Published in Br J Cancer on September 01, 1996
Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol Sci (2009) 1.37
Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells. Nucleic Acids Res (2007) 1.36
Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles. Br J Cancer (2005) 1.05
Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro. Invest New Drugs (1998) 0.86
Cytotoxic activity of topotecan in human tumour cell lines and primary cultures of human tumour cells from patients. Br J Cancer (1997) 0.85
Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga. Biochem J (2002) 0.80
Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients. Invest New Drugs (2008) 0.79
Brunn: an open source laboratory information system for microplates with a graphical plate layout design process. BMC Bioinformatics (2011) 0.79
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system. Invest New Drugs (2012) 0.78
Structure-activity relationship analysis of cytotoxic cyanoguanidines: selection of CHS 828 as candidate drug. BMC Res Notes (2009) 0.75
Comparison of the cytotoxic activity of melphalan with L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine in human tumour cell lines and primary cultures of tumour cells from patients. Br J Cancer (1998) 0.75
4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms. Croat Med J (2017) 0.75
Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro. Invest New Drugs (2007) 0.75
Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science (1992) 24.32
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res (1988) 9.96
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst (1991) 9.39
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (1992) 8.84
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J Natl Cancer Inst (1989) 4.97
Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J Clin Oncol (1989) 2.89
Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents. J Natl Cancer Inst (1994) 2.78
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res (1994) 2.49
Neural computing in cancer drug development: predicting mechanism of action. Science (1992) 2.38
Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin. Cancer Res (1987) 1.88
Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein. Cancer Res (1986) 1.75
Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen. Mol Pharmacol (1994) 1.70
The cell biology of multiple drug resistance. Biochem Pharmacol (1987) 1.55
Development and characterization of a melphalan-resistant human multiple myeloma cell line. Cancer Res (1991) 1.50
Antineoplastic drug screening belongs in the laboratory, not in the clinic. J Natl Cancer Inst (1992) 1.44
Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26). Cancer Res (1987) 1.44
Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line. Cancer Res (1990) 1.39
Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26. Biochemistry (1988) 1.38
Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA). Int J Cancer (1992) 1.37
Role of the glutathione redox cycle in acquired and de novo multidrug resistance. Science (1988) 1.34
Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen. J Clin Invest (1995) 1.30
Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells. Cancer Res (1987) 1.21
Current results of the screening program at the Division of Cancer Treatment, National Cancer Institute. Eur J Cancer (1981) 1.07
Up-regulation of gamma-glutamylcysteine synthetase activity in melphalan-resistant human multiple myeloma cells expressing increased glutathione levels. Cancer Chemother Pharmacol (1994) 1.07
Detection of tumor-specific cytotoxic drug activity in vitro using the fluorometric microculture cytotoxicity assay and primary cultures of tumor cells from patients. Int J Cancer (1994) 1.04
A two-dimensional gel database of rat liver proteins useful in gene regulation and drug effects studies. Electrophoresis (1991) 1.03
Predictive statistics and artificial intelligence in the U.S. National Cancer Institute's Drug Discovery Program for Cancer and AIDS. Stem Cells (1994) 0.98
Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors. Semin Oncol (1995) 0.92
Clinical drug development: an analysis of phase II trials, 1970-1985. Cancer Treat Rep (1987) 0.92
Differential in vitro sensitivity of human tumor and normal cells to chemotherapeutic agents and resistance modulators. Int J Cancer (1991) 0.89
Development of vincristine resistance and increased sensitivity to cyclosporin A and verapamil in the human U-937 lymphoma cell line without overexpression of the 170-kDa P-glycoprotein. Int J Cancer (1994) 0.89
A rapid fluorometric method for semiautomated determination of cytotoxicity and cellular proliferation of human tumor cell lines in microculture. Anticancer Res (1989) 0.89
Multidrug resistance from the clinical point of view. Eur J Cancer (1991) 0.87
Feasibility of the fluorometric microculture cytotoxicity assay (FMCA) for cytotoxic drug sensitivity testing of tumor cells from patients with acute lymphoblastic leukemia. Leukemia (1992) 0.85
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II. Cancer Res (1991) 0.85
Verapamil and cyclosporin A sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+ concentration. Biosci Rep (1990) 0.85
Current status of cancer drug development: failure or limited success? Cancer Cells (1990) 0.84
The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL. Br J Cancer (1995) 0.83
In vitro activity of 2-chlorodeoxyadenosine (CdA) in primary cultures of human haematological and solid tumours. Eur J Cancer (1994) 0.83
2 chlorodeoxyadenosine activity and cross resistance patterns in primary cultures of human hematologic neoplasms. Br J Cancer (1993) 0.83
Chemotherapeutic drug sensitivity testing of human leukemia cells in vitro using a semiautomated fluorometric assay. Leukemia (1990) 0.82
Characterisation of a vindesine-resistant human small-cell lung cancer cell line. Br J Cancer (1993) 0.80
Drug resistance mechanisms in leukaemia. Baillieres Clin Haematol (1991) 0.79
Drug resistance. Br Med Bull (1991) 0.78
An etoposide-resistant lung cancer subline overexpresses the multidrug resistance-associated protein. Br J Cancer (1995) 0.77
Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer (1976) 14.08
Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas. Proc Natl Acad Sci U S A (1974) 5.13
Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. Int J Cancer (1976) 4.35
The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol (2007) 4.22
A massive binary black-hole system in OJ 287 and a test of general relativity. Nature (2008) 3.50
Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines. J Exp Med (1976) 3.49
Fasting capillary glucose as a screening test for gestational diabetes mellitus. BJOG (2006) 3.23
Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient. Clin Exp Immunol (1970) 3.17
A primordial tRNA modification required for the evolution of life? EMBO J (2001) 3.01
The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV. Int J Cancer (1971) 2.96
K562--a human erythroleukemic cell line. Int J Cancer (1979) 2.84
Phenotypic and cytogenetic characteristics of human B-lymphoid cell lines and their relevance for the etiology of Burkitt's lymphoma. Adv Cancer Res (1982) 2.68
High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families. J Natl Cancer Inst (2000) 2.41
Classification and biological nature of established human hematopoietic cell lines. Int J Cancer (1975) 2.16
Susceptibility to infection by the human immunodeficiency virus (HIV) correlates with T4 expression in a parental monocytoid cell line and its subclones. Virology (1987) 2.11
Phorbol ester-induced differentiation of chronic lymphocytic leukaemia cells. Nature (1980) 2.08
High-frequency establishment of human immunoglobulin-producing lymphoblastoid lines from normal and malignant lymphoid tissue and peripheral blood. Int J Cancer (1971) 2.06
Specific binding of proinsulin C-peptide to human cell membranes. Proc Natl Acad Sci U S A (1999) 1.91
MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation. Leuk Res (1999) 1.90
Tumorigenicity of human hematopoietic cell lines in athymic nude mice. Int J Cancer (1977) 1.84
Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin. Transplantation (2000) 1.83
Early prediction of response to first-line chemotherapy by sequential [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in patients with advanced colorectal cancer. Ann Oncol (2009) 1.77
Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes. Ups J Med Sci (2000) 1.74
Nasal continuous positive airway pressure: experiences with a new technical approach. Acta Paediatr (1993) 1.74
Transfer RNA modification: influence on translational frameshifting and metabolism. FEBS Lett (1999) 1.73
Phenotypic characterization of the human mast-cell line HMC-1. Scand J Immunol (1994) 1.73
Establishment and characteristics of two unique cell lines from patients with lymphosarcoma. Int J Cancer (1974) 1.73
Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc. Oncogene (1994) 1.69
Radio imaging of the very-high-energy gamma-ray emission region in the central engine of a radio galaxy. Science (2009) 1.66
Very-high-energy gamma rays from a distant quasar: how transparent is the universe? Science (2008) 1.65
Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? Diabetes (1999) 1.65
A systematic overview of chemotherapy effects in colorectal cancer. Acta Oncol (2001) 1.61
Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis: prognosis and treatment of recurrences in a cohort study. Eur J Surg Oncol (2012) 1.58
Production of beta 2-microglobulin by normal and malignant human cell lines and peripheral lymphocytes. Transplant Rev (1974) 1.57
Model describing the relationship between pharmacokinetics and hematologic toxicity of the epirubicin-docetaxel regimen in breast cancer patients. J Clin Oncol (2004) 1.51
The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia. Leukemia (2006) 1.47
A systematic overview of chemotherapy effects in gastric cancer. Acta Oncol (2001) 1.46
Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internalization. Cell Stress Chaperones (1998) 1.45
Characteristics of Epstein-Barr virus activation of human B lymphocytes. J Exp Med (1981) 1.43
Natural killer cells kill tumour cells at a given stage of differentiation. Nature (1981) 1.43
Interleukin-2 and a T cell hybridoma (MP6) derived B cell-stimulatory factor act synergistically to induce proliferation and differentiation of human B-chronic lymphocytic leukemia cells. Leukemia (1989) 1.42
Surface characteristics of the U-937 human histiocytic lymphoma cell line: specific changes during inducible morphologic and functional differentiation in vitro. Haematol Blood Transfus (1981) 1.42
Summary report on the ISOBM TD-4 Workshop: analysis of 56 monoclonal antibodies against the MUC1 mucin. San Diego, Calif., November 17-23, 1996. Tumour Biol (1998) 1.40
Variable very-high-energy gamma-ray emission from the microquasar LS I +61 303. Science (2006) 1.40
A novel mutation in the beta-protein coding region of the amyloid beta-protein precursor (APP) gene. Hum Genet (1992) 1.39
C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway. J Immunol (1996) 1.37
Induction of differentiation of the human histiocytic lymphoma cell line U-937 by 1 alpha,25-dihydroxycholecalciferol. Cancer Res (1983) 1.37
Targeted resequencing of candidate genes using selector probes. Nucleic Acids Res (2010) 1.37
Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA). Int J Cancer (1992) 1.37
A systematic overview of chemotherapy effects in breast cancer. Acta Oncol (2001) 1.36
Formation and growth of multicellular spheroids of human origin. Int J Cancer (1983) 1.35
In vitro maturation of mononuclear phagocytes and susceptibility to HIV-1 infection. J Acquir Immune Defic Syndr (1991) 1.34
Phenotypic changes of human neuroblastoma cells in culture induced by 12-O-tetradecanoyl-phorbol-13-acetate. Int J Cancer (1981) 1.33
The initial change in tumor size predicts response and survival in patients with metastatic colorectal cancer treated with combination chemotherapy. Ann Oncol (2011) 1.33
Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells. Anticancer Drugs (2001) 1.33
Lipoprotein abnormalities are associated with increased rate of progression of human chronic renal insufficiency. Nephrol Dial Transplant (1997) 1.33
Effects of ticlopidine in AV-fistula surgery in uremia. Fistula Study Group. Scand J Urol Nephrol (1998) 1.30
Stem cell factor is a chemotactic factor for human mast cells. J Immunol (1994) 1.29
Immune functions of human synovial cells. Phenotypic and T cell regulatory properties of macrophage-like cells that express HLA-DR. Arthritis Rheum (1982) 1.29
Entrapment of animal cells for production of monoclonal antibodies and other biomolecules. Nature (1983) 1.29
Circular chromosomal map of a temperate Bacillus phage. Virology (1967) 1.28
Expression and function of chemokine receptors in human multiple myeloma. Leukemia (2003) 1.26
A new non-thrombogenic surface prepared by selective covalent binding of heparin via a modified reducing terminal residue. Biomater Med Devices Artif Organs (1983) 1.25
Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage. Leukemia (1994) 1.25
Analysis of oligonucleotide probe affinities using surface plasmon resonance: a means for mutational scanning. Anal Biochem (1997) 1.24
ATP is required for in vitro assembly of MHC class I antigens but not for transfer of peptides across the ER membrane. Cell (1991) 1.23
Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood (1992) 1.23
Physiology of canine intraventricular conduction and endocardial excitation. Circ Res (1972) 1.22
Independent expression of the two HL-A antigen polypeptide chains. Eur J Immunol (1976) 1.22
Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines. Blood (1996) 1.21
Identification of a cell-surface glycoprotein mediating cell adhesion in EBV-immortalized normal B cells. Int J Cancer (1986) 1.19
Spontaneous systemic lupus erythematosus and acelylator phenotype. Acta Med Scand (1977) 1.19
Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome. Blood (2001) 1.19
Bead-to-bead transfer of Chinese hamster ovary cells using macroporous microcarriers. Cytotechnology (1994) 1.18
Beta 2-microglobulin in chronic lymphocytic leukaemia. Scand J Haematol (1980) 1.18
Surface glycoprotein patterns of normal and malignant human lymphoid cells. II. B cells, B blasts and Epstein-Barr virus (EBV)-positive and -negative B lymphoid cell lines. Int J Cancer (1977) 1.18
Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study. Br J Cancer (2004) 1.17
Beta 2-microglobulin production in vitro by human hematopoietic, mesenchymal, and epithelial cells. J Immunol (1974) 1.17
Lipoprotein abnormalities without hyperlipidaemia in moderate renal insufficiency. Nephrol Dial Transplant (1994) 1.17
Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias. Leukemia (1994) 1.16
Population pharmacokinetic modelling of unbound and total plasma concentrations of paclitaxel in cancer patients. Eur J Cancer (2003) 1.16
Accessory function of human tumor cell lines. I. Production of interleukin 1 by the human histiocytic lymphoma cell line U-937. Eur J Immunol (1982) 1.15
Establishment and characterization of cell lines from human small cell and large cell carcinomas of the lung. Acta Pathol Microbiol Immunol Scand A (1985) 1.14
Development of immunocytes and immunoglobulin production in long-term cultures from normal and malignant human lymph nodes. Int J Cancer (1968) 1.14
Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18). J Cell Sci (1997) 1.13
Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. Proc Natl Acad Sci U S A (1988) 1.12
Hope for a cure and altruism are the main motives behind participation in phase 3 clinical cancer trials. Eur J Cancer Care (Engl) (2014) 1.11
Characteristics of established myeloma and lymphoblastoid cell lines derived from an E myeloma patient: a comparative study. Int J Cancer (1971) 1.11
Epstein-Barr virus (EBV) can immortalize B-cll cells activated by cytokines. Leukemia (1994) 1.11
Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood (1992) 1.11
Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulation. Blood (1998) 1.11
Consumption of refined sugar by patients with Crohn's disease, ulcerative colitis, or irritable bowel syndrome. Scand J Gastroenterol (1983) 1.10
A new device for administration of nasal continuous positive airway pressure in the newborn: an experimental study. Crit Care Med (1988) 1.10
Differential expression of platelet-derived growth factor and transforming growth factor genes in small- and non-small-cell human lung carcinoma lines. Int J Cancer (1988) 1.08
Neurone specific enolase: a useful diagnostic serum marker for small cell carcinoma of the lung. Thorax (1985) 1.08
Expression of gamma-subunit of enolase, neuron-specific enolase, in human non-neuroendocrine tumors and derived cell lines. Lab Invest (1986) 1.07
Expression of intermediate filaments in established human lung cancer cell lines. An indicator of differentiation and derivation. Lab Invest (1984) 1.07
Dynamics of nonstructural carbohydrates and biomass yield in a fodder legume tree at different harvest intensities. Tree Physiol (2001) 1.07