Published in Cancer Res on September 01, 1990
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci U S A (1994) 2.71
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci U S A (1994) 2.52
Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein. J Clin Invest (1994) 1.30
Tamoxifen blocks chloride channels. A possible mechanism for cataract formation. J Clin Invest (1994) 1.26
Multidrug resistance gene (P-glycoprotein) expression in the human fetus. Am J Pathol (1992) 1.08
Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells. Br J Cancer (1993) 1.08
Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype. Proc Natl Acad Sci U S A (1992) 1.08
Drug resistance features and S-phase fraction as possible determinants for drug response in a panel of human ovarian cancer xenografts. Br J Cancer (2000) 1.06
Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein. Br J Cancer (1991) 1.05
Anti-cancer drug characterisation using a human cell line panel representing defined types of drug resistance. Br J Cancer (1996) 1.03
Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line. Br J Cancer (1992) 1.03
Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites. Br J Cancer (1993) 0.98
Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer. Br J Cancer (1995) 0.92
High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines. Br J Cancer (1992) 0.87
Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression. Br J Cancer (1991) 0.86
cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene. Biochem J (1996) 0.85
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines. Br J Cancer (1995) 0.84
Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells. Br J Cancer (1993) 0.84
P-glycoprotein overexpression cannot explain the complete doxorubicin-resistance phenotype in rat glioblastoma cell lines. Br J Cancer (1992) 0.81
Ascorbic acid increases drug accumulation and reverses vincristine resistance of human non-small-cell lung-cancer cells. Biochem J (1994) 0.79
Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia. Br J Cancer (1997) 0.79
Modulation of vinblastine sensitivity by dipyridamole in multidrug resistant fibrosarcoma cells lacking mdr1 expression. Br J Cancer (1991) 0.79
Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells. Br J Cancer (1995) 0.79
Activity of cyclosporins as resistance modifiers in primary cultures of human haematological and solid tumours. Br J Cancer (1994) 0.77
Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF. Br J Cancer (1994) 0.76
Characterisation of a navelbine-resistant bladder carcinoma cell line cross-resistant to taxoids. Br J Cancer (1994) 0.75
High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science (1990) 10.72
WT-1 is required for early kidney development. Cell (1993) 7.05
Synthesis of and chains of rabbit hemoglobin in a cell-free extract from Krebs II ascites cells. Proc Natl Acad Sci U S A (1971) 5.92
Isolation and localization of DNA segments from specific human chromosomes. Proc Natl Acad Sci U S A (1980) 5.76
Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell (1986) 5.51
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res (2001) 4.05
Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues. J Cell Biol (1995) 4.04
Initiation of haemoglobin synthesis by methionyl-tRNA. Nature (1970) 3.99
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. J Pathol (2001) 3.94
Initiation of hemoglobin synthesis. Specific inhibition by antibiotics and bacteriophage ribonucleic acid. Biochemistry (1971) 3.50
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells. Proc Natl Acad Sci U S A (1999) 3.33
The candidate Wilms' tumour gene is involved in genitourinary development. Nature (1990) 3.13
Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis (1994) 3.12
Precise localization of human beta-globin gene complex on chromosome 11. Proc Natl Acad Sci U S A (1979) 3.05
Commitment to erythroid differentiation by friend erythroleukemia cells: a stochastic analysis. Cell (1976) 2.88
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci U S A (1994) 2.71
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res (1997) 2.67
Automated high resolution optical mapping using arrayed, fluid-fixed DNA molecules. Proc Natl Acad Sci U S A (1998) 2.50
Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy. Nat Genet (1996) 2.46
Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes. Proc Natl Acad Sci U S A (1973) 2.40
Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA. Nat Genet (1996) 2.36
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol (1989) 2.35
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science (1996) 2.35
A fine-structure deletion map of human chromosome 11p: analysis of J1 series hybrids. Somat Cell Mol Genet (1989) 2.29
Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis. Genes Dev (1987) 2.24
Expression of the Wilms' tumor gene WT1 in the murine urogenital system. Genes Dev (1991) 2.20
Absence of messenger RNA and gene DNA for beta-globin chains in hereditary persistence of fetal hemoglobin. Cell (1976) 2.10
The multidrug resistance (mdr1) gene product functions as an ATP channel. Proc Natl Acad Sci U S A (1993) 2.09
Cloning and characterization of a second member of the mouse mdr gene family. Mol Cell Biol (1988) 2.06
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3). Proc Natl Acad Sci U S A (1997) 2.01
The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood. Gastroenterology (2001) 1.99
Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res (1993) 1.99
The Fanconi anaemia group G gene FANCG is identical with XRCC9. Nat Genet (1998) 1.99
Somatic mosaicism in Fanconi anemia: molecular basis and clinical significance. Eur J Hum Genet (1997) 1.89
Stability of globin mRNA in terminally differentiating murine erythroleukemia cells. Cell (1981) 1.87
Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1. Am J Med Genet (1994) 1.86
Tissue distribution of the multidrug resistance protein. Am J Pathol (1996) 1.84
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci U S A (2000) 1.83
Genetic fine-structure mapping in human chromosome 11 by use of repetitive DNA sequences. Proc Natl Acad Sci U S A (1982) 1.83
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res (1996) 1.82
Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res (1993) 1.81
Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism. Nat Genet (1999) 1.81
HA-966 effects on striatal dopamine metabolism: implications for dopamine compartmentalization. J Pharm Pharmacol (1980) 1.80
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology (1997) 1.79
Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance. Int J Cancer (1988) 1.78
Induction of erythroid differentiation in vitro by purines and purine analogues. Cell (1976) 1.76
Platelet: transporter of vascular endothelial growth factor. Clin Cancer Res (1997) 1.74
Vaults are up-regulated in multidrug-resistant cancer cell lines. J Biol Chem (1998) 1.74
Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol Ther (1990) 1.73
Effects of 5-bromo-2' -deoxyuridine on production of globin messenger RNA in dimethyl sulfoxide-stimulated Friend leukemia cells. Proc Natl Acad Sci U S A (1973) 1.73
Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res (1994) 1.73
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res (1999) 1.72
Variability in the amount of beta-globin mRNA in beta0 thalassemia. Cell (1978) 1.70
Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9. Proc Natl Acad Sci U S A (1985) 1.70
The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc Natl Acad Sci U S A (1988) 1.69
Tissue distribution of the human MDR3 P-glycoprotein. Lab Invest (1994) 1.69
Quantitative immunofluorescence. Standardization and calibration in microfluorometry. Histochemie (1971) 1.69
The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM. Nat Genet (2000) 1.64
High frequency of large intragenic deletions in the Fanconi anemia group A gene. Am J Hum Genet (1999) 1.60
MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci U S A (1999) 1.59
Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia. Nature (1981) 1.56
Mice with a targeted disruption of the Fanconi anemia homolog Fanca. Hum Mol Genet (2000) 1.56
Interactions between exogenous deoxyribonucleic acid and membrane vesicles isolated from competent and noncompetent Bacillus subtilis. J Bacteriol (1975) 1.55
A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Schizophrenia Collaborative Linkage Group (Chromosome 22). Am J Med Genet (1996) 1.55
Absence of messenger RNA for beta globin chain in beta(0) thalassaemia. Nature (1974) 1.55
Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation. J Clin Pathol (1998) 1.54
Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy. J Cardiovasc Electrophysiol (1999) 1.53
Synthesis of cyclic oligonucleotides by a modified phosphotriester approach. Nucleic Acids Res (1988) 1.52
Localization of DNA sequences in region Xp21 of the human X chromosome: search for molecular markers close to the Duchenne muscular dystrophy locus. Am J Hum Genet (1985) 1.52
Isolation of a cDNA representing the Fanconi anemia complementation group E gene. Am J Hum Genet (2000) 1.51
Determination of serum iron and latent iron-binding capacity (LIBC). Clin Chim Acta (1971) 1.50
The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Hum Mol Genet (2000) 1.48
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. Cancer Res (2001) 1.45
Cell culture models for oxidative stress: superoxide and hydrogen peroxide versus normobaric hyperoxia. Mutat Res (1992) 1.43
Clinical significance of P-glycoprotein in multidrug resistance malignancies. Blood (1993) 1.43
Microcell mediated chromosome transfer maps the Fanconi anaemia group D gene to chromosome 3p. Nat Genet (1995) 1.43
A DNA polymorphism for Huntington's disease marks the future. Arch Neurol (1985) 1.43
Genes amplified and overexpressed in human multidrug-resistant cell lines. Cancer Res (1988) 1.42
Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein. Biochemistry (1998) 1.41
Long-term results of children with acute myeloid leukemia: a report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891. Leukemia (2005) 1.40
Effects of maternal thyroid status on thyroid hormones and growth in congenitally hypothyroid goat fetuses during the second half of gestation. Endocrinology (1997) 1.39
Characterization of an erythroid precursor cell of high proliferative capacity in normal human peripheral blood. Proc Natl Acad Sci U S A (1977) 1.39
Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2. Am J Med Genet (1994) 1.39
Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT. Am J Hum Genet (1991) 1.39
A mouse model of the aniridia-Wilms tumor deletion syndrome. Science (1990) 1.38
Different nuclease activities in competent and noncompetent Bacillus subtilis. J Bacteriol (1975) 1.37
Changes in the rate of DNA replication fork movement during S phase in mammalian cells. J Mol Biol (1975) 1.37
Recombination in a balanced complex translocation of a mother leading to a balanced reciprocal translocation in the child. Review of 60 cases of balanced complex translocations. Hum Genet (1997) 1.34
Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br J Cancer (1995) 1.32
A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA. Proc Natl Acad Sci U S A (1999) 1.32
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest (2000) 1.32
Functional synergism of the magainins PGLa and magainin-2 in Escherichia coli, tumor cells and liposomes. Eur J Biochem (1995) 1.32
The fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation. Proc Natl Acad Sci U S A (1998) 1.30
Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line. Cancer Res (1995) 1.29
Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. Blood (2000) 1.29
Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development. Nat Genet (1992) 1.28
Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines. Int J Cancer (1996) 1.27
Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J Clin Oncol (1998) 1.26