Somatic microsatellite mutations as molecular tumor clocks.

PubWeight™: 1.31‹?› | Rank: Top 10%

🔗 View Article (PMID 8640559)

Published in Nat Med on June 01, 1996

Authors

D Shibata1, W Navidi, R Salovaara, Z H Li, L A Aaltonen

Author Affiliations

1: Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033, USA.

Articles citing this

DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol (1999) 2.78

Human cancers express mutator phenotypes: origin, consequences and targeting. Nat Rev Cancer (2011) 2.77

The mutation rate and cancer. Genetics (1998) 1.88

Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res (2008) 1.83

Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells. J Clin Invest (1997) 1.69

Alternative genetic pathways in colorectal carcinogenesis. Proc Natl Acad Sci U S A (1997) 1.68

Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A (2000) 1.63

DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. Gut (2000) 1.58

Colorectal adenoma and cancer divergence. Evidence of multilineage progression. Am J Pathol (1999) 1.50

Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers. J Mol Diagn (2006) 1.30

Direct selection for mutators in Escherichia coli. J Bacteriol (1999) 1.15

Estimating cell depth from somatic mutations. PLoS Comput Biol (2008) 1.06

Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers. Am J Pathol (2001) 1.04

The clonal origin and clonal evolution of epithelial tumours. Int J Exp Pathol (2000) 1.04

Hypermutable DNA chronicles the evolution of human colon cancer. Proc Natl Acad Sci U S A (2014) 1.02

Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture. Am J Pathol (1998) 0.91

Molecular tumor clocks and dynamic phenotype. Am J Pathol (1997) 0.87

Development and progression of colorectal neoplasia. Cancer Biomark (2010) 0.85

Building a lineage from single cells: genetic techniques for cell lineage tracking. Nat Rev Genet (2017) 0.83

Intestinal stem cell division and genetic diversity. A computer and experimental analysis. Am J Pathol (1997) 0.83

Microsatellite instability in thyroid tumours and tumour-like lesions. Br J Cancer (1999) 0.81

Genomic landscape of DNA repair genes in cancer. Oncotarget (2016) 0.76

Inferring average generation via division-linked labeling. J Math Biol (2016) 0.75

Articles by these authors

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature (1998) 10.35

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell (1993) 9.93

Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A (1992) 9.15

Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med (1998) 8.47

Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology (2000) 8.41

Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science (1998) 7.08

Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer (1999) 6.73

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res (1993) 4.93

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet (1997) 4.27

Genetic mapping of a locus predisposing to human colorectal cancer. Science (1993) 4.12

Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol (2000) 3.98

A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. Am J Respir Crit Care Med (1999) 3.71

Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci U S A (2001) 3.31

A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med (1999) 3.18

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology (2000) 3.01

Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer (1995) 2.85

BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing. J Med Genet (2004) 2.75

Loss-of-function mutations in PPAR gamma associated with human colon cancer. Mol Cell (1999) 2.71

Better survival rates in patients with MLH1-associated hereditary colorectal cancer. Gastroenterology (1996) 2.60

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet (2001) 2.50

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res (1993) 2.48

Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nat Med (1995) 2.40

Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas. J Natl Cancer Inst (1993) 2.34

Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut (2005) 2.13

Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC). Cancer Res (2001) 2.12

The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet (2004) 2.10

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet (1994) 2.08

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers. Am J Pathol (2000) 2.03

Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res (2001) 1.93

Specific genetic analysis of microscopic tissue after selective ultraviolet radiation fractionation and the polymerase chain reaction. Am J Pathol (1992) 1.91

MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis. Genes Chromosomes Cancer (1997) 1.83

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene (2000) 1.83

Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am J Hum Genet (2001) 1.81

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum Mol Genet (1999) 1.79

LKB1 somatic mutations in sporadic tumors. Am J Pathol (1999) 1.79

Semiautomated assessment of loss of heterozygosity and replication error in tumors. Cancer Res (1996) 1.77

Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. Cancer Res (1998) 1.75

p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition. Cancer Res (2001) 1.74

Diagnostic cancer genome sequencing and the contribution of germline variants. Science (2013) 1.65

Genetic reconstruction of individual colorectal tumor histories. Proc Natl Acad Sci U S A (2000) 1.63

COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. Br J Cancer (2009) 1.62

Increased risk of cancer in patients with fumarate hydratase germline mutation. J Med Genet (2005) 1.61

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. J Med Genet (2006) 1.56

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet (1999) 1.56

Colorectal adenoma and cancer divergence. Evidence of multilineage progression. Am J Pathol (1999) 1.50

The snoRNA domain of vertebrate telomerase RNA functions to localize the RNA within the nucleus. RNA (2001) 1.48

Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome. Cancer Res (1997) 1.47

Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology. Am J Pathol (2001) 1.46

A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. Proc Natl Acad Sci U S A (2001) 1.46

The I1307K polymorphism of the APC gene in colorectal cancer. Gastroenterology (1999) 1.43

Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis. Oncogene (2006) 1.43

Gene expression signatures for colorectal cancer microsatellite status and HNPCC. Br J Cancer (2005) 1.40

Residential indoor PM2.5 in wood stove homes: follow-up of the Libby changeout program. Indoor Air (2012) 1.40

Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. Br J Cancer (2009) 1.40

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo. Antimicrob Agents Chemother (1994) 1.39

Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer. Am J Pathol (1999) 1.38

The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck. J Med Genet (2005) 1.34

Los Angeles study of residential magnetic fields and childhood brain tumors. Am J Epidemiol (1996) 1.34

Screening for microsatellite instability target genes in colorectal cancers. J Med Genet (2002) 1.29

Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers. Proc Natl Acad Sci U S A (1999) 1.28

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer. Br J Cancer (2012) 1.24

Individual variation in recombination among human males. Am J Hum Genet (1996) 1.22

Extensive somatic microsatellite mutations in normal human tissue. Cancer Res (2001) 1.22

Unequal exchange at the Charcot-Marie-Tooth disease type 1A recombination hot-spot is not elevated above the genome average rate. Hum Mol Genet (2000) 1.21

Frequent loss of SMAD4/DPC4 protein in colorectal cancers. Gut (2002) 1.18

Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage. Am J Hum Genet (1994) 1.18

Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug. Drug Metab Dispos (1996) 1.17

Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients. J Med Genet (1999) 1.16

Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families. Proc Natl Acad Sci U S A (1994) 1.14

The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative study. Fam Cancer (2001) 1.13

Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor. Int J Hematol (1995) 1.13

CHEK2 1100delC and colorectal cancer. J Med Genet (2003) 1.12

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants. Br J Cancer (2010) 1.11

The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers. J Med Genet (2000) 1.11

No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas. Cancer Res (2000) 1.11

No SMAD4 hypermethylation in colorectal cancer. Br J Cancer (2000) 1.10

CHEK2 I157T associates with familial and sporadic colorectal cancer. J Med Genet (2006) 1.10

SMAD genes in juvenile polyposis. Genes Chromosomes Cancer (1999) 1.10