Published in Curr Opin Immunol on August 01, 1996
Mitochondrial dysfunction in ataxia-telangiectasia. Blood (2011) 1.93
Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells. Mol Biol Cell (2000) 1.54
ATM-heterozygous germline mutations contribute to breast cancer-susceptibility. Am J Hum Genet (2000) 1.42
EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci (2013) 1.06
Deficiencies in CD4+ and CD8+ T cell subsets in ataxia telangiectasia. Clin Exp Immunol (2002) 0.98
KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion. Proc Natl Acad Sci U S A (1998) 0.82
Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia. Clin Exp Immunol (2001) 0.80
Induction and characterization of human glioma clones with different radiosensitivities. Neoplasia (1999) 0.79
Spontaneous and oxidative stress-induced programmed cell death in lymphocytes from patients with ataxia telangiectasia (AT). Clin Exp Immunol (2000) 0.79
Population and allelic variation of A-to-I RNA editing in human transcriptomes. Genome Biol (2017) 0.75
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell (1996) 10.40
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A (2000) 5.64
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell (1995) 4.34
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature (2000) 3.96
The genetic defect in ataxia-telangiectasia. Annu Rev Immunol (1997) 3.69
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum Mol Genet (1995) 3.05
Recombinant ATM protein complements the cellular A-T phenotype. Oncogene (1997) 2.95
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
Interaction between ATM protein and c-Abl in response to DNA damage. Nature (1997) 2.70
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature (2000) 2.44
Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem (2001) 2.43
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J Biol Chem (2000) 2.42
ATM: a mediator of multiple responses to genotoxic stress. Oncogene (1999) 2.06
Predominance of null mutations in ataxia-telangiectasia. Hum Mol Genet (1996) 2.06
Fragments of ATM which have dominant-negative or complementing activity. Mol Cell Biol (1997) 1.99
ATM: from gene to function. Hum Mol Genet (1998) 1.97
The ATM gene and the radiobiology of ataxia-telangiectasia. Int J Radiat Biol (1996) 1.70
Ataxia-telangiectasia: linkage analysis in highly inbred Arab and Druze families and differentiation from an ataxia-microcephaly-cataract syndrome. Hum Genet (1992) 1.68
Characterization of ATM gene mutations in 66 ataxia telangiectasia families. Hum Mol Genet (1999) 1.66
ATM binds to beta-adaptin in cytoplasmic vesicles. Proc Natl Acad Sci U S A (1998) 1.63
Genotype-phenotype relationships in ataxia-telangiectasia and variants. Am J Hum Genet (1998) 1.55
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol (2001) 1.54
Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. Cancer Res (2001) 1.46
Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues. Cancer Res (1988) 1.45
Relatively low proportion of dystrophin gene deletions in Israeli Duchenne and Becker muscular dystrophy patients. Am J Med Genet (1994) 1.44
Ataxia-telangiectasia: mutations in ATM cDNA detected by protein-truncation screening. Am J Hum Genet (1996) 1.43
The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. Proc Natl Acad Sci U S A (1997) 1.39
Duchenne muscular dystrophy and idiopathic hyperCKemia segregating in a family. Am J Med Genet (1995) 1.39
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium. Am J Hum Genet (1991) 1.34
Genomic Organization of the ATM gene. Genomics (1996) 1.32
Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue. Oncogene (2006) 1.29
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks. J Biol Chem (2000) 1.29
Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress? Bioessays (1997) 1.27
Definition and refinement of chromosome 11 regions of loss of heterozygosity in breast cancer: identification of a new region at 11q23.3. Cancer Res (1995) 1.26
Differential amplification, assembly, and relocation of multiple DNA sequences in human neuroblastomas and neuroblastoma cell lines. Proc Natl Acad Sci U S A (1985) 1.23
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem (2001) 1.22
Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene. Genome Res (1997) 1.19
The ATC (ataxia-telangiectasia complementation group C) locus localizes to 11q22-q23. Genomics (1991) 1.11
A single origin of phenylketonuria in Yemenite Jews. Nature (1990) 1.11
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene (2001) 1.09
Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36. Hum Genet (1986) 1.09
Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase. Trends Biochem Sci (1995) 1.06
Loss of heterozygosity at 11q23.1 in breast carcinomas: indication for involvement of a gene distal and close to ATM. Genes Chromosomes Cancer (1997) 1.05
The ATM gene and protein: possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress. Cancer Surv (1997) 1.05
Ataxia-telangiectasia: founder effect among north African Jews. Hum Mol Genet (1996) 1.05
Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression. Nucleic Acids Res (1997) 1.04
Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. Cancer Res (1999) 1.03
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. Genomics (1996) 1.02
Abnormal response of ataxia-telangiectasia cells to agents that break the deoxyribose moiety of DNA via a targeted free radical mechanism. Carcinogenesis (1983) 1.02
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents. Cancer Res (1981) 1.01
Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice. Proc Natl Acad Sci U S A (1998) 1.01
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics (1996) 0.99
Amplification of c-myc and c-erbB-2 proto-oncogenes in human solid tumors: frequency and clinical significance. Int J Cancer (1989) 0.98
Induction and repair of DNA damage in normal and ataxia-telangiectasia skin fibroblasts treated with neocarzinostatin. Carcinogenesis (1983) 0.97
Detection of ataxia telangiectasia heterozygous cell lines by postirradiation cumulative labeling index: measurements with coded samples. Cancer Res (1987) 0.97
Physical localization of microsatellite markers at the ataxia-telangiectasia locus at 11q22-q23. Genomics (1994) 0.97
Genetic haplotyping of ataxia-telangiectasia families localizes the major gene to an approximately 850 kb region on chromosome 11q23.1. Int J Radiat Biol (1994) 0.96
Rapid cloning of multiple amplified nucleotide sequences from human neuroblastoma cell lines by phenol emulsion competitive DNA reassociation. Gene (1987) 0.95
A high-density microsatellite map of the ataxia-telangiectasia locus. Hum Genet (1995) 0.95
Many faces of ATM: eighth international workshop on ataxia-telangiectasia. Biochim Biophys Acta (1999) 0.95
Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene (2001) 0.94
A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia. Genomics (1994) 0.93
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype. Cancer Res (2001) 0.92
Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells. J Biol Chem (1997) 0.92
Identification of ATM mutations using extended RT-PCR and restriction endonuclease fingerprinting, and elucidation of the repertoire of A-T mutations in Israel. Hum Mutat (1998) 0.92
Colony-forming ability of ataxia-telangiectasia skin fibroblasts is an indicator of their early senescence and increased demand for growth factors. Exp Cell Res (1982) 0.91
The response of ataxia-telangiectasia homozygous and heterozygous skin fibroblasts to neocarzinostatin. Carcinogenesis (1982) 0.90
Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas. Cancer Res (1986) 0.90
Novel DNA sequences at chromosome 10q26 are amplified in human gastric carcinoma cell lines: molecular cloning by competitive DNA reassociation. Nucleic Acids Res (1991) 0.89
Cellular and molecular characteristics of an immortalized ataxia-telangiectasia (group AB) cell line. Cancer Res (1989) 0.88
A haplotype common to intermediate radiosensitivity variants of ataxia-telangiectasia in the UK. Int J Radiat Biol (1994) 0.88
Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells. Somat Cell Mol Genet (1995) 0.87
Expression and assay of recombinant ATM. Methods Mol Biol (2000) 0.87
Ataxia-telangiectasia: linkage evidence for genetic heterogeneity. Am J Hum Genet (1992) 0.86
Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice. EMBO J (2001) 0.85
Repair of potentially lethal and sublethal damage induced by neocarzinostatin in normal and ataxia-telangiectasia skin fibroblasts. Biochem Biophys Res Commun (1983) 0.84
An improved technique of preparing bone-marrow specimens for cytogenetic analysis. In Vitro (1978) 0.84
Physical and genetic mapping at the ATA/ATC locus on chromosome 11q22-23. Int J Radiat Biol (1994) 0.84
Detection of amplified DNA sequences in human tumor cell lines by fluorescence in situ hybridization. Genes Chromosomes Cancer (1992) 0.83
Three dinucleotide repeat polymorphisms at the ataxia-telangiectasia locus. Hum Mol Genet (1994) 0.83
Compound heterozygosity in nonphenylketonuria hyperphenylalanemia: the contribution of mutations for classical phenylketonuria. Am J Hum Genet (1991) 0.82
A YAC contig spanning the ataxia-telangiectasia locus (groups A and C) at 11q22-q23. Genomics (1994) 0.82
Molecular and cytologic analysis of DNA amplification in retinoblastoma. Cancer Genet Cytogenet (1985) 0.82
The human T cell antigen Leu-2 (T8) is encoded on chromosome 2. Hum Genet (1985) 0.82
Carrier detection in ataxia-telangiectasia. Lancet (1986) 0.81
Defective potassium currents in ataxia telangiectasia fibroblasts. Genes Dev (1998) 0.81
Paired STSs amplified from radiation hybrids, and from associated YACs, identify highly polymorphic loci flanking the ataxia telangiectasia locus on chromosome 11q22-23. Hum Mol Genet (1993) 0.80
Absence of mutations in ATM, the gene responsible for ataxia telangiectasia in patients with cerebellar ataxia. J Neurol (1999) 0.80
Medical genetics in Israel. J Med Genet (1989) 0.80
Targeting double-strand breaks to replicating DNA identifies a subpathway of DSB repair that is defective in ataxia-telangiectasia cells. Biochem Biophys Res Commun (1999) 0.80
Reduced inhibition of replicon initiation and chain elongation by neocarzinostatin in skin fibroblasts from patients with ataxia telangiectasia. Biochim Biophys Acta (1982) 0.79
A defective splice site at the phenylalanine hydroxylase gene in phenylketonuria and benign hyperphenylalaninemia among Palestinian Arabs. Hum Mutat (1992) 0.79
Rapamycin resistance in ataxia-telangiectasia. Oncogene (1996) 0.79
Origins of hyperphenylalaninemia in Israel. Eur J Hum Genet (1994) 0.79
DNA amplification in human gastric carcinomas. Cancer Genet Cytogenet (1993) 0.78
DNA-based detection of chromosome deletion and amplification: diagnostic and mechanistic significance. Cold Spring Harb Symp Quant Biol (1986) 0.78
In vitro phenotype of ataxia-telangiectasia (AT) fibroblast strains: clues to the nature of the "AT DNA lesion" and the molecular defect in AT. Kroc Found Ser (1985) 0.77