PubRank

J C Hutton

Author PubWeight™ 136.41‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 1997 4.77
2 Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Nature 1988 2.07
3 Insulin release: the fuel hypothesis. Metabolism 1979 1.84
4 Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate. Biochem J 1983 1.65
5 T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature 1990 1.64
6 Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. J Biol Chem 1996 1.64
7 The internal pH and membrane potential of the insulin-secretory granule. Biochem J 1982 1.59
8 The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function. Biochem J 1978 1.52
9 The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events. Diabetologia 1979 1.52
10 Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes 1999 1.52
11 Cathepsin B-related proteases in the insulin secretory granule. J Biol Chem 1984 1.47
12 Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes 1999 1.39
13 Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell. Semin Cell Dev Biol 2000 1.38
14 Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials. Diabetologia 2009 1.37
15 The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets. Eur J Biochem 1978 1.36
16 Isolation and characterisation of insulin secretory granules from a rat islet cell tumour. Diabetologia 1982 1.36
17 Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family. J Biol Chem 1992 1.34
18 The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Biochem J 1987 1.33
19 Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. Biochem J 1989 1.32
20 Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. J Biol Chem 2001 1.28
21 T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet 1991 1.26
22 Dynamics of O2 consumption in rat pancreatic islets. Diabetologia 1980 1.24
23 Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype. Diabetologia 2007 1.23
24 Regulation of calcium fluxes and their regulatory roles in pancreatic islets. Ann N Y Acad Sci 1978 1.23
25 Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera. Biochem J 1998 1.22
26 Global gene expression profiling and histochemical analysis of the developing human fetal pancreas. Diabetologia 2007 1.21
27 Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. J Clin Endocrinol Metab 2010 1.19
28 A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase. Biochem J 1992 1.19
29 Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Diabetes 1996 1.17
30 Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules. Biochem J 1987 1.16
31 Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules. Biochem J 1982 1.15
32 Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. J Mol Endocrinol 2002 1.14
33 Production and characterization of monoclonal antibodies to insulin secretory granule membranes. Biochem J 1987 1.13
34 Isolation and characterization of calmodulin from an insulin-secreting tumour. Biochem J 1981 1.12
35 Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia 2009 1.10
36 The stimulus-secretion coupling of amino acid-induced insulin release: metabolism and cationic effects of leucine. Diabetes 1980 1.10
37 Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. Diabetologia 2008 1.08
38 The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets. Pflugers Arch 1978 1.07
39 IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm. J Comp Neurol 2001 1.07
40 Calcium antagonists and islet function: VII. Effect of calcium deprivation. J Membr Biol 1978 1.07
41 T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. Diabetes 1995 1.05
42 The mechanism of chromogranin A processing. Nature 1987 1.05
43 Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins. Biochem J 1991 1.05
44 Carboxypeptidase activity in the insulin secretory granule. FEBS Lett 1983 1.04
45 The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans. J Biol Chem 1992 1.04
46 Identification of a transferable sorting domain for the regulated pathway in the prohormone convertase PC2. J Biol Chem 1996 1.03
47 Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. Diabetologia 2012 1.03
48 Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. J Clin Invest 1996 1.03
49 Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release. Endocrinology 1980 1.03
50 The stimulus secretion coupling of glucose-induced insulin release. Arch Biochem Biophys 1979 1.03
51 The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets. Biochem J 1979 1.02
52 Secretory granules. Experientia 1984 1.02
53 Insulin secretion by a transplantable rat islet cell tumour. Diabetologia 1981 1.02
54 Ca2+-dependent binding of cytosolic components to insulin-secretory granules results in Ca2+-dependent protein phosphorylation. Biochem J 1983 1.02
55 The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets. Biochim Biophys Acta 1981 1.00
56 Molecular and cellular regulation of prohormone processing. Semin Cell Dev Biol 1998 1.00
57 Cell-specific processing of chromogranin A in endocrine cells of the rat stomach. J Histochem Cytochem 2001 0.98
58 beta-Granins: 21 kDa co-secreted peptides of the insulin granule closely related to adrenal medullary chromogranin A. FEBS Lett 1985 0.97
59 Identification of the region within the neuroendocrine polypeptide 7B2 responsible for the inhibition of prohormone convertase PC2. J Biol Chem 1995 0.97
60 Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas. Diabetologia 2006 0.97
61 Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma. Biochem J 1984 0.97
62 Biosynthesis of insulin secretory granule membrane proteins. Control by glucose. Biochem J 1987 0.97
63 Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin. J Biol Chem 1989 0.96
64 Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene. Diabetes 1999 0.96
65 The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. J Clin Invest 1978 0.96
66 Proprotein-processing endopeptidases of the insulin secretory granule. Enzyme 1991 0.95
67 The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2. Biochem J 1994 0.94
68 Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: correlation with fusion gene expression in the islet-derived betaTC-3 and hamster insulinoma tumor cell lines. Diabetes 2001 0.94
69 Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes. Diabetes 1998 0.94
70 Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes. Diabetologia 2000 0.94
71 Role of microtubules in the synthesis, conversion, and release of (pro)insulin. A biochemical and radioautographic study in rat islets. J Clin Invest 1979 0.93
72 Two proteins act as the IUF1 insulin gene enhancer binding factor. FEBS Lett 1991 0.93
73 An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age. Diabetologia 2011 0.93
74 Involvement of protein kinase C in the phosphorylation of an insulin-granule membrane protein. Biochem J 1984 0.92
75 Calcium-binding proteins and secretion. Cell Calcium 1986 0.92
76 Interaction of branched chain amino acids and keto acids upon pancreatic islet metabolism and insulin secretion. J Biol Chem 1980 0.90
77 The tissue distribution of rat chromogranin A-derived peptides: evidence for differential tissue processing from sequence specific antisera. Histochemistry 1991 0.90
78 A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2. Diabetologia 2006 0.90
79 T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient. Proc Natl Acad Sci U S A 1996 0.89
80 Kinetic analysis of the type-1 proinsulin endopeptidase by a monoclonal antibody-based immunoadsorbent assay. Biochem J 1992 0.89
81 A phogrin-aequorin chimaera to image free Ca2+ in the vicinity of secretory granules. Biochem J 1998 0.89
82 Autoantibodies to protein tyrosine phosphatase-like proteins in type I diabetes. Overlapping specificities to phogrin and ICA512/IA-2. Diabetes 1996 0.89
83 Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients. Clin Exp Immunol 2013 0.88
84 Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue. Biochem J 1999 0.88
85 Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules. J Biol Chem 1989 0.88
86 Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell. Biochem J 1997 0.88
87 Polyol metabolism in monkey-kidney epithelial-cell cultures. Sorbitol synthesis. Eur J Biochem 1974 0.87
88 Ca2+--Calmodulin dependent myosin light-chain phosphorylating activity in insulin-secreting tissues. FEBS Lett 1982 0.87
89 Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia 2007 0.86
90 Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals. Diabetes Metab Res Rev 2011 0.86
91 Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. Biochem Biophys Res Commun 1996 0.85
92 A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells. Diabetes 1996 0.85
93 Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. J Mol Endocrinol 2004 0.85
94 Proinsulin processing in the diabetic Goto-Kakizaki rat. J Endocrinol 2002 0.85
95 The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides. Biochem J 1989 0.85
96 Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. Endocrinology 1991 0.84
97 Pancreatic B-cells secrete a range of novel peptides besides insulin. Biochim Biophys Acta 1984 0.84
98 Radiometric assay for carboxypeptidase H (EC 3.4.17.10) and other carboxypeptidase B-like enzymes. Anal Biochem 1989 0.84
99 Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour. Biochem J 1984 0.84
100 Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells. Diabetologia 1995 0.84
101 Localization of pancreastatin immunoreactivity in porcine endocrine cells. Endocrinology 1988 0.83
102 Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens. Ann N Y Acad Sci 2008 0.83
103 T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse. Diabetes 2001 0.82
104 Argyrophilia and granin (chromogranin/secretogranin) expression in female breast carcinomas. Their relationship to survival and other disease parameters. Am J Surg Pathol 1992 0.82
105 The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans. Mol Cell Endocrinol 1995 0.82
106 Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. J Biol Chem 1993 0.82
107 Pancreatic hormones are expressed on the surfaces of human and rat islet cells through exocytotic sites. Eur J Cell Biol 1989 0.81
108 The stimulus--secretion coupling 4-methyl-2-oxopentanoate-induced insulin release. Biochem J 1979 0.81
109 Chromogranin A and its derived peptides in the rat and porcine gastro-entero-pancreatic system. Expression, localization, and characterization. Adv Exp Med Biol 2000 0.81
110 Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants. Diabetes 1999 0.80
111 Carboxypeptidase E (CPE): immunocytochemical localization in the rat central nervous system and pituitary gland. J Neurosci 1990 0.80
112 Secretagogue-dependent phosphorylation of the insulin granule membrane protein phogrin is mediated by cAMP-dependent protein kinase. J Biol Chem 2001 0.80
113 A rapid, sensitive and versatile two-site immunoradiometric assay for insulin. Mol Cell Endocrinol 1989 0.80
114 Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans. Biochem J 1989 0.80
115 Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system. Histochem Cell Biol 1997 0.79
116 Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2. Biochem J 1995 0.78
117 Sorbitol metabolism in the retina: accumulation of pathway intermediates in streptozotocin induced diabetes in the rat. Aust J Exp Biol Med Sci 1974 0.78
118 The stimulus-secretion coupling of glucose-induced insulin release. XLII. Effects of extracellular pH on insulin release: their dependency on nutrient concentration. Horm Metab Res 1980 0.78
119 Beta-cell reactive T-cell clones from type I diabetes patients are not beta cell specific and recognize multiple antigens. J Autoimmun 1995 0.78
120 Development of a procedure for the direct cloning of T-cell epitopes using bacterial expression systems. J Immunol Methods 1996 0.77
121 5-Hydroxytryptamine transport in cells and secretory granules from a transplantable rat insulinoma. Biochem J 1983 0.77
122 The interplay between metabolic and cationic events in islet cells: coupling factors and feedback mechanisms. Horm Metab Res Suppl 1980 0.77
123 The stimulus-secretion coupling of amino acid-induced insulin release. Synergistic effects of L-glutamine and 2-keto acids upon insulin secretion. Biochim Biophys Acta 1981 0.77
124 Protein tyrosine phosphatase-like proteins: link with IDDM. Diabetes Care 1997 0.77
125 Characterization of the unusual insulin of Psammomys obesus, a rodent with nutrition-induced NIDDM-like syndrome. Diabetes 1997 0.77
126 Evidence for recognition of novel islet T cell antigens by granule-specific T cell lines from new onset type 1 diabetic patients. Clin Exp Immunol 2000 0.76
127 The localisation of sorbitol pathway activity in the rat renal cortex and its relationship to the pathogenesis of the renal complications of diabetes mellitus. Aust J Exp Biol Med Sci 1975 0.76
128 Targeting of a phogrin-green fluorescent protein chimaera to insulin secretory granules of pancreatic beta-cells in transgenic mice. Diabetes Metab 2002 0.76
129 Nucleotide and bivalent cation specificity of the insulin-granule proton translocase. Biochem J 1983 0.76
130 In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions. Diabetologia 2013 0.75
131 The failure of aldose reductase inhibitor 3,3'-tetramethylene glutaric acid to inhibit in vivo sorbitol accumulation in lens and retina in diabetes. Biochem Pharmacol 1974 0.75
132 Th1-like cytokine production profile and individual specific alterations in TCRBV-gene usage of T cells from newly diagnosed type 1 diabetes patients after stimulation with beta-cell antigens. J Autoimmun 1997 0.75
133 Metabolic sensitivity of Fasciola hepatica to mammalian hormones in vitro. Comp Biochem Physiol B 1972 0.75
134 Localisation of islet amyloid polypeptide and its carboxy terminal flanking peptide in islets of diabetic man and monkey. Diabetologia 1991 0.75
135 The effect of an unsaturated-fat diet on cataract formation in streptozotocin-induced diabetic rats. Br J Nutr 1976 0.75
136 Relationship of endogenous to dietary sorbitol. A study in normal and diabetic rats. Diabete Metab 1979 0.75
137 Fuel and signal function of 2-keto acids in insulin secretion. Horm Metab Res Suppl 1980 0.75
138 [Biogenesis of the insulin secretion granule]. Journ Annu Diabetol Hotel Dieu 1989 0.75
139 Osmotic effects of sorbitol accumulation in monkey kidney epithelial cell cultures. Aust J Biol Sci 1975 0.75
140 The insulin secretory granule: features and functions in common with other endocrine granules. Adv Exp Med Biol 1986 0.75