Published in J Biol Chem on September 06, 2001
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab (2010) 2.58
The adipocyte as an endocrine cell. Endocrinol Metab Clin North Am (2008) 2.20
The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol (2008) 2.00
Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. CMAJ (2005) 1.90
Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med (2006) 1.81
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
What's new in our understanding of the role of adipokines in rheumatic diseases? Nat Rev Rheumatol (2011) 1.63
The gut microbiota and its relationship to diet and obesity: new insights. Gut Microbes (2012) 1.52
Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota. PLoS One (2009) 1.47
Adipocyte, adipose tissue, and infectious disease. Infect Immun (2006) 1.36
Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue. Diabetes (2011) 1.35
Endothelial activation markers are linked to HIV status and are independent of antiretroviral therapy and lipoatrophy. J Acquir Immune Defic Syndr (2008) 1.25
Vascular biology of metabolic syndrome. J Vasc Surg (2011) 1.21
Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation. J Biol Chem (2010) 1.18
Acute-phase serum amyloid A as a marker of insulin resistance in mice. Exp Diabetes Res (2008) 1.11
Lack of "immunological fitness" during fasting in metabolically challenged animals. J Lipid Res (2012) 1.08
Vascular pathology and blood-brain barrier disruption in cognitive and psychiatric complications of type 2 diabetes mellitus. Cardiovasc Psychiatry Neurol (2011) 1.02
A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance. Am J Physiol Endocrinol Metab (2011) 1.01
Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis (2011) 0.98
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis. J Biol Chem (2011) 0.97
Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2. Br J Pharmacol (2012) 0.95
Is insulin an endogenous cardioprotector? Crit Care (2002) 0.94
Sarcopenic obesity and endocrinal adaptation with age. Int J Endocrinol (2013) 0.91
Serum amyloid A is a growth factor for 3T3-L1 adipocytes, inhibits differentiation and promotes insulin resistance. Int J Obes (Lond) (2011) 0.88
Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? Nutr Metab (Lond) (2009) 0.87
Beyond fat mass: exploring the role of adipokines in rheumatic diseases. ScientificWorldJournal (2011) 0.87
Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice. PLoS One (2014) 0.87
Differential screening identifies transcripts with depot-dependent expression in white adipose tissues. BMC Genomics (2008) 0.85
Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging. Biofactors (2013) 0.84
Microbial regulation of SAA3 expression in mouse colon and adipose tissue. Gut Microbes (2010) 0.83
Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Exp Ther Med (2014) 0.82
Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties. Diabetol Metab Syndr (2014) 0.82
Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling. Am J Transl Res (2012) 0.82
Adipose tissue, diabetes and Chagas disease. Adv Parasitol (2011) 0.81
World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease: part 3. Diabetes Care (2011) 0.78
Adipokines as potential biomarkers in rheumatoid arthritis. Mediators Inflamm (2014) 0.78
Orosomucoid serum concentrations and fat depot-specific mRNA and protein expression in humans. Mol Cells (2011) 0.77
Psychoneuroimmune implications of type 2 diabetes: redux. Immunol Allergy Clin North Am (2009) 0.76
Predictors of limb fat gain in HIV positive patients following a change to tenofovir-emtricitabine or abacavir-lamivudine. PLoS One (2011) 0.75
Effect of Chronic Pioglitazone Treatment on Hepatic Gene Expression Profile in Obese C57BL/6J Mice. Int J Mol Sci (2015) 0.75
Interactions between C-reactive protein genotypes with markers of nutritional status in relation to inflammation. Nutrients (2014) 0.75
Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer--Norfolk study. Cardiovasc Diabetol (2015) 0.75
Localization and possible function of nrF-AGP, an alpha-1-acid glycoprotein-like protein in viviparous fish Neoditrema ransonnetii (Perciformes, Embiotocidae). Fish Physiol Biochem (2014) 0.75
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med (2001) 9.68
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem (1998) 6.26
Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease. J Cell Biol (1994) 5.29
Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol (1994) 4.87
Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol (1999) 4.70
An integrative genomics approach to the reconstruction of gene networks in segregating populations. Cytogenet Genome Res (2004) 4.16
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest (2001) 3.64
Adiponectin--journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med (2005) 3.29
Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J Biol Chem (1994) 3.29
Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem (1997) 3.14
Oligomeric structure of caveolin: implications for caveolae membrane organization. Proc Natl Acad Sci U S A (1995) 3.13
Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem (1996) 3.05
The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol (1998) 3.00
Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest (1996) 2.98
Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J Biol Chem (1996) 2.95
Adiponectin: mechanistic insights and clinical implications. Diabetologia (2012) 2.71
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature (1998) 2.66
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev (1999) 2.37
Overfeeding rapidly induces leptin and insulin resistance. Diabetes (2001) 2.32
Sequential action of mitochondrial chaperones in protein import into the matrix. EMBO J (1991) 2.27
Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science (1999) 2.21
Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett (2000) 2.10
Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Diabetes (1997) 2.10
Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Mol Endocrinol (2000) 2.04
Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1. J Biol Chem (1999) 2.00
Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes (1990) 1.93
The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem (2000) 1.87
RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol Cell Biol (1995) 1.86
Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology (1998) 1.84
Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J Biol Chem (1998) 1.80
Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. J Biol Chem (1999) 1.79
Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis. J Biol Chem (1998) 1.77
Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol (1996) 1.75
Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia (2005) 1.69
Divergent functional roles for p90rsk kinase domains. J Biol Chem (1995) 1.66
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem (1999) 1.65
Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice. Am J Physiol (1995) 1.64
Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. J Biol Chem (1996) 1.62
Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J Clin Invest (1993) 1.61
Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem (1997) 1.61
Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes (1993) 1.60
Caveolae purification and glycosylphosphatidylinositol-linked protein sorting in polarized epithelia. Methods Enzymol (1995) 1.54
Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem Biophys Res Commun (1996) 1.53
Ultrasonography as an aid to diagnosis and treatment in a rural African hospital: a prospective study of 1,119 cases. Am J Trop Med Hyg (1999) 1.53
Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation. J Mol Biol (2000) 1.53
Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation. Int J Obes Relat Metab Disord (2003) 1.53
In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. J Clin Invest (1995) 1.52
Differential gene expression between visceral and subcutaneous fat depots. Horm Metab Res (2003) 1.50
Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem (1995) 1.49
Crowded little caves: structure and function of caveolae. Cell Signal (1998) 1.49
Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest (1997) 1.49
Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. Am J Hum Genet (1998) 1.46
Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem (1996) 1.46
Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia (2005) 1.44
Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem (1997) 1.42
Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms. Diabetologia (1995) 1.40
Comparative sensitivity of alternative single-strand conformation polymorphism (SSCP) methods. Biotechniques (1994) 1.40
Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Mol Cell Biol (2001) 1.38
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab (1991) 1.38
Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. J Clin Invest (1997) 1.37
Caloric restriction, body fat and ageing in experimental models. Obes Rev (2004) 1.37
Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle. Am J Physiol (1996) 1.34
Adipose tissue mass and location affect circulating adiponectin levels. Diabetologia (2011) 1.32
Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Mol Endocrinol (2000) 1.32
Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes. FEBS Lett (1998) 1.31
Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia (2007) 1.29
Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer. Mol Endocrinol (1998) 1.27
Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance. J Clin Endocrinol Metab (1994) 1.24
Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity. J Biol Chem (2001) 1.23
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab (1993) 1.22
Constitutively active mitogen-activated protein kinase kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis. J Biol Chem (1999) 1.21
Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury. Proc Natl Acad Sci U S A (1998) 1.21
The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo. J Biol Chem (1999) 1.20
Caveolae, transmembrane signalling and cellular transformation. Mol Membr Biol (1995) 1.20
Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo. J Immunol (2000) 1.18
Molecular and cellular biology of caveolae paradoxes and plasticities. Trends Cardiovasc Med (1997) 1.18
A role for the caveolin scaffolding domain in mediating the membrane attachment of caveolin-1. The caveolin scaffolding domain is both necessary and sufficient for membrane binding in vitro. J Biol Chem (1999) 1.17
Inhibition of adipocyte differentiation by HIV protease inhibitors. J Clin Endocrinol Metab (1999) 1.17
Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action. Endocrinology (1998) 1.16
The role of fat cell derived peptides in age-related metabolic alterations. Mech Ageing Dev (2001) 1.15
Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity? Int J Obes (Lond) (2005) 1.12
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene. Proc Natl Acad Sci U S A (2000) 1.12
Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. Endocrinology (1991) 1.12
Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology (1993) 1.11
Isolation and haracterization nonconverting mutants of bacteriophage epsilon 34. J Bacteriol (1971) 1.07
New approaches in the treatment of type 2 diabetes. Curr Opin Chem Biol (2000) 1.07
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3. Mol Cell Biol (1994) 1.07
The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake. J Biol Chem (1997) 1.06
Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice. J Biol Chem (1994) 1.05
The road from discovery to clinic: adiponectin as a biomarker of metabolic status. Clin Pharmacol Ther (2009) 1.05
Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. Am J Physiol (1997) 1.04
Metabolically healthy and unhealthy obese--the 2013 Stock Conference report. Obes Rev (2014) 1.04
Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms. Diabetes (1991) 1.04
Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations. Int J Obes (Lond) (2008) 1.03
The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene (1994) 1.03
L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding. J Biol Chem (1999) 1.01