Published in Annu Rev Genet on January 01, 1995
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J (2001) 5.34
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev (2006) 5.03
Non-coding RNAs: the architects of eukaryotic complexity. EMBO Rep (2001) 4.74
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev (2003) 4.73
Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha). EMBO J (1998) 3.99
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A (2001) 3.87
X-chromosome silencing in the germline of C. elegans. Development (2002) 3.69
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev (2010) 3.49
Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Mol Cell Biol (1998) 3.30
Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans. Development (1998) 3.14
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol (2002) 3.13
Maintenance of genomic imprinting at the Arabidopsis medea locus requires zygotic DDM1 activity. Genes Dev (1999) 2.97
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell (2010) 2.80
Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci U S A (1999) 2.76
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci U S A (2003) 2.67
The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci U S A (2001) 2.65
The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex. Proc Natl Acad Sci U S A (1998) 2.52
Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev (2002) 2.37
The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain. J Cell Biol (1998) 2.29
RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J (1999) 2.11
Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2. Genetics (1998) 2.08
Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo. Genes Dev (2004) 2.01
PIE1, an ISWI family gene, is required for FLC activation and floral repression in Arabidopsis. Plant Cell (2003) 1.95
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer (2010) 1.93
Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci U S A (2012) 1.90
Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. Mol Cell Biol (1997) 1.89
Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia. EMBO J (2000) 1.87
RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. Mol Cell Biol (1997) 1.83
Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci U S A (2007) 1.80
The Drosophila brahma complex is an essential coactivator for the trithorax group protein zeste. Genes Dev (2000) 1.79
Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression. Mol Cell Biol (2002) 1.74
Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J (1997) 1.67
The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster. Mol Cell Biol (1999) 1.66
Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. Proc Natl Acad Sci U S A (1999) 1.53
Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells. Mol Cell Biol (2001) 1.52
A genetic screen for modifiers of E2F in Drosophila melanogaster. Genetics (1999) 1.51
Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery. Genes Dev (2002) 1.51
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO J (2004) 1.49
Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev (2003) 1.47
Native and recombinant polycomb group complexes establish a selective block to template accessibility to repress transcription in vitro. Mol Cell Biol (2002) 1.47
Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. Proc Natl Acad Sci U S A (1997) 1.44
Polycomb group response elements in Drosophila and vertebrates. Adv Genet (2013) 1.43
Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase. Genetics (2004) 1.42
Trithorax and ASH1 interact directly and associate with the trithorax group-responsive bxd region of the Ultrabithorax promoter. Mol Cell Biol (1999) 1.38
Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol Cell Biol (1996) 1.36
Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx. PLoS One (2009) 1.32
BRCA1 is a negative modulator of the PRC2 complex. EMBO J (2013) 1.31
The Arabidopsis MALE MEIOCYTE DEATH1 gene encodes a PHD-finger protein that is required for male meiosis. Plant Cell (2003) 1.28
Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge. Genes Dev (2011) 1.26
Phenotypic plasticity in Drosophila pigmentation caused by temperature sensitivity of a chromatin regulator network. PLoS Genet (2007) 1.25
The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein. Proc Natl Acad Sci U S A (2008) 1.22
Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins. Mol Cell Biol (2001) 1.21
Transcriptional silencing by polycomb-group proteins. Cold Spring Harb Perspect Biol (2014) 1.19
Multiple activities contribute to Pc2 E3 function. EMBO J (2004) 1.19
Polycomb group repression is blocked by the Drosophila suppressor of Hairy-wing [su(Hw)] insulator. Genetics (1998) 1.18
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics (2011) 1.18
Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions. Genome Biol (2007) 1.18
The SAND domain protein ULTRAPETALA1 acts as a trithorax group factor to regulate cell fate in plants. Genes Dev (2009) 1.17
MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A (2004) 1.16
GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element. Nucleic Acids Res (2003) 1.15
A complex array of DNA-binding proteins required for pairing-sensitive silencing by a polycomb group response element from the Drosophila engrailed gene. Genetics (2002) 1.13
Genetic analysis of incurvata mutants reveals three independent genetic operations at work in Arabidopsis leaf morphogenesis. Genetics (2000) 1.13
Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein. Proc Natl Acad Sci U S A (1997) 1.12
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J (2010) 1.12
Position-dependent methylation and transcriptional silencing of transgenes in inverted T-DNA repeats: implications for posttranscriptional silencing of homologous host genes in plants. Mol Cell Biol (1998) 1.11
Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster. Genetics (1998) 1.11
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat Med (2015) 1.10
Essential role of Drosophila Hdac1 in homeotic gene silencing. Proc Natl Acad Sci U S A (2001) 1.10
A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function. Genetics (1998) 1.10
Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth. Cancer Genet (2014) 1.10
Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila. Curr Genomics (2008) 1.09
A double-bromodomain protein, FSH-S, activates the homeotic gene ultrabithorax through a critical promoter-proximal region. Mol Cell Biol (2007) 1.09
pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex. Mol Cell Biol (2002) 1.08
In vivo chromatin accessibility correlates with gene silencing in Drosophila. Genetics (1998) 1.08
Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene. Proc Natl Acad Sci U S A (1998) 1.08
Homeobox genes in mammary gland development and neoplasia. Breast Cancer Res (2000) 1.07
The Promoter Targeting Sequence mediates epigenetically heritable transcription memory. Genes Dev (2004) 1.06
Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med (Maywood) (2010) 1.06
huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions. Proc Natl Acad Sci U S A (2000) 1.05
CPP1, a DNA-binding protein involved in the expression of a soybean leghemoglobin c3 gene. Proc Natl Acad Sci U S A (2000) 1.04
Diverse involvement of EZH2 in cancer epigenetics. Am J Transl Res (2015) 1.04
Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and Pleiohomeotic. Mol Cell Biol (2006) 1.04
Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes. Genetics (1999) 1.02
Transvection and silencing of the Scr homeotic gene of Drosophila melanogaster. Genetics (2002) 0.98
Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb. Proc Natl Acad Sci U S A (2001) 0.97
Dynamic changes in Ezh2 gene occupancy underlie its involvement in neural stem cell self-renewal and differentiation towards oligodendrocytes. PLoS One (2012) 0.96
Bmi-1: At the crossroads of physiological and pathological biology. Genes Dis (2015) 0.95
Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem (2011) 0.94
Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster. Proc Natl Acad Sci U S A (2003) 0.94
A screen for genes that interact with the Drosophila pair-rule segmentation gene fushi tarazu. Genetics (2004) 0.93
ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumour-suppressor activities in pancreatic cancer cell lines. Br J Cancer (2013) 0.93
Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations. EMBO J (1998) 0.92
Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila. Development (2012) 0.90
A molecular portrait of Arabidopsis meiosis. Arabidopsis Book (2006) 0.90
Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation. Chin J Cancer (2014) 0.89
The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus. Genetics (2002) 0.89
E2f6 and Bmi1 cooperate in axial skeletal development. Dev Dyn (2008) 0.89
PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression. Nucleic Acids Res (2015) 0.88
Molecular mechanisms governing differential robustness of development and environmental responses in plants. Ann Bot (2015) 0.87