Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate.

PubWeight™: 1.36‹?› | Rank: Top 10%

🔗 View Article (PMID 8663198)

Published in J Biol Chem on July 05, 1996

Authors

X Wang1, P Penzes, J L Napoli

Author Affiliations

1: Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA.

Articles citing this

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily. Expert Opin Drug Metab Toxicol (2008) 3.37

Retinoid-binding proteins: mediators of retinoid action. Biochem J (2000) 2.64

The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev (2001) 2.04

Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta (2011) 1.86

Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A (1999) 1.43

Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids. Biochemistry (2005) 1.42

Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways. Dev Genet (1999) 1.35

Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl (2010) 1.34

Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice. J Biol Chem (2002) 1.19

Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J Biol Chem (2004) 1.10

Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans. Proc Natl Acad Sci U S A (2010) 1.04

Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. J Biol Chem (2010) 1.01

Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid. Biochem J (1999) 1.01

Metabolism and transactivation activity of 13,14-dihydroretinoic acid. J Biol Chem (2005) 0.95

Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C/EBPbeta interaction. Biochem Pharmacol (2008) 0.94

Characterization of retinaldehyde dehydrogenase 3. Biochem J (2006) 0.92

Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish. PLoS One (2009) 0.91

Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. Biochemistry (2007) 0.91

Leukocyte homing, fate, and function are controlled by retinoic acid. Physiol Rev (2015) 0.88

4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal. BMC Pharmacol (2002) 0.84

Localization of retinaldehyde dehydrogenases and retinoid binding proteins to sustentacular cells, glia, Bowman's gland cells, and stroma: potential sites of retinoic acid synthesis in the postnatal rat olfactory organ. J Comp Neurol (2006) 0.84

Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice. J Biol Chem (2014) 0.84

Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover. J Biol Chem (2010) 0.82

The hepatic Raldh1 expression is elevated in Zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells. PLoS One (2012) 0.81

Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer. Development (2010) 0.80

Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner. Biochem Pharmacol (2015) 0.80

Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition. Chem Biol Interact (2012) 0.79

Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations. J Lipid Res (2014) 0.79

Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility. Fertil Steril (2014) 0.78

Analysis of follicular fluid retinoids in women undergoing in vitro fertilization: retinoic acid influences embryo quality and is reduced in women with endometriosis. Reprod Sci (2013) 0.76

Pathways of retinoid synthesis in mouse macrophages and bone marrow cells. J Leukoc Biol (2016) 0.75

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors. Chem Biol Interact (2015) 0.75

Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases. Pharmacol Ther (2017) 0.75

Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia. Invest Ophthalmol Vis Sci (2016) 0.75

Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance. ISRN Hepatol (2013) 0.75

Retinoic Acid Synthesis and Degradation. Subcell Biochem (2016) 0.75

Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells. Int J Mol Med (2017) 0.75

Articles by these authors

(truncated to the top 100)

Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer. Clin Chem (1993) 3.87

Quantification of circulating 1,25-dihydroxyvitamin D by radioimmunoassay with 125I-labeled tracer. Clin Chem (1996) 1.76

Expression of cellular retinoic acid binding protein (CRABP) in Escherichia coli. Characterization and evidence that holo-CRABP is a substrate in retinoic acid metabolism. J Biol Chem (1991) 1.35

Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation site. J Biol Chem (2000) 1.31

Improved radioimmunoassay for vitamin D and its use in assessing vitamin D status. Clin Chem (1985) 1.30

Direct chemical synthesis of 1 alpha,25-dihydroxy[26,27-3H]vitamin D3 with high specific activity: its use in receptor studies. Biochemistry (1980) 1.30

Changing patterns of the retinoic acid system in the developing retina. Dev Biol (1993) 1.25

Quantitation of vitamin D and its metabolites and their plasma concentrations in five species of animals. Anal Biochem (1981) 1.22

Molecular characterization of a mouse short chain dehydrogenase/reductase active with all-trans-retinol in intact cells, mRDH1. J Biol Chem (2001) 1.22

Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasma. J Lipid Res (1985) 1.11

Metabolism of retinoic acid and retinol during differentiation of F9 embryonal carcinoma cells. Proc Natl Acad Sci U S A (1985) 1.10

Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition. Mol Psychiatry (2011) 1.09

Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue. Biochem J (1999) 1.08

Dietary phosphate deprivation increases 1,25-dihyroxyvitamin D3 synthesis in rat kidney in vitro. J Biol Chem (1983) 1.05

Impaired 24,25-dihydroxyvitamin D production in anephric human and pig. J Clin Invest (1981) 1.05

Quantification of physiological levels of retinoic acid. Methods Enzymol (1986) 1.03

Retinol metabolism in LLC-PK1 Cells. Characterization of retinoic acid synthesis by an established mammalian cell line. J Biol Chem (1986) 1.03

cDNA cloning and characterization of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase. J Biol Chem (1997) 1.01

Isolation and identification of 5, 6-epoxyretinoic acid: a biologically active metabolite of retinoic acid. Biochemistry (1978) 1.00

Biosynthesis of all-trans-retinoic acid from retinal. Recognition of retinal bound to cellular retinol binding protein (type I) as substrate by a purified cytosolic dehydrogenase. J Biol Chem (1992) 0.99

Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase. J Biol Chem (1995) 0.99

Retinoic acid, dibutyryl-cAMP, and differentiation affect the expression of retinoic acid receptors in F9 cells. Proc Natl Acad Sci U S A (1990) 0.98

Expression of cellular retinoic acid-binding protein (type II) in Escherichia coli. Characterization and comparison to cellular retinoic acid-binding protein (type I). J Biol Chem (1993) 0.98

Holocellular retinol binding protein as a substrate for microsomal retinal synthesis. Biochemistry (1991) 0.98

Synthesis of 25-hydroxy[26,27-3h]vitamin D3 with high specific activity. Anal Biochem (1979) 0.98

cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme. J Biol Chem (1998) 0.95

Cellular retinol-binding protein-supported retinoic acid synthesis. Relative roles of microsomes and cytosol. J Biol Chem (1996) 0.95

Identification of 5,6-epoxyretinoic acid as an endogenous retinol metabolite. J Biol Chem (1982) 0.95

Cloning of a cDNA for a second retinol dehydrogenase type II. Expression of its mRNA relative to type I. J Biol Chem (1995) 0.93

Microsomal retinoic acid metabolism. Effects of cellular retinoic acid-binding protein (type I) and C18-hydroxylation as an initial step. J Biol Chem (1994) 0.93

Cellular expression of retinal dehydrogenase types 1 and 2: effects of vitamin A status on testis mRNA. J Cell Physiol (2001) 0.92

The isolation and identification of vitamin D2 and vitamin D3 from Medicago sativa (alfalfa plant). Arch Biochem Biophys (1984) 0.91

24-Hydroxylation of 1,25-dihydroxyergocalciferol. An unambiguous deactivation process. J Biol Chem (1986) 0.91

Vitamin A metabolism: alpha-tocopherol modulates tissue retinol levels in vivo, and retinyl palmitate hydrolysis in vitro. Arch Biochem Biophys (1984) 0.91

19-nor-10-ketovitamin D derivatives: unique metabolites of vitamin D3, vitamin D2, and 25-hydroxyvitamin D3. Biochemistry (1983) 0.91

Identification of 9-cis,13-cis-retinoic acid as a major circulating retinoid in plasma. Biochemistry (1995) 0.90

13-cis-retinoic acid metabolism in vivo. The major tissue metabolites in the rat have the all-trans configuration. Biochemistry (1983) 0.90

cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12. J Biol Chem (2000) 0.89

High-pressure liquid chromatography of vitamin A metabolites and analogs. Methods Enzymol (1980) 0.88

The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem (1999) 0.88

High concentrations of vitamin D2 in human milk associated with pharmacologic doses of vitamin D2. J Pediatr (1984) 0.88

23S,25-dihydroxyvitamin D3 as a circulating metabolite of vitamin D3. Its role in 25-hydroxyvitamin D3-26,23-lactone biosynthesis. J Biol Chem (1982) 0.88

Cloning of a rat cDNA encoding retinal dehydrogenase isozyme type I and its expression in E. coli. Gene (1997) 0.88

Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III. Gene (1996) 0.87

25,26-dihydroxyvitamin D3 is not a major intermediate in 25-hydroxyvitamin D3-26,23-lactone formation. Arch Biochem Biophys (1981) 0.87

Synthesis of vitamin D5: its biological activity relative to vitamins D3 and D2. Arch Biochem Biophys (1979) 0.87

The biosynthesis of retinoic acid from retinol by rat tissues in vitro. Arch Biochem Biophys (1987) 0.87

Analysis of mouse retinal dehydrogenase type 2 promoter and expression. Genomics (2001) 0.87

Effects of sulfhydryl reagents, retinoids, and solubilization on the activity of microsomal retinol dehydrogenase. Arch Biochem Biophys (1995) 0.86

Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes. Mol Genet Metab (1999) 0.86

Cholate-independent retinyl ester hydrolysis. Stimulation by Apo-cellular retinol-binding protein. J Biol Chem (1991) 0.86

Discrimination in the metabolism of orally dosed ergocalciferol and cholecalciferol by the pig, rat and chick. Biochem J (1982) 0.86

23-keto-25-hydroxyvitamin D3 and 23-keto-1,25-dihydroxyvitamin D3: two new vitamin D3 metabolites with high affinity for the 1,25-dihydroxyvitamin D3 receptor. Biochem Biophys Res Commun (1982) 0.85

1 Alpha-25,26-trihydroxyvitamin D3: an in vivo and in vitro metabolite of vitamin D3. Biochemistry (1981) 0.85

9,13-Di-cis-retinoic acid is the major circulating geometric isomer of retinoic acid in the periparturient period. Arch Biochem Biophys (1995) 0.85

Characterization of a microsomal retinol dehydrogenase: a short-chain alcohol dehydrogenase with integral and peripheral membrane forms that interacts with holo-CRBP (type I). Biochemistry (1995) 0.85

Alpha-tocopherol and phylloquinone as non-competitive inhibitors of retinyl ester hydrolysis. Biochem J (1984) 0.85

Formation of 19-nor-10-keto-25-hydroxyvitamin D3 in cultured mammalian cells. Biochem Biophys Res Commun (1984) 0.84

5,6-epoxyretinoic acid is a physiological metabolite of retinoic acid in the rat. Biochem J (1980) 0.84

Quantification and characteristics of retinoid synthesis from retinol and beta-carotene in tissue fractions and established cell lines. Methods Enzymol (1990) 0.84

High-pressure liquid chromatographic resolution of vitamin A compounds. Anal Biochem (1978) 0.84

23-Keto-25-hydroxyvitamin D3: a vitamin D3 metabolite with high affinity for the 1,25-dihydroxyvitamin D specific cytosol receptor. Biochemistry (1983) 0.83

Enzymatic characteristics of retinal dehydrogenase type I expressed in Escherichia coli. Biochim Biophys Acta (1997) 0.83

C(24)- and C(23)-oxidation, converging pathways of intestinal 1,25-dihydroxyvitamin D3 metabolism: identification of 24-keto-1,23,25-trihydroxyvitamin D3. Biochemistry (1983) 0.83

1 alpha-hydroxy-25-fluorovitamin D3: a potent analogue of 1 alpha,25-dihydroxyvitamin D3. Biochemistry (1978) 0.83

Tissue dependence of retinoic acid metabolism in vivo. Biochim Biophys Acta (1981) 0.83

Holo-cellular retinol-binding protein: distinction of ligand-binding affinity from efficiency as substrate in retinal biosynthesis. Biochemistry (1999) 0.83

23, 25, 26-trihydroxycholecalciferol. A 25-hydroxycholecalciferol-26,23-lactone precursor. Biochem J (1982) 0.83

Vitamin A metabolism: analysis of steady-state neutral metabolites in rat tissues. J Lipid Res (1984) 0.82

The effects of retinol on in vitro immunoglobulin synthesis by cord blood and adult peripheral blood mononuclear cells. Clin Exp Immunol (1993) 0.82

Rat liver cytosolic retinal dehydrogenase: comparison of 13-cis-, 9-cis-, and all-trans-retinal as substrates and effects of cellular retinoid-binding proteins and retinoic acid on activity. Biochemistry (1994) 0.81

Retinoic acid synthesis by cytosol from the alcohol dehydrogenase negative deermouse. Arch Biochem Biophys (1989) 0.81

Metabolism of 5,6-epoxyretinoic acid in vivo: isolation of a major intestinal metabolite. Biochemistry (1982) 0.81

Intestinal synthesis of 24-keto-1,25-dihydroxyvitamin D3. A metabolite formed in vivo with high affinity for the vitamin D cytosolic receptor. J Biol Chem (1983) 0.81

Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver. Arch Biochem Biophys (1984) 0.81

Assessment of retinoid-induced differentiation of F9 embryonal carcinoma cells with an enzyme-linked immunoadsorbent assay for laminin: statistical comparison of dose-response curves. Anal Biochem (1987) 0.81

10-Keto or 25-hydroxy substitution confer equivalent in vitro bone-resorbing activity to vitamin D3. Arch Biochem Biophys (1985) 0.81

Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid. Proc Natl Acad Sci U S A (1978) 0.79

Coexpression of the mRNAs encoding retinol dehydrogenase isozymes and cellular retinol-binding protein. J Cell Physiol (1997) 0.79

A new in vivo metabolite of vitamin D3: 1,25,26-trihydroxyvitamin D3. Biochem Biophys Res Commun (1981) 0.79

Retinoic acid regulates the morphological development of sympathetic neurons. J Neurobiol (2000) 0.79

Ring hydroxylation of 25-hydroxycholecalciferol by rat renal microsomes. J Steroid Biochem (1988) 0.79

Induction, inhibition, and analysis of vitamin D metabolism in cultured cells. Methods Enzymol (1991) 0.78

Isolation and identification of vitamin D metabolites. Methods Enzymol (1986) 0.78

Specific, covalent binding of an azidoretinoid to cellular retinoic acid-binding protein. Biochem Biophys Res Commun (1986) 0.78

Use of Fourier transform 1H NMR in the identification of vitamin D2 metabolites. Anal Biochem (1987) 0.78

Solanum glaucophyllum as source of 1,25-dihydroxyvitamin D3. J Biol Chem (1977) 0.78

Isolation of 5,8-oxyretinoic acid from rat intestinal mucosa. Arch Biochem Biophys (1979) 0.78

Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17beta/3alpha-hydroxysteroid/retinoid short chain dehydrogenase/reductase. Endocrinology (1999) 0.78

(23S)-1,23,25-Trihydroxycholecalciferol, an intestinal metabolite of 1,25-dihydroxycholecalciferol. Biochem J (1983) 0.78

Evidence for the metabolism of 24R-hydroxy-25-fluorovitamin D3 and 1alpha-hydroxy-25-fluorovitamin D3 to 1alpha,24R-dihydroxy-25-fluorovitamin D3. Arch Biochem Biophys (1979) 0.77

Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. J Med Chem (1989) 0.77

Inhibition of retinoic acid metabolism by imidazole antimycotics in F9 embryonal carcinoma cells. Biochem Pharmacol (1987) 0.77

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces diverse retinoic acid metabolites in multiple tissues of the Sprague-Dawley rat. Toxicol Appl Pharmacol (1995) 0.77

The N-terminus of retinol dehydrogenase type 1 signals cytosolic orientation in the microsomal membrane. Biochemistry (2001) 0.77

Bile salt-independent retinyl ester hydrolase activities associated with membranes of rat tissues. Methods Enzymol (1990) 0.76

(23S)-1,23,25-Trihydroxyvitamin D3: its biologic activity and role in 1 alpha,25-dihydroxyvitamin D3 26,23-lactone biosynthesis. Biochemistry (1984) 0.76

Increase in beta-1,4-galactosyltransferase activity during PC12 cell differentiation induced by forskolin and 2-chloroadenosine. J Neurochem (1991) 0.75

Production of C-24- and C-23-oxidized metabolites of 1,25-dihydroxycholecalciferol by cultured kidney cells (LLC PK1) and their presence in kidney in vivo. Biochem J (1984) 0.75

Renal tubular necrosis after gastroenteritis in infants. Br Med J (1971) 0.75