Published in Mol Cell Biol on May 01, 2002
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci (2011) 3.89
Tumor adaptation and resistance to RAF inhibitors. Nat Med (2013) 3.11
Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J (2002) 1.99
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling. J Exp Med (2005) 1.90
Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO Rep (2005) 1.62
pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model. Biol Direct (2007) 1.46
Direct inhibition of T-lymphocyte activation by anthrax toxins in vivo. Infect Immun (2005) 1.43
Akt and ERK1/2 pathways are components of the vasopressin signaling network in rat native IMCD. Am J Physiol Renal Physiol (2008) 1.29
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol Ther (2006) 1.27
Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J (2002) 1.19
Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes. Diabetes (2012) 1.18
Vitamin K enhancement of sorafenib-mediated HCC cell growth inhibition in vitro and in vivo. Int J Cancer (2010) 1.10
Non-classical actions of testosterone and spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.09
Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase. J Biol Chem (2007) 1.08
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J (2008) 1.06
Vitamin D and differentiation in cancer. Crit Rev Clin Lab Sci (2009) 1.05
Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Mol Cell Biol (2005) 1.04
A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation. Mol Cell Biol (2003) 1.03
Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling. Cell Death Dis (2014) 0.99
Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation. J Biol Chem (2010) 0.98
Raf-1 signaling is required for the later stages of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells but is not mediated by the MEK/ERK module. J Cell Physiol (2006) 0.97
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Proc Natl Acad Sci U S A (2013) 0.96
Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells. J Biol Chem (2014) 0.96
Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A (2013) 0.93
Regulation of Sertoli-germ cell adhesion and sperm release by FSH and nonclassical testosterone signaling. Mol Endocrinol (2010) 0.93
Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation. J Biol Chem (2009) 0.90
TIMP-2 disrupts FGF-2-induced downstream signaling pathways. Microvasc Res (2008) 0.90
Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms. Mol Cell Biol (2006) 0.89
C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons. Biochem J (2003) 0.87
A knowledge base of vasopressin actions in the kidney. Am J Physiol Renal Physiol (2014) 0.86
Ras-mutant cancer cells display B-Raf binding to Ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase A phosphorylation. J Biol Chem (2013) 0.86
DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Mol Cell Biol (2003) 0.84
Identifying biological network structure, predicting network behavior, and classifying network state with High Dimensional Model Representation (HDMR). PLoS One (2012) 0.84
Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation. J Cell Mol Med (2008) 0.84
An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene (2013) 0.83
Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device. Cell Cycle (2015) 0.81
Potentiation of carbachol-induced detrusor smooth muscle contractions by beta-adrenoceptor activation. Eur J Pharmacol (2009) 0.80
Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit. J Biol Chem (2013) 0.79
A novel noncanonical signaling pathway for the μ-opioid receptor. Mol Pharmacol (2013) 0.78
Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling. Nat Commun (2015) 0.78
Differential effects of vitamin K1 on AFP and DCP levels in patients with unresectable HCC and in HCC cell lines. Dig Dis Sci (2010) 0.78
Integrated modulation of phorbol ester-induced Raf activation in EL4 lymphoma cells. Cell Signal (2009) 0.76
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. Oncotarget (2016) 0.76
Epidermal Growth Factor-dependent Activation of the Extracellular Signal-regulated Kinase Pathway by DJ-1 Protein through Its Direct Binding to c-Raf Protein. J Biol Chem (2015) 0.75
A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol (2016) 0.75
CD99-derived agonist ligands inhibit fibronectin-induced activation of β1 integrin through PKA/SHP2/ERK/PTPN12/FAK signaling pathway. Mol Cell Biol (2017) 0.75
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem (1989) 11.06
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell (1996) 7.81
14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol (2000) 6.94
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J (2000) 6.55
Increasing complexity of Ras signaling. Oncogene (1998) 5.71
Signal transduction through MAP kinase cascades. Adv Cancer Res (1998) 5.65
Phosphorylation and regulation of Raf by Akt (protein kinase B). Science (1999) 5.61
Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate. Science (1993) 4.61
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science (1999) 4.10
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J (1995) 3.86
The complexity of Raf-1 regulation. Curr Opin Cell Biol (1997) 3.25
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature (1998) 2.93
A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature (1998) 2.89
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol Cell Biol (1993) 2.80
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J (1999) 2.79
Identification of the major phosphorylation sites of the Raf-1 kinase. J Biol Chem (1993) 2.70
Autoregulation of the Raf-1 serine/threonine kinase. Proc Natl Acad Sci U S A (1998) 2.47
Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat Cell Biol (2000) 2.37
Mechanism of inhibition of Raf-1 by protein kinase A. Mol Cell Biol (1994) 2.18
Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. Mol Cell Biol (1994) 2.08
14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol Cell Biol (1998) 2.07
Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J (2002) 1.99
Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation. J Biol Chem (2000) 1.87
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling. Mol Cell Biol (1997) 1.79
14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner. Mol Cell Biol (1995) 1.77
Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv (1996) 1.74
Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro. Mol Cell Biol (1995) 1.60
Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues. Mol Cell Biol (1994) 1.56
Negative regulation of Raf-1 by phosphorylation of serine 621. Mol Cell Biol (1996) 1.52
Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. J Biol Chem (1994) 1.37
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms. Oncogene (1998) 1.31
Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling. Mol Pharmacol (2000) 1.29
Dephosphorylation of Ser-259 regulates Raf-1 membrane association. J Biol Chem (2001) 1.25
Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association. Biochem J (2000) 1.10
Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling. EMBO J (1998) 1.07
Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo. Mech Dev (1997) 0.99
Phosphorylation of c-Raf-1 by protein kinase A interferes with activation. Biochem Biophys Res Commun (1994) 0.97
cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway. Cell Signal (2000) 0.94
Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase. J Biol Chem (2000) 0.94
Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway. Mol Cell Biol (1998) 0.91
Regulation and role of Raf-1/B-Raf heterodimerization. Mol Cell Biol (2006) 4.84
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet (2005) 3.49
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell (2007) 3.47
Signalling ballet in space and time. Nat Rev Mol Cell Biol (2010) 3.32
Clinical proteomics: A need to define the field and to begin to set adequate standards. Proteomics Clin Appl (2007) 2.84
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science (2004) 2.66
The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier. Sci Signal (2010) 2.40
Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol (2006) 2.29
Urinary proteomics in diabetes and CKD. J Am Soc Nephrol (2008) 2.12
Urine in clinical proteomics. Mol Cell Proteomics (2008) 2.05
Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J (2002) 1.99
Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics (2010) 1.90
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell (2004) 1.79
Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res (2005) 1.78
Advances in urinary proteome analysis and biomarker discovery. J Am Soc Nephrol (2007) 1.77
Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition. Cancer Res (2010) 1.74
Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochem J (2005) 1.70
Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. J Clin Oncol (2006) 1.67
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A (2008) 1.65
Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone. Mol Cell Biol (2007) 1.65
Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy. Kidney Int (2005) 1.63
Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines. Cancer Res (2004) 1.61
Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. Lab Chip (2009) 1.61
Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines. J Biol Chem (2002) 1.59
Recommendations for biomarker identification and qualification in clinical proteomics. Sci Transl Med (2010) 1.59
Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry. Rapid Commun Mass Spectrom (2004) 1.57
CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics Clin Appl (2008) 1.57
Untying the regulation of the Raf-1 kinase. Arch Biochem Biophys (2002) 1.57
Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease. J Proteome Res (2009) 1.56
Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. Sci Signal (2010) 1.54
Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases. J Cell Sci (2002) 1.53
Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis. Nat Med (2006) 1.52
Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future. J Proteome Res (2007) 1.52
Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models. Bioinformatics (2008) 1.51
Computational approaches for analyzing information flow in biological networks. Sci Signal (2012) 1.49
Urinary proteome analysis identifies infants but not older children requiring pyeloplasty. Pediatr Nephrol (2010) 1.48
Urinary proteomic biomarkers in coronary artery disease. Mol Cell Proteomics (2007) 1.47
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol Cell (2011) 1.44
Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circ Cardiovasc Genet (2014) 1.44
Urinary proteome analysis to exclude severe vesicoureteral reflux. Pediatrics (2012) 1.42
Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. Cancer Res (2005) 1.41
Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. J Cell Sci (2009) 1.41
Systems biology-embedded target validation: improving efficacy in drug discovery. Wiley Interdiscip Rev Syst Biol Med (2013) 1.41
Identification and validation of urinary biomarkers for differential diagnosis and evaluation of therapeutic intervention in anti-neutrophil cytoplasmic antibody-associated vasculitis. Mol Cell Proteomics (2009) 1.41
Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev (2004) 1.39
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes (2003) 1.39
Urinary proteomics for early diagnosis in diabetic nephropathy. Diabetes (2012) 1.38
Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5. Nat Cell Biol (2006) 1.36
When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling. Cell Commun Signal (2013) 1.36
Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separation. Electrophoresis (2006) 1.33
Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation. Blood (2004) 1.33
The role of MAPK pathways in the action of chemotherapeutic drugs. Carcinogenesis (2002) 1.32
Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Mol Syst Biol (2009) 1.31
Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3. Oncogene (2004) 1.31
Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes. Kidney Int (2004) 1.29
Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis. Hepatology (2011) 1.28
PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway. Oncogene (2002) 1.27
Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery. Mass Spectrom Rev (2005) 1.26
Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases. Electrophoresis (2007) 1.26
Modeling and simulation of intracellular dynamics: choosing an appropriate framework. IEEE Trans Nanobioscience (2004) 1.25
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst Biol (2012) 1.25
Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine. Electrophoresis (2005) 1.24
Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients. Am J Transplant (2005) 1.24
Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. Cell Signal (2011) 1.21
Urinary proteomics for prediction of preeclampsia. Hypertension (2011) 1.20
MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability. Mol Cell Biol (2009) 1.20
Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells. Anal Chem (2009) 1.20
Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J (2002) 1.19
Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1. Nucleic Acids Res (2008) 1.18
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells. Cell Signal (2010) 1.18
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res (2010) 1.17
Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway. J Biol Chem (2002) 1.17
Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β. Cancer Res (2011) 1.17
Addressing the challenge of defining valid proteomic biomarkers and classifiers. BMC Bioinformatics (2010) 1.16
Crosstalk and signaling switches in mitogen-activated protein kinase cascades. Front Physiol (2012) 1.16
Determination of peptides and proteins in human urine with capillary electrophoresis-mass spectrometry, a suitable tool for the establishment of new diagnostic markers. J Chromatogr A (2003) 1.16
Phosphatase and feedback regulation of Raf-1 signaling. Cell Cycle (2007) 1.15
ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin. J Biol Chem (2002) 1.14
Modulation of gene expression and tumor cell growth by redox modification of STAT3. Cancer Res (2010) 1.14
Impact of diabetic nephropathy and angiotensin II receptor blockade on urinary polypeptide patterns. Kidney Int (2005) 1.13
The secret life of kinases: functions beyond catalysis. Cell Commun Signal (2011) 1.13
Urinary proteomic biomarkers for diagnosis and risk stratification of autosomal dominant polycystic kidney disease: a multicentric study. PLoS One (2013) 1.12
Identification of a unique urinary biomarker profile in patients with autosomal dominant polycystic kidney disease. Kidney Int (2009) 1.12
Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: towards new diagnostic and therapeutic approaches. Electrophoresis (2005) 1.12
Identification of urinary protein pattern in type 1 diabetic adolescents with early diabetic nephropathy by a novel combined proteome analysis. J Diabetes Complications (2005) 1.12
Multicentric validation of proteomic biomarkers in urine specific for diabetic nephropathy. PLoS One (2010) 1.12
Comprehensive human urine standards for comparability and standardization in clinical proteome analysis. Proteomics Clin Appl (2010) 1.12
Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. Gut (2012) 1.11
The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease. Proteomics (2009) 1.11
Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem (2003) 1.11
Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury. Kidney Int (2010) 1.10