Published in Science on May 03, 1996
Macrophages in the pathogenesis of atherosclerosis. Cell (2011) 7.78
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58
Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. Proc Natl Acad Sci U S A (2004) 3.85
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ (2009) 3.43
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Proc Natl Acad Sci U S A (2006) 3.00
The combined role of P- and E-selectins in atherosclerosis. J Clin Invest (1998) 2.53
Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest (2005) 2.50
P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med (2000) 2.32
The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae. J Clin Invest (1999) 1.94
Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol (2004) 1.86
CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med (2004) 1.80
Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. J Clin Invest (2002) 1.80
Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. J Clin Invest (1998) 1.76
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J Clin Invest (2010) 1.67
The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice. J Clin Invest (1997) 1.67
High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest (2000) 1.67
Absence of P-selectin delays fatty streak formation in mice. J Clin Invest (1997) 1.63
Lymphocytes are important in early atherosclerosis. J Clin Invest (2001) 1.57
The roles of senescence and telomere shortening in cardiovascular disease. Nat Rev Cardiol (2013) 1.48
Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration. Am J Pathol (2009) 1.47
Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice. Brain (2015) 1.43
Delivery of negatively charged liposomes into the atherosclerotic plaque of apolipoprotein E-deficient mouse aortic tissue. J Liposome Res (2014) 1.40
Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. Pathol Int (2010) 1.29
Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc Natl Acad Sci U S A (1999) 1.28
Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A (1998) 1.26
Mechanisms that regulate macrophage burden in atherosclerosis. Circ Res (2014) 1.26
Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages. PLoS One (2011) 1.25
ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis. J Clin Invest (2001) 1.24
Genetic modifiers of atherosclerosis in mice. Arterioscler Thromb Vasc Biol (2000) 1.22
Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice. Environ Health Perspect (2003) 1.22
The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis. Biomaterials (2011) 1.21
Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes. J Clin Invest (1997) 1.20
Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice. Atherosclerosis (2006) 1.15
Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease. Am J Pathol (2003) 1.14
In utero arsenic exposure induces early onset of atherosclerosis in ApoE-/- mice. Reprod Toxicol (2007) 1.14
Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice. Proc Natl Acad Sci U S A (1999) 1.13
Structure and function of phosphatidylcholine transfer protein (PC-TP)/StarD2. Biochim Biophys Acta (2007) 1.11
Atherosclerosis research from past to present--on the track of two pathologists with opposing views, Carl von Rokitansky and Rudolf Virchow. Virchows Arch (2006) 1.11
No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice. J Biol Chem (2010) 1.11
Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PLoS One (2011) 1.10
Molecular evidence for arterial repair in atherosclerosis. Proc Natl Acad Sci U S A (2005) 1.09
Long-chain n-3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease. Br J Pharmacol (2009) 1.07
High-density lipoprotein and atherosclerosis regression: evidence from preclinical and clinical studies. Circ Res (2014) 1.04
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis. Proc Natl Acad Sci U S A (1997) 1.02
Chlamydia pneumoniae induces inflammatory changes in the heart and aorta of normocholesterolemic C57BL/6J mice. Infect Immun (2000) 1.01
The APO(*)E3-Leiden mouse as an animal model for basal laminar deposit. Br J Ophthalmol (2000) 0.99
Complex adaptive system models and the genetic analysis of plasma HDL-cholesterol concentration. Perspect Biol Med (2006) 0.97
Microarray gene profiling of laser-captured cells: a new tool to study atherosclerosis in mice. Atherosclerosis (2008) 0.97
Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice. Proc Natl Acad Sci U S A (2001) 0.95
Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci (2012) 0.94
Liraglutide increases FGF-21 activity and insulin sensitivity in high fat diet and adiponectin knockdown induced insulin resistance. PLoS One (2012) 0.93
Porcine models of accelerated coronary atherosclerosis: role of diabetes mellitus and hypercholesterolemia. J Diabetes Res (2013) 0.93
Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition. Neurobiol Aging (2007) 0.93
Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. J Lipid Res (2011) 0.93
Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice. Atherosclerosis (2008) 0.93
Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes (2009) 0.92
A novel dual staining method for identification of apoptotic cells reveals a modest apoptotic response in infarcted mouse myocardium. Histochem Cell Biol (2007) 0.92
Imaging of wall motion coupled with blood flow velocity in the heart and vessels in vivo: a feasibility study. Ultrasound Med Biol (2011) 0.92
RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality. Proc Natl Acad Sci U S A (2015) 0.91
Exposure to moderate arsenic concentrations increases atherosclerosis in ApoE-/- mouse model. Toxicol Sci (2011) 0.91
Differences in aortic arch geometry, hemodynamics, and plaque patterns between C57BL/6 and 129/SvEv mice. J Biomech Eng (2009) 0.90
From Mice to Men: research models of developmental programming. J Dev Orig Health Dis (2013) 0.89
Implications of autophagy for vascular smooth muscle cell function and plasticity. Free Radic Biol Med (2013) 0.88
Scavenging new insights into atherogenesis. J Clin Invest (2000) 0.88
Fibrinogen deficiency is compatible with the development of atherosclerosis in mice. J Clin Invest (1998) 0.87
Preclinical mouse models and methods for the discovery of the causes and treatments of atherosclerosis. Expert Opin Drug Discov (2012) 0.87
The role of oxysterols in control of endothelial stiffness. J Lipid Res (2012) 0.87
Murine norovirus increases atherosclerotic lesion size and macrophages in Ldlr(-/-) mice. Comp Med (2011) 0.86
An agomir of miR-144-3p accelerates plaque formation through impairing reverse cholesterol transport and promoting pro-inflammatory cytokine production. PLoS One (2014) 0.86
Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide. Br J Pharmacol (1999) 0.86
Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice. J Cereb Blood Flow Metab (2010) 0.86
Increased locomotor activity in mice lacking the low-density lipoprotein receptor. Behav Brain Res (2008) 0.86
ACAT inhibition reduces the progression of preexisting, advanced atherosclerotic mouse lesions without plaque or systemic toxicity. Arterioscler Thromb Vasc Biol (2012) 0.86
PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE. J Lipid Res (2014) 0.86
Rhythm changes of clock genes, apoptosis-related genes and atherosclerosis-related genes in apolipoprotein E knockout mice. Can J Cardiol (2009) 0.85
Laser capture microdissection for analysis of macrophage gene expression from atherosclerotic lesions. Methods Mol Biol (2013) 0.85
Endothelial primary cilia inhibit atherosclerosis. EMBO Rep (2016) 0.85
Novel cerebrovascular pathology in mice fed a high cholesterol diet. Mol Neurodegener (2009) 0.85
The role of invariant natural killer T cells in lupus and atherogenesis. Immunol Res (2006) 0.84
CD34⁺/M-cadherin⁺ bone marrow progenitor cells promote arteriogenesis in ischemic hindlimbs of ApoE⁻/⁻ mice. PLoS One (2011) 0.84
HIV-1 antiretrovirals induce oxidant injury and increase intima-media thickness in an atherogenic mouse model. Toxicol Lett (2009) 0.84
Improved analysis of the vascular response to arterial ligation using a multivariate approach. Am J Pathol (2004) 0.83
Moderate beer consumption does not change early or mature atherosclerosis in mice. Nutr J (2004) 0.83
Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature. BMC Geriatr (2014) 0.82
Gene expression analyses of mouse aortic endothelium in response to atherogenic stimuli. Arterioscler Thromb Vasc Biol (2013) 0.82
Macrophages, dendritic cells, and regression of atherosclerosis. Front Physiol (2012) 0.82
Genetic susceptibility to atherosclerosis. Stroke Res Treat (2012) 0.82
Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. Am J Pathol (1997) 0.82
Liver X receptors at the intersection of lipid metabolism and atherogenesis. Atherosclerosis (2015) 0.81
A novel mouse model of in-stent restenosis. Atherosclerosis (2009) 0.81
Physiological difference in autophagic flux in macrophages from 2 mouse strains regulates cholesterol ester metabolism. Arterioscler Thromb Vasc Biol (2013) 0.81
GDF-15 protects from macrophage accumulation in a mousemodel of advanced atherosclerosis. Eur J Med Res (2013) 0.80
Stat3β mitigates development of atherosclerosis in apolipoprotein E-deficient mice. J Mol Med (Berl) (2013) 0.80
NMR-based metabolomics of urine for the atherosclerotic mouse model using apolipoprotein-E deficient mice. Magn Reson Chem (2009) 0.80
The complex fate in plasma of gadolinium incorporated into high-density lipoproteins used for magnetic imaging of atherosclerotic plaques. Bioconjug Chem (2013) 0.80
Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice. Endocrinology (2014) 0.79
Evaluation of the contribution of the ATP binding cassette transporter, P-glycoprotein, to in vivo cholesterol homeostasis. Mol Pharm (2013) 0.79
Extravascular inflammation does not increase atherosclerosis in apoE-deficient mice. Biochem Biophys Res Commun (2009) 0.79