Published in Am J Hum Genet on September 01, 1996
Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet (2008) 3.54
Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am J Hum Genet (2002) 2.47
Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region. Arthritis Rheum (2009) 1.87
Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. Mol Med (2008) 1.69
Genetics of rheumatoid arthritis: confronting complexity. Arthritis Res (1999) 1.63
HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis. Ann Rheum Dis (2004) 1.61
Rheumatoid arthritis: a view of the current genetic landscape. Genes Immun (2008) 1.32
The role of genetic factors in autoimmune disease: implications for environmental research. Environ Health Perspect (1999) 1.20
Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk. World J Gastroenterol (2008) 1.06
LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. Immunogenetics (2005) 1.06
Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis. Immunogenetics (2006) 1.00
Differential association of polymorphisms in the TNFalpha region with psoriatic arthritis but not psoriasis. Ann Rheum Dis (2002) 0.96
Potential of ayurgenomics approach in complex trait research: leads from a pilot study on rheumatoid arthritis. PLoS One (2012) 0.96
The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes. Arthritis Res (2000) 0.93
High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations. Rheumatol Int (2008) 0.91
Tumour necrosis factor gene polymorphisms as severity markers in rheumatoid arthritis. Ann Rheum Dis (1999) 0.86
High-density map of short tandem repeats across the human major histocompatibility complex. Immunogenetics (2003) 0.85
Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians. J Gerontol A Biol Sci Med Sci (2010) 0.83
Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis. Ann Rheum Dis (2004) 0.82
Gene expression profiling and network analysis reveals lipid and steroid metabolism to be the most favored by TNFalpha in HepG2 cells. PLoS One (2010) 0.82
Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis. Ann Rheum Dis (2001) 0.82
Gene polymorphisms and pharmacogenetics in rheumatoid arthritis. Curr Genomics (2008) 0.80
Polymorphisms in tumour necrosis factor alpha (TNFalpha) gene in patients with acute pancreatitis. Mediators Inflamm (2010) 0.78
Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature. World J Gastrointest Pathophysiol (2014) 0.76
The role of polymorphism of interleukin-2, -10, -13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis. Postepy Dermatol Alergol (2016) 0.75
Genetic analysis of the 3' untranslated region of the tumour necrosis factor shows a highly conserved region in rheumatoid arthritis affected and unaffected subjects. J Med Genet (1999) 0.75
Characterization of a canine tetranucleotide microsatellite marker located in the first intron of the tumor necrosis factor alpha gene. J Vet Med Sci (2013) 0.75
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet (1993) 51.42
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum (1987) 14.21
MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS. Nature (1964) 13.26
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J (1991) 8.31
Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med (1978) 7.97
Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med (1990) 7.49
Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science (1987) 7.01
Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (1995) 5.26
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum (1993) 5.05
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature (1994) 4.37
Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature (1986) 4.24
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet (1995) 3.87
Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis. Nature (1988) 3.46
The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med (1992) 3.36
HLA class II induction in human islet cells by interferon-gamma plus tumour necrosis factor or lymphotoxin. Nature (1987) 2.96
Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci U S A (1990) 2.88
Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex. Proc Natl Acad Sci U S A (1986) 2.42
TNF alpha--a pivotal role in rheumatoid arthritis? Br J Rheumatol (1992) 2.34
The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat Genet (1995) 2.17
The Arthritis and Rheumatism Council's National Repository of Family Material: pedigrees from the first 100 rheumatoid arthritis families containing affected sibling pairs. Br J Rheumatol (1994) 2.14
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. Eur J Immunol (1993) 1.95
Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis. Proc Natl Acad Sci U S A (1995) 1.85
Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin. J Immunol (1991) 1.73
Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred. Genet Epidemiol (1991) 1.60
Highly informative typing of the human TNF locus using six adjacent polymorphic markers. Genomics (1993) 1.56
Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nat Med (1995) 1.36
The genetic basis of rheumatoid arthritis. The shared epitope hypothesis. Rheum Dis Clin North Am (1992) 1.15
New HLA DNA polymorphisms associated with autoimmune diseases. Nature (1986) 1.11
Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci. Nucleic Acids Res (1990) 1.10
Investigation of the HLA component involved in rheumatoid arthritis (RA) by using the marker association-segregation chi-square (MASC) method: rejection of the unifying-shared-epitope hypothesis. Am J Hum Genet (1993) 1.07
Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6. Gastroenterology (1996) 1.06
Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo. Nat Med (1995) 1.06
Involvement of class II MHC molecules in the LPS-induction of IL-1/TNF secretions by human monocytes. Quantitative differences at the polymorphic level. J Immunol (1989) 1.04
Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype. Hum Mol Genet (1995) 1.04
HLA-linked rheumatoid arthritis. Am J Hum Genet (1994) 1.03
Genetic variability at the human tumor necrosis factor loci. J Immunol (1990) 1.01
A multicase family study of rheumatoid arthritis in south west Ireland. Dis Markers (1986) 0.94
Multiple sclerosis: TNF revisited, with promise. Nat Med (1995) 0.91
HLA class II sequence polymorphisms and susceptibility to rheumatoid arthritis in Greeks. The HLA-DR beta shared-epitope hypothesis accounts for the disease in only a minority of Greek patients. Arthritis Rheum (1992) 0.91
The susceptibility to insulin-dependent diabetes mellitus is associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA-DR3,4 heterozygotes. Immunogenetics (1988) 0.90
The association of DNA variants at or near the IgH locus with rheumatoid arthritis. J Immunogenet (1988) 0.90
The role of T cell receptor beta chain genes in susceptibility to rheumatoid arthritis. Arthritis Rheum (1995) 0.90
Multiplex ARMS-RFLP: a simple and rapid method for HLA-DR4 subtyping. Eur J Immunogenet (1993) 0.83
Variable-constant segment genotype of immunoglobulin kappa is associated with increased risk for rheumatoid arthritis. Arthritis Rheum (1992) 0.81
Effect of introducing antenatal diagnosis on reproductive behaviour of families at risk for thalassaemia major. Br Med J (1980) 5.61
Association of young maternal age with adverse reproductive outcomes. N Engl J Med (1995) 5.56
Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group. Ann Intern Med (1995) 5.18
Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell (1999) 5.01
Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A (1997) 4.89
Cerebral sinovenous thrombosis in children. N Engl J Med (2001) 4.81
Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis (2005) 4.67
Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet (1999) 4.54
Assessing genetic linkage and association with robust components of variance approaches. Ann Hum Genet (1996) 4.41
Unpublished rating scales: a major source of bias in randomised controlled trials of treatments for schizophrenia. Br J Psychiatry (2000) 4.23
mtDNA sequences suggest a recent evolutionary divergence for Beringian and northern North American populations. Am J Hum Genet (1993) 4.18
A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am J Hum Genet (2001) 4.17
A comparison of the genetic infrastructure of the Ye'cuana and the Yanomama: a likelihood analysis of genotypic variation among populations. Genetics (1978) 4.03
Regulation of nitrogen fixation by Rhizobia. Export of fixed N2 as NH+4. Biochim Biophys Acta (1976) 3.83
Evaluating pedigree data. I. The estimation of pedigree error in the presence of marker mistyping. Am J Hum Genet (1983) 3.82
Content and quality of 2000 controlled trials in schizophrenia over 50 years. BMJ (1998) 3.81
Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut (2010) 3.67
The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J Exp Med (1996) 3.56
Estimating substitution rates from molecular data using the coalescent. Proc Natl Acad Sci U S A (1992) 3.48
Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions. Genet Epidemiol (1997) 3.45
Traits of fluorescent Pseudomonas spp. involved in suppression of plant root pathogens. Microbiol Rev (1992) 3.41
Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis? Lancet (1994) 3.22
The retrieval of ancient human DNA sequences. Am J Hum Genet (1996) 3.10
A major lung cancer susceptibility locus maps to chromosome 6q23-25. Am J Hum Genet (2004) 3.05
BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res (2000) 3.01
A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol (1990) 2.98
Anti-neutrophil cytoplasmic antibodies in ulcerative colitis. Comparison with other colitides/diarrheal illnesses. Gastroenterology (1991) 2.93
The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum (1999) 2.92
Pol kappa: A DNA polymerase required for sister chromatid cohesion. Science (2000) 2.92
Costs of an emergency department-based accelerated diagnostic protocol vs hospitalization in patients with chest pain: a randomized controlled trial. JAMA (1997) 2.86
Cytokine gene polymorphism in human disease: on-line databases. Genes Immun (1999) 2.86
Exploitation of gene(s) involved in 2,4-diacetylphloroglucinol biosynthesis to confer a new biocontrol capability to a Pseudomonas strain. Appl Environ Microbiol (1992) 2.78
In vitro selection criteria for probiotic bacteria of human origin: correlation with in vivo findings. Am J Clin Nutr (2001) 2.73
Physicians' perceptions of dysplasia and approaches to surveillance colonoscopy in ulcerative colitis. Am J Gastroenterol (1995) 2.73
Small, stable shuttle vectors based on the minimal pVS1 replicon for use in gram-negative, plant-associated bacteria. Mol Plant Microbe Interact (2000) 2.71
Crohn's disease: factors associated with exposure to high levels of diagnostic radiation. Gut (2008) 2.69
A prospective study of the relationship between specific language impairment, phonological disorders and reading retardation. J Child Psychol Psychiatry (1990) 2.67
The role of a signaling protein in bacterial sensing: behavioral effects of increased gene expression. Proc Natl Acad Sci U S A (1984) 2.59
Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia. J Virol (1991) 2.58
First-trimester fetal diagnosis for haemoglobinopathies: three cases. Lancet (1982) 2.55
High risk of HIV-1 infection for first-born twins. The International Registry of HIV-exposed Twins. Lancet (1991) 2.51
Emergency department treatment of severe asthma. Metered-dose inhaler plus holding chamber is equivalent in effectiveness to nebulizer. Chest (1993) 2.49
Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee. Arthritis Rheum (1993) 2.49
Evaluating pedigree data. II. Identifying the cause of error in families with inconsistencies. Hum Hered (1983) 2.45
Pathways of activation of the Epstein-Barr virus productive cycle. J Virol (1991) 2.42
Admixture studies and the detection of selection. Science (1973) 2.41
Audit of prenatal diagnosis for haemoglobin disorders in the United Kingdom: the first 20 years. BMJ (1997) 2.40
Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. Cancer Res (2001) 2.37
Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. Gut (2003) 2.37
Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut (1993) 2.35
Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. J Natl Cancer Inst (2000) 2.33
The genetic structure of a tribal population, the Yanomama Indians XI. Gene frequencies for 10 blood groups and the ABH-Le secretor traits in the Yanomama and their neighbors; the uniqueness of the tribe. Am J Hum Genet (1975) 2.28
Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome). A Department of Veterans Affairs Cooperative Study. Arthritis Rheum (1996) 2.24
Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients. J Natl Cancer Inst (1998) 2.16
Effect of fetal diagnostic testing on birth-rate of thalassaemia major in Britain. Lancet (1984) 2.16
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry (2012) 2.16
Mutagen sensitivity as a risk factor for second malignant tumors following malignancies of the upper aerodigestive tract. J Natl Cancer Inst (1994) 2.15
Identification of a bacterial sensing protein and effects of its elevated expression. J Bacteriol (1985) 2.14
Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials. Antonie Van Leeuwenhoek (1999) 2.14
Insulin-dependent diabetes mellitus and coeliac disease. Lancet (1997) 2.14
Distinct associations of HLA class II genes with inflammatory bowel disease. Gastroenterology (1993) 2.10
Reduced mtDNA diversity in the Ngöbé Amerinds of Panamá. Genetics (1995) 2.06
Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology (1991) 2.06
Oral mesalamine (Asacol) for mildly to moderately active ulcerative colitis. A multicenter study. Ann Intern Med (1991) 2.03
Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1. Nat Genet (2001) 2.00
Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet (1998) 1.99
Acute melioidosis outbreak in Western Australia. Epidemiol Infect (1999) 1.99
Searching the right database. A comparison of four databases for psychiatry journals. Health Libr Rev (1999) 1.98
Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther (2001) 1.97
Cytokine gene polymorphism in human disease: on-line databases, supplement 1. Genes Immun (2001) 1.94
Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum (1998) 1.93
Village and tribal genetic distances among American Indians, and the possible implications for human evolution. Proc Natl Acad Sci U S A (1970) 1.92
Evaluation of 40 x 22 mm coverslip area in cervical cancer screening. Cytopathology (1998) 1.91
p53 is frequently mutated in Burkitt's lymphoma cell lines. EMBO J (1991) 1.91
Beyond conflict of interest. Sponsored drug trials show more-favourable outcomes. BMJ (1999) 1.86
Quantification of the placebo response in ulcerative colitis. Gastroenterology (1997) 1.86
Mast cell heterogeneity: effects of neuroenteric peptides on histamine release. J Immunol (1985) 1.85
Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis. A Department of Veterans Affairs Cooperative Study. Arthritis Rheum (1996) 1.85
Genetics of type 1 diabetes mellitus. Genes Immun (2002) 1.84
Frequent association of beta-catenin and WT1 mutations in Wilms tumors. Cancer Res (2000) 1.82
B30.2-like domain proteins: update and new insights into a rapidly expanding family of proteins. Mol Biol Evol (1998) 1.82
Benzo[a]pyrene diol epoxide and bleomycin sensitivity and susceptibility to cancer of upper aerodigestive tract. J Natl Cancer Inst (1998) 1.81
Albinism and Hermansky-Pudlak syndrome in Puerto Rico. Bol Asoc Med P R (1990) 1.79
The Fas counterattack in vivo: apoptotic depletion of tumor-infiltrating lymphocytes associated with Fas ligand expression by human esophageal carcinoma. J Immunol (1998) 1.78
Gene frequencies and microdifferentiation among the Makiritare Indians. IV. A comparison of a genetic network with ethnohistory and migration matrices; a new index of genetic isolation. Am J Hum Genet (1970) 1.78
Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development. Proc Natl Acad Sci U S A (1989) 1.77
Relationship between head circumference and height in normal adults and in the nevoid basal cell carcinoma syndrome and neurofibromatosis type I. Am J Med Genet (1991) 1.77
Expression of Fas ligand by human gastric adenocarcinomas: a potential mechanism of immune escape in stomach cancer. Gut (1999) 1.75
Bacterial strain-specific induction of Foxp3+ T regulatory cells is protective in murine allergy models. Clin Exp Allergy (2010) 1.73
Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis. Circulation (1995) 1.73
Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain. J Comp Neurol (1997) 1.72
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. N Engl J Med (1986) 1.70
mtDNA variation in the Chibcha Amerindian Huetar from Costa Rica. Hum Biol (1994) 1.69
TNFRSF1A mutations and autoinflammatory syndromes. Curr Opin Immunol (2000) 1.68
Pulmonary disease during the treatment of rheumatoid arthritis with low dose pulse methotrexate. Semin Arthritis Rheum (1987) 1.68
Multiple sclerosis: updated risks for relatives. Am J Med Genet (1988) 1.67
Fingerprinting bacterial chromosomal DNA with restriction endonuclease EcoRI: comparison of Rhizobium spp. and identification of mutants. Can J Microbiol (1979) 1.67