Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA.

PubWeight™: 1.38‹?› | Rank: Top 10%

🔗 View Article (PMID 8641567)

Published in FASEB J on February 01, 1996

Authors

J G de la Asuncion1, A Millan, R Pla, L Bruseghini, A Esteras, F V Pallardo, J Sastre, J Viña

Author Affiliations

1: Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Spain.

Articles citing this

Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76

Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal (2009) 2.28

The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet (2007) 2.25

Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct (2011) 1.94

Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J (2009) 1.89

Effects of age and caloric restriction on glutathione redox state in mice. Free Radic Biol Med (2003) 1.86

Hydrogen sulfide in biochemistry and medicine. Antioxid Redox Signal (2012) 1.64

Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One (2010) 1.57

Mitochondrial glutathione transport: physiological, pathological and toxicological implications. Chem Biol Interact (2006) 1.57

Role of the ascorbate-glutathione cycle of mitochondria and peroxisomes in the senescence of pea leaves Plant Physiol (1998) 1.53

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet (2013) 1.51

Glutathione and apoptosis. Free Radic Res (2008) 1.48

Dairy intake is associated with brain glutathione concentration in older adults. Am J Clin Nutr (2014) 1.41

Lactobacillus fermentum ME-3 - an antimicrobial and antioxidative probiotic. Microb Ecol Health Dis (2009) 1.38

Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions. Redox Biol (2013) 1.28

Glutathione and modulation of cell apoptosis. Biochim Biophys Acta (2012) 1.27

Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon. J Bioenerg Biomembr (1998) 1.21

Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acids Res (1997) 1.20

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol (2014) 1.16

Is there more to aging than mitochondrial DNA and reactive oxygen species? FEBS J (2009) 1.14

AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins. J Clin Invest (1998) 1.13

Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12

Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver. J Bioenerg Biomembr (2004) 1.09

Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain. J Bioenerg Biomembr (2005) 1.08

Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restriction. Exp Gerontol (2008) 1.08

In situ detection of AP sites and DNA strand breaks bearing 3'-phosphate termini in ischemic mouse brain. FASEB J (2000) 1.06

Effect of short-term caloric restriction on H2O2 production and oxidative DNA damage in rat liver mitochondria and location of the free radical source. J Bioenerg Biomembr (2001) 1.02

Influence of vitamin C diet supplementation on endogenous antioxidant defences during exhaustive exercise. Pflugers Arch (2003) 1.00

Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells. Free Radic Biol Med (2009) 0.99

Effect of antioxidant-enriched diets on glutathione redox status in tissue homogenates and mitochondria of the senescence-accelerated mouse. Free Radic Biol Med (2005) 0.98

Mitochondrial thiols in the regulation of cell death pathways. Antioxid Redox Signal (2012) 0.97

Energy metabolism and inflammation in brain aging and Alzheimer's disease. Free Radic Biol Med (2016) 0.95

Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart. J Bioenerg Biomembr (2009) 0.92

The free radical theory of aging revisited: the cell signaling disruption theory of aging. Antioxid Redox Signal (2013) 0.92

Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice. Exp Gerontol (2006) 0.91

Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction. Exp Gerontol (2007) 0.89

Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. J Biol Chem (2010) 0.86

Ethanol feeding enhances age-related deterioration of the rat hepatic mitochondrion. Am J Physiol Gastrointest Liver Physiol (2005) 0.86

Resuscitation with 100% oxygen causes intestinal glutathione oxidation and reoxygenation injury in asphyxiated newborn piglets. Ann Surg (2004) 0.86

Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage. J Bioenerg Biomembr (2006) 0.85

The effects of dietary restriction on oxidative stress in rodents. Free Radic Biol Med (2013) 0.85

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart. J Bioenerg Biomembr (2011) 0.84

Comparison between the effects of aging and hyperoxia on glutathione redox state and protein mixed disulfides in Drosophila melanogaster. Mech Ageing Dev (2006) 0.82

Effects of Gingko Extract (EGb761) on oxidative damage under different conditions of serum supply. J Bioenerg Biomembr (2009) 0.82

Mitochondrial DNA damage and animal longevity: insights from comparative studies. J Aging Res (2011) 0.78

Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione. Apoptosis (2013) 0.78

Increased vulnerability of brain to estrogen withdrawal-induced mitochondrial dysfunction with aging. J Bioenerg Biomembr (2009) 0.77

Age-associated decreases in human DNA repair capacity: Implications for the skin. Age (Omaha) (1999) 0.77

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress. J Bioenerg Biomembr (2013) 0.77

Effect of aging on mitochondrial and nuclear DNA oxidative damage in the heart and brain throughout the life-span of the rat. J Am Aging Assoc (2001) 0.75

Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging. Aging (Albany NY) (2016) 0.75

The Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-"Chemobrain". Aging Dis (2016) 0.75

Bioavailability Study of an Innovative Orobuccal Formulation of Glutathione. Oxid Med Cell Longev (2015) 0.75

Effects of ischemia-reperfusion on hepatic glutathione and plasmatic markers of graft function during in situ split-liver transplantation in adult recipients. Dig Dis Sci (2000) 0.75

Articles by these authors

Coupling between regional blood flow and oxygen utilization in the normal human brain. A study with positron tomography and oxygen 15. Arch Neurol (1983) 2.19

Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics (2001) 2.15

Association of CYP2C9 genotypes leading to high enzyme activity and colorectal cancer risk. Carcinogenesis (2001) 1.94

Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. Gut (2008) 1.84

Effect of intermittent hypoxia on hematological parameters after recombinant human erythropoietin administration. Eur J Appl Physiol (2009) 1.82

Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines. Ann Oncol (1996) 1.76

A further evaluation of the clinical use of specific IgE antibody testing in allergic diseases. Allergy (2003) 1.57

Bronchial responsiveness to bakery-derived allergens is strongly dependent on specific skin sensitivity. Allergy (2006) 1.50

Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: a phase II multicentric study. Ann Oncol (1998) 1.47

Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis. Gut (2005) 1.44

A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer. Ann Oncol (2013) 1.42

Olive pollen allergy: searching for immunodominant T-cell epitopes on the Ole e 1 molecule. Clin Exp Allergy (1998) 1.41

[Clinical pattern and therapeutic results obtained in Germ-Cell testicular cancer in Spain based on a consecutive series of 1250 patients]. Med Clin (Barc) (2001) 1.39

The hybrid algorithm (Hbmr) to fight against blood doping in sports. Scand J Med Sci Sports (2010) 1.39

Allergy to goat and sheep cheese with good tolerance to cow cheese. Clin Exp Allergy (1999) 1.38

Treatment of the elderly colorectal cancer patient: SIOG expert recommendations. Ann Oncol (2008) 1.29

Mitochondria, oxidative stress and aging. Free Radic Res (2000) 1.24

Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration. Am J Physiol (1992) 1.23

Maintenance of glutathione content is isolated hepatocyctes. Biochem J (1978) 1.23

Ratio of reduced to oxidized glutathione as indicator of oxidative stress status and DNA damage. Methods Enzymol (1999) 1.20

Mitochondrial oxidative stress plays a key role in aging and apoptosis. IUBMB Life (2000) 1.20

Specific IgE antibodies in the diagnosis of atopic disease. Clinical evaluation of a new in vitro test system, UniCAP, in six European allergy clinics. Allergy (1998) 1.19

Prediction of trace element mobility in contaminated soils by sequential extraction. J Environ Qual (2003) 1.19

Capecitabine (Xeloda) in combination with oxaliplatin: a phase I, dose-escalation study in patients with advanced or metastatic solid tumors. Ann Oncol (2002) 1.16

Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes. J Biol Chem (1993) 1.15

AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins. J Clin Invest (1998) 1.13

Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitro. FASEB J (1999) 1.13

Mechanism of free radical production in exhaustive exercise in humans and rats; role of xanthine oxidase and protection by allopurinol. IUBMB Life (2000) 1.10

Aging of the liver: age-associated mitochondrial damage in intact hepatocytes. Hepatology (1996) 1.10

L-cysteine and glutathione metabolism are impaired in premature infants due to cystathionase deficiency. Am J Clin Nutr (1995) 1.10

Genetic aspects of allergic rhinitis. J Investig Allergol Clin Immunol (2009) 1.10

Air pollution and allergens. J Investig Allergol Clin Immunol (2007) 1.09

A high-performance liquid chromatography method for measurement of oxidized glutathione in biological samples. Anal Biochem (1994) 1.08

Role of cytokines and oxidative stress in the pathophysiology of acute pancreatitis: therapeutical implications. Curr Drug Targets Inflamm Allergy (2002) 1.07

Involvement of gamma-glutamyltransferase in amino-acid uptake by the lactating mammary gland of the rat. Biochem J (1981) 1.07

Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings. Ann Oncol (2013) 1.06

Pentoxifylline ameliorates cerulein-induced pancreatitis in rats: role of glutathione and nitric oxide. J Pharmacol Exp Ther (2000) 1.06

Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am J Physiol (1999) 1.05

Alpha-adrenergic modulation of glutathione metabolism in isolated rat hepatocytes. Am J Physiol (1988) 1.05

A randomized, placebo-controlled phase 2 study of ganitumab or conatumumab in combination with FOLFIRI for second-line treatment of mutant KRAS metastatic colorectal cancer. Ann Oncol (2013) 1.04

Free radicals in exhaustive physical exercise: mechanism of production, and protection by antioxidants. IUBMB Life (2001) 1.03

The effect of cysteine oxidation on isolated hepatocytes. Biochem J (1983) 1.03

Stress and allergy. J Investig Allergol Clin Immunol (2009) 1.03

Blood glutathione as an index of radiation-induced oxidative stress in mice and humans. Free Radic Biol Med (1997) 1.02

Effect of H1 antihistamines upon the central nervous system. J Investig Allergol Clin Immunol (2006) 1.01

p38 MAPK: a dual role in hepatocyte proliferation through reactive oxygen species. Free Radic Res (2013) 1.01

Synthesis of ethyl 8-fluoro-5,6-dihydro-5-[11C]methyl-6-oxo-4H-imidazo [1,5-a] [1,4]benzodiazepine-3-carboxylate (RO 15.1788-11C): a specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography. Int J Appl Radiat Isot (1984) 1.00

Eosinophils transcribe and translate messenger RNA for inducible nitric oxide synthase. J Immunol (1997) 1.00

A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress. Free Radic Biol Med (1998) 1.00

Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats. Eur Respir J (2001) 0.99

Role of mitochondrial oxidative stress to explain the different longevity between genders: protective effect of estrogens. Free Radic Res (2006) 0.99

Noninvasive methods for assessment of airway inflammation in occupational settings. Allergy (2009) 0.99

Scleroderma-like alterations in collagen metabolism occurring in the TSK (tight skin) mouse. Arthritis Rheum (1984) 0.98

Validation of the Spanish version of the Asthma Control Test (ACT). J Asthma (2007) 0.97

Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol (2006) 0.97

Liver intracellular L-cysteine concentration is maintained after inhibition of the trans-sulfuration pathway by propargylglycine in rats. Br J Nutr (1997) 0.96

Clinical pattern and therapeutic results achieved in 1490 patients with germ-cell tumours of the testis: the experience of the Spanish Germ-Cell Cancer Group (GG). Eur Urol (2002) 0.95

Six years of experience with the use of room air for the resuscitation of asphyxiated newly born term infants. Biol Neonate (2001) 0.95

Effect of premature weaning on amino acid uptake by the mammary gland of lactating rats. Biochem J (1981) 0.95

Increased biosynthesis of glycosaminoglycans by scleroderma fibroblasts in culture. Arthritis Rheum (1984) 0.95

Asthma and exposure to cleaning products - a European Academy of Allergy and Clinical Immunology task force consensus statement. Allergy (2013) 0.94

Multicenter study evaluating a dual policy of postorchiectomy surveillance and selective adjuvant single-agent carboplatin for patients with clinical stage I seminoma. Ann Oncol (2003) 0.94

Determination of oxidized glutathione in blood: high-performance liquid chromatography. Methods Enzymol (1994) 0.92

Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma. Allergy (2006) 0.92

Lack of allergic cross-reactivity to cephalosporins among patients allergic to penicillins. Clin Exp Allergy (2001) 0.92

Targeting mitochondria: a new promising approach for the treatment of liver diseases. Curr Med Chem (2010) 0.91

Chicken serum albumin (Gal d 5*) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome. Allergy (2001) 0.91

Successful desensitization of a fixed drug eruption caused by allopurinol. J Allergy Clin Immunol (1998) 0.91

Recombinant lipid transfer protein Tri a 14: a novel heat and proteolytic resistant tool for the diagnosis of baker's asthma. Clin Exp Allergy (2009) 0.91

Molecular diagnosis in allergology: application of the microarray technique. J Investig Allergol Clin Immunol (2009) 0.91

Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver. Hepatology (1999) 0.91

Genetic and epigenetic profile of sporadic pheochromocytomas. J Med Genet (2004) 0.90

Increased prostaglandin E2 levels in the airway of patients with eosinophilic bronchitis. Allergy (2007) 0.89

Immunotherapy with a Phleum pratense allergen extract induces an immune response to a grass-mix allergen extract. J Investig Allergol Clin Immunol (2010) 0.89

Effect of ethanol on glutathione concentration in isolated hepatocytes. Biochem J (1980) 0.89

Effect of xanthine oxidase-generated extracellular superoxide on skeletal muscle force generation. Am J Physiol Regul Integr Comp Physiol (2009) 0.89

Phase II open-label study of erlotinib in combination with gemcitabine in unresectable and/or metastatic adenocarcinoma of the pancreas: relationship between skin rash and survival (Pantar study). Ann Oncol (2011) 0.89

Molecular cloning of paramyosin, a new allergen of Anisakis simplex. Int Arch Allergy Immunol (2000) 0.89

EAACI consensus statement for investigation of work-related asthma in non-specialized centres. Allergy (2012) 0.89

Intravenous and oral magnesium supplementations in the prophylaxis of cisplatin-induced hypomagnesemia. Results of a controlled trial. Am J Clin Oncol (1992) 0.88

Use of antihistamines in pediatrics. J Investig Allergol Clin Immunol (2007) 0.88

Production of calcium oxalate monohydrate, dihydrate or trihydrate. A comparative study. Urol Res (1990) 0.88

Role of prolactin in amino acid uptake by the lactating mammary gland of the rat. FEBS Lett (1981) 0.88

Physiological changes in glutathione metabolism in foetal and newborn rat liver. Biochem J (1991) 0.87

In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects. J Nutr (1994) 0.87

Allergic rhinitis and school performance. J Investig Allergol Clin Immunol (2009) 0.87

Effect of bilastine upon the ocular symptoms of allergic rhinoconjunctivitis. J Investig Allergol Clin Immunol (2011) 0.87

Epigenetic biomarkers: A new perspective in laboratory diagnostics. Clin Chim Acta (2012) 0.87