Published in Proc Natl Acad Sci U S A on October 01, 1996
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol (2012) 5.86
Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. J Exp Med (2000) 2.25
Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc Natl Acad Sci U S A (1998) 1.70
Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med (2000) 1.60
Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. J Clin Invest (2004) 1.53
Early B cell defects. Clin Exp Immunol (2000) 1.43
The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Mol Cell Biol (2000) 1.40
Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha. J Exp Med (2002) 1.34
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. BMC Immunol (2001) 1.29
Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase. Mol Cell Biol (1999) 1.19
B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation. J Exp Med (1998) 1.06
Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proc Natl Acad Sci U S A (2001) 1.06
Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase. EMBO J (1998) 1.01
Safety and activity of BTK inhibitor ibrutinib combined with ofatumumab in chronic lymphocytic leukemia: a phase 1b/2 study. Blood (2015) 0.98
B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2. J Immunol (2009) 0.97
Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies. J Clin Oncol (2014) 0.97
Dissecting the mechanisms of Notch induced hyperplasia. EMBO J (2012) 0.95
Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus. Arthritis Res Ther (2012) 0.92
Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells. J Exp Med (1998) 0.91
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry (1980) 11.70
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell (1992) 8.51
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell (1991) 8.13
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature (1993) 7.39
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science (1995) 5.65
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science (1993) 5.50
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell (1993) 5.37
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science (1992) 5.00
Molecular and biological characterization of a murine ligand for CD40. Nature (1992) 4.83
Defective B cell development and function in Btk-deficient mice. Immunity (1995) 4.20
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature (1992) 4.12
Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science (1993) 4.08
Frequency of B lymphocytes responsive to anti-immunoglobulin. J Exp Med (1982) 3.30
Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol (1993) 2.86
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature (1995) 2.78
A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2. J Exp Med (1996) 2.70
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature (1995) 2.50
Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc Natl Acad Sci U S A (1994) 1.83
Impaired expansion of mouse B cell progenitors lacking Btk. Immunity (1995) 1.79
bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med (1996) 1.79
Activation of murine B lymphocytes by anti-immunoglobulin is an inductive signal leading to immunoglobulin secretion. J Exp Med (1980) 1.60
Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis. J Immunol (1995) 1.54
Lack of mature B cells in nude mice with X-linked immune deficiency. J Exp Med (1982) 1.52
Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells. Proc Natl Acad Sci U S A (1994) 1.45
Role of Bruton's tyrosine kinase in immunodeficiency. Curr Opin Immunol (1994) 1.37
Phenotypic features and proliferative activity of B cell progenitors in X-linked agammaglobulinemia. J Immunol (1990) 1.35
Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4. J Immunol (1993) 1.33
Role of the thymus in directing the development of a subset of B lymphocytes. J Exp Med (1982) 1.32
Protein tyrosine kinases in the initiation of antigen receptor signaling. Curr Opin Immunol (1995) 1.30
CD40 signaling-mediated induction of Bcl-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth. J Immunol (1995) 1.29
B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. Proc Natl Acad Sci U S A (1995) 1.27
Activation and proliferation signals in mouse B cells. I. A comparison of the capacity of anti-Ig antibodies or phorbol myristic acetate to activate B cells from CBA/N or normal mice into G1. Eur J Immunol (1984) 1.24
Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival. Immunol Today (1994) 1.17
Regulation of B cell survival in xid mice by the proto-oncogene bcl-2. J Immunol (1996) 1.09
Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues. Int Immunol (1995) 1.08
CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regular of CD38 induced signal transduction. Int Immunol (1995) 1.04
B cells from CBA/N mice do not proliferate following ligation of CD40. Eur J Immunol (1994) 1.03
Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells. Proc Natl Acad Sci U S A (1994) 1.01
Expression of bcl-x during mouse B cell differentiation and following activation by various stimuli. Eur J Immunol (1996) 0.91
Radiation-induced apoptosis is differentially regulated in primary B cells from normal mice and mice with the CBA/N X-linked immunodeficiency. J Immunol (1995) 0.90
Immature B lymphocytes are deficient in expression of the src-family kinases p59fyn and p55fgr1. J Immunol (1995) 0.87
LPS-activated CBA/N mouse B cells respond to anti-Ig and a BSF-1-like factor. J Immunol (1986) 0.83
Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int (2008) 5.15
Antibody production studied by means of the LHG assay. I. The splenic response of CBA mice to sheep erythrocytes. Immunology (1966) 3.97
Thymus dependence of theta-bearing cells in the peripheral lymphoid tissues of mice. Immunology (1970) 3.84
Thymus dependence of antibody response: variation with dose of antigen and class of antibody. Nature (1968) 3.79
Rosetting of human red blood cells to thymocytes and thymus-derived cells. Clin Exp Immunol (1973) 2.39
Immunological responses of 'nude' mice. Clin Exp Immunol (1971) 2.34
Emerging functions of autophagy in kidney transplantation. Am J Transplant (2014) 2.08
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem (2000) 2.07
Antibody production studied by means of the localized haemolysis in gel (LHG) assay. 3. Mouse cells producing five different classes of antibody. Immunology (1969) 2.04
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane. J Biol Chem (2001) 2.00
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res (2001) 2.00
Rosette formation by guinea pig thymocytes and thymus derived lymphocytes with rabbit red blood cells. J Immunol (1973) 1.99
Developmental switches in chemokine response profiles during B cell differentiation and maturation. J Exp Med (2000) 1.96
Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res (2001) 1.93
Abnormal development of the thymus in "nude" mice. J Exp Med (1971) 1.91
Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. Int Immunol (1991) 1.90
Helicobacter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, China. J Natl Cancer Inst (2001) 1.84
Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis. Oncogene (2006) 1.82
The pathological role of Bax in cisplatin nephrotoxicity. Kidney Int (2007) 1.82
Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. Oncogene (1998) 1.81
Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. Clin Cancer Res (1995) 1.71
Modulation of tumor cell response to chemotherapy by the organ environment. Cancer Metastasis Rev (1994) 1.69
Immunological studies of nude mice. Contemp Top Immunobiol (1974) 1.60
Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med (2000) 1.60
Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis (1999) 1.58
The effect of pertussis vaccine on the immune response of mice to sheep red blood cells. Clin Exp Immunol (1970) 1.56
p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389. J Biol Chem (1999) 1.55
Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene. J Natl Cancer Inst (1997) 1.55
Lack of mature B cells in nude mice with X-linked immune deficiency. J Exp Med (1982) 1.52
Structural and thermotropic properties of synthetic C16:0 (palmitoyl) ceramide: effect of hydration. J Lipid Res (1995) 1.51
Antibody production studied by means of the localized haemolysis in gel (LHG) assay. II. Assay procedure. Immunology (1968) 1.51
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc Natl Acad Sci U S A (1997) 1.47
SHED differentiate into functional odontoblasts and endothelium. J Dent Res (2010) 1.46
Scanning electron microscopy of human T-cell and B-cell rosettes. N Engl J Med (1973) 1.45
Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. J Invest Dermatol (1997) 1.44
Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells. Mol Cell Biol (1996) 1.44
Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element. Cancer Res (1996) 1.41
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med (1995) 1.37
Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway. Cancer Res (1999) 1.37
Role of antigen-specific B cells in the induction of SRBC-specific T cell proliferation. J Immunol (1984) 1.33
Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. Proc Natl Acad Sci U S A (1998) 1.33
Apoptosis: definition, mechanisms, and relevance to disease. Am J Med (1999) 1.31
Mechanisms of cell death in hypoxia/reoxygenation injury. Oncogene (1998) 1.29
Influence of Igh-linked gene products on the generation of T helper cells in the response to sheep erythrocytes. J Exp Med (1981) 1.27
B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. Proc Natl Acad Sci U S A (1995) 1.27
Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803. Biochem Biophys Res Commun (2001) 1.27
Completion of base excision repair by mammalian DNA ligases. Prog Nucleic Acid Res Mol Biol (2001) 1.25
P0 is constitutively expressed in the rat neural crest and embryonic nerves and is negatively and positively regulated by axons to generate non-myelin-forming and myelin-forming Schwann cells, respectively. Mol Cell Neurosci (1997) 1.24
ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10. J Biol Chem (2000) 1.23
Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res (1999) 1.22
Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions. Cell Mol Life Sci (2008) 1.20
The relationship between the immunoglobulin class of B-cell precursors and the degree of synergism obtained from the presence of T cells. Clin Exp Immunol (1974) 1.20
Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase. Mol Cell Biol (1999) 1.19
Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Res (2001) 1.18
Requirement of Erk, but not JNK, for arsenite-induced cell transformation. J Biol Chem (1999) 1.18
Antigen-specific B cells efficiently present low doses of antigen for induction of T cell proliferation. J Immunol (1985) 1.18
Saccharomyces cerevisiae rad51 mutants are defective in DNA damage-associated sister chromatid exchanges but exhibit increased rates of homology-directed translocations. Genetics (2001) 1.17
Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res (2001) 1.16
Enrichment of ovarian cancer stem-like cells is associated with epithelial to mesenchymal transition through an miRNA-activated AKT pathway. Cell Prolif (2013) 1.15
Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes. Oncogene (2010) 1.15
Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis. J Biol Chem (2001) 1.15
Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury. Am J Physiol Renal Physiol (2000) 1.14
Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1. J Biol Chem (2001) 1.14
Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma. Oncogene (2011) 1.13
UVB irradiation-induced activator protein-1 activation correlates with increased c-fos gene expression in a human keratinocyte cell line. J Biol Chem (1998) 1.13
Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J Biol Chem (2001) 1.12
The biological effects of anti-thyroid antibodies. Thyroid eosinophilia following passive transfer of anti-thyroglobulin antibody. Immunology (1967) 1.09
Activation of nitric oxide synthase gene for inhibition of cancer metastasis. J Leukoc Biol (1996) 1.09
A rapid colorimetric in situ mRNA hybridization technique using hyperbiotinylated oligonucleotide probes for analysis of mdr1 in mouse colon carcinoma cells. J Histochem Cytochem (1993) 1.09
Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3'-digallate. FASEB J (2001) 1.08
Targeting signal transduction pathways by chemopreventive agents. Mutat Res (2004) 1.08
Inhibition of ultraviolet B-induced activator protein-1 (AP-1) activity by aspirin in AP-1-luciferase transgenic mice. J Biol Chem (1997) 1.08
Signal transduction pathways: targets for chemoprevention of skin cancer. Lancet Oncol (2000) 1.08
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Carcinogenesis (2000) 1.08
Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J Biol Chem (2001) 1.08
MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. J Biol Chem (2001) 1.07
Cannabinoid-receptor-independent cell signalling by N-acylethanolamines. Biochem J (2001) 1.06
Transforming growth factor-beta1 is the predominant isoform required for breast cancer cell outgrowth in bone. Oncogene (2008) 1.06
Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration. Oncogene (2009) 1.06
Sex-lethal interactions with protein and RNA. Roles of glycine-rich and RNA binding domains. J Biol Chem (1997) 1.05
Downregulation of mitogen-activated protein kinases in human colon cancers. Anticancer Res (2000) 1.05
MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. J Biol Chem (2001) 1.05
Mouse spleen dendritic cells present soluble antigens to antigen-specific T cell hybridomas. J Exp Med (1983) 1.05
Ultraviolet B-induced activated protein-1 activation does not require epidermal growth factor receptor but is blocked by a dominant negative PKClambda/iota. J Biol Chem (1996) 1.03
Lymphoproliferative disorders in renal transplant patients in Japan. Int J Cancer (2001) 1.03
DNA polymerase III accessory proteins. III. holC and holD encoding chi and psi. J Biol Chem (1993) 1.03
Regulation of thymus-independent responses: unresponsiveness to a second challenge of TNP-Ficoll is mediated by hapten-specific antibodies. J Immunol (1980) 1.03
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins. Mol Cell Biol (1998) 1.03
Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages. J Immunol (1994) 1.03
Protein-tyrosine phosphatase SHP-1 is dispensable for FcgammaRIIB-mediated inhibition of B cell antigen receptor activation. J Biol Chem (1997) 1.03
Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation. Oncogene (1998) 1.03
Effect of immunosuppressive therapy for renal allografts on the number of circulating sheep red blood cells rosetting cells. Transplantation (1975) 1.02
The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell Death Differ (2011) 1.02
Lister strain of vaccinia virus armed with endostatin-angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer. Gene Ther (2009) 1.02
Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Res (1998) 1.02