Assembly, peptide loading, and transport of MHC class I molecules in a calnexin-negative cell line.

PubWeight™: 0.99‹?› | Rank: Top 15%

🔗 View Article (PMID 8824400)

Published in Cold Spring Harb Symp Quant Biol on January 01, 1995

Authors

B K Sadasivan1, A Cariappa, G L Waneck, P Cresswell

Author Affiliations

1: Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

Articles citing this

Calreticulin: one protein, one gene, many functions. Biochem J (1999) 3.16

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome. Proc Natl Acad Sci U S A (1997) 2.39

Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex. EMBO J (2005) 1.47

Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol (2002) 1.22

The majority of H2-M3 is retained intracellularly in a peptide-receptive state and traffics to the cell surface in the presence of N-formylated peptides. J Exp Med (1999) 1.22

Intracellular assembly and trafficking of MHC class I molecules. Traffic (2009) 1.12

Structural and functional dissection of human cytomegalovirus US3 in binding major histocompatibility complex class I molecules. J Virol (2000) 1.01

Pathogen evasion strategies for the major histocompatibility complex class I assembly pathway. Immunology (2008) 0.92

What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules? Immunol Res (2010) 0.86

Calnexin and calreticulin bind to enzymically active tissue-type plasminogen activator during biosynthesis and are not required for folding to the native conformation. Biochem J (1997) 0.83

Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules. J Immunol (2011) 0.81

Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain. Immunogenetics (2004) 0.75

Articles by these authors

(truncated to the top 100)

Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics (1985) 5.30

Mechanisms of MHC class I--restricted antigen processing. Annu Rev Immunol (1998) 4.54

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature (1992) 4.53

Glycosylation and the immune system. Science (2001) 4.39

Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid. EMBO J (1986) 3.78

HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell (1995) 3.64

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature (1990) 3.54

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature (1990) 3.44

Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity (1996) 3.18

NK susceptibility varies inversely with target cell class I HLA antigen expression. J Immunol (1987) 3.06

Modulation of cell surface iron transferrin receptors by cellular density and state of activation. J Supramol Struct (1979) 3.02

Papain-solubilized HL-A antigens from cultured human lymphocytes contain two peptide fragments. Proc Natl Acad Sci U S A (1973) 2.96

The small subunit of HL-A antigens is beta 2-microglobulin. J Exp Med (1973) 2.68

Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature (1990) 2.65

Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc Natl Acad Sci U S A (1988) 2.64

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature (1992) 2.54

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc Natl Acad Sci U S A (2001) 2.49

Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT). Proc Natl Acad Sci U S A (2000) 2.40

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome. Proc Natl Acad Sci U S A (1997) 2.39

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes. Proc Natl Acad Sci U S A (1989) 2.32

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules. Proc Natl Acad Sci U S A (1991) 2.25

Aiolos regulates B cell activation and maturation to effector state. Immunity (1998) 2.24

Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens. J Immunol (1982) 2.18

A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes. Science (1997) 2.18

Defective antigen processing in GILT-free mice. Science (2001) 2.16

Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proc Natl Acad Sci U S A (1993) 2.16

The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation. Proc Natl Acad Sci U S A (1997) 2.14

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain. Nature (1991) 2.14

Microfilariae of Wuchereria bancrofti in cytologic smears. Acta Cytol (1983) 2.11

Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nat Med (1999) 2.08

Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2. Proc Natl Acad Sci U S A (1991) 2.07

Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis. Proc Natl Acad Sci U S A (1985) 1.98

MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding. Nature (1994) 1.93

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220. Immunity (1998) 1.90

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity (1994) 1.87

Cell-specific heterogeneity in sensitivity of phosphatidylinositol-anchored membrane antigens to release by phospholipase C. J Immunol Methods (1988) 1.85

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR. J Immunol (1990) 1.85

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules. Nature (1992) 1.83

Molecular biology of the H-2 histocompatibility complex. Science (1986) 1.81

Immunological identity of the small subunit of HL-A antigens and beta2-microglobulin and its turnover on the cell membrane. Proc Natl Acad Sci U S A (1974) 1.80

Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer. Nature (1992) 1.79

Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis. J Exp Med (1991) 1.77

HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J Exp Med (1996) 1.77

The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. J Immunol (1998) 1.69

Differential transport requirements of HLA and H-2 class I glycoproteins. Immunogenetics (1989) 1.67

Purification of papain-solubilized histocompatibility antigens from a cultured human lymphoblastoid line, RPMI 4265. J Biol Chem (1975) 1.66

Antisera to human B-lymphocyte membrane glycoproteins block stimulation in mixed lymphocyte culture. Nature (1975) 1.64

Lack of detectable endocytosis of B lymphocyte MHC class II antigens using an antibody-independent technique. J Immunol (1990) 1.60

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity (1994) 1.59

Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex. Proc Natl Acad Sci U S A (1984) 1.59

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading. Immunity (1998) 1.58

Negative regulation by HLA-DO of MHC class II-restricted antigen processing. Science (1997) 1.55

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus. Proc Natl Acad Sci U S A (1991) 1.54

Monoclonal antibody to HLA-A3. Hybridoma (1982) 1.54

Natural killing target antigens as inducers of interferon: studies with an immunoselected, natural killing-resistant human T lymphoblastoid cell line. J Immunol (1985) 1.52

Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system. Proc Natl Acad Sci U S A (1980) 1.50

Abelson leukemia virus induces lymphoid and erythroid colonies in infected fetal cell cultures. Cell (1981) 1.50

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens. J Cell Biol (1990) 1.49

The immunoglobulin-like structure of human histocompatibility antigens. Transplant Rev (1974) 1.48

Human transporters associated with antigen processing possess a promiscuous peptide-binding site. Immunity (1994) 1.46

Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action. J Biol Chem (2000) 1.45

Transferrin receptors on human B and T lymphoblastoid cell lines. Biochim Biophys Acta (1979) 1.44

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. J Exp Med (1995) 1.44

Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers. J Immunol (1993) 1.41

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes. J Immunol (1992) 1.40

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation. J Immunol (1992) 1.39

HLA-A2 as a target for cell-mediated lympholysis: evidence from immunoselected HLA-A2 negative mutant cell lines. Hum Immunol (1980) 1.39

Processing and delivery of peptides presented by MHC class I molecules. Curr Opin Immunol (1996) 1.38

Intracellular transport of class I MHC molecules in antigen processing mutant cell lines. J Immunol (1993) 1.38

Class I processing-defective Burkitt's lymphoma cells are recognized efficiently by CD4+ EBV-specific CTLs. J Immunol (1997) 1.34

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines. J Cell Biol (1994) 1.34

The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation. J Cell Biol (1991) 1.32

Association of human class I MHC alleles with the adenovirus E3/19K protein. J Immunol (1994) 1.30

The alpha 1/alpha 2 domains of class I HLA molecules confer resistance to natural killing. J Immunol (1989) 1.30

A role for calnexin (IP90) in the assembly of class II MHC molecules. EMBO J (1994) 1.29

Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2). Proc Natl Acad Sci U S A (1994) 1.27

Assembly, intracellular localization, and nucleotide binding properties of the human peptide transporters TAP1 and TAP2 expressed by recombinant vaccinia viruses. J Biol Chem (1995) 1.21

The transport of class I major histocompatibility complex antigens is determined by sequences in the alpha 1 and alpha 2 protein domains. Immunogenetics (1990) 1.21

A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum. J Immunol (2001) 1.20

Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone. J Biol Chem (1993) 1.20

Tissue-specific expression of cell-surface Qa-2 antigen from a transfected Q7b gene of C57BL/10 mice. J Exp Med (1987) 1.18

Dimeric and monomeric forms of HL-A antigens solubilized by detergent. J Immunol (1975) 1.17

Involvement of carbohydrate in the immunochemical determinant area of HL-A substances. Nat New Biol (1971) 1.17

Spatial arrangement of H-2 specificities: evidence from antibody adsorption and kinetic studies. Transplantation (1968) 1.17

Identification of the region on the class I histocompatibility molecule that interacts with the molecular chaperone, p88 (calnexin, IP90). J Biol Chem (1993) 1.16

Evidence for two trans-acting genes regulating HLA class II antigen expression. J Immunol (1985) 1.16

The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex. Curr Biol (1998) 1.14

A human leukocyte antigen identified by a monoclonal antibody. Hum Immunol (1981) 1.13

The N-terminal region of tapasin is required to stabilize the MHC class I loading complex. Eur J Immunol (1999) 1.13

Different MHC class I alleles compete for presentation of overlapping viral epitopes. Immunity (1995) 1.13

Molecular requirements for the interaction of class II major histocompatibility complex molecules and invariant chain with calnexin. J Biol Chem (1995) 1.13

HLA class II on HIV particles is functional in superantigen presentation to human T cells: implications for HIV pathogenesis. AIDS Res Hum Retroviruses (1995) 1.12

Peptide-induced modulation of target cell sensitivity to natural killing. J Immunol (1992) 1.12

Interferon-gamma rapidly increases peptide transporter (TAP) subunit expression and peptide transport capacity in endothelial cells. J Biol Chem (1997) 1.10

HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments. Immunity (1996) 1.09

Transport properties of free and MHC class II-associated oligomers containing different isoforms of human invariant chain. Int Immunol (1994) 1.08

Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo. J Immunol (1993) 1.07

The protease inhibitor, N-acetyl-L-leucyl-L-leucyl-leucyl-L-norleucinal, decreases the pool of major histocompatibility complex class I-binding peptides and inhibits peptide trimming in the endoplasmic reticulum. J Exp Med (1996) 1.07

Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2. J Immunol (1992) 1.07

Invariant chain associates with HLA class II antigens via its extracytoplasmic region. J Immunol (1986) 1.03