Glutathione and modulation of cell apoptosis.

PubWeight™: 1.27‹?› | Rank: Top 10%

🔗 View Article (PMC 3437743)

Published in Biochim Biophys Acta on June 23, 2012

Authors

Magdalena L Circu1, Tak Yee Aw

Author Affiliations

1: Department of Molecular & Cellular Physiology, Louisiana University Health Sciences Center, Shreveport, LA 71130, USA.

Articles citing this

Glutathione: new roles in redox signaling for an old antioxidant. Front Pharmacol (2014) 1.25

Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4-hydroxynonenal. Antioxid Redox Signal (2014) 0.92

Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells. FEBS Lett (2013) 0.88

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways. Neurobiol Dis (2014) 0.85

Interaction between glutathione and apoptosis in systemic lupus erythematosus. Autoimmun Rev (2012) 0.83

Chinese medicinal formula Guanxin Shutong capsule protects the heart against oxidative stress and apoptosis induced by ischemic myocardial injury in rats. Exp Ther Med (2014) 0.81

Metformin induces apoptosis via a mitochondria-mediated pathway in human breast cancer cells in vitro. Exp Ther Med (2016) 0.81

Degree of glutathione deficiency and redox imbalance depend on subtype of mitochondrial disease and clinical status. PLoS One (2014) 0.80

Glutathione depletion in survival and apoptotic pathways. Front Pharmacol (2014) 0.80

Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes. PLoS One (2013) 0.79

Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line. Front Pharmacol (2016) 0.79

Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract. BMC Complement Altern Med (2016) 0.78

Three week dietary intervention using apricots, pomegranate juice or/and fermented sour sobya and impact on biomarkers of antioxidative activity, oxidative stress and erythrocytic glutathione transferase activity among adults. Nutr J (2016) 0.78

Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. BMC Cancer (2016) 0.77

Extracellular Cysteine in Connexins: Role as Redox Sensors. Front Physiol (2016) 0.77

Mitophagy in TGEV infection counteracts oxidative stress and apoptosis. Oncotarget (2016) 0.77

Effects of resveratrol on vitrified porcine oocytes. Oxid Med Cell Longev (2013) 0.76

4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells. Sci Rep (2016) 0.76

Induction of Apoptosis and Reduction of Endogenous Glutathione Level by the Ethyl-Acetate Soluble Fraction of the Methanol Extract of the Roots of Potentilla fulgens in Cancer Cells. PLoS One (2015) 0.76

Differential cell death and Bcl-2 expression in the mouse retina after glutathione decrease by systemic D,L-buthionine sulphoximine administration. Mol Cells (2013) 0.76

Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress. BMC Res Notes (2017) 0.75

siRNA Delivery Strategies: A Comprehensive Review of Recent Developments. Nanomaterials (Basel) (2017) 0.75

Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival. Int J Mol Sci (2016) 0.75

β-elemene reverses the drug resistance of A549/DDP lung cancer cells by activating intracellular redox system, decreasing mitochondrial membrane potential and P-glycoprotein expression, and inducing apoptosis. Thorac Cancer (2014) 0.75

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells. Genes Nutr (2016) 0.75

Laparotomy in mice induces blood cell expression of inflammatory and stress genes. J Interferon Cytokine Res (2014) 0.75

Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli. PLoS One (2015) 0.75

ABCC1 is related to the protection of the distal nephron against hyperosmolality and high sodium environment: possible implications for cancer chemotherapy. PLoS One (2013) 0.75

Quercetin inhibited cadmium-induced autophagy in the mouse kidney via inhibition of oxidative stress. J Toxicol Pathol (2016) 0.75

Using Sensors and Generators of H2O2 to Elucidate the Toxicity Mechanism of Piperlongumine and Phenethyl Isothiocyanate. Antioxid Redox Signal (2016) 0.75

Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain. Evid Based Complement Alternat Med (2015) 0.75

Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution. Oncotarget (2016) 0.75

D-Galactose Causes Motor Coordination Impairment, and Histological and Biochemical Changes in the Cerebellum of Rats. Mol Neurobiol (2016) 0.75

Familial Alzheimer's Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants. Mol Neurobiol (2016) 0.75

Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. Int J Oncol (2017) 0.75

A Rationally Designed Reversible 'Turn-Off' Sensor for Glutathione. Biosensors (Basel) (2017) 0.75

Effects of GSH1 and GSH2 Gene Mutation on Glutathione Synthetases Activity of Saccharomyces cerevisiae. Protein J (2017) 0.75

Articles cited by this

(truncated to the top 100)

Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer (1972) 35.74

Glutathione. Annu Rev Biochem (1983) 15.18

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15

Oxidized redox state of glutathione in the endoplasmic reticulum. Science (1992) 6.91

Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07

Cell death. N Engl J Med (2009) 4.75

Regulation of JNK signaling by GSTp. EMBO J (1999) 4.06

Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol (2007) 3.90

Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90

Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization. Annu Rev Biochem (1976) 3.84

Protein sulfenic acids in redox signaling. Annu Rev Pharmacol Toxicol (2004) 3.56

Mechanisms of cell death in oxidative stress. Antioxid Redox Signal (2007) 3.33

Direct evidence for S-nitrosation of mitochondrial complex I. Biochem J (2006) 2.88

Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal (2008) 2.67

Redox state of glutathione in human plasma. Free Radic Biol Med (2000) 2.60

The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis (2007) 2.59

The organization and inheritance of the mitochondrial genome. Nat Rev Genet (2005) 2.57

S-glutathionylation in protein redox regulation. Free Radic Biol Med (2007) 2.53

Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci U S A (2006) 2.51

Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology. Free Radic Biol Med (2007) 2.47

The CD95 type I/type II model. Semin Immunol (2003) 2.34

Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem (2003) 2.28

Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway. Circ Res (2006) 2.24

How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol (2006) 2.14

gamma-Glutamyl transpeptidase: catalytic, structural and functional aspects. Mol Cell Biochem (1981) 1.98

Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair (Amst) (2006) 1.96

Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radic Biol Med (2002) 1.94

Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem (2007) 1.92

Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress. J Biol Chem (2008) 1.91

Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites. J Biol Chem (1996) 1.85

Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis. Free Radic Biol Med (2007) 1.81

Molecular mechanisms and potential clinical significance of S-glutathionylation. Antioxid Redox Signal (2008) 1.78

Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. J Biol Chem (2007) 1.73

Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins. Toxicol Appl Pharmacol (2005) 1.68

Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation. J Biol Chem (2007) 1.68

Role of mitochondria in oxidative stress and aging. Ann N Y Acad Sci (2002) 1.64

The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix. J Biol Chem (2008) 1.63

CFTR mediates cadmium-induced apoptosis through modulation of ROS level in mouse proximal tubule cells. Free Radic Biol Med (2008) 1.60

Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain. Biochem J (2004) 1.54

Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Arch Toxicol (2007) 1.53

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology (1998) 1.52

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death Differ (2002) 1.48

The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stress. Circ Res (2005) 1.46

Rescue of cells from apoptosis by inhibition of active GSH extrusion. FASEB J (1998) 1.45

Cell death mechanisms and their implications in toxicology. Toxicol Sci (2010) 1.43

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas. J Cell Biol (2009) 1.42

Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. FASEB J (1996) 1.38

Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage. J Biol Chem (2008) 1.36

Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis. Mol Cell Biol (2010) 1.30

The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites. Eur J Biochem (1996) 1.28

Redox compartmentalization and cellular stress. Diabetes Obes Metab (2010) 1.27

Thioredoxin and protein kinases in redox signaling. Semin Cancer Biol (2006) 1.27

Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria. J Biol Chem (2007) 1.26

Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases. Mol Cells (2008) 1.26

Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers. J Pharmacol Exp Ther (1998) 1.26

Redox control systems in the nucleus: mechanisms and functions. Antioxid Redox Signal (2010) 1.25

Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci U S A (1998) 1.23

Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment. Biochim Biophys Acta (1988) 1.23

Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP kinase pathway. FASEB J (2002) 1.23

Mitogen-activated protein kinases in mammalian oxidative stress responses. Antioxid Redox Signal (2011) 1.22

Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver. J Appl Toxicol (2008) 1.19

Activation of c-Jun-N-terminal kinase is required for apoptosis triggered by glutathione disulfide in neuroblastoma cells. Free Radic Biol Med (2005) 1.19

Multi-faceted regulation of gamma-glutamylcysteine synthetase. J Cell Physiol (2000) 1.18

Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport. Arch Biochem Biophys (2000) 1.17

Mitochondrial glutathione: hepatocellular survival-death switch. J Gastroenterol Hepatol (2006) 1.16

Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo. Biochim Biophys Acta (2010) 1.16

Glutathionylation of adenine nucleotide translocase induced by carbon monoxide prevents mitochondrial membrane permeabilization and apoptosis. J Biol Chem (2010) 1.15

Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J Biol Chem (2007) 1.15

Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation. Antioxid Redox Signal (2008) 1.15

Recruitment of glutathione into the nucleus during cell proliferation adjusts whole-cell redox homeostasis in Arabidopsis thaliana and lowers the oxidative defence shield. Plant J (2010) 1.14

SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis. J Biol Chem (2006) 1.14

Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion. Am J Physiol Heart Circ Physiol (2005) 1.14

Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12

Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia. J Biol Chem (2004) 1.10

Inhibition of caspase-3 activity and activation by protein glutathionylation. Biochem Pharmacol (2008) 1.08

Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production. FASEB J (2002) 1.08

Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity. Mutagenesis (2006) 1.07

Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. J Biol Chem (2002) 1.06

Role of reduced glutathione efflux in apoptosis of immortalized human keratinocytes induced by UVA. J Biol Chem (2002) 1.06

Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation. Gastroenterology (2008) 1.04

Differential susceptibility of naive and differentiated PC-12 cells to methylglyoxal-induced apoptosis: influence of cellular redox. Curr Neurovasc Res (2005) 1.03

Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line. J Pharmacol Exp Ther (2010) 1.02

Early redox imbalance mediates hydroperoxide-induced apoptosis in mitotic competent undifferentiated PC-12 cells. Cell Death Differ (2002) 1.01

Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter. J Pharmacol Exp Ther (2002) 1.01

Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol. J Clin Invest (1987) 1.00

The non-protein thiol of rat liver mitochondria. Biochim Biophys Acta (1974) 0.99

Redox mechanisms involved in the selective activation of Nrf2-mediated resistance versus p53-dependent apoptosis in adenocarcinoma cells. J Biol Chem (2009) 0.99

Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis. J Pharmacol Exp Ther (2005) 0.99

Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells. Free Radic Biol Med (2009) 0.99

p38(MAPK) and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y. Biochem Pharmacol (2012) 0.98

Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis. J Biol Chem (2008) 0.98

Decreased susceptibility of differentiated PC12 cells to oxidative challenge: relationship to cellular redox and expression of apoptotic protease activator factor-1. Cell Death Differ (2005) 0.97

Apoptosis signaling kinases: from stress response to health outcomes. Antioxid Redox Signal (2011) 0.96

Role of nitric oxide-mediated glutathionylation in neuronal function: potential regulation of energy utilization. Biochem J (2010) 0.95

The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells. Biochem Pharmacol (2008) 0.94

CFTR mediates apoptotic volume decrease and cell death by controlling glutathione efflux and ROS production in cultured mice proximal tubules. Am J Physiol Renal Physiol (2009) 0.94

Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activity. Antioxid Redox Signal (2011) 0.94

Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb. J Biol Chem (2007) 0.93

Lipid hydroperoxide-induced apoptosis in human colonic CaCo-2 cells is associated with an early loss of cellular redox balance. FASEB J (2000) 0.92

Articles by these authors

Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76

Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis. Free Radic Biol Med (2007) 1.81

Glutathione and apoptosis. Free Radic Res (2008) 1.48

Neuronal apoptosis in neurodegeneration. Antioxid Redox Signal (2007) 1.29

NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis. Curr Neurovasc Res (2006) 1.14

Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: role for NO and Kupffer cell-derived oxidants. Hepatology (2004) 1.12

Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production. FASEB J (2002) 1.08

Differential susceptibility of naive and differentiated PC-12 cells to methylglyoxal-induced apoptosis: influence of cellular redox. Curr Neurovasc Res (2005) 1.03

S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells. Mol Pharmacol (2009) 1.03

Age-dependent and tissue-related glutathione redox status in a mouse model of Alzheimer's disease. J Alzheimers Dis (2012) 1.00

Intestinal redox biology and oxidative stress. Semin Cell Dev Biol (2012) 0.99

Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells. Free Radic Biol Med (2009) 0.99

The cystine/glutamate antiporter regulates dendritic cell differentiation and antigen presentation. J Immunol (2010) 0.97

Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells. J Biol Chem (2003) 0.97

Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose. Free Radic Biol Med (2008) 0.96

The ROS scavenger, NAC, regulates hepatic Vα14iNKT cells signaling during Fas mAb-dependent fulminant liver failure. PLoS One (2012) 0.96

The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells. Biochem Pharmacol (2008) 0.94

The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism. J Biol Chem (2002) 0.93

S-Glutathionyl quantification in the attomole range using glutaredoxin-3-catalyzed cysteine derivatization and capillary gel electrophoresis with laser-induced fluorescence detection. Anal Bioanal Chem (2011) 0.92

Redox biology of the intestine. Free Radic Res (2011) 0.92

Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: relationship to cellular redox and activator protease factor-1 expression. Curr Neurovasc Res (2005) 0.92

Apoptosis: a key in neurodegenerative disorders. Curr Neurovasc Res (2004) 0.91

Glutathione in cerebral microvascular endothelial biology and pathobiology: implications for brain homeostasis. Int J Cell Biol (2012) 0.89

Disruption of pyridine nucleotide redox status during oxidative challenge at normal and low-glucose states: implications for cellular adenosine triphosphate, mitochondrial respiratory activity, and reducing capacity in colon epithelial cells. Antioxid Redox Signal (2011) 0.89

Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis. Curr Neurovasc Res (2009) 0.89

Apoptosis in acute and chronic neurological disorders. Front Biosci (2004) 0.88

Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: role for glutathione-dependent metabolism of methylglyoxal. Free Radic Biol Med (2012) 0.88

Chronic exposure to subtoxic levels of peroxidized lipids suppresses mucosal cell turnover in rat small intestine and reversal by glutathione. Dig Dis Sci (2003) 0.86

Inhibition of glutathione synthesis in brain endothelial cells lengthens S-phase transit time in the cell cycle: Implications for proliferation in recovery from oxidative stress and endothelial cell damage. Redox Biol (2013) 0.84

V(alpha)14iNKT cells promote liver pathology during adenovirus infection by inducing CCL5 production: implications for gene therapy. J Virol (2010) 0.84

Lipid peroxide-induced redox imbalance differentially mediates CaCo-2 cell proliferation and growth arrest. Cell Prolif (2002) 0.84

Vα14iNKT cell deficiency prevents acetaminophen-induced acute liver failure by enhancing hepatic glutathione and altering APAP metabolism. Biochem Biophys Res Commun (2012) 0.83

Phosphate and succinate use different mechanisms to inhibit sugar-induced cell death in yeast: insight into the Crabtree effect. J Biol Chem (2011) 0.82

Apolipoprotein A-IV attenuates oxidant-induced apoptosis in mitotic competent, undifferentiated cells by modulating intracellular glutathione redox balance. Am J Physiol Cell Physiol (2005) 0.81

Influence of glutathione on the electroretinogram in diabetic and non-diabetic rats. Curr Eye Res (2011) 0.78

Activation of promoter activity of the catalytic subunit of γ-glutamylcysteine ligase (GCL) in brain endothelial cells by insulin requires antioxidant response element 4 and altered glycemic status: implication for GCL expression and GSH synthesis. Free Radic Biol Med (2011) 0.78

Tissue oxidative stress revisited: significance of ROS and redox signaling. Semin Cell Dev Biol (2012) 0.77

Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase. Cancer Sci (2012) 0.77

Endothelial cells maintain a reduced redox environment even as mitochondrial function declines. Am J Physiol Cell Physiol (2002) 0.76

Chronic lipid hydroperoxide stress suppresses mucosal proliferation in rat intestine: potentiation of ornithine decarboxylase activity by epidermal growth factor. Dig Dis Sci (2003) 0.76

Off to a good start and a promising future in communicating cutting edge developments in redox biology. Redox Biol (2013) 0.75