Published in Proc Natl Acad Sci U S A on February 14, 2003
Chromatin remodelling during development. Nature (2010) 5.86
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev (2005) 3.89
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol (2008) 3.80
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell (2008) 3.42
Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet (2010) 3.29
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J (2006) 3.21
Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol (2013) 2.96
Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev (2010) 2.63
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol (2010) 2.55
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res (2010) 2.37
Polycomb group complexes--many combinations, many functions. Trends Cell Biol (2009) 2.36
Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1. Mol Cell Biol (2005) 2.27
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell (2014) 2.20
NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression. EMBO J (2011) 2.09
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell (2011) 2.01
Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat Rev Genet (2013) 1.98
Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells. J Cell Biol (2007) 1.82
Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells. PLoS One (2008) 1.72
Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis (2011) 1.70
A new world of Polycombs: unexpected partnerships and emerging functions. Nat Rev Genet (2013) 1.67
Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A (2010) 1.64
Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health. Epigenetics (2010) 1.63
Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol (2013) 1.61
Chromatin regulatory mechanisms in pluripotency. Annu Rev Cell Dev Biol (2010) 1.51
O-GlcNAc cycling: emerging roles in development and epigenetics. Semin Cell Dev Biol (2010) 1.50
Bivalent histone modifications in early embryogenesis. Curr Opin Cell Biol (2012) 1.48
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS One (2009) 1.47
Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Mol Cell Biol (2005) 1.46
Epigenetic control of embryonic stem cell fate. J Exp Med (2010) 1.40
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32
Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. Dev Biol (2009) 1.30
Monoubiquitination of H2AX protein regulates DNA damage response signaling. J Biol Chem (2011) 1.29
Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. Proc Natl Acad Sci U S A (2008) 1.28
REST-mediated recruitment of polycomb repressor complexes in mammalian cells. PLoS Genet (2012) 1.26
Changes in the distributions and dynamics of polycomb repressive complexes during embryonic stem cell differentiation. Mol Cell Biol (2008) 1.26
Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. Development (2010) 1.20
Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion. Mol Cell Biol (2007) 1.19
The JARID2-PRC2 duality. Genes Dev (2010) 1.18
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics (2011) 1.18
The many faces of ubiquitinated histone H2A: insights from the DUBs. Cell Div (2008) 1.18
Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Nucleic Acids Res (2011) 1.16
Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation. Genes Dev (2015) 1.12
Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. Cell Res (2012) 1.12
Mechanisms regulating epidermal stem cells. EMBO J (2012) 1.07
The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development. Genes Dev (2015) 1.07
Genomic approaches to deconstruct pluripotency. Annu Rev Genomics Hum Genet (2011) 1.06
Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus. Sci Signal (2012) 1.06
Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. EMBO J (2005) 1.02
The role of PTIP in maintaining embryonic stem cell pluripotency. Stem Cells (2009) 1.01
Anterior-posterior differences in HoxD chromatin topology in limb development. Development (2012) 1.00
RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy. Cell Res (2014) 0.99
The polycomb repressive complex 2 is a potential target of SUMO modifications. PLoS One (2008) 0.99
RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development. Proc Natl Acad Sci U S A (2013) 0.97
FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription. PLoS Genet (2013) 0.95
The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation. EMBO J (2013) 0.94
Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression. Cell Cycle (2016) 0.93
Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene (2013) 0.92
Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells. Genes Dev (2012) 0.91
Establishment of epigenetic patterns in development. Chromosoma (2012) 0.90
The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment. Nat Commun (2014) 0.90
The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development. PLoS One (2013) 0.87
The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis. PLoS One (2013) 0.86
The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells. Oncotarget (2014) 0.84
USP7 cooperates with SCML2 to regulate the activity of PRC1. Mol Cell Biol (2015) 0.83
Polycomb repressive complex 2 in embryonic stem cells: an overview. Protein Cell (2011) 0.83
KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. Mol Cell Biol (2014) 0.83
Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells. Cancer Res (2014) 0.82
Epigenetic regulation of cardiac development and function by polycomb group and trithorax group proteins. Dev Dyn (2012) 0.82
Gene expression dynamics in deer antler: mesenchymal differentiation toward chondrogenesis. Mol Genet Genomics (2006) 0.81
Molecular basis of Mammalian embryonic stem cell pluripotency and self-renewal. Acta Naturae (2010) 0.81
Parallel gateways to pluripotency: open chromatin in stem cells and development. Curr Opin Genet Dev (2010) 0.81
Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol (2014) 0.80
The Polycomb protein and E3 ubiquitin ligase Ring1B harbors an IRES in its highly conserved 5' UTR. PLoS One (2008) 0.79
ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf. Oncogene (2010) 0.78
Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells. BMC Genomics (2011) 0.78
Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth. Dev Biol (2013) 0.78
Epigenetics of pluripotent cells. Acta Naturae (2012) 0.78
Nuclear reprogramming in mouse primordial germ cells: epigenetic contribution. Stem Cells Int (2011) 0.77
The roles and regulation of Polycomb complexes in neural development. Cell Tissue Res (2014) 0.77
The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging. PLoS One (2016) 0.77
Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Sci Rep (2016) 0.76
The evolutionary landscape of PRC1 core components in green lineage. Planta (2016) 0.76
Autophagy regulation: RNF2 targets AMBRA1. Cell Res (2014) 0.75
Proteomic profile of maternal-aged blastocoel fluid suggests a novel role for ubiquitin system in blastocyst quality. J Assist Reprod Genet (2016) 0.75
UbE2E1/UBCH6 is a critical in vivo E2 for the PRC1 catalyzed ubiquitination of H2A at K119. J Biol Chem (2017) 0.75
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. Elife (2016) 0.75
Role of Polycomb RYBP in Maintaining the B-1-to-B-2 B-Cell Lineage Switch in Adult Hematopoiesis. Mol Cell Biol (2015) 0.75
Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2. Sci Rep (2016) 0.75
Molecular architecture of polycomb repressive complexes. Biochem Soc Trans (2017) 0.75
Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. Genes Dev (2016) 0.75
Polycomb enables primitive endoderm lineage priming in embryonic stem cells. Elife (2016) 0.75
Rnf2 knockdown reduces cell viability and promotes cell cycle arrest in gastric cancer cells. Oncol Lett (2017) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
A generic protein purification method for protein complex characterization and proteome exploration. Nat Biotechnol (1999) 25.13
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
A gene complex controlling segmentation in Drosophila. Nature (1978) 23.75
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res (1990) 20.53
Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell (2002) 13.05
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature (1999) 12.60
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41
Hox genes in vertebrate development. Cell (1994) 9.27
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science (2002) 7.33
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther (1996) 7.12
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev (1994) 6.10
Maternal control of embryogenesis by MEDEA, a polycomb group gene in Arabidopsis. Science (1998) 6.08
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet (1999) 5.58
Reconstitution of a functional core polycomb repressive complex. Mol Cell (2001) 4.39
Imprinting a determined state into the chromatin of Drosophila. Trends Genet (1990) 4.04
The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet (1995) 4.03
Polycombing the genome: PcG, trxG, and chromatin silencing. Cell (1998) 3.97
A gene product required for correct initiation of segmental determination in Drosophila. Nature (1981) 3.97
Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Mol Cell Biol (1998) 3.30
The eed mutation disrupts anterior mesoderm production in mice. Development (1995) 3.17
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol (2002) 3.13
Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta (2002) 2.96
Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev (1997) 2.96
The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development (1998) 2.90
Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev (1997) 2.83
Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster. Genetics (1982) 2.78
Locking in stable states of gene expression: transcriptional control during Drosophila development. Curr Opin Cell Biol (1995) 2.75
Polycomb group proteins and heritable silencing of Drosophila Hox genes. Development (2001) 2.67
The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci U S A (2001) 2.65
Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat Genet (2001) 2.63
A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development (1987) 2.44
A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Development (1996) 2.33
Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature (1996) 2.31
Establishment of Polycomb silencing requires a transient interaction between PC and ESC. Genes Dev (2001) 2.23
Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development (2001) 2.21
Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol (1998) 2.17
The Polycomb group--no longer an exclusive club? Curr Opin Genet Dev (2001) 2.05
Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development (1997) 2.00
Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene (1997) 1.98
The Polycomb group in Caenorhabditis elegans and maternal control of germline development. Development (1998) 1.97
Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. Mol Cell Biol (1997) 1.89
Early role of the esc+ gene product in the determination of segments in Drosophila. Cell (1982) 1.86
Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Mol Cell Biol (2002) 1.85
RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. Mol Cell Biol (1997) 1.83
Linking the Rb and polycomb pathways. Mol Cell (2001) 1.76
Polycomb group protein complexes: do different complexes regulate distinct target genes? Biochim Biophys Acta (1999) 1.75
Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development (1990) 1.71
Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J (1997) 1.67
Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development (1997) 1.65
Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice. Development (2000) 1.50
Initiation, establishment and maintenance of Hox gene expression patterns in the mouse. Int J Dev Biol (1999) 1.31
Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development (2002) 1.26
Genetic interactions and dosage effects of Polycomb group genes in mice. Development (1998) 1.18
The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene (1998) 1.06
Cell memory and cancer--the story of the trithorax and Polycomb group genes. Cancer Metastasis Rev (1999) 0.91
Restricted oncogenicity of BCR/ABL p190 in transgenic mice. Cancer Res (1992) 0.89
Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development. Development (1990) 0.79
Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer (2006) 11.48
Stem cells and cancer; the polycomb connection. Cell (2004) 7.43
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol Cell (2010) 6.71
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature (2004) 4.82
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev (2005) 3.89
Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med (2004) 3.88
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet (2006) 3.83
Polycomb complexes and silencing mechanisms. Curr Opin Cell Biol (2004) 3.25
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity (2004) 3.25
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25
Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. PLoS Biol (2009) 3.24
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J (2006) 3.21
Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell (2007) 3.14
Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta (2002) 2.96
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. Proc Natl Acad Sci U S A (2005) 2.81
Stem cell regulation by polycomb repressors: postponing commitment. Curr Opin Cell Biol (2008) 2.81
Epigenetics and cancer. Genes Dev (2004) 2.72
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet (2002) 2.53
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet (2008) 2.37
Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol (2004) 2.31
Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1. Mol Cell Biol (2005) 2.27
Chromatin position effects assayed by thousands of reporters integrated in parallel. Cell (2013) 2.16
Hox genes and regional patterning of the vertebrate body plan. Dev Biol (2010) 2.09
Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A (2004) 2.08
Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest (2012) 2.03
Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell (2009) 2.01
Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev (2002) 1.95
A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat Protoc (2009) 1.95
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med (2006) 1.94
Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development (2002) 1.91
In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell (2013) 1.89
Interactions among Polycomb domains are guided by chromosome architecture. PLoS Genet (2011) 1.76
Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells. PLoS One (2008) 1.72
PRC1 coordinates timing of sexual differentiation of female primordial germ cells. Nature (2013) 1.65
Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma. Int J Cancer (2007) 1.62
Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide. Pain Med (2010) 1.54
Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J (2003) 1.53
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol (2011) 1.52
Validation of reference genes for quantitative RT-PCR studies in porcine oocytes and preimplantation embryos. BMC Dev Biol (2007) 1.51
Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation. J Neurosci (2005) 1.48
Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J (2003) 1.48
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J Biol Chem (2001) 1.46
Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium. Curr Biol (2008) 1.45
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene (2002) 1.45
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A. Breast Cancer Res (2009) 1.44
EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res (2008) 1.42
The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. J Biol Chem (2002) 1.42
Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One (2010) 1.41
Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol Cell Biol (2003) 1.41
BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev (2004) 1.40
Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo. Development (2003) 1.36
RUNX: a trilogy of cancer genes. Cancer Cell (2002) 1.34
The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development (2006) 1.28
The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev (2009) 1.24
Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development (2003) 1.24
The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos. Development (2012) 1.23
Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1. Mol Cell (2003) 1.20
Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One (2010) 1.20
Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. Hum Mol Genet (2012) 1.18
Differences in early lineage segregation between mammals. Dev Dyn (2008) 1.17
Retinoids regulate the anterior expression boundaries of 5' Hoxb genes in posterior hindbrain. EMBO J (2003) 1.15
The emerging role of Polycomb repressors in the response to DNA damage. J Cell Sci (2012) 1.14
Cdx2 determines the fate of postnatal intestinal endoderm. Development (2011) 1.10
Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems? Int J Dev Biol (2006) 1.09
Polycomb function during oogenesis is required for mouse embryonic development. Genes Dev (2012) 1.09
Cerebellar granule cells: insights into proliferation, differentiation, and role in medulloblastoma pathogenesis. Int J Biochem Cell Biol (2008) 1.08
Evaluation of olfactory dysfunction in neurodegenerative diseases. J Neurol Sci (2012) 1.06
Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression. Immunity (2008) 1.05
Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion. Neoplasia (2008) 1.04
Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development (2011) 1.04
Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res (2010) 1.03
Extracellular matrix components direct porcine muscle stem cell behavior. Exp Cell Res (2009) 1.03
Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes. Cancer Res (2010) 1.02
Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J Immunol (2006) 1.01
Intercenter differences in diffusion tensor MRI acquisition. J Magn Reson Imaging (2010) 1.01
The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. Proc Natl Acad Sci U S A (2011) 1.00
Hox, Cdx, and anteroposterior patterning in the mouse embryo. Curr Top Dev Biol (2009) 1.00
Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence. Biol Reprod (2011) 1.00
Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice. Proc Natl Acad Sci U S A (2008) 0.99
Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development (2006) 0.99
Conditional activation of Bmi1 expression regulates self-renewal, apoptosis, and differentiation of neural stem/progenitor cells in vitro and in vivo. Stem Cells (2011) 0.99
Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse. Mech Dev (2002) 0.98
Cancer testis antigen expression in gastrointestinal stromal tumors: new markers for early recurrence. Int J Cancer (2008) 0.98
Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2. Cancer Res (2006) 0.97
Isolation and characterization of porcine adult muscle-derived progenitor cells. J Cell Biochem (2008) 0.96
Developmental biology: two paths to silence merge. Nature (2006) 0.95
Congenital talipes equinovarus: an epidemiological study in Sicily. Acta Orthop (2012) 0.95
Neural stem cells, tumour stem cells and brain tumours: dangerous relationships? Biochim Biophys Acta (2007) 0.95
Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J (2011) 0.94
The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation. EMBO J (2013) 0.94
Bmi1 is expressed in postnatal myogenic satellite cells, controls their maintenance and plays an essential role in repeated muscle regeneration. PLoS One (2011) 0.93
Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies. Clin Cancer Res (2010) 0.93
Analysis of co-expression of OCT4, NANOG and SOX2 in pluripotent cells of the porcine embryo, in vivo and in vitro. Theriogenology (2010) 0.92
The effects of growth factors on in vitro-cultured porcine testicular cells. Reproduction (2009) 0.92