Published in Proc Natl Acad Sci U S A on March 01, 1986
GTP-binding domain: three consensus sequence elements with distinct spacing. Proc Natl Acad Sci U S A (1987) 5.16
Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic. EMBO J (1989) 3.70
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Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A (1986) 2.83
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Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins. Proc Natl Acad Sci U S A (1987) 2.15
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A second form of the beta subunit of signal-transducing G proteins. Proc Natl Acad Sci U S A (1987) 1.21
Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins. Proc Natl Acad Sci U S A (1987) 1.17
Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. Proc Natl Acad Sci U S A (1988) 1.13
Human cancer and cellular oncogenes. Biochem J (1987) 1.07
The Drosophila gene coding for the alpha subunit of a stimulatory G protein is preferentially expressed in the nervous system. Proc Natl Acad Sci U S A (1989) 1.05
Molecular cloning and characterization of cDNA encoding the GTP-binding protein alpha i and identification of a related protein, alpha h. Proc Natl Acad Sci U S A (1986) 1.05
Aberrant transmembrane signal transduction in Dictyostelium cells expressing a mutated ras gene. Proc Natl Acad Sci U S A (1987) 0.99
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GDP stimulates the phosphorylation of a 36-kDa membrane protein in Dictyostelium discoideum. Proc Natl Acad Sci U S A (1989) 0.82
Identification of the probable site of choleragen-catalyzed ADP-ribosylation in a Go alpha-like protein based on cDNA sequence. Proc Natl Acad Sci U S A (1986) 0.81
Diphtheria toxin prevents catecholamine desensitization of A431 human epidermoid carcinoma cells. Proc Natl Acad Sci U S A (1987) 0.78
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In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell (1985) 11.63
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Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell (1984) 6.87
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain. J Biol Chem (1984) 6.58
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Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature (1983) 5.90
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The nucleotide sequence of the cloned tufA gene of Escherichia coli. Gene (1980) 4.17
Homologies between signal transducing G proteins and ras gene products. Science (1984) 3.85
Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase. J Biol Chem (1984) 3.82
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Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors. Nature (1983) 3.21
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1986) 2.87
Sequence of the initiation factor IF2 gene: unusual protein features and homologies with elongation factors. Proc Natl Acad Sci U S A (1984) 2.72
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Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. Science (1985) 2.46
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science (1985) 2.35
Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.34
Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin. J Biol Chem (1984) 2.17
The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins. J Biol Chem (1983) 2.12
GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.09
Expression of chimeric genes in the early region of SV40. J Mol Appl Genet (1983) 1.65
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. J Biol Chem (1983) 1.60
The amino acid sequence of elongation factor Tu of Escherichia coli. The complete sequence. J Biol Chem (1981) 1.33
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The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell (1984) 12.54
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Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem (1989) 11.06
G proteins and dual control of adenylate cyclase. Cell (1984) 11.05
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev (1997) 8.51
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell (1995) 7.66
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain. J Biol Chem (1984) 6.58
The LDL receptor gene: a mosaic of exons shared with different proteins. Science (1985) 5.49
Human genes involved in cholesterol metabolism: chromosomal mapping of the loci for the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA probes. Proc Natl Acad Sci U S A (1985) 5.33
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GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell (1996) 4.76
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell (1997) 4.74
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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science (1998) 4.62
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science (1997) 4.52
Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science (1985) 4.51
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (1994) 4.43
Plasmids for the cloning and expression of full-length double-stranded cDNAs under control of the SV40 early or late gene promoter. Nucleic Acids Res (1983) 4.33
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science (1998) 4.32
Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Cell (1984) 4.21
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev (1998) 4.11
Homologies between signal transducing G proteins and ras gene products. Science (1984) 3.85
The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis. J Biol Chem (1987) 3.84
Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell (1992) 3.81
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Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci U S A (1982) 3.73
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature (1994) 3.54
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. J Biol Chem (1986) 3.54
The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors. Cell (1986) 3.44
The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein. Annu Rev Genet (1990) 3.40
Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia. Cell (1987) 3.31
Purification and characterization of smooth muscle cell caveolae. J Cell Biol (1994) 3.18
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Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem (1983) 3.11
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. J Biol Chem (1982) 3.09
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur J Biochem (1985) 3.04
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Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
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Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1987) 2.93
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Nucleotide sequence of the yeast alcohol dehydrogenase II gene. J Biol Chem (1983) 2.82
Purification of the regulatory component of adenylate cyclase. Proc Natl Acad Sci U S A (1980) 2.81
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science (1986) 2.76
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Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia. J Biol Chem (1987) 2.67
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum. Nature (1984) 2.66
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Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. J Biol Chem (1995) 2.61
Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science (1989) 2.59
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
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Direct and moderating effects of community context on the psychological well-being of African American women. J Pers Soc Psychol (2000) 2.47
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Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. J Biol Chem (1984) 2.43
Mutational analysis of the ligand binding domain of the low density lipoprotein receptor. J Biol Chem (1988) 2.43
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G protein involvement in receptor-effector coupling. J Biol Chem (1988) 2.38
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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A (1999) 2.20
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G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells. Proc Natl Acad Sci U S A (1990) 2.13