Published in Drug Metab Dispos on March 01, 1996
Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology (2007) 1.81
Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines. Chem Res Toxicol (2011) 1.38
Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Biochem J (1999) 1.10
Searching for tissue-specific expression pattern-linked nucleotides of UGT1A isoforms. PLoS One (2007) 1.05
Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants. Breast Cancer Res (2006) 1.02
Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites. Drug Metab Dispos (2009) 0.98
Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen. Ann N Y Acad Sci (2009) 0.98
Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos (2008) 0.92
Glucuronidation of 3'-azido-3'-deoxythymidine (zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid. Antimicrob Agents Chemother (1998) 0.91
Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors. Drug Metab Rev (2010) 0.88
Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. Biochem Pharmacol (2007) 0.84
Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities. Drug Metab Dispos (2011) 0.81
Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals. Acta Pharmacol Sin (2010) 0.77
UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis. ISRN Oncol (2013) 0.75
Stereoselective glucuronidation of carvedilol by Chinese liver microsomes. J Zhejiang Univ Sci B (2007) 0.75
OleD Loki as a Catalyst for Tertiary Amine and Hydroxamate Glycosylation. Chembiochem (2017) 0.75
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest (1998) 2.62
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics (1997) 2.55
UDP-glucuronosyltransferases. Curr Drug Metab (2000) 1.94
The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). Drug Metab Dispos (1998) 1.58
Methanol poisoning in human subjects. Role for formic acid accumulation in the metabolic acidosis. Am J Med (1980) 1.49
Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Role of a porphyrin-like inhibitor of protohaem ferro-lyase. Biochem J (1979) 1.46
Methanol poisoning: ocular toxicity produced by formate. Toxicol Appl Pharmacol (1978) 1.42
The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450. Biochem Biophys Res Commun (1971) 1.41
Human UGT2B7 catalyzes morphine glucuronidation. Drug Metab Dispos (1997) 1.40
Effect of 3-amino-1,2,4-triazole on the stimulation of hepatic microsomal heme synthesis and induction of hepatic microsomal oxidases produced by phenobarbital. Mol Pharmacol (1969) 1.35
Separation, purification and characterization of three isoenzymes of UDP-glucuronyltransferase from rat liver microsomes. Arch Biochem Biophys (1983) 1.31
Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics (1997) 1.31
Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7. J Steroid Biochem Mol Biol (1999) 1.24
3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7). Drug Metab Dispos (2000) 1.20
UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions. Biochem Pharmacol (1983) 1.14
Morphine metabolism. III. Solubilization and separation of morphine and p-nitrophenol uridine diphosphoglucuronyltransferases. Mol Pharmacol (1975) 1.13
Effect of drugs on heme synthesis in the liver. Metabolism (1971) 1.12
4-hydroxyretinoic acid, a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. J Biol Chem (2000) 1.11
Methyl alcohol poisoning III. Ocular toxicity. Arch Ophthalmol (1977) 1.10
Glucuronidation of 6 alpha-hydroxy bile acids by human liver microsomes. J Clin Invest (1987) 1.09
Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos (1998) 1.09
Identification of N-methylprotoporphyrin IX in livers of untreated mice and mice treated with 3, 5-diethoxycarbonyl- 1, 4-dihydrocollidine: source of the methyl group. Arch Biochem Biophys (1981) 1.06
Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteins. Drug Metab Dispos (1998) 1.06
Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides. Drug Metab Dispos (1995) 1.05
Morphine metabolism. I. Evidence for separate enzymes in the glucuronidation of morphine and p-nitrophenol by rat hepatic microsomes. Drug Metab Dispos (1974) 1.05
Methanol poisoning. V. Role of formate metabolism in the monkey. J Pharmacol Exp Ther (1977) 1.03
The regulation of heme synthesis related to drug metabolism. Drug Metab Dispos (1974) 1.02
Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. Drug Metab Dispos (1995) 1.02
Inhibition of protohaem ferro-lyase in experimental porphyria. Isolation and partial characterization of a modified porphyrin inhibitor. Biochem J (1980) 1.02
Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase. Biochem J (1986) 1.02
Methyl alcohol poisoning. IV. Alterations of the morphological findings of the retina and optic nerve. Arch Ophthalmol (1977) 1.02
Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10. Drug Metab Dispos (1999) 1.01
Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. Carcinogenesis (1999) 1.01
Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7. Toxicol Sci (1998) 1.00
Further studies on the relationship of the stimulatory effects of phenobarbital and 3,4-benzpyrene on hepatic heme synthesis to their effects on hepatic microsomal drug oxidations. Arch Biochem Biophys (1970) 1.00
Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities. Biochem J (1978) 0.99
The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1. Arch Biochem Biophys (1996) 0.99
Formate assay in body fluids: application in methanol poisoning. Biochem Med (1975) 0.97
Methyl alcohol poisoning. II. Development of a model for ocular toxicity in methyl alcohol poisoning using the rhesus monkey. Arch Ophthalmol (1977) 0.96
Improved estimation of formate in body fluids and tissues. Clin Chem (1982) 0.96
Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate. Arch Biochem Biophys (1999) 0.95
UDP-glucuronosyltransferases in human intestinal mucosa. Biochim Biophys Acta (1998) 0.94
Glucuronidation of bile acids by rat liver 3-OH androgen UDP-glucuronyltransferase. J Biol Chem (1984) 0.94
Formaldehyde poisoning. Rapid metabolism to formic acid. JAMA (1981) 0.94
High-pressure liquid chromatography separation and determination of rat liver folates. Arch Biochem Biophys (1981) 0.93
Morphine metabolism. II. Studies on morphine glucuronyltransferase activity in intestinal microsomes of rats. Drug Metab Dispos (1974) 0.92
Methanol toxicity: treatment with folic acid and 5-formyl tetrahydrofolic acid. Alcohol Clin Exp Res (1980) 0.92
Methanol poisoning. I. The role of formic acid in the development of metabolic acidosis in the monkey and the reversal by 4-methylpyrazole. Biochem Med (1975) 0.91
The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene. Biochem Biophys Res Commun (1969) 0.91
The role of hepatic microbody and soluble oxidases in the peroxidation of methanol in the rat and monkey. Mol Pharmacol (1968) 0.91
Methanol poisoning and formate oxidation in nitrous oxide-treated rats. J Pharmacol Exp Ther (1981) 0.90
Morphine metabolism. V. Isolation of separate glucuronyltransferase activities for morphine and p-nitrophenol from rabbit liver microsomes. Drug Metab Dispos (1977) 0.90
The enzymatic mechanism of glucuronidation catalyzed by two purified rat liver steroid UDP-glucuronosyltransferases. J Biol Chem (1987) 0.90
Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase. Mol Pharmacol (1989) 0.90
Steroid 3- and 17-OH UDP-glucuronosyltransferase activities in rat and rabbit liver microsomes. Drug Metab Dispos (1983) 0.90
Folate and 10-formyltetrahydrofolate dehydrogenase (FDH) expression in the central nervous system of the mature rat. Brain Res (1997) 0.89
Purification of properties of rabbit liver estrone and p-nitrophenol UDP-glucuronyltransferases. Arch Biochem Biophys (1981) 0.89
Isolation and purification of two human liver UDP-glucuronosyltransferases. Mol Pharmacol (1987) 0.89
Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8. Arch Biochem Biophys (1998) 0.88
Studies on methanol toxicity and formate metabolism in isolated hepatocytes. The role of methionine in folate-dependent reactions. Biochem Pharmacol (1979) 0.88
Blood methanol concentrations in normal adult subjects administered abuse doses of aspartame. J Toxicol Environ Health (1981) 0.88
Role of hepatic tetrahydrofolate in the species difference in methanol toxicity. Proc Natl Acad Sci U S A (1985) 0.87
UDP glucuronosyltransferase in the cirrhotic rat liver. J Gastroenterol Hepatol (1996) 0.86
Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds. Drug Metab Dispos (1997) 0.86
Substrate specificity and characterization of rat liver p-nitrophenol, 3 alpha-hydroxysteroid and 17 beta-hydroxysteroid UDP-glucuronosyltransferases. Biochem J (1986) 0.86
Lack of a role for formaldehyde in methanol poisoning in the monkey. Biochem Pharmacol (1979) 0.86
Methanol toxicity in the monkey: effects of nitrous oxide and methionine. J Pharmacol Exp Ther (1983) 0.86
delta-Aminolevulinic acid synthetase-sensitive methods in liver for hemoprotein biosynthesis. Methods Enzymol (1978) 0.86
Inhibition of drug metabolism. V. Inhibition of drug metabolism by steroids. Mol Pharmacol (1968) 0.86
The role of substrates for glycine acyltransferase, and the role of sulfanilamide and acetate in the reversal of chemically-induced porphyria in the rat. Enzyme (1973) 0.85
The role of methionine in regulating folate-dependent reactions in isolated rat hepatocytes. Arch Biochem Biophys (1981) 0.85
Structural requirements in the reaction of morphine uridine diphosphate glucuronyltransferase with opioid substances. Biochem J (1978) 0.84
Phospholipid-dependence of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase. Biochem J (1979) 0.84
The formation of N-alkylprotoporphyrin IX and destruction of cytochrome P-450 in the liver of rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine and its 4-ethyl analog. Arch Biochem Biophys (1982) 0.84
Isolation and purification of rat liver morphine UDP-glucuronosyltransferase. Mol Pharmacol (1986) 0.84
Methanol poisoning in the folate-deficient rat. Nature (1976) 0.84
A comparison of rat and human liver formaldehyde dehydrogenase. Biochim Biophys Acta (1971) 0.83
Comparative N-glucuronidation kinetics of ketotifen and amitriptyline by expressed human UDP-glucuronosyltransferases and liver microsomes. Drug Metab Dispos (2000) 0.83
Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin. Mol Pharmacol (1995) 0.83
Identification of cobalt protoporphyrin IX formation in vivo following cobalt administration to rats. Biochem Pharmacol (1980) 0.83
Metabolism of formate in the rat. J Toxicol Environ Health (1975) 0.83
Studies on the mechanism of experimental porphyria and ferrochelatase inhibition produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Int J Biochem (1980) 0.83
Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase. Arch Biochem Biophys (1990) 0.83
Effects of metals on heme biosynthesis and metabolism. Fed Proc (1978) 0.83
A possible role of copper in the regulation of heme biosynthesis through ferrochelatase. Adv Exp Med Biol (1975) 0.82
Studies on the role of folic acid and folate-dependent enzymes in human methanol poisoning. Mol Pharmacol (1987) 0.82
Analysis of opioid binding to UDP-glucuronosyltransferase 2B7 fusion proteins using nuclear magnetic resonance spectroscopy. Mol Pharmacol (2001) 0.82
A procedure for the rapid separation and purification of UDP-glucuronosyltransferases from rabbit liver microsomes. Drug Metab Dispos (1982) 0.82
Role of the intracellular distribution of hepatic catalase in the peroxidative oxidation of methanol. Ann N Y Acad Sci (1969) 0.82
Separation, purification, and characterization of digitoxigenin-monodigitoxoside UDP-glucuronosyltransferase activity. Drug Metab Dispos (1986) 0.82
Methanol metabolism in the monkey. Mol Pharmacol (1968) 0.81
The reversal of experimental porphyria and the prevention of induction of hepatic mixed-function oxidase by acetate. Arch Biochem Biophys (1974) 0.81
Alcohol metabolism: role of microsomal oxidation in vivo. Science (1969) 0.81
Safety of long-term large doses of aspartame. Arch Intern Med (1989) 0.81
Glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by rat UDP-glucuronosyltransferase 2B1. Drug Metab Dispos (1999) 0.81
Studies on the properties of retinal alcohol dehydrogenase from the rat. J Neurochem (1971) 0.80
N-glucuronidation of carcinogenic aromatic amines catalyzed by rat hepatic microsomal preparations and purified rat liver uridine 5'-diphosphate-glucuronosyltransferases. Cancer Res (1987) 0.80
Induction of hepatic mitochondrial ferrochelatase by phenobarbital. Biochem Biophys Res Commun (1970) 0.80
The regulation of one-carbon oxidation in the rat by nitrous oxide and methionine. Arch Biochem Biophys (1982) 0.80
Nucleotide and deduced amino acid sequence of rat liver 17 beta-hydroxysteroid UDP-glucuronosyltransferase. Nucleic Acids Res (1987) 0.80