Published in Mol Endocrinol on April 01, 1996
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev (2010) 4.95
Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol (2011) 4.31
Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol (2011) 2.95
Cervical remodeling during pregnancy and parturition. Trends Endocrinol Metab (2010) 1.71
Functional significance of the rapid regulation of brain estrogen action: where do the estrogens come from? Brain Res (2006) 1.58
Opposing actions of prostaglandins and oxytocin determine the onset of murine labor. Proc Natl Acad Sci U S A (1998) 1.47
Minireview: fetal-maternal hormonal signaling in pregnancy and labor. Mol Endocrinol (2009) 1.44
MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor. Proc Natl Acad Sci U S A (2012) 1.20
Vaginal progesterone vs. cervical cerclage for the prevention of preterm birth in women with a sonographic short cervix, previous preterm birth, and singleton gestation: a systematic review and indirect comparison metaanalysis. Am J Obstet Gynecol (2012) 1.15
Temporal changes in myeloid cells in the cervix during pregnancy and parturition. J Immunol (2009) 1.14
Unexpected virilization in male mice lacking steroid 5 alpha-reductase enzymes. Endocrinology (2001) 1.06
Overexpression of SK3 channels dampens uterine contractility to prevent preterm labor in mice. Biol Reprod (2008) 1.04
Prostate formation in a marsupial is mediated by the testicular androgen 5 alpha-androstane-3 alpha,17 beta-diol. Proc Natl Acad Sci U S A (2000) 1.02
The molecular mechanisms of cervical ripening differ between term and preterm birth. Endocrinology (2011) 1.01
Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. J Perinat Med (2010) 1.00
The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor. Mol Endocrinol (2012) 0.97
Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth. Endocrinology (2012) 0.95
Transcriptional regulation of the mouse steroid 5alpha-reductase type II gene by progesterone in brain. Nucleic Acids Res (2002) 0.92
Androgens in pregnancy: roles in parturition. Hum Reprod Update (2014) 0.89
Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female mice. Behav Brain Res (2011) 0.88
Mass spectrometric assay and physiological-pharmacological activity of androgenic neurosteroids. Neurochem Int (2007) 0.86
Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal. Biochim Biophys Acta (2006) 0.85
Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice. PLoS One (2011) 0.85
MicroRNAs--mediators of myometrial contractility during pregnancy and labour. Nat Rev Endocrinol (2013) 0.84
Sex Differences in Ethanol's Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5α-Reductase Type 1 Gene. Behav Genet (2014) 0.84
Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency. J Endocrinol (2009) 0.84
Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA. Biochem J (1998) 0.83
Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5α-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex. Neurosci Lett (2013) 0.83
Null mutation of 5α-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner. Behav Genet (2014) 0.81
A molecular signature of an arrest of descent in human parturition. Am J Obstet Gynecol (2011) 0.81
Stimulatory effect of insulin on 5alpha-reductase type 1 (SRD5A1) expression through an Akt-dependent pathway in ovarian granulosa cells. Endocrinology (2010) 0.80
Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, mice. Behav Brain Res (2013) 0.80
Inhibition of 5α-reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspring. J Neuroendocrinol (2011) 0.79
Genetic evidence of multiple loci in dystocia--difficult labour. BMC Med Genet (2010) 0.79
Relative adrenal insufficiency in mice deficient in 5α-reductase 1. J Endocrinol (2014) 0.78
5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients. Psychopharmacology (Berl) (2014) 0.78
Female mice with deletion of Type One 5α-reductase have reduced reproductive responding during proestrus and after hormone-priming. Pharmacol Biochem Behav (2014) 0.78
Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin. Exp Cell Res (2009) 0.77
Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells. Mol Endocrinol (2016) 0.77
Progesterone and allopregnanolone improves stroke outcome in male mice via distinct mechanisms but neither promotes neurogenesis. J Neurochem (2014) 0.77
The effect of 5α-reductase-2 deficiency on human fertility. Fertil Steril (2014) 0.76
Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5α-dihydroprogesterone. Proc Natl Acad Sci U S A (2014) 0.75
Progesterone action in the myometrium and decidua in preterm birth. Facts Views Vis Obgyn (2012) 0.75
Metabolic dysfunction in female mice with disruption of 5α-reductase 1. J Endocrinol (2016) 0.75
The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell (1984) 12.54
Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu Rev Cell Biol (1985) 11.53
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem (1989) 11.06
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev (1997) 8.51
The LDL receptor gene: a mosaic of exons shared with different proteins. Science (1985) 5.49
Human genes involved in cholesterol metabolism: chromosomal mapping of the loci for the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA probes. Proc Natl Acad Sci U S A (1985) 5.33
Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2. J Virol (1998) 4.71
Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science (1985) 4.51
Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Cell (1984) 4.21
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev (1998) 4.11
The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis. J Biol Chem (1987) 3.84
Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell (1992) 3.81
The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors. Cell (1986) 3.44
The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. Annu Rev Genet (1990) 3.40
Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia. Cell (1987) 3.31
Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain. Cell (1985) 3.13
Nucleotide sequence of the yeast alcohol dehydrogenase II gene. J Biol Chem (1983) 2.82
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science (1986) 2.76
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature (1987) 2.74
Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J Biol Chem (1991) 2.70
Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia. J Biol Chem (1987) 2.67
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum. Nature (1984) 2.66
Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration. J Virol (1997) 2.65
Reasoned action and social reaction: willingness and intention as independent predictors of health risk. J Pers Soc Psychol (1998) 2.55
DNA sequences of two yeast promoter-up mutants. Nature (1983) 2.50
DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors. J Virol (1994) 2.50
Hemimethylation prevents DNA replication in E. coli. Cell (1987) 2.48
Direct and moderating effects of community context on the psychological well-being of African American women. J Pers Soc Psychol (2000) 2.47
Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia. J Lipid Res (1998) 2.46
Mutational analysis of the ligand binding domain of the low density lipoprotein receptor. J Biol Chem (1988) 2.43
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region. Mol Cell Biol (1986) 2.36
Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3. Nat Genet (1994) 2.35
The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum. J Biol Chem (1987) 2.29
Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes. J Virol (2000) 2.26
Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. Proc Natl Acad Sci U S A (1997) 2.22
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A (1999) 2.20
Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A (1997) 2.15
Characterization of transposable element-associated mutations that alter yeast alcohol dehydrogenase II expression. Mol Cell Biol (1983) 2.09
Deletions and single base pair changes in the yeast mating type locus that prevent homothallic mating type conversions. Proc Natl Acad Sci U S A (1983) 2.09
Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia. Proc Natl Acad Sci U S A (1986) 2.04
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. Cell (1987) 2.03
Adeno-associated virus vector integration junctions. J Virol (1997) 2.03
The metabolism of aromatic compounds in higer plants. X. Properties of the cinnamic acid 4-hydroxylase of pea seedlings and some aspects of its metabolic and developmental control. J Biol Chem (1971) 2.02
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. J Biol Chem (1991) 2.01
Cassette of eight exons shared by genes for LDL receptor and EGF precursor. Science (1985) 1.99
cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA. Proc Natl Acad Sci U S A (1983) 1.98
Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia. N Engl J Med (1987) 1.96
Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia. J Biol Chem (1986) 1.94
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Science (1988) 1.91
Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest (1993) 1.88
Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation. J Biol Chem (1996) 1.87
Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun (2006) 1.86
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J Biol Chem (1998) 1.86
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A (1986) 1.86
The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol (1999) 1.83
Climate change and the integrity of science. Science (2010) 1.80
Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase. J Biol Chem (1996) 1.80
Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J Biol Chem (1990) 1.79
Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts. J Biol Chem (1986) 1.79
Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors. Mol Ther (2001) 1.77
Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J Biol Chem (2000) 1.76
Conservation of function between mammalian and plant steroid 5alpha-reductases. Proc Natl Acad Sci U S A (1997) 1.75
cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1. Cell (1991) 1.71
Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism. Nature (1991) 1.69
Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. J Clin Invest (1998) 1.68
Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene. Proc Natl Acad Sci U S A (1985) 1.63
Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J Biol Chem (2000) 1.60
Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors. Hum Gene Ther (1996) 1.60
Steroid 5 alpha-reductase 2 deficiency. Endocr Rev (1993) 1.60
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Proc Natl Acad Sci U S A (1990) 1.57
Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. J Biol Chem (1987) 1.56
Blood cholesterol screening influence of fasting state on cholesterol results and management decisions. J Gen Intern Med (2000) 1.55
Design and packaging of adeno-associated virus gene targeting vectors. J Virol (2000) 1.54
Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation. J Biol Chem (1989) 1.52
The effectiveness of psychological interventions for the rehabilitation of low back pain: a randomized controlled trial evaluation. Pain (1992) 1.51
Purification and characterization of a ribosome dissociation factor (eukaryotic initiation factor 6) from wheat germ. J Biol Chem (1979) 1.45
Simple method for determining isoniazid acetylator phenotype. Br Med J (1970) 1.40
Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. J Biol Chem (1992) 1.37
Molecular genetics of steroid 5 alpha-reductase 2 deficiency. J Clin Invest (1992) 1.36
Subcellular localization of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Pisum sativum seedlings. Arch Biochem Biophys (1975) 1.34
Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate. J Biol Chem (1997) 1.33
AvaII polymorphism in the human LDL receptor gene. Nucleic Acids Res (1987) 1.33
The cinnamic acid 4-hydroxylase of pea seedlings. Arch Biochem Biophys (1967) 1.32
Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding. J Lipid Res (2001) 1.30
Job-related stress, social support, and burnout among classroom teachers. J Appl Psychol (1987) 1.26
Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors. Blood (2001) 1.25
Packaging cells based on inducible gene amplification for the production of adeno-associated virus vectors. J Virol (1998) 1.25
Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc Natl Acad Sci U S A (1997) 1.25
High-fidelity correction of mutations at multiple chromosomal positions by adeno-associated virus vectors. J Virol (1999) 1.24
Brief report: the molecular basis of steroid 5 alpha-reductase deficiency in a large Dominican kindred. N Engl J Med (1992) 1.23
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J Biol Chem (2000) 1.20
Transport-deficient mutations in the low density lipoprotein receptor. Alterations in the cysteine-rich and cysteine-poor regions of the protein block intracellular transport. J Biol Chem (1988) 1.19
The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem (2001) 1.19
Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess. Mol Endocrinol (1997) 1.15
Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase. J Clin Invest (1992) 1.15
mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits. Proc Natl Acad Sci U S A (1987) 1.14
Characterization of Chinese hamster ovary cell lines expressing human steroid 5 alpha-reductase isozymes. J Biol Chem (1993) 1.14