Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases.

PubWeight™: 6.77‹?› | Rank: Top 1%

🔗 View Article (PMC 364405)

Published in Mol Cell Biol on May 01, 1992

Authors

J Kulkosky1, K S Jones, R A Katz, J P Mack, A M Skalka

Author Affiliations

1: Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111.

Articles citing this

(truncated to the top 100)

Insertion sequences. Microbiol Mol Biol Rev (1998) 14.03

Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J Virol (1992) 6.07

A purified mariner transposase is sufficient to mediate transposition in vitro. EMBO J (1996) 5.34

Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. EMBO J (1993) 4.39

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol (1995) 4.27

Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding. Proc Natl Acad Sci U S A (1993) 3.99

Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells. J Virol (1992) 3.85

Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection. EMBO J (2001) 3.60

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells. J Virol (1995) 3.56

Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein. Nucleic Acids Res (1993) 3.42

Complementation between HIV integrase proteins mutated in different domains. EMBO J (1993) 3.32

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc Natl Acad Sci U S A (2000) 3.26

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J (2001) 3.23

A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a common "D35E" motif. Proc Natl Acad Sci U S A (1994) 3.07

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase. Proc Natl Acad Sci U S A (2000) 3.00

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc Natl Acad Sci U S A (1998) 2.98

Transposon Tn5090 of plasmid R751, which carries an integron, is related to Tn7, Mu, and the retroelements. J Bacteriol (1994) 2.97

Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction. EMBO J (1998) 2.84

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design. Proc Natl Acad Sci U S A (1999) 2.69

The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. J Virol (1994) 2.56

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity. Proc Natl Acad Sci U S A (1996) 2.46

Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. J Virol (1995) 2.43

Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J (1997) 2.42

Cloning of a new murine endogenous retrovirus, MuERV-L, with strong similarity to the human HERV-L element and with a gag coding sequence closely related to the Fv1 restriction gene. J Virol (1997) 2.35

Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication. J Virol (2002) 2.32

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev (1999) 2.28

Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain. J Virol (1995) 2.22

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A (2010) 2.16

Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex. J Virol (1999) 2.16

Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues. Proc Natl Acad Sci U S A (1995) 2.09

Functional and structural characterization of the integrase from the prototype foamy virus. Nucleic Acids Res (2008) 2.07

Characterization of the minimal DNA-binding domain of the HIV integrase protein. Nucleic Acids Res (1994) 1.98

Identification of residues in the Mu transposase essential for catalysis. Proc Natl Acad Sci U S A (1994) 1.94

Inhibitors of human immunodeficiency virus integrase. Proc Natl Acad Sci U S A (1993) 1.91

Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol (2011) 1.87

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues. J Virol (1994) 1.84

Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis. Nucleic Acids Res (1993) 1.79

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA. EMBO J (1997) 1.75

The Tn7 transposase is a heteromeric complex in which DNA breakage and joining activities are distributed between different gene products. EMBO J (1996) 1.74

HIV DNA integration. Cold Spring Harb Perspect Med (2012) 1.73

Genetic analysis of homomeric interactions of human immunodeficiency virus type 1 integrase using the yeast two-hybrid system. Proc Natl Acad Sci U S A (1993) 1.65

Retroviral DNA integration. Microbiol Mol Biol Rev (1999) 1.64

Isolation of novel human endogenous retrovirus-like elements with foamy virus-related pol sequence. J Virol (1995) 1.62

Penelope, a new family of transposable elements and its possible role in hybrid dysgenesis in Drosophila virilis. Proc Natl Acad Sci U S A (1997) 1.58

Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: critical residues for protein oligomerization and DNA binding. J Virol (1998) 1.58

Functional analysis of insertion sequence ISAba1, responsible for genomic plasticity of Acinetobacter baumannii. J Bacteriol (2009) 1.57

Directed integration of viral DNA mediated by fusion proteins consisting of human immunodeficiency virus type 1 integrase and Escherichia coli LexA protein. J Virol (1996) 1.55

Tc1 transposase of Caenorhabditis elegans is an endonuclease with a bipartite DNA binding domain. EMBO J (1994) 1.54

Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells. J Virol (2000) 1.53

Isolation of a novel IS3 group insertion element and construction of an integration vector for Lactobacillus spp. J Bacteriol (1994) 1.52

Revised nomenclature for transposable genetic elements. Plasmid (2008) 1.50

Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase. J Virol (1996) 1.50

3'-processing and strand transfer catalysed by retroviral integrase in crystallo. EMBO J (2012) 1.49

Complementation of integrase function in HIV-1 virions. EMBO J (1997) 1.46

Substrate features important for recognition and catalysis by human immunodeficiency virus type 1 integrase identified by using novel DNA substrates. J Virol (1994) 1.45

Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation. J Virol (1998) 1.44

Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication. J Virol (1996) 1.44

Specific and independent recognition of U3 and U5 att sites by human immunodeficiency virus type 1 integrase in vivo. J Virol (1998) 1.42

Nuclear landscape of HIV-1 infection and integration. Nat Rev Microbiol (2016) 1.41

Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzyme-substrate interactions. J Virol (1998) 1.40

Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA. Nucleic Acids Res (1994) 1.40

Conjugative transposition: Tn916 integrase contains two independent DNA binding domains that recognize different DNA sequences. EMBO J (1994) 1.38

Structural biology of retroviral DNA integration. Virology (2011) 1.37

Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with those of closely related Bacillus species. J Bacteriol (2008) 1.37

Mutations in the mariner transposase: the D,D(35)E consensus sequence is nonfunctional. Proc Natl Acad Sci U S A (1997) 1.37

Novel mouse type D endogenous proviruses and ETn elements share long terminal repeat and internal sequences. J Virol (2000) 1.36

Organization and dynamics of the Mu transpososome: recombination by communication between two active sites. Genes Dev (1999) 1.36

Activities of the feline immunodeficiency virus integrase protein produced in Escherichia coli. J Virol (1994) 1.35

Integrating prokaryotes and eukaryotes: DNA transposases in light of structure. Crit Rev Biochem Mol Biol (2010) 1.35

Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases. J Virol (1997) 1.34

Endonucleolytic cleavages and DNA-joining activities of the integration protein of human foamy virus. J Virol (1993) 1.33

Integrase mutants of human immunodeficiency virus type 1 with a specific defect in integration. J Virol (1994) 1.33

A Ty1 integrase nuclear localization signal required for retrotransposition. Mol Cell Biol (1998) 1.31

DNA binding induces dissociation of the multimeric form of HIV-1 integrase: a time-resolved fluorescence anisotropy study. Proc Natl Acad Sci U S A (2001) 1.31

Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase. J Virol (2005) 1.30

Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediate. J Virol (2007) 1.30

Inhibitors of HIV-1 replication [corrected; erratum to be published] that inhibit HIV integrase. Proc Natl Acad Sci U S A (1996) 1.28

Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase. J Virol (2005) 1.28

Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase. J Virol (1997) 1.27

Analysis of natural sequence variation and covariation in human immunodeficiency virus type 1 integrase. J Virol (2008) 1.27

Identification of amino acids in HIV-2 integrase involved in site-specific hydrolysis and alcoholysis of viral DNA termini. Nucleic Acids Res (1993) 1.27

Role of the His-Cys finger of Moloney murine leukemia virus integrase protein in integration and disintegration. J Virol (1993) 1.25

Mutational analysis of the adeno-associated virus Rep68 protein: identification of critical residues necessary for site-specific endonuclease activity. J Virol (1997) 1.24

The ORF1 protein encoded by LINE-1: structure and function during L1 retrotransposition. J Biomed Biotechnol (2006) 1.22

Site-specific insertion of IS1301 and distribution in Neisseria meningitidis strains. J Bacteriol (1996) 1.21

Requirement for a conserved serine in both processing and joining activities of retroviral integrase. Proc Natl Acad Sci U S A (1992) 1.20

Retroviral integrase proteins and HIV-1 DNA integration. J Biol Chem (2012) 1.20

Folding of the multidomain human immunodeficiency virus type-I integrase. Protein Sci (1994) 1.20

Assembly and catalytic properties of retrovirus integrase-DNA complexes capable of efficiently performing concerted integration. J Virol (1995) 1.19

Mapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases. J Virol (1995) 1.19

Human endogenous retrovirus K10 encodes a functional integrase. J Virol (1996) 1.16

Factors responsible for target site selection in Tn10 transposition: a role for the DDE motif in target DNA capture. EMBO J (1997) 1.16

An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA. J Virol (2003) 1.16

Bacterial interspersed mosaic elements (BIMEs) are a major source of sequence polymorphism in Escherichia coli intergenic regions including specific associations with a new insertion sequence. Genetics (1997) 1.16

Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. J Virol (1998) 1.15

Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids. J Virol (1999) 1.14

The application of a homologous recombination assay revealed amino acid residues in an LTR-retrotransposon that were critical for integration. J Virol (1998) 1.13

Alpha3, a transposable element that promotes host sexual reproduction. Genes Dev (2009) 1.12

Amino acid sequence homology between Piv, an essential protein in site-specific DNA inversion in Moraxella lacunata, and transposases of an unusual family of insertion elements. J Bacteriol (1994) 1.12

IS4 family goes genomic. BMC Evol Biol (2008) 1.09

Articles cited by this

A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res (1984) 181.98

Correct integration of retroviral DNA in vitro. Cell (1987) 10.73

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99

A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev (1989) 8.80

Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc Natl Acad Sci U S A (1989) 8.13

Unified approach to alignment and phylogenies. Methods Enzymol (1990) 7.29

The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell (1990) 7.19

Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism. EMBO J (1991) 7.16

Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes. Proc Natl Acad Sci U S A (1986) 6.94

Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity. Proc Natl Acad Sci U S A (1990) 6.85

The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol (1989) 6.83

HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell (1991) 6.54

Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence. Cell (1989) 6.04

Retroviral DNA integration directed by HIV integration protein in vitro. Science (1990) 5.87

Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science (1991) 5.42

Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res (1991) 4.39

Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein. Science (1990) 3.77

Tn552, a novel transposable element from Staphylococcus aureus. Mol Microbiol (1990) 3.73

Functional similarities between retroviruses and the IS3 family of bacterial insertion sequences? Mol Microbiol (1990) 3.08

The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction. EMBO J (1991) 3.00

Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein. Nucleic Acids Res (1991) 2.93

Mechanism of bacteriophage mu transposition. Annu Rev Genet (1986) 2.26

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis. J Biol Chem (1990) 2.12

Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins. Virology (1985) 2.07

Properties of avian sarcoma-leukosis virus pp32-related pol-endonucleases produced in Escherichia coli. J Virol (1988) 2.03

Pilin expression in Neisseria gonorrhoeae is under both positive and negative transcriptional control. EMBO J (1988) 1.88

A covalent complex between retroviral integrase and nicked substrate DNA. Proc Natl Acad Sci U S A (1991) 1.61

HIV DNA integration: observations and interferences. J Acquir Immune Defic Syndr (1990) 1.54

Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase. Biochemistry (1988) 1.19

Articles by these authors

The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell (1990) 7.19

The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol (1989) 6.83

Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31

Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res (1991) 4.39

The retroviral enzymes. Annu Rev Biochem (1994) 4.21

A conserved cis-acting sequence in the 5' leader of avian sarcoma virus RNA is required for packaging. J Virol (1986) 3.95

Nucleotide sequence analysis of the long terminal repeat (LTR) of avian retroviruses: structural similarities with transposable elements. Cell (1980) 3.53

Control of retroviral RNA splicing through maintenance of suboptimal processing signals. Mol Cell Biol (1990) 3.18

Nucleotide sequence of acceptor site and termini of integrated avian endogenous provirus ev1: integration creates a 6 bp repeat of host DNA. Cell (1981) 3.10

HTLV-III gag protein is processed in yeast cells by the virus pol-protease. Science (1986) 3.06

Prospective analysis of hip arthroscopy with 2-year follow-up. Arthroscopy (2000) 3.05

Restriction endonuclease and nucleotide sequence analyses of molecularly cloned unintegrated avian tumor virus DNA: structure of large terminal repeats in circle junctions. J Virol (1982) 3.02

Nucleotide sequence of noncoding regions in Rous-associated virus-2: comparisons delineate conserved regions important in replication and oncogenesis. J Virol (1984) 2.71

A role for DNA-PK in retroviral DNA integration. Science (1999) 2.68

Avian sarcoma and leukosis virus pol-endonuclease recognition of the tandem long terminal repeat junction: minimum site required for cleavage is also required for viral growth. J Virol (1987) 2.62

The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA. Genes Dev (1991) 2.58

Generation of diversity in retroviruses. Annu Rev Genet (1990) 2.53

Retroviral integrase functions as a multimer and can turn over catalytically. J Biol Chem (1992) 2.48

Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. I. Kinetics of synthesis and size of minus- and plus-strand transcripts. J Virol (1981) 2.45

Selective cleavage in the avian retroviral long terminal repeat sequence by the endonuclease associated with the alpha beta form of avian reverse transcriptase. Proc Natl Acad Sci U S A (1983) 2.40

Retroviral DNA H structures: displacement-assimilation model of recombination. Cell (1982) 2.37

Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expression. J Virol (1991) 2.26

Complete nucleotide sequence of the influenza A/PR/8/34 virus NS gene and comparison with the NS genes of the A/Udorn/72 and A/FPV/Rostock/34 strains. Nucleic Acids Res (1980) 2.25

Site-directed mutagenesis of the avian retrovirus nucleocapsid protein, pp 12. Mutation which affects RNA binding in vitro blocks viral replication. J Biol Chem (1988) 2.25

High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J Mol Biol (1995) 2.16

Isolation and characterization of recombinant DNA clones of avian retroviruses: size heterogeneity and instability of the direct repeat. J Virol (1980) 2.15

Circles with two tandem long terminal repeats are specifically cleaved by pol gene-associated endonuclease from avian sarcoma and leukosis viruses: nucleotide sequences required for site-specific cleavage. J Virol (1985) 2.08

HIV-1 integrase: structural organization, conformational changes, and catalysis. Adv Virus Res (1999) 2.06

Properties of avian sarcoma-leukosis virus pp32-related pol-endonucleases produced in Escherichia coli. J Virol (1988) 2.03

DNA replication--bacteriophage lambda. Curr Top Microbiol Immunol (1977) 1.92

Endogenous avian retroviruses contain deficient promoter and leader sequences. Proc Natl Acad Sci U S A (1983) 1.90

Sequence comparison in the crossover region of an oncogenic avian retrovirus recombinant and its nononcogenic parent: genetic regions that control growth rate and oncogenic potential. Mol Cell Biol (1982) 1.89

cis-acting intron mutations that affect the efficiency of avian retroviral RNA splicing: implication for mechanisms of control. J Virol (1988) 1.88

Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. II. Evidence for a strand displacement mechanism in plus-strand synthesis. J Virol (1981) 1.87

Proteolytic processing of avian sarcoma and leukosis viruses pol-endo recombinant proteins reveals another pol gene domain. J Virol (1987) 1.85

Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons. Proc Natl Acad Sci U S A (1986) 1.83

Comparison between the viral transforming gene (src) of recovered avian sarcoma virus and its cellular homolog. Mol Cell Biol (1981) 1.78

Concerted integration of linear retroviral DNA by the avian sarcoma virus integrase in vitro: dependence on both long terminal repeat termini. J Virol (1996) 1.72

HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro. J Virol (1999) 1.71

Molecular analysis of the c-myc locus in normal tissue and in avian leukosis virus-induced lymphomas. J Virol (1982) 1.70

The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations. Structure (1996) 1.64

Retroviral DNA integration and the DNA damage response. Cell Death Differ (2005) 1.63

A covalent complex between retroviral integrase and nicked substrate DNA. Proc Natl Acad Sci U S A (1991) 1.61

Molecular modeling of the HIV-1 protease and its substrate binding site. Science (1989) 1.60

Retroviral integrase, putting the pieces together. J Biol Chem (1996) 1.58

HIV DNA integration: observations and interferences. J Acquir Immune Defic Syndr (1990) 1.54

Molecular mechanisms in retrovirus DNA integration. Antiviral Res (1997) 1.54

Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses. Mol Cell Biol (2001) 1.53

Brain-computer interfaces based on the steady-state visual-evoked response. IEEE Trans Rehabil Eng (2000) 1.51

Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase. J Virol (1996) 1.50

Assembly and processing of avian retroviral gag polyproteins containing linked protease dimers. J Virol (1991) 1.48

Products of reverse transcription in avian retrovirus analyzed by electron microscopy. J Virol (1982) 1.47

Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J Biol Chem (1997) 1.47

Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control. Mol Cell Biol (1986) 1.47

Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: in vitro activities and incorporation of a fusion protein into viral particles. Virology (1996) 1.45

Synthetic peptides as substrates and inhibitors of a retroviral protease. Proc Natl Acad Sci U S A (1988) 1.41

EEG suppression and increased blood-brain barrier permeability following intracarotid injection of iothalamate meglumine (Conray) in dogs. J Neurosurg Anesthesiol (1990) 1.39

Snakes and ladders: getting patients into metropolitan public hospitals. Med J Aust (1996) 1.39

Medicine of the future. Med J Aust (1966) 1.37

Genetic recombination in avian retroviruses. J Cell Biochem (1982) 1.37

Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase. J Biol Chem (1995) 1.35

Activity of avian retroviral protease expressed in Escherichia coli. J Virol (1988) 1.34

Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases. J Virol (1997) 1.34

A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. J Virol (1988) 1.30

Avian retroviral protease and cellular aspartic proteases are distinguished by activities on peptide substrates. J Biol Chem (1989) 1.29

Biological activity of cloned retroviral DNA in microinjected cells. Proc Natl Acad Sci U S A (1981) 1.29

Regulation of the human c-myc gene: 5' noncoding sequences do not affect translation. Mol Cell Biol (1985) 1.26

Terminal nucleotides of the preintegrative linear form of HIV-1 DNA deduced from the sequence of circular DNA junctions. J Acquir Immune Defic Syndr (1990) 1.26

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc Natl Acad Sci U S A (1998) 1.25

Nucleotide sequence of the long terminal repeat and flanking cellular sequences of avian endogenous retrovirus ev-2: variation in Rous-associated virus-0 expression cannot be explained by differences in primary sequence. J Virol (1983) 1.25

A preferred target DNA structure for retroviral integrase in vitro. J Biol Chem (1998) 1.24

What is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins? Bioessays (1989) 1.22

Hip arthroscopy in athletes. Clin Sports Med (2001) 1.22

Requirement for a conserved serine in both processing and joining activities of retroviral integrase. Proc Natl Acad Sci U S A (1992) 1.20

Analysis of substrate interactions of the Rous sarcoma virus wild type and mutant proteases and human immunodeficiency virus-1 protease using a set of systematically altered peptide substrates. J Biol Chem (1992) 1.20

Mutations that alter the activity of the Rous sarcoma virus protease. J Biol Chem (1992) 1.20

Modeling the late steps in HIV-1 retroviral integrase-catalyzed DNA integration. J Biol Chem (2000) 1.19

Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase. Virology (1995) 1.18