Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMID 8941098)

Published in Circulation on December 01, 1996

Authors

K Robinson1, A Gupta, V Dennis, K Arheart, D Chaudhary, R Green, P Vigo, E L Mayer, J Selhub, M Kutner, D W Jacobsen

Author Affiliations

1: Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA. robinsk@ccsmtp.ccf.org

Articles citing this

The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis. BMJ (2012) 1.63

NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia. Antioxid Redox Signal (2012) 1.32

Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia. Hypertension (2012) 1.31

The treatment of hyperhomocysteinemia. Annu Rev Med (2009) 1.23

Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91phox gene. Free Radic Biol Med (2010) 1.12

Redox signaling via lipid raft clustering in homocysteine-induced injury of podocytes. Biochim Biophys Acta (2009) 1.12

Hyperhomocysteinemia promotes insulin resistance by inducing endoplasmic reticulum stress in adipose tissue. J Biol Chem (2013) 1.08

Renal dysfunction and acceleration of coronary disease. Heart (2004) 0.96

Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects. PLoS One (2013) 0.94

Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. Am J Physiol Endocrinol Metab (2011) 0.89

NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. Antioxid Redox Signal (2010) 0.89

Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions. J Clin Invest (2004) 0.88

[Atherosclerosis and uremia: signifance of non-traditional risk factors]. Wien Klin Wochenschr (2003) 0.86

Epithelial-to-mesenchymal transition in podocytes mediated by activation of NADPH oxidase in hyperhomocysteinemia. Pflugers Arch (2011) 0.85

Hyperhomocysteinemia in renal diseases. J Med Life (2010) 0.85

Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. J Nutr (2012) 0.84

Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies. BMC Med Genet (2008) 0.83

Inhibition of hyperhomocysteinemia-induced inflammasome activation and glomerular sclerosis by NLRP3 gene deletion. Cell Physiol Biochem (2014) 0.83

Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension. Pharmacol Res (2016) 0.77

Homocysteine in Renal Injury. Kidney Dis (Basel) (2016) 0.75

Carotid intima-media thickness in children with end-stage renal disease on dialysis. Indian J Nephrol (2010) 0.75

Malnutrition-inflammation-atherosclerosis syndrome in Chronic Kidney disease. Indian J Clin Biochem (2008) 0.75

Association between adherence to folic acid supplements and serum folate, and plasma homocysteine among hemodialysis patients. J Ren Nutr (2010) 0.75

Variations in the lipid profile of patients with chronic renal failure treated with pyridoxine. Lipids Health Dis (2003) 0.75

Articles by these authors

PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol (2001) 12.26

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet (2013) 9.46

The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med (1999) 6.22

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature (1995) 5.42

Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation (1996) 4.62

A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome. Nature (1995) 4.59

Amyand's hernia: a report of 18 consecutive patients over a 15-year period. Hernia (2006) 4.51

The guanosine binding site of the Tetrahymena ribozyme. Nature (1989) 4.43

Electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology (2007) 4.22

The small RNA, DsrA, is essential for the low temperature expression of RpoS during exponential growth in Escherichia coli. EMBO J (1996) 4.10

Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr (2001) 3.80

AMP-activated protein kinase, super metabolic regulator. Biochem Soc Trans (2003) 3.72

Characterization of rotavirus strains from newborns in New Delhi, India. J Clin Microbiol (1994) 3.50

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res (1997) 3.36

Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation (1997) 3.23

Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol (2001) 3.03

Recovered memories of childhood sexual abuse. Implications for clinical practice. Br J Psychiatry (1998) 3.02

Hidden from view: violent deaths among pregnant women in the District of Columbia, 1988-1996. J Midwifery Womens Health (2001) 2.95

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet (2001) 2.93

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. J Neurosci (2000) 2.90

High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch Neurol (1998) 2.77

Role of CED-4 in the activation of CED-3. Nature (1997) 2.76

Retinal blood flow in nonischemic central retinal vein occlusion. Ophthalmology (1998) 2.72

Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol (1995) 2.62

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nat Struct Biol (2001) 2.56

Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation (1998) 2.31

Acquired immunodeficiency with reversed T4/T8 ratios in infants born to promiscuous and drug-addicted mothers. JAMA (1983) 2.29

Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status. Neurology (2003) 2.28

Etiology and chemoprevention of esophageal squamous cell carcinoma. Carcinogenesis (2001) 2.27

Comparison of a generic (SF-36) and a disease specific (WOMAC) (Western Ontario and McMaster Universities Osteoarthritis Index) instrument in the measurement of outcomes after knee replacement surgery. J Rheumatol (1995) 2.23

Effect of HCV, HIV and coinfection in kidney transplant recipients: mate kidney analyses. Am J Transplant (2014) 2.22

Base-pairing between 23S rRNA and tRNA in the ribosomal A site. Mol Cell (1999) 2.19

Science and government. Navigating the anthropocene: improving Earth system governance. Science (2012) 2.19

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin Genet (2007) 2.15

A randomized, controlled trial of the distal splenorenal shunt. Ann Surg (1978) 2.15

Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin Chem (1994) 2.14

Effect of insulin therapy on progression of retinopathy in noninsulin-dependent diabetes mellitus. Am J Ophthalmol (1993) 2.13

Accurate measurement of liver, kidney, and spleen volume and mass by computerized axial tomography. Ann Intern Med (1979) 2.11

Bowen-Conradi syndrome in an Indian infant: first non Hutterite case. Clin Dysmorphol (2001) 2.08

Current concepts in the diagnosis of cobalamin deficiency. Neurology (1995) 2.08

Visceral leishmaniasis: an unusual case of fever in a renal transplant recipient. Nephrol Dial Transplant (1991) 2.07

Primary and metastatic diseases in malignant melanoma of the gastrointestinal tract. Curr Opin Oncol (2000) 2.07

Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev (2000) 2.06

Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit. Proc Natl Acad Sci U S A (2001) 2.06

The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis (2001) 2.06

Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol (1999) 2.06

Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation (1996) 2.06

Outbreak of polyarthritis with pyrexia in Western Rajasthan. J Assoc Physicians India (2001) 2.01

Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn Reson Med (2009) 1.99

Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove. Science (1991) 1.96

Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Mol Psychiatry (2008) 1.92

Homocysteine, vitamin B6, and vascular disease in AD patients. Neurology (2002) 1.91

Isolation of primary HIV-1 that target CD8+ T lymphocytes using CD8 as a receptor. Nat Med (2001) 1.88

Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: the Framingham Study. Ann Intern Med (1999) 1.86

Folic acid fortification of the food supply. Potential benefits and risks for the elderly population. JAMA (1996) 1.84

Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Thorax (2005) 1.81

Cerebrovascular reactivity during hypothermia and rewarming. Br J Anaesth (2007) 1.80

Detection of choledocholithiasis: comparison of unenhanced helical CT and endoscopic retrograde cholangiopancreatography. Radiology (1997) 1.78

Ten years portal hypertensive surgery at Emory. Results and new perspectives. Ann Surg (1982) 1.78

Homocysteine and thrombotic disease. Blood (1997) 1.77

Multi-dimensional phenotyping: towards a new taxonomy for airway disease. Clin Exp Allergy (2005) 1.77

Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr (1997) 1.75

Comparison of immediate and delayed free TRAM flap breast reconstruction in patients receiving postmastectomy radiation therapy. Plast Reconstr Surg (2001) 1.74

Angiography in portal hypertension: clinical significance in surgery. Am J Surg (1980) 1.72

Acute renal failure in falciparum malaria--increasing prevalence in some areas of India--a need for awareness. Nephrol Dial Transplant (1996) 1.71

Sexual identity of 37 children raised by homosexual or transsexual parents. Am J Psychiatry (1978) 1.71

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 1.71

Character and spatial distribution of OH/H2O on the surface of the Moon seen by M3 on Chandrayaan-1. Science (2009) 1.70

Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation (2001) 1.69

Pitfalls in the diagnosis of esophageal atresia. Indian Pediatr (2000) 1.67

Dengue virus infection in renal allograft recipients: a case series during 2010 outbreak. Transpl Infect Dis (2011) 1.67

Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits. Am J Clin Nutr (1996) 1.67

Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism. Ann Intern Med (1999) 1.64

The profile of acute poisonings in Harayana-Rohtak Study. J Assoc Physicians India (1995) 1.64

Healing potential of Calotropis procera on dermal wounds in Guinea pigs. J Ethnopharmacol (1999) 1.63

Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care (2001) 1.63

Power Shortage: clinical trials testing the "homocysteine hypothesis" against a background of folic acid-fortified cereal grain flour. Ann Intern Med (2001) 1.63

The optional E. coli prr locus encodes a latent form of phage T4-induced anticodon nuclease. EMBO J (1990) 1.61

Purification of biologically active simian virus 40 small tumor antigen. Proc Natl Acad Sci U S A (1983) 1.61

Endovascular treatment of renal artery thrombosis caused by umbilical artery catheterization. J Vasc Surg (1998) 1.61

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

Two cases of cauda equina syndrome following spinal-epidural anesthesia. Reg Anesth (1997) 1.60

Sentinel lymph node localization in early breast cancer. J Nucl Med (1998) 1.59

Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch. Cell Tissue Res (1987) 1.59

Indomethacin reduces the risks of severe intraventricular hemorrhage. J Pediatr (1989) 1.59

Restoration of suppressor T-cell functions in children with AIDS following intravenous gamma globulin treatment. Am J Dis Child (1986) 1.58

Comparison of a generic and a disease-specific measure of pain and physical function after knee replacement surgery. Med Care (1995) 1.57

Review article: medical, surgical and radiological management of perianal Crohn's fistulas. Aliment Pharmacol Ther (2010) 1.57

Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res (2001) 1.56

A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci U S A (1998) 1.56

Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr (1999) 1.55

Postoperative pain relief after total hip arthroplasty: a randomized, double-blind comparison between intrathecal morphine and local infiltration analgesia. Br J Anaesth (2013) 1.54

Natural gums and modified natural gums as sustained-release carriers. Drug Dev Ind Pharm (2000) 1.54

The biogenesis of ethylene in penicillium digitatum. Plant Physiol (1968) 1.53

Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study. Arthritis Rheum (2007) 1.53

Plasma concentrations of immunoreactive atrial natriuretic peptide in hospitalized cirrhotic and noncirrhotic patients: evidence for a role of deficient atrial natriuretic peptide in pathogenesis of cirrhotic ascites. Am J Gastroenterol (1988) 1.53

Supraventricular tachycardia induced by Datex patient monitoring system. Anesth Analg (1998) 1.53

Associations of demographic, functional, and behavioral characteristics with activity-related fear of falling among older adults transitioning to frailty. J Am Geriatr Soc (2001) 1.52