Published in Virology on August 01, 1996
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J Virol (2002) 6.69
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol (2002) 5.21
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog (2008) 3.81
Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO J (2002) 3.33
Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol (2005) 2.94
Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines. J Virol (2000) 2.89
Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog (2009) 2.52
Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J Virol (1999) 2.24
Regulation of PKR and IRF-1 during hepatitis C virus RNA replication. Proc Natl Acad Sci U S A (2002) 1.96
The native form and maturation process of hepatitis C virus core protein. J Virol (1998) 1.91
The ins and outs of hepatitis C virus entry and assembly. Nat Rev Microbiol (2013) 1.69
Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol (2004) 1.67
Interaction of hepatitis C virus core protein with viral sense RNA and suppression of its translation. J Virol (1999) 1.63
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment. J Virol (2002) 1.56
Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. EMBO J (2000) 1.49
Molecular determinants and dynamics of hepatitis C virus secretion. PLoS Pathog (2012) 1.41
A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly. PLoS Pathog (2011) 1.41
Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features. J Virol (2005) 1.34
Trafficking of hepatitis C virus core protein during virus particle assembly. PLoS Pathog (2011) 1.32
Hepatitis C virus-like particle morphogenesis. J Virol (2002) 1.32
Molecular determinants for subcellular localization of hepatitis C virus core protein. J Virol (2005) 1.31
Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly. PLoS Pathog (2012) 1.24
Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1 alpha-mediated glycolytic adaptation. J Virol (2010) 1.23
hepatitis c Virus p7 is critical for capsid assembly and envelopment. PLoS Pathog (2013) 1.20
Virion assembly and release. Curr Top Microbiol Immunol (2013) 1.15
Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly. J Virol (2013) 1.09
Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells. J Virol (2004) 1.08
Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression. Virol J (2006) 1.08
The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model. Gut (2007) 1.06
Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model. J Virol (2002) 1.05
Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions. J Virol (2009) 1.01
Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91. J Virol (2011) 1.01
Analysis of hepatitis C virus RNA dimerization and core-RNA interactions. Nucleic Acids Res (2006) 0.99
Hepatitis C virus (HCV) infection and hepatic steatosis. Int J Med Sci (2006) 0.98
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog (2012) 0.98
Identification of basic amino acids at the N-terminal end of the core protein that are crucial for hepatitis C virus infectivity. J Virol (2010) 0.98
The human cytomegalovirus protein UL37 exon 1 associates with internal lipid rafts. J Virol (2010) 0.96
Access of viral proteins to mitochondria via mitochondria-associated membranes. Rev Med Virol (2009) 0.95
Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies. RNA (2011) 0.94
Transcriptional activation of the interleukin-2 promoter by hepatitis C virus core protein. J Virol (2001) 0.92
Development of specific antibodies to an ARF protein in treated patients with chronic HCV infection. Dig Dis Sci (2007) 0.91
Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction. J Viral Hepat (2010) 0.90
Hepatitis C virus infection: establishment of chronicity and liver disease progression. EXCLI J (2014) 0.90
Mechanism of hepatitis C virus (HCV)-induced osteopontin and its role in epithelial to mesenchymal transition of hepatocytes. J Biol Chem (2013) 0.89
Kinetic analysis of the nucleic acid chaperone activity of the hepatitis C virus core protein. Nucleic Acids Res (2010) 0.89
Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices. J Lipid Res (2013) 0.87
Conserved determinants for membrane association of nonstructural protein 5A from hepatitis C virus and related viruses. J Virol (2006) 0.86
Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus. J Virol (2014) 0.85
Hepatitis C virus assembly imaging. Viruses (2011) 0.85
A disulfide-bonded dimer of the core protein of hepatitis C virus is important for virus-like particle production. J Virol (2010) 0.84
The wild-type hepatitis C virus core inhibits initiation of antigen-specific T- and B-cell immune responses in BALB/c mice. Clin Vaccine Immunol (2010) 0.84
Chronic ethanol diet increases regulatory T-cell activity and inhibits hepatitis C virus core-specific cellular immune responses in mice. Hepatol Res (2013) 0.84
Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein. J Virol (2005) 0.83
Hepatitis C virus core protein induces apoptosis-like caspase independent cell death. Virol J (2009) 0.83
Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses. PLoS One (2015) 0.83
Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes. World J Gastroenterol (2015) 0.82
Functional characterization of bovine viral diarrhea virus nonstructural protein 5A by reverse genetic analysis and live cell imaging. J Virol (2013) 0.82
Metabolic factors and chronic hepatitis C: a complex interplay. Biomed Res Int (2013) 0.82
Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: studies in vitro and in conditionally transgenic mice. World J Gastroenterol (2007) 0.82
Hepatitis C virus and vaccine development. Int J Mol Cell Med (2014) 0.80
Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases. World J Gastroenterol (2014) 0.80
Dengue Virus Uses a Non-Canonical Function of the Host GBF1-Arf-COPI System for Capsid Protein Accumulation on Lipid Droplets. Traffic (2015) 0.80
Expression of the murine norovirus (MNV) ORF1 polyprotein is sufficient to induce apoptosis in a virus-free cell model. PLoS One (2014) 0.79
Peroxisomes and the antiviral responses of mammalian cells. Subcell Biochem (2013) 0.78
Role of hepatitis C virus induced osteopontin in epithelial to mesenchymal transition, migration and invasion of hepatocytes. PLoS One (2014) 0.78
Properties and Functions of the Dengue Virus Capsid Protein. Annu Rev Virol (2016) 0.77
Metabolic syndrome in chronic hepatitis C infection: does it still matter in the era of directly acting antiviral therapy? Hepat Med (2014) 0.77
Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization. World J Gastroenterol (2014) 0.76
Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein. PLoS One (2016) 0.76
Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A. PLoS Pathog (2016) 0.75
Inhibition effect of Chinese herbal medicine on transcription of hepatitis C virus structural gene in vitro. World J Gastroenterol (2005) 0.75
Last stop before exit - hepatitis C assembly and release as antiviral drug targets. Viruses (2010) 0.75
Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient. J Med Virol (2001) 3.29
Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med (1996) 3.04
Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell (1999) 2.92
A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med (1991) 2.68
Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 2.59
Hepatitis C virus: epidemiology and transmission. Hepatology (1997) 2.43
Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. Hepatology (1992) 2.31
Circulating immune complexes and complement activation in primary biliary cirrhosis. N Engl J Med (1978) 2.30
The pathogenesis of arthritis associated with acute hepatitis-B surface antigen-positive hepatitis. Complement activation and characterization of circulating immune complexes. J Clin Invest (1975) 2.13
Serial studies of hepatitis-associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders. Gastroenterology (1975) 2.08
Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. Hepatology (1998) 2.01
Posttranscriptional regulation of hepatitis B virus replication by the precore protein. J Virol (1997) 1.96
Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol (1998) 1.96
The increasing incidence of hepatocellular carcinoma. N Engl J Med (1999) 1.92
Hepatitis B virus X protein is not central to the viral life cycle in vitro. J Virol (1992) 1.92
The native form and maturation process of hepatitis C virus core protein. J Virol (1998) 1.91
Primary hepatocellular carcinoma. N Engl J Med (1991) 1.91
Decreased suppressor cell activity in inflammatory bowel disease. Clin Exp Immunol (1978) 1.75
A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. Mol Cell Biol (1996) 1.73
Normal serum ferritin concentrations in precirrhotic hemochromatosis. N Engl J Med (1976) 1.68
Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res (2000) 1.64
Cell-mediated immunity in acute and chronic hepatitis. J Clin Invest (1975) 1.63
Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication. J Virol (1991) 1.61
Dynamics of genome change in the E2/NS1 region of hepatitis C virus in vivo. Virology (1993) 1.60
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer (2008) 1.59
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. Genes Dev (1995) 1.59
Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization. Gastroenterology (1997) 1.58
Alteration in suppressor cell activity in chronic active hepatitis. Proc Natl Acad Sci U S A (1978) 1.57
Hepatitis B transmission by dentists. JAMA (1974) 1.57
High affinity monoclonal antibodies to hepatitis B surface antigen (HBsAg) produced by somatic cell hybrids. Gastroenterology (1981) 1.55
Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame. Virology (1997) 1.52
Immunodiagnosis of hepatitis B with high-affinity IgM monoclonal antibodies. Proc Natl Acad Sci U S A (1981) 1.48
Interaction between duck hepatitis B virus and a 170-kilodalton cellular protein is mediated through a neutralizing epitope of the pre-S region and occurs during viral infection. J Virol (1995) 1.48
TT virus infection in hemodialysis patients. Am J Gastroenterol (1999) 1.47
Establishment and characterization of a new human hepatocellular carcinoma cell line. In Vitro (1984) 1.43
Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma. J Clin Invest (1996) 1.43
Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. J Virol (1987) 1.42
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest (1999) 1.42
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc Natl Acad Sci U S A (1998) 1.42
Fulminant hepatitis complicated by pancreatitis. Johns Hopkins Med J (1973) 1.40
Arthritis associated with intestinal-bypass procedure for morbid obesity. Complement activation and characterization of circulating cryoproteins. N Engl J Med (1976) 1.39
Rapid identification of low level hepatitis B-related viral genome in serum. J Clin Invest (1989) 1.37
The Wilms tumor suppressor gene wt1 is required for development of the spleen. Curr Biol (1999) 1.34
Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci (1997) 1.31
Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J Immunol (1997) 1.30
Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence. J Biol Chem (1994) 1.29
Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. Cancer Res (1997) 1.27
Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation. Cancer Res (2000) 1.26
WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant. Science (1993) 1.25
Isolation, characterization, and distribution of an unusual pancreatic human secretory protein. J Clin Invest (1985) 1.24
Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication. Gastroenterology (1979) 1.24
Hepatitis B virus infection in patients with idiopathic liver disease. Hepatology (1991) 1.23
Hepatitis B in an oncology unit. N Engl J Med (1974) 1.23
Monoclonal radioimmunoassays for hepatitis B surface antigen: demonstration of hepatitis B virus DNA or related sequences in serum and viral epitopes in immune complexes. Proc Natl Acad Sci U S A (1982) 1.23
Two genes encoding gas vacuole proteins in Halobacterium halobium. Mol Gen Genet (1988) 1.23
Demonstration of previously undetected hepatitis B viral determinants in an Australian Aboriginal population by monoclonal anti-hbs antibody radioimmunoassays. Lancet (1982) 1.23
The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. Proc Natl Acad Sci U S A (1992) 1.22
Monoclonal IgM radioimmunoassay for hepatitis B surface antigen: high binding activity in serum that is unreactive with conventional antibodies. Proc Natl Acad Sci U S A (1982) 1.22
Impaired placentation in fetal alcohol syndrome. Placenta (2007) 1.21
Effect of insulin and glucagon on fulminant murine hepatitis. N Engl J Med (1976) 1.20
Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain. Cell Mol Life Sci (2006) 1.19
Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease. Lab Invest (2000) 1.19
Recent advances in the natural history of hepatocellular carcinoma. Carcinogenesis (2008) 1.18
A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype. J Clin Invest (1996) 1.18
Carboxypeptidase D is an avian hepatitis B virus receptor. J Virol (1999) 1.18
The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour. Nat Genet (1997) 1.17
Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor beta1-induced apoptosis. Cancer Res (1996) 1.17
Alterations of T-cell subsets in primary biliary cirrhosis. Clin Exp Immunol (1982) 1.16
Properties of hepatitis B virus pre-S1 deletion mutants. Virology (1994) 1.15
Characterization and biological properties of a hepatitis B virus isolated from a patient without hepatitis B virus serologic markers. Hepatology (1990) 1.14
Characterization of three novel monoclonal antibodies against hepatitis C virus core protein. J Med Virol (1996) 1.14
The relation between an esophageal cancer and associated cancers in adjacent organs. Cancer (1995) 1.14
Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection. Hepatology (1991) 1.12
Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons. Cell Mol Life Sci (2002) 1.12
Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids. J Immunol (1997) 1.12
Urticaria associated with acute viral hepatitis type B: studies of pathogenesis. Ann Intern Med (1978) 1.11
Purification and analysis of an extremely halophilic beta-galactosidase from Haloferax alicantei. Biochim Biophys Acta (1997) 1.11
A pilot study of ribavirin and interferon beta for the treatment of chronic hepatitis C. Gastroenterology (1993) 1.11
Serum interleukin 6 levels in patients with chronic hepatitis B. Am J Gastroenterol (1991) 1.10
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev (1998) 1.10
Ethanol impairs insulin receptor substrate-1 mediated signal transduction during rat liver regeneration. Biochem Biophys Res Commun (1994) 1.10
Immunotherapy in nude mice of human hepatoma using monoclonal antibodies against hepatitis B virus. Nature (1982) 1.09
Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma. Biochem Biophys Res Commun (1992) 1.09
Geographic classification of dengue-2 virus strains by antigen signature analysis. Virology (1986) 1.08
Hepatitis B viral antigenic structure: signature analysis by monoclonal radioimmunoassays. Proc Natl Acad Sci U S A (1984) 1.06
The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted. J Virol (1997) 1.05
Characterization of a 120-Kilodalton pre-S-binding protein as a candidate duck hepatitis B virus receptor. J Virol (1996) 1.05
Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus. J Virol (1999) 1.05
Binding activity of norovirus and sapovirus to histo-blood group antigens. Arch Virol (2006) 1.04
Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template. Biochem Biophys Res Commun (1992) 1.04
The Müllerian duct: recent insights into its development and regression. Sex Dev (2007) 1.03
Familial hemochromatosis: characteristics of the precirrhotic stage in a large kindred. Medicine (Baltimore) (1977) 1.03
Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci. Oncogene (1999) 1.03
Familial hemochromatosis. Physiologic studies in the precirrhotic stage of the disease. N Engl J Med (1977) 1.02
Identification and expression of glycine decarboxylase (p120) as a duck hepatitis B virus pre-S envelope-binding protein. J Biol Chem (1999) 1.02
Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes. Hepatology (1997) 1.01
Immune system reconstitution following allogeneic bone marrow transplantation in man: a multiparameter analysis. Transplant Proc (1976) 1.01
Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules. J Biol Chem (1996) 1.01