Published in Structure on January 15, 1996
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Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc Natl Acad Sci U S A (1998) 2.98
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The same two monomers within a MuA tetramer provide the DDE domains for the strand cleavage and strand transfer steps of transposition. EMBO J (1998) 1.16
An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA. J Virol (2003) 1.16
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Molecular dynamics studies on the HIV-1 integrase catalytic domain. Biophys J (1999) 1.06
Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis. J Virol (1999) 1.00
Transposase makes critical contacts with, and is stimulated by, single-stranded DNA at the P element termini in vitro. EMBO J (1998) 0.98
Role of metal ions in catalysis by HIV integrase analyzed using a quantitative PCR disintegration assay. Nucleic Acids Res (2006) 0.95
Isolation and characterization of Tn7 transposase gain-of-function mutants: a model for transposase activation. EMBO J (2000) 0.95
Biochemical and random mutagenesis analysis of the region carrying the catalytic E152 amino acid of HIV-1 integrase. Nucleic Acids Res (2004) 0.90
Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking. J Biol Chem (2011) 0.90
Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/M154I catalytic domain. Biophys J (2005) 0.88
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Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody. Retrovirology (2006) 0.84
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Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase. J Biomol NMR (2000) 0.82
Patterns of sequence conservation at termini of long terminal repeat (LTR) retrotransposons and DNA transposons in the human genome: lessons from phage Mu. Nucleic Acids Res (2003) 0.81
Metal cofactors in the structure and activity of the fowlpox resolvase. J Mol Biol (2010) 0.81
Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase {alpha}4 helix. Nucleic Acids Res (2009) 0.81
Evolution of the genetic code by incorporation of amino acids that improved or changed protein function. J Mol Evol (2013) 0.81
Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors. Antimicrob Agents Chemother (2005) 0.80
An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF. PLoS One (2009) 0.79
A crystal structure of the catalytic core domain of an avian sarcoma and leukemia virus integrase suggests an alternate dimeric assembly. PLoS One (2011) 0.79
Unprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravir. PLoS One (2012) 0.76
Structural studies of the catalytic core of the primate foamy virus (PFV-1) integrase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.76
Retroviral integrase protein and intasome nucleoprotein complex structures. World J Biol Chem (2017) 0.75
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Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease. Science (1989) 7.15
The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol (1989) 6.83
Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases. Mol Cell Biol (1992) 6.77
Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31
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Nucleotide sequence analysis of the long terminal repeat (LTR) of avian retroviruses: structural similarities with transposable elements. Cell (1980) 3.53
Control of retroviral RNA splicing through maintenance of suboptimal processing signals. Mol Cell Biol (1990) 3.18
Nucleotide sequence of acceptor site and termini of integrated avian endogenous provirus ev1: integration creates a 6 bp repeat of host DNA. Cell (1981) 3.10
HTLV-III gag protein is processed in yeast cells by the virus pol-protease. Science (1986) 3.06
Catalytic triads and their relatives. Trends Biochem Sci (1998) 3.06
Restriction endonuclease and nucleotide sequence analyses of molecularly cloned unintegrated avian tumor virus DNA: structure of large terminal repeats in circle junctions. J Virol (1982) 3.02
The structural basis for spectral variations in green fluorescent protein. Nat Struct Biol (1997) 2.79
Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution. Science (1989) 2.74
Crystal structure of a retroviral protease proves relationship to aspartic protease family. Nature (1989) 2.72
Nucleotide sequence of noncoding regions in Rous-associated virus-2: comparisons delineate conserved regions important in replication and oncogenesis. J Virol (1984) 2.71
A role for DNA-PK in retroviral DNA integration. Science (1999) 2.68
Avian sarcoma and leukosis virus pol-endonuclease recognition of the tandem long terminal repeat junction: minimum site required for cleavage is also required for viral growth. J Virol (1987) 2.62
The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA. Genes Dev (1991) 2.58
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Retroviral integrase functions as a multimer and can turn over catalytically. J Biol Chem (1992) 2.48
New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature (1991) 2.47
Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. I. Kinetics of synthesis and size of minus- and plus-strand transcripts. J Virol (1981) 2.45
Selective cleavage in the avian retroviral long terminal repeat sequence by the endonuclease associated with the alpha beta form of avian reverse transcriptase. Proc Natl Acad Sci U S A (1983) 2.40
Retroviral DNA H structures: displacement-assimilation model of recombination. Cell (1982) 2.37
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Site-directed mutagenesis of the avian retrovirus nucleocapsid protein, pp 12. Mutation which affects RNA binding in vitro blocks viral replication. J Biol Chem (1988) 2.25
High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J Mol Biol (1995) 2.16
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Endogenous avian retroviruses contain deficient promoter and leader sequences. Proc Natl Acad Sci U S A (1983) 1.90
Sequence comparison in the crossover region of an oncogenic avian retrovirus recombinant and its nononcogenic parent: genetic regions that control growth rate and oncogenic potential. Mol Cell Biol (1982) 1.89
cis-acting intron mutations that affect the efficiency of avian retroviral RNA splicing: implication for mechanisms of control. J Virol (1988) 1.88
Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. II. Evidence for a strand displacement mechanism in plus-strand synthesis. J Virol (1981) 1.87
Proteolytic processing of avian sarcoma and leukosis viruses pol-endo recombinant proteins reveals another pol gene domain. J Virol (1987) 1.85
Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons. Proc Natl Acad Sci U S A (1986) 1.83
Comparison between the viral transforming gene (src) of recovered avian sarcoma virus and its cellular homolog. Mol Cell Biol (1981) 1.78
Comparison of two highly refined structures of bovine pancreatic trypsin inhibitor. J Mol Biol (1987) 1.77
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Concerted integration of linear retroviral DNA by the avian sarcoma virus integrase in vitro: dependence on both long terminal repeat termini. J Virol (1996) 1.72
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Retroviral DNA integration and the DNA damage response. Cell Death Differ (2005) 1.63
A covalent complex between retroviral integrase and nicked substrate DNA. Proc Natl Acad Sci U S A (1991) 1.61
Molecular modeling of the HIV-1 protease and its substrate binding site. Science (1989) 1.60
The refined crystal structure of ribonuclease A at 2.0 A resolution. J Biol Chem (1982) 1.58
Retroviral integrase, putting the pieces together. J Biol Chem (1996) 1.58
Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping. J Mol Biol (1999) 1.57
Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy. Proc Natl Acad Sci U S A (1993) 1.56
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. Structure (1995) 1.54
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Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses. Mol Cell Biol (2001) 1.53
Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase. J Virol (1996) 1.50
Assembly and processing of avian retroviral gag polyproteins containing linked protease dimers. J Virol (1991) 1.48
Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor. Biochemistry (1991) 1.48
Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J Biol Chem (1997) 1.47
Products of reverse transcription in avian retrovirus analyzed by electron microscopy. J Virol (1982) 1.47
Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control. Mol Cell Biol (1986) 1.47
Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: in vitro activities and incorporation of a fusion protein into viral particles. Virology (1996) 1.45
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Comparison of the substrate-binding pockets of the Rous sarcoma virus and human immunodeficiency virus type 1 proteases. J Biol Chem (1993) 1.40
The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant. FEBS Lett (1996) 1.39