Published in RNA on August 25, 2011
MicroRNA-122 dependent binding of Ago2 protein to hepatitis C virus RNA is associated with enhanced RNA stability and translation stimulation. PLoS One (2013) 1.62
Manipulation of cellular processing bodies and their constituents by viruses. DNA Cell Biol (2013) 1.40
Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure. Nucleic Acids Res (2013) 1.02
HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. J Virol (2012) 0.94
Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors. Nat Commun (2014) 0.94
Retroviral GAG proteins recruit AGO2 on viral RNAs without affecting RNA accumulation and translation. Nucleic Acids Res (2011) 0.93
MicroRNAs and hepatitis C virus: toward the end of miR-122 supremacy. Virol J (2012) 0.84
The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122. Nucleic Acids Res (2013) 0.83
Cytoplasmic RNA Granules and Viral Infection. Annu Rev Virol (2014) 0.79
Hepatitis C Virus Exploitation of Processing Bodies. J Virol (2016) 0.75
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science (1999) 24.31
Switching from repression to activation: microRNAs can up-regulate translation. Science (2007) 17.00
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science (2005) 16.84
A guided tour into subcellular colocalization analysis in light microscopy. J Microsc (2006) 16.73
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
Identification of microRNAs of the herpesvirus family. Nat Methods (2005) 12.98
Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell (2006) 12.73
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab (2006) 12.41
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45
The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol (2007) 8.98
P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol (2007) 7.96
A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54
Model systems, lipid rafts, and cell membranes. Annu Rev Biophys Biomol Struct (2004) 7.52
Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A (2007) 6.79
miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol (2004) 6.44
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol (2006) 6.41
Identification of novel argonaute-associated proteins. Curr Biol (2005) 6.13
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell (2007) 5.87
Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol (2005) 5.52
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol (2003) 5.41
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol (2002) 5.21
microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J (2008) 4.24
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A (2006) 4.02
Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med (2009) 3.72
In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci U S A (2008) 3.43
The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev (2009) 3.30
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med (2010) 3.27
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. Proc Natl Acad Sci U S A (2002) 3.21
The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. J Biol Chem (2007) 3.11
Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing. Proc Natl Acad Sci U S A (2008) 3.03
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell (2009) 2.98
Unscrambling hepatitis C virus-host interactions. Nature (2005) 2.83
Interference of hepatitis C virus RNA replication by short interfering RNAs. Proc Natl Acad Sci U S A (2003) 2.64
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog (2010) 2.62
Colocalization of fluorescent markers in confocal microscope images of plant cells. Nat Protoc (2008) 2.53
Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol (2010) 2.51
Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus. J Gen Virol (2007) 2.41
The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA (2009) 2.37
The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Mol Biol Cell (2008) 2.25
P bodies, stress granules, and viral life cycles. Cell Host Microbe (2008) 2.23
Comparison of siRNA-induced off-target RNA and protein effects. RNA (2007) 2.22
Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein. Virology (1996) 2.18
Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication. J Virol (2007) 2.15
Is RNA interference involved in intrinsic antiviral immunity in mammals? Nat Immunol (2006) 2.02
Analysis of the interaction of primate retroviruses with the human RNA interference machinery. J Virol (2007) 1.93
Monoclonal antibodies to double-stranded RNA as probes of RNA structure in crude nucleic acid extracts. Nucleic Acids Res (1991) 1.92
Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. J Virol (2010) 1.88
Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies. Mol Biol Cell (2007) 1.83
Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates. Proc Natl Acad Sci U S A (2009) 1.73
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem (2007) 1.65
Studying hepatitis C virus: making the best of a bad virus. J Virol (2007) 1.62
The Argonautes. Cold Spring Harb Symp Quant Biol (2006) 1.56
On track with P-bodies. Biochem Soc Trans (2010) 1.49
DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation. J Virol (2010) 1.45
Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nat Struct Mol Biol (2010) 1.45
siRNA in human cells selectively localizes to target RNA sites. Proc Natl Acad Sci U S A (2006) 1.39
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication. J Virol (2004) 1.36
Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral response. Gastroenterology (2006) 1.31
Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody. J Immunol Methods (2006) 1.20
Five questions about viruses and microRNAs. PLoS Pathog (2010) 1.14
Suppression of short interfering RNA-mediated gene silencing by the structural proteins of hepatitis C virus. J Gen Virol (2008) 1.01
Markers of mRNA stabilization and degradation, and RNAi within astrocytoma GW bodies. J Neurosci Res (2007) 0.88
Coil-in-to snRNP assembly and Cajal bodies. Nat Struct Mol Biol (2010) 0.77
RNA silencing as a natural antiviral defense system in mammals: where are we now? Mol Ther (2010) 0.76
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12
Adding new chemistries to the genetic code. Annu Rev Biochem (2010) 6.32
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (2010) 5.50
Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci U S A (2002) 5.28
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
An expanded eukaryotic genetic code. Science (2003) 4.66
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A (2006) 3.83
Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proc Natl Acad Sci U S A (2002) 3.77
Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nat Methods (2007) 3.45
Expanding the genetic code. Annu Rev Biophys Biomol Struct (2006) 3.36
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
A stem cell-based approach to cartilage repair. Science (2012) 3.22
An enhanced system for unnatural amino acid mutagenesis in E. coli. J Mol Biol (2009) 3.20
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci U S A (2008) 3.13
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. J Am Chem Soc (2002) 2.88
Addition of the keto functional group to the genetic code of Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.84
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A (2009) 2.80
Expanding the genetic code. Angew Chem Int Ed Engl (2004) 2.78
Genomically recoded organisms expand biological functions. Science (2013) 2.73
Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A (2006) 2.65
A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proc Natl Acad Sci U S A (2007) 2.62
Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence. Proc Natl Acad Sci U S A (2009) 2.59
An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A (2006) 2.51
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A (2013) 2.49
Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A (2003) 2.45
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc Natl Acad Sci U S A (2008) 2.39
A chemical toolkit for proteins--an expanded genetic code. Nat Rev Mol Cell Biol (2006) 2.39
Recombinant expression of selectively sulfated proteins in Escherichia coli. Nat Biotechnol (2006) 2.31
Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31
Efficient incorporation of unnatural amino acids into proteins in Escherichia coli. Nat Methods (2006) 2.24
Substrate recognition by the AAA+ chaperone ClpB. Nat Struct Mol Biol (2004) 2.19
Oxysterols direct immune cell migration via EBI2. Nature (2011) 2.19
An expanded genetic code with a functional quadruplet codon. Proc Natl Acad Sci U S A (2004) 2.09
Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A (2003) 2.06
A facile system for encoding unnatural amino acids in mammalian cells. Angew Chem Int Ed Engl (2009) 2.02
Control of protein phosphorylation with a genetically encoded photocaged amino acid. Nat Chem Biol (2007) 1.99
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc Natl Acad Sci U S A (2012) 1.99
Identification of small molecule activators of cryptochrome. Science (2012) 1.95
A role for chemistry in stem cell biology. Nat Biotechnol (2004) 1.95
A genetically encoded fluorescent amino acid. J Am Chem Soc (2006) 1.93
The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination. Nat Biotechnol (2004) 1.93
Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae. J Am Chem Soc (2003) 1.93
Exploring the limits of codon and anticodon size. Chem Biol (2002) 1.89
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (2008) 1.79
A combinatorial scaffold approach toward kinase-directed heterocycle libraries. J Am Chem Soc (2002) 1.79
A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proc Natl Acad Sci U S A (2006) 1.78
A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell (2009) 1.78
A general approach to site-specific antibody drug conjugates. Proc Natl Acad Sci U S A (2014) 1.77
Directed evolution of the site specificity of Cre recombinase. Proc Natl Acad Sci U S A (2002) 1.77
Profiling protein function with small molecule microarrays. Proc Natl Acad Sci U S A (2002) 1.77
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73
An efficient system for the evolution of aminoacyl-tRNA synthetase specificity. Nat Biotechnol (2002) 1.73
A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli. ACS Chem Biol (2007) 1.72
A genetically encoded infrared probe. J Am Chem Soc (2006) 1.71
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.71
Modulation of allostery by protein intrinsic disorder. Nature (2013) 1.69
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A (2003) 1.68
Progress toward an expanded eukaryotic genetic code. Chem Biol (2003) 1.66
A genetically encoded fluorescent amino acid. Proc Natl Acad Sci U S A (2006) 1.66
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem (2007) 1.65
Site-directed spin labeling of a genetically encoded unnatural amino acid. Proc Natl Acad Sci U S A (2009) 1.65
A genetically encoded photocaged amino acid. J Am Chem Soc (2004) 1.65
A small-molecule inducer of the antioxidant response element. Chem Biol (2010) 1.65
Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol (2004) 1.64
Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc (2004) 1.63
Tom40 protein import channel binds to non-native proteins and prevents their aggregation. Nat Struct Biol (2003) 1.62
Generation of a bacterium with a 21 amino acid genetic code. J Am Chem Soc (2003) 1.62
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol (2004) 1.60
A genetically encoded bidentate, metal-binding amino acid. Angew Chem Int Ed Engl (2007) 1.57
In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy. J Am Chem Soc (2008) 1.57
Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc (2004) 1.56
A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer. J Am Chem Soc (2008) 1.56
A genetically encoded photocaged tyrosine. Angew Chem Int Ed Engl (2006) 1.56
A genetically encoded boronate-containing amino acid. Angew Chem Int Ed Engl (2008) 1.54
Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. J Am Chem Soc (2007) 1.54
Beyond the canonical 20 amino acids: expanding the genetic lexicon. J Biol Chem (2010) 1.53
A new strategy for the site-specific modification of proteins in vivo. Biochemistry (2003) 1.52
Bispecific small molecule-antibody conjugate targeting prostate cancer. Proc Natl Acad Sci U S A (2013) 1.52
Enthalpy arrays. Proc Natl Acad Sci U S A (2004) 1.52
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A (2013) 1.51
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci U S A (2002) 1.51
Three-color single-molecule fluorescence resonance energy transfer. Chemphyschem (2005) 1.50
Identification of p53 regulators by genome-wide functional analysis. Proc Natl Acad Sci U S A (2004) 1.48
Structural plasticity and the evolution of antibody affinity and specificity. J Mol Biol (2003) 1.47
A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci U S A (2007) 1.44
A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl (2005) 1.44
Retracted A new strategy for the synthesis of glycoproteins. Science (2004) 1.44
Ribosomal route to small-molecule diversity. J Am Chem Soc (2011) 1.43
Expanding the genetic code. Chem Commun (Camb) (2002) 1.43
Site-specific PEGylation of proteins containing unnatural amino acids. Bioorg Med Chem Lett (2004) 1.43