Published in Cancer Surv on January 01, 1996
The extended protein kinase C superfamily. Biochem J (1998) 5.84
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol (2000) 3.24
Untangling the wires: a strategy to trace functional interactions in signaling and gene networks. Proc Natl Acad Sci U S A (2002) 3.18
TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J (1999) 3.05
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J (1999) 2.79
MEK kinase activity is not necessary for Raf-1 function. EMBO J (2001) 2.36
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol (2000) 2.27
p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Mol Cell Biol (1999) 1.83
Stimulation of gene induction and cell growth by the Ras effector Rlf. EMBO J (1997) 1.69
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259. Mol Cell Biol (2002) 1.63
The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Mol Cell Biol (2000) 1.60
Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. Gastroenterology (2007) 1.58
NF-kappaB activation in melanoma. Pigment Cell Res (2006) 1.55
Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation. J Biol Chem (2008) 1.50
Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways. Mol Cell Biol (2001) 1.38
B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts. Mol Cell Biol (2004) 1.28
Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. Mol Cell Biol (1999) 1.27
The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component. Mol Biol Cell (2004) 1.16
Intestinal adenomagenesis involves core molecular signatures of the epithelial-mesenchymal transition. J Mol Histol (2008) 1.12
Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia (2002) 1.11
14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo. Mol Cell Biol (1998) 1.10
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation. Mol Cell (2008) 1.08
Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter. Mol Cell Biol (2000) 1.07
MAP Kinases and Prostate Cancer. J Signal Transduct (2011) 1.06
Host cell-virus cross talk: phosphorylation of a hepatitis B virus envelope protein mediates intracellular signaling. J Virol (1998) 1.03
Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1. Mol Cell Biol (2000) 0.99
Ras-related TC21 is activated by mutation in a breast cancer cell line, but infrequently in breast carcinomas in vivo. Br J Cancer (1998) 0.95
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines. Endocrinology (2008) 0.93
Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III. Proc Natl Acad Sci U S A (2000) 0.92
Mammalian transcription factor LSF is a target of ERK signaling. J Cell Biochem (2003) 0.89
ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells. PLoS One (2011) 0.87
Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2009) 0.86
Effects of membrane cholesterol depletion and GPI-anchored protein reduction on osteoblastic mechanotransduction. J Cell Physiol (2011) 0.86
IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia. Front Cell Neurosci (2014) 0.84
Viral oncolysis that targets Raf-1 signaling control of nuclear transport. J Virol (2009) 0.83
Activation of B-Raf and regulation of the mitogen-activated protein kinase pathway by the G(o) alpha chain. Mol Biol Cell (2000) 0.83
Inflammatory response of monocytes to ambient particles varies by highway proximity. Am J Respir Cell Mol Biol (2014) 0.82
Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem death. Br J Pharmacol (2011) 0.81
Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway. Biochem J (1998) 0.81
Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism. Proc Natl Acad Sci U S A (2004) 0.81
Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. J Mol Biol (2008) 0.80
P2Y(2) receptors and GRK2 are involved in oscillatory fluid flow induced ERK1/2 responses in chondrocytes. J Orthop Res (2010) 0.80
RKIP and 14-3-3ε exert an opposite effect on human gastric cancer cells SGC7901 by regulating the ERK/MAPK pathway differently. Dig Dis Sci (2012) 0.80
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells. J Cell Physiol (2011) 0.78
Lack of BRAFV600E mutation in stage I and II of colorectal cancer. Gastroenterol Hepatol Bed Bench (2016) 0.75
β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation. Oncotarget (2016) 0.75
Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation. J Biol Chem (2016) 0.75
Defining the cancer master switch. World J Surg (2011) 0.75
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell (1994) 9.73
All ras proteins are polyisoprenylated but only some are palmitoylated. Cell (1989) 9.68
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature (1994) 6.16
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell (1990) 6.08
Activation of the MAP kinase pathway by the protein kinase raf. Cell (1992) 5.95
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product. Nature (1988) 4.33
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J (1995) 4.17
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. EMBO J (1992) 4.00
Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature (1983) 3.86
Involvement of p21ras in activation of extracellular signal-regulated kinase 2. Nature (1992) 3.78
Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature (1998) 3.67
A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. EMBO J (1991) 3.64
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol Cell Biol (1998) 3.58
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis. EMBO J (1989) 3.51
Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production. Nature (1986) 3.41
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol (1994) 3.06
Dynamic fatty acylation of p21N-ras. EMBO J (1987) 2.99
Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc Natl Acad Sci U S A (1988) 2.99
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia. Nature (1985) 2.90
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf. Methods Enzymol (1995) 2.82
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J (1999) 2.79
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J (2001) 2.66
Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. EMBO J (1995) 2.51
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J Biol Chem (1997) 2.47
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol (1998) 2.33
rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. EMBO J (1993) 2.31
Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res (1991) 2.30
DNA in medicine. Oncogenes. Lancet (1984) 2.28
Post-translational modifications of p21rho proteins. J Biol Chem (1992) 2.17
Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B). EMBO J (1991) 2.09
Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas. J Natl Cancer Inst (1977) 2.07
Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science (1998) 2.06
Mesoderm induction in Xenopus caused by activation of MAP kinase. Nature (1995) 1.86
Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1. J Biol Chem (1993) 1.79
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals. Mol Cell Biol (1999) 1.77
A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras. J Biol Chem (1993) 1.74
Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds. Cancer Res (1994) 1.71
A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway. EMBO J (1994) 1.68
A transforming gene present in human sarcoma cell lines. Nature (1982) 1.67
Biochemical and biological properties of the human N-ras p21 protein. Mol Cell Biol (1987) 1.65
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. EMBO J (1984) 1.56
Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis. Oncogene (1989) 1.50
The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action. FEBS Lett (1994) 1.47
Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression. EMBO J (1986) 1.46
The influence of the MAPK pathway on T cell lineage commitment. Immunity (1997) 1.43
Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein. Curr Biol (1997) 1.41
Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene (1999) 1.41
CLINICAL EXPERIENCES WITH PERCAIN, A NEW LOCAL ANAESTHETIC. Br Med J (1930) 1.40
Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide. Nature (1984) 1.40
Cost savings controversy. J Ophthalmic Nurs Technol (1991) 1.39
The urease ELISA for H-Y antibody. A cautionary tale. J Immunol Methods (1990) 1.38
Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization. Neuroscience (1989) 1.37
Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling. Mol Cell Biol (2001) 1.37
Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems. Oncogene (1988) 1.37
Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis. Mol Cell Biol (1999) 1.37
p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C. EMBO J (1989) 1.36
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients. Oncogene (1988) 1.35
A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogene. Nucleic Acids Res (1986) 1.33
p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J Exp Med (1993) 1.32
Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function. Mol Cell Biol (1993) 1.31
Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination. Proc Natl Acad Sci U S A (1986) 1.29
Stimulation of phosphatidylcholine hydrolysis, diacylglycerol release, and arachidonic acid production by oncogenic ras is a consequence of protein kinase C activation. J Biol Chem (1989) 1.26
Inheritance of proliferative breast disease in breast cancer kindreds. Science (1990) 1.24
Activation of the Ral and phosphatidylinositol 3' kinase signaling pathways by the ras-related protein TC21. Mol Cell Biol (2001) 1.23
Signal transduction. Hot lips and phosphorylation of protein kinases. Nature (1994) 1.23
Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3. J Biol Chem (1995) 1.19
Synthesis of ribosomal RNA in synkaryons and heterokaryons formed between human and rodent cells. J Cell Sci (1975) 1.18
Nuclear location and cell cycle regulation of the BRCA2 protein. Cancer Res (1997) 1.17
Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells. Proc Natl Acad Sci U S A (1986) 1.16
Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vitro. Development (1992) 1.15
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. EMBO J (1999) 1.11
Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo. Br J Cancer (2005) 1.10
MAP kinase regulation--the oncogene connection. Trends Cell Biol (1992) 1.09
Cell block preparation as an adjunctive diagnostic technique in ThinPrep monolayer preparations: a case report. Diagn Cytopathol (2001) 1.07
Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma. EMBO J (1984) 1.07
Cell signalling. Raf gets it together. Nature (1996) 1.06
Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway. Mol Cell Biol (1997) 1.05
Localisation of the human N-ras oncogene to chromosome 1cen - p21 by in situ hybridisation. EMBO J (1983) 1.02
Targeting of oncoproteins to membranes by fatty acylation. J Cell Sci Suppl (1989) 1.02
Cooperation of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways during granulocyte colony-stimulating factor-induced hemopoietic cell proliferation. J Biol Chem (1999) 1.01
Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer. Oncogene (2010) 1.00
gamma-Glutamyltranspeptidase and the ras-induced transformation of a rat liver cell line. Cancer Res (1986) 1.00
The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors. Structure (1995) 0.99
Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase. Nature (1993) 0.99
Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway. Mol Cell Biol (1997) 0.97
The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells. FEBS Lett (1994) 0.97
Ice-active proteins from the Antarctic nematode Panagrolaimus davidi. Cryobiology (2005) 0.96
Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells. FEBS Lett (1993) 0.96
Specific cytogenetic abnormalities and k-ras mutation in two new human colorectal-adenoma-derived cell lines. Int J Cancer (1992) 0.95
The role of MAP kinase kinase in interleukin-3 stimulation of proliferation. Blood (1996) 0.93
A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: high-throughput screening and identification of selective enzyme inhibitors. Anal Biochem (1999) 0.93
Cold tolerance of an Antarctic nematode that survives intracellular freezing: comparisons with other nematode species. J Comp Physiol B (2007) 0.93
Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes. J Biol Chem (1995) 0.93