependent signal pathways. Cell (1997) 5.10
RB and cell cycle progression. Oncogene (2006) 3.77
Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem (1996) 3.05
Response to radioembolization with yttrium-90 resin microspheres may allow surgical treatment with curative intent and prolonged survival in previously unresectable hepatocellular carcinoma. Eur J Surg Oncol (2012) 2.96
Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis. Mol Cell (2001) 2.69
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci U S A (1994) 2.29
Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ (1996) 2.18
Induction of functional inducible nitric oxide synthase in monocytes of patients with congestive heart failure. Link with tumour necrosis factor-alpha. Eur Heart J (1999) 2.12
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res (1997) 2.05
p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription. EMBO J (1997) 2.05
Sympathetic deactivation by growth hormone treatment in patients with dilated cardiomyopathy. Eur Heart J (1998) 2.05
Simian virus-40 large-T antigen binds p53 in human mesotheliomas. Nat Med (1997) 2.01
Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene (1993) 1.99
The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. Oncogene (2007) 1.97
Attenuation of unfavorable remodeling by exercise training in postinfarction patients with left ventricular dysfunction: results of the Exercise in Left Ventricular Dysfunction (ELVD) trial. Circulation (1997) 1.97
High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality. Clin Microbiol Infect (2012) 1.92
Cardiac effects of long term thyrotropin-suppressive therapy with levothyroxine. J Clin Endocrinol Metab (1993) 1.80
An information aid for newly diagnosed multiple sclerosis patients improves disease knowledge and satisfaction with care. Mult Scler (2010) 1.74
Vascular smooth muscle cell dysfunction in patients with migraine. Neurology (2009) 1.71
The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas. Nat Med (1997) 1.69
Control of adrenergic overactivity by beta-blockade improves the quality of life in patients receiving long term suppressive therapy with levothyroxine. J Clin Endocrinol Metab (1994) 1.69
Spontaneous delayed recovery of perfusion and contraction after the first 5 weeks after anterior infarction. Evidence for the presence of hibernating myocardium in the infarcted area. Circulation (1994) 1.68
Decorin-induced growth suppression is associated with up-regulation of p21, an inhibitor of cyclin-dependent kinases. J Biol Chem (1996) 1.67
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes. Oncogene (2006) 1.60
Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer. Crit Rev Eukaryot Gene Expr (1995) 1.58
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
Fatigue effects on body balance. Electroencephalogr Clin Neurophysiol (1997) 1.53
Steal phenomenon from mammary side branches: when does it occur? Ann Thorac Surg (1998) 1.53
Endothelial dysfunction in young patients with rheumatoid arthritis and low disease activity. Ann Rheum Dis (2004) 1.53
p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300. Cancer Res (1998) 1.51
Repair of ventral hernias with expanded polytetrafluoroethylene patch. Br J Surg (1998) 1.50
Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patients. J Clin Endocrinol Metab (2000) 1.49
FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc Natl Acad Sci U S A (2001) 1.48
Retinoblastoma-related protein pRb2/p130 and suppression of tumor growth in vivo. J Natl Cancer Inst (1998) 1.48
Cell cycle and apoptosis. Neoplasia (2001) 1.47
p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res (1994) 1.46
Synergistic interactions of physiologic increments of glucagon, epinephrine, and cortisol in the dog: a model for stress-induced hyperglycemia. J Clin Invest (1979) 1.46
Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. Cancer Res (2000) 1.45
Independent and incremental prognostic value of Doppler-derived mitral deceleration time of early filling in both symptomatic and asymptomatic patients with left ventricular dysfunction. J Am Coll Cardiol (1996) 1.45
Liver transplantation in cirrhotic patients with diabetes mellitus: midterm results, survival, and adverse events. Liver Transpl (2001) 1.44
Current management of esophageal foreign bodies. Arch Otolaryngol (1981) 1.44
Growth hormone and heart performance. A novel mechanism of cardiac wall stress regulation in humans. Eur Heart J (1997) 1.43
Prevalence of the metabolic syndrome using ATP-derived definitions and its relation to insulin-resistance in a cohort of Italian outpatient children. J Endocrinol Invest (2010) 1.41
[Resistance of Mycobacterium tuberculosis in the province of Castellón]. Arch Bronconeumol (1996) 1.40
Brain perfusion abnormalities in Alzheimer's disease: comparison between patients with focal temporal lobe dysfunction and patients with diffuse cognitive impairment. J Neurol Neurosurg Psychiatry (2001) 1.40
The influence of parity on multinodular goiter prevalence in areas with moderate iodine deficiency. J Endocrinol Invest (2002) 1.40
Changed epidemiology of ICU acquired bloodstream infections over 12 years in an Italian teaching hospital. Minerva Anestesiol (2014) 1.40
Endocrine predictors of acute hemodynamic effects of growth hormone in congestive heart failure. Am Heart J (1999) 1.39
Assessment of oxygen uptake during the six-minute walk test in patients with heart failure. Chest (1997) 1.39
[In re the therapeutic aspects of the carcinoid syndrome]. Rev Esp Enferm Dig (1992) 1.39
Liver transplantation in cirrhotic patients over 60 years of age. Rev Esp Enferm Dig (1998) 1.38
Considerations about the use and misuse of Rasch analysis in rehabilitation outcome studies. Eur J Phys Rehabil Med (2009) 1.38
Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure. Circulation (1997) 1.38
Responses of leg muscles in humans displaced while standing. Effects of types of perturbation and of postural set. Brain (1990) 1.37
Risk of recurrent spontaneous abortion for pregnancies discovered in the fifth week of gestation. Lancet (1994) 1.37
Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ. J Anat (2008) 1.36
Hip fractures in Italy: 2000-2005 extension study. Osteoporos Int (2009) 1.36
Left ventricular diastolic dysfunction in patients with subclinical hypothyroidism. J Clin Endocrinol Metab (1999) 1.36
Impact of hyperthyroidism and its correction on vascular reactivity in humans. Circulation (2001) 1.34
Clinical significance of incidental focal colorectal (18)F-fluorodeoxyglucose uptake: our experience and a review of the literature. Colorectal Dis (2012) 1.32
Structure of liver ribosomes studied by negative staining. J Mol Biol (1971) 1.32
Biosynthesis and processing of ribophorins in the endoplasmic reticulum. J Cell Biol (1984) 1.32
Selection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis: results of a multicenter study. Liver Transpl (2001) 1.31
Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. European Group for the Study of Insulin Resistance (EGIR). Hypertension (1997) 1.30
Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: a multicenter analysis. Ann Oncol (2009) 1.30
Müllerian defects in women with normal reproductive outcome. Fertil Steril (1991) 1.29
CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F. Proc Natl Acad Sci U S A (1996) 1.28
Is there a specific visuo-spatial impairment in Parkinsonians? J Neurol Neurosurg Psychiatry (1986) 1.28
AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res (1997) 1.25
Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma. Liver Transpl (2001) 1.25
Acute noradrenergic activation induces insulin resistance in human skeletal muscle. Am J Physiol (1994) 1.24
Early detection of diabetic cardiomyopathy: usefulness of tissue Doppler imaging. Diabet Med (2005) 1.23
Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7 TeV. Phys Rev Lett (2012) 1.23
Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein. Oncogene (1993) 1.23
The adipose organ: white-brown adipocyte plasticity and metabolic inflammation. Obes Rev (2012) 1.22
Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. Cancer Res (2000) 1.22
Identification, clinical distribution, and susceptibility to methicillin and 18 additional antibiotics of clinical Staphylococcus isolates: nationwide investigation in Italy. J Clin Microbiol (1984) 1.21
Risk factors and clinical significance of ertapenem-resistant Klebsiella pneumoniae in hospitalised patients. J Hosp Infect (2011) 1.21
Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo. Oncogene (1999) 1.20
Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother. Cancer Res (2001) 1.19
Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV. Phys Rev Lett (2012) 1.19
Doppler-derived mitral deceleration time of early filling as a strong predictor of pulmonary capillary wedge pressure in postinfarction patients with left ventricular systolic dysfunction. J Am Coll Cardiol (1994) 1.19
Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76 TeV. Phys Rev Lett (2012) 1.19
Retinoblastoma protein family in cell cycle and cancer: a review. J Cell Biochem (1996) 1.19
The retinoblastoma gene is involved in multiple aspects of stem cell biology. Oncogene (2006) 1.19
The COOH-terminal region of pRb2/p130 binds to histone deacetylase 1 (HDAC1), enhancing transcriptional repression of the E2F-dependent cyclin A promoter. Cancer Res (1998) 1.18
Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats. Circulation (2001) 1.18
Activated Raf-1 causes growth arrest in human small cell lung cancer cells. J Clin Invest (1998) 1.17
Intrinsic radiation sensitivity may not be the major determinant of the poor clinical outcome of glioblastoma multiforme. Int J Radiat Oncol Biol Phys (1993) 1.16