GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells.

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev (2004) 9.24

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol (2001) 8.03

Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J (1998) 5.96

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol (2000) 5.73

Translational control in the endoplasmic reticulum stress response. J Clin Invest (2002) 4.56

A mitochondrial specific stress response in mammalian cells. EMBO J (2002) 3.95

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. Biochem J (1999) 3.19

Identification of novel stress-induced genes downstream of chop. EMBO J (1998) 2.93

Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells. J Virol (2002) 1.93

CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI. Mol Cell Biol (1999) 1.68

TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. EMBO J (1998) 1.60

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR. Nucleic Acids Res (2001) 1.58

Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders. Sleep Med Rev (2009) 1.27

ER stress and apoptosis: a new mechanism for retinal cell death. Exp Diabetes Res (2011) 1.25

Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells. Oncogene (2006) 1.25

Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153). Biochem J (2003) 1.22

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells. Proc Natl Acad Sci U S A (2007) 1.04

Endoplasmic reticulum stress as a pro-fibrotic stimulus. Biochim Biophys Acta (2012) 1.03

Expression profile of genes regulated by activity of the Na-H exchanger NHE1. BMC Genomics (2004) 0.97

Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis. Am J Pathol (2010) 0.95

Adiponectin protects rat myocardium against chronic intermittent hypoxia-induced injury via inhibition of endoplasmic reticulum stress. PLoS One (2014) 0.92

C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes. Blood (2011) 0.92

Gene trapping identifies transiently induced survival genes during programmed cell death. Genome Biol (2001) 0.92

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. J Cell Sci (2010) 0.92

Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci U S A (1999) 0.91

Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2. J Biol Chem (2015) 0.89

Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells. J Biol Chem (2008) 0.85

Methylation status of DDIT3 gene in chronic myeloid leukemia. J Exp Clin Cancer Res (2010) 0.84

Endoplasmic reticulum stress response in yeast and humans. Biosci Rep (2014) 0.83

A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells. BMC Genomics (2009) 0.82

Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress. Sci Rep (2015) 0.82

Mouse pancreatic islets are resistant to indoleamine 2,3 dioxygenase-induced general control nonderepressible-2 kinase stress pathway and maintain normal viability and function. Am J Pathol (2008) 0.81

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun (2016) 0.81

Cyclophilin B is involved in p300-mediated degradation of CHOP in tumor cell adaptation to hypoxia. Cell Death Differ (2013) 0.80

Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response. Mol Pharmacol (2012) 0.79

Clinical significance of GADD153 expression in stage I non-small cell lung cancer. Oncol Lett (2012) 0.79

Neuregulin 1-Beta cytoprotective role in AML 12 mouse hepatocytes exposed to pentachlorophenol. Int J Environ Res Public Health (2006) 0.78

Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint. Autophagy (2016) 0.76

Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway. Sci Rep (2016) 0.75