Published in Am J Physiol on August 01, 1996
AMPK and PPARdelta agonists are exercise mimetics. Cell (2008) 6.39
Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. J Physiol (2003) 1.78
Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985) (2010) 1.67
Exercise acts as a drug; the pharmacological benefits of exercise. Br J Pharmacol (2012) 1.61
Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol (2005) 1.59
PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab (2010) 1.56
Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol (2006) 1.48
Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia In vivo. J Neurosci (1998) 1.39
Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Mol Cell Biol (2001) 1.38
Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise. Biol Rev Camb Philos Soc (2010) 1.23
GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase. Biochem J (2001) 1.21
Reactive oxygen species: impact on skeletal muscle. Compr Physiol (2011) 1.14
Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery. J Physiol (2009) 1.10
Interaction between signalling pathways involved in skeletal muscle responses to endurance exercise. Pflugers Arch (2006) 1.10
Exercise stimulates the mitogen-activated protein kinase pathway in human skeletal muscle. J Clin Invest (1997) 1.10
Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation. PLoS One (2012) 1.04
Effect of aging on cellular mechanotransduction. Ageing Res Rev (2009) 1.04
Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle. J Physiol (2004) 0.98
Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle. J Physiol (2001) 0.96
Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction. Metabolism (2009) 0.95
Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle. Diabetologia (2014) 0.93
Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice. Pflugers Arch (2005) 0.93
Exercise attenuates the major hallmarks of aging. Rejuvenation Res (2015) 0.87
JNK1 deficiency does not enhance muscle glucose metabolism in lean mice. Biochem Biophys Res Commun (2006) 0.87
Endurance exercise is a leptin signaling mimetic in hypothalamus of Wistar rats. Lipids Health Dis (2011) 0.86
Changes in growth-related kinases in head, neck and limb muscles with age. Exp Gerontol (2010) 0.81
Simultaneous dystrophin and dysferlin deficiencies associated with high-level expression of the coxsackie and adenovirus receptor in transgenic mice. Am J Pathol (2006) 0.80
Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle. J Physiol (2003) 0.80
Resistance exercise, but not endurance exercise, induces IKKβ phosphorylation in human skeletal muscle of training-accustomed individuals. Pflugers Arch (2013) 0.79
Skeletal muscle signaling response to sprint exercise in men and women. Eur J Appl Physiol (2011) 0.79
Diabetes alters contraction-induced mitogen activated protein kinase activation in the rat soleus and plantaris. Exp Diabetes Res (2008) 0.79
Exercise-induced hormesis may help healthy aging. Dose Response (2010) 0.78
Improved insulin sensitivity with calorie restriction does not require reduced JNK1/2, p38, or ERK1/2 phosphorylation in skeletal muscle of 9-month-old rats. Am J Physiol Regul Integr Comp Physiol (2011) 0.78
Role of the cytoskeleton in muscle transcriptional responses to altered use. Physiol Genomics (2013) 0.78
NOX2 Inhibition Impairs Early Muscle Gene Expression Induced by a Single Exercise Bout. Front Physiol (2016) 0.77
Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol (2016) 0.76
Sensitivity of rat soleus muscle to a mechanical stimulus is decreased following hindlimb unweighting. Eur J Appl Physiol (2005) 0.76
Effect of an acute bout of aerobic exercise on chemerin levels in obese adults. Diabetes Metab Syndr (2015) 0.75
The effect of exercise-intensity on skeletal muscle stress kinase and insulin protein signaling. PLoS One (2017) 0.75
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest (1996) 2.98
Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles. Science (2001) 2.73
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev (1999) 2.37
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science (1999) 2.21
Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett (2000) 2.10
Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Diabetes (1997) 2.10
Genetic analysis of enterovirus 71 isolated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998. Virus Res (2000) 1.95
Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes (1990) 1.93
RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol Cell Biol (1995) 1.86
Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology (1998) 1.84
Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol (1996) 1.75
Prevalence of shoulder and upper-limb disorders among workers in the fish-processing industry. Scand J Work Environ Health (1993) 1.67
Divergent functional roles for p90rsk kinase domains. J Biol Chem (1995) 1.66
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem (1999) 1.65
Pathogenesis of carcinoma of the colon and rectum in schistosomiasis japonica: a study on 90 cases. Chin Med J (1965) 1.62
Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. J Biol Chem (1996) 1.62
Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes (1993) 1.60
Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem Biophys Res Commun (1996) 1.53
Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation. J Mol Biol (2000) 1.53
Prenatal and neonatal intussusception. Pediatr Surg Int (1998) 1.50
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. J Clin Invest (1999) 1.50
Risk factors for primary lung cancer among non-smoking women in Taiwan. Int J Epidemiol (1997) 1.48
Ultrasound-guided fluid aspiration and prenatal diagnosis of duplicated hydrometrocolpos with uterus didelphys and septate vagina. Prenat Diagn (1996) 1.47
Hyperglycemia-induced production of acute phase reactants in adipose tissue. J Biol Chem (2001) 1.47
Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem (1996) 1.46
Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem (1997) 1.42
Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms. Diabetologia (1995) 1.40
Comparative sensitivity of alternative single-strand conformation polymorphism (SSCP) methods. Biotechniques (1994) 1.40
Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Mol Cell Biol (2001) 1.38
The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise. J Biol Chem (2001) 1.32
Exercise and insulin cause GLUT-4 translocation in human skeletal muscle. Am J Physiol (1999) 1.30
Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer. Mol Endocrinol (1998) 1.27
Effects of contractile activity on tyrosine phosphoproteins and PI 3-kinase activity in rat skeletal muscle. Am J Physiol (1995) 1.24
Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance. J Clin Endocrinol Metab (1994) 1.24
Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity. J Biol Chem (2001) 1.23
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab (1993) 1.22
Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo. J Immunol (2000) 1.18
Inhibition of adipocyte differentiation by HIV protease inhibitors. J Clin Endocrinol Metab (1999) 1.17
Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action. Endocrinology (1998) 1.16
Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion. Am J Physiol Endocrinol Metab (2000) 1.14
Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. Endocrinology (1991) 1.12
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene. Proc Natl Acad Sci U S A (2000) 1.12
Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology (1993) 1.11
Tattooing as a risk of hepatitis C virus infection. J Med Virol (1992) 1.11
Blood lead levels in Taiwanese adults: distribution and influencing factors. Sci Total Environ (1996) 1.10
Exercise stimulates the mitogen-activated protein kinase pathway in human skeletal muscle. J Clin Invest (1997) 1.10
New approaches in the treatment of type 2 diabetes. Curr Opin Chem Biol (2000) 1.07
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3. Mol Cell Biol (1994) 1.07
Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice. J Biol Chem (1994) 1.05
Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci Total Environ (1996) 1.05
Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms. Diabetes (1991) 1.04
Exercise stimulates c-Jun NH2 kinase activity and c-Jun transcriptional activity in human skeletal muscle. Biochem Biophys Res Commun (1998) 1.03
L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding. J Biol Chem (1999) 1.01
Occupational lead exposure and blood pressure. Int J Epidemiol (1996) 1.01
Contractile activity stimulates the c-Jun NH2-terminal kinase pathway in rat skeletal muscle. J Biol Chem (1997) 1.00
Prospective study of noise exposure during pregnancy on birth weight. Am J Epidemiol (1996) 0.99
Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues. J Clin Invest (1992) 0.99
Overexpression of hexokinase II in transgenic mice. Evidence that increased phosphorylation augments muscle glucose uptake. J Biol Chem (1996) 0.98
Both coactivator LXXLL motif-dependent and -independent interactions are required for peroxisome proliferator-activated receptor gamma (PPARgamma) function. J Biol Chem (2000) 0.98
Mutant insulin receptors in syndromes of insulin resistance. Clin Endocrinol (Oxf) (1992) 0.96
Skeletal muscle contractile activity in vitro stimulates mitogen-activated protein kinase signaling. Am J Physiol (1999) 0.94
Response of sensitive human ataxia and resistant T-1 cell lines to accelerated heavy ions. Br J Cancer Suppl (1984) 0.93
Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia. Endocrinology (1996) 0.93
Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. J Med Chem (2000) 0.92
A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. J Clin Invest (1990) 0.91
Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population. Diabetologia (1992) 0.91
Differential regulation of MAP kinase, p70(S6K), and Akt by contraction and insulin in rat skeletal muscle. Am J Physiol (1999) 0.91
Dilatation of the biliary tree in children: sonographic diagnosis and its clinical significance. J Ultrasound Med (2000) 0.91
Neonatal-onset chronic intestinal pseudo-obstruction syndrome. Clin Pediatr (Phila) (1995) 0.89
Effects of lead and noise exposures on hearing ability. Arch Environ Health (2000) 0.89
Evidence for peroxisome proliferator-activated receptor (PPAR)alpha-independent peroxisome proliferation: effects of PPARgamma/delta-specific agonists in PPARalpha-null mice. Mol Pharmacol (2000) 0.89
A nosocomial outbreak of malaria associated with contaminated catheters and contrast medium of a computed tomographic scanner. Infect Control Hosp Epidemiol (1999) 0.89
A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus. Mol Cell Endocrinol (2000) 0.89
Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators. J Biol Chem (2000) 0.89
Study of noise exposure and high blood pressure in shipyard workers. Am J Ind Med (1987) 0.88
Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation. J Biol Chem (1992) 0.88
Surveillance of noise-induced hearing loss in Taiwan, ROC: a report of the PRESS-NHL results. Prev Med (1998) 0.88
Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activation. Methods (2001) 0.87
Epinephrine and insulin stimulate different mitogen-activated protein kinase signaling pathways in rat skeletal muscle. Diabetes (1998) 0.87
Insulin stimulation of mitogen-activated protein kinase, p90rsk, and p70 S6 kinase in skeletal muscle of normal and insulin-resistant mice. Implications for the regulation of glycogen synthase. J Biol Chem (1995) 0.86
Drastic G2 arrest in mammalian cells after irradiation with heavy-ion beams. Radiat Res (1979) 0.86
Sex hormone-binding globulin mediates prostate androgen receptor action via a novel signaling pathway. Endocrinology (1998) 0.86
Pars plana vitrectomy in the management of paediatric uveitis: the Massachusetts Eye Research and Surgery Institution experience. Eye (Lond) (2010) 0.86
Cell-cycle-dependent recovery from heavy-ion damage in G1-phase cells. Radiat Res Suppl (1985) 0.86
Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. Diabetes (1991) 0.85
A study of the relationship between ambient lead and blood lead among lead battery workers. Int Arch Occup Environ Health (1997) 0.85
Reducing lead exposure by surveillance system: the Taiwan experience. Arch Environ Health (1998) 0.85
Outcomes after surgery in patients with previous stroke. Br J Surg (2014) 0.85
Clinical and perinatal sonographic features of congenital adrenal cystic neuroblastoma: a case report with review of the literature. Ultrasound Obstet Gynecol (1997) 0.85
Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals. Diabetologia (1999) 0.85
Synthesis of a biological active tumor growth factor from the predicted DNA sequence of Shope fibroma virus. Biochemistry (1988) 0.84
Conservative treatment of neonatal hydronephrosis. J Formos Med Assoc (1992) 0.83
Growth and differentiation of human lens epithelial cells in vitro on matrix. Invest Ophthalmol Vis Sci (2000) 0.83
Blood lead levels in the general population of Taiwan, Republic of China. Int Arch Occup Environ Health (1994) 0.83
Aircraft noise, hearing ability, and annoyance. Arch Environ Health (1996) 0.83
Colorectal cancer and schistosomiasis. Lancet (1981) 0.82