Published in PLoS One on June 11, 2013
Reference Standardization for Mass Spectrometry and High-resolution Metabolomics Applications to Exposome Research. Toxicol Sci (2015) 0.95
Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells. Am J Physiol Endocrinol Metab (2014) 0.82
Vitamin B-6 restriction reduces the production of hydrogen sulfide and its biomarkers by the transsulfuration pathway in cultured human hepatoma cells. J Nutr (2014) 0.81
Metabolomic analysis of diet-induced type 2 diabetes using UPLC/MS integrated with pattern recognition approach. PLoS One (2014) 0.80
The metabolic fate of acetate in cancer. Nat Rev Cancer (2016) 0.78
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users. Am J Clin Nutr (2015) 0.76
Short-Term Vitamin B-6 Restriction Does Not Affect Plasma Concentrations of Hydrogen Sulfide Biomarkers Lanthionine and Homolanthionine in Healthy Men and Women. J Nutr (2016) 0.75
Metabolomics connects aberrant bioenergetic, transmethylation, and gut microbiota in sarcoidosis. Metabolomics (2016) 0.75
Identification of altered brain metabolites associated with TNAP activity in a mouse model of hypophosphatasia using untargeted NMR-based metabolomics analysis. J Neurochem (2017) 0.75
Proteomics and (1)H NMR-based metabolomics analysis of pathogenic Vibrio vulnificus aquacultures isolated from sewage drains. Environ Sci Pollut Res Int (2017) 0.75
Trimethylamine-N-oxide and its biological variations in vegetarians. Eur J Nutr (2016) 0.75
Investigation of vitamin B6 inadequacy, induced by exposure to the anti-B6 factor 1-amino D-proline, on plasma lipophilic metabolites of rats: a metabolomics approach. Eur J Nutr (2015) 0.75
Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA (1998) 7.09
Targeted profiling: quantitative analysis of 1H NMR metabolomics data. Anal Chem (2006) 4.36
Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem (2007) 4.04
750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma. Anal Chem (1995) 3.61
Regulation of glutaminase activity and glutamine metabolism. Annu Rev Nutr (1995) 3.40
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63
Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. JAMA (2010) 2.39
Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation (1998) 2.31
Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin Chem (1999) 2.24
Foods, fortificants, and supplements: Where do Americans get their nutrients? J Nutr (2011) 2.23
The effect of a subnormal vitamin B-6 status on homocysteine metabolism. J Clin Invest (1996) 1.91
Homocysteine, vitamin B6, and vascular disease in AD patients. Neurology (2002) 1.91
Multivariate paired data analysis: multilevel PLSDA versus OPLSDA. Metabolomics (2009) 1.58
The effect of vitamin B6 deficiency induced by desoxypyridoxine in human beings. J Lab Clin Med (1953) 1.49
Interorgan amino acid transport and its regulation. J Nutr (2003) 1.38
Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr (2008) 1.37
Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am J Epidemiol (1996) 1.34
Influence of acute phytochemical intake on human urinary metabolomic profiles. Am J Clin Nutr (2007) 1.29
Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile. Anal Biochem (2003) 1.24
Serum B vitamin levels and risk of lung cancer. JAMA (2010) 1.20
Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations. Circulation (1996) 1.19
Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. J Nutr (2011) 1.18
Stability of pyridoxal-5-phosphate semicarbazone: applications in plasma vitamin B6 analysis and population surveys of vitamin B6 nutritional status. J Chromatogr (1985) 1.14
Low vitamin B6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification. Stroke (2003) 1.11
Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr (2009) 1.09
Individual variation in macronutrient regulation measured by proton magnetic resonance spectroscopy of human plasma. Am J Physiol Regul Integr Comp Physiol (2009) 1.08
Biochemical assessment of the nutritional status of vitamin B 6 in the human. Am J Clin Nutr (1972) 1.07
Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women. J Nutr (2006) 1.04
Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets. J Nutr (2006) 1.04
Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine. J Nutr (2007) 1.01
Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men. Am J Clin Nutr (2005) 1.01
Deficiencies of folate and vitamin B(6) exert distinct effects on homocysteine, serine, and methionine kinetics. Am J Physiol Endocrinol Metab (2001) 0.99
Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats. J Nutr (2005) 0.98
Metabolomics in the opening decade of the 21st century: building the roads to individualized health. J Nutr (2004) 0.98
Monitoring diet effects via biofluids and their implications for metabolomics studies. Anal Chem (2007) 0.97
The nutritional phenotype in the age of metabolomics. J Nutr (2005) 0.96
Vitamin B6 deficiency affects antioxidant defences in rat liver and heart. Biochem Mol Biol Int (1998) 0.95
Vitamin B6: a challenging link between nutrition and inflammation in CVD. Br J Nutr (2011) 0.94
Effects of exhaustive exercise and vitamin B6 deficiency on free radical oxidative process in male trained rats. Free Radic Biol Med (1996) 0.93
Evaluation of endogenous plasma peptide extraction methods for mass spectrometric biomarker discovery. J Proteome Res (2007) 0.93
Global hypothesis testing for high-dimensional repeated measures outcomes. Stat Med (2011) 0.92
A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. J Nutr (2009) 0.92
Oxidant/antioxidant status in liver tissue of vitamin B6 deficient rats. Clin Nutr (2005) 0.91
Production of 1-carbon units from glycine is extensive in healthy men and women. J Nutr (2009) 0.91
Between-person comparison of metabolite fitting for NMR-based quantitative metabolomics. Anal Chem (2011) 0.91
The influence of EDTA and citrate anticoagulant addition to human plasma on information recovery from NMR-based metabolic profiling studies. Mol Biosyst (2009) 0.91
Low vitamin B6 levels and the risk of recurrent venous thromboembolism. Haematologica (2007) 0.89
Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. Am J Physiol Endocrinol Metab (2011) 0.89
Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women. Am J Clin Nutr (2009) 0.88
Effect of vitamin B6 depletion in adult man on the excretion of cystathionine and other methionine metabolites. J Nutr (1970) 0.88
A sulfur amino acid-free meal increases plasma lipids in humans. J Nutr (2011) 0.85
Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. J Nutr (2012) 0.84
Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects. Eur Heart J (2007) 0.84
Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate. Am J Cardiol (1995) 0.84
Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis. Anal Chem (2008) 0.84
Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users. Thromb Res (2003) 0.83
Low plasma levels of vitamin B(6) are independently associated with a heightened risk of deep-vein thrombosis. Circulation (2001) 0.81
Metabolic profiling of vitamin C deficiency in Gulo-/- mice using proton NMR spectroscopy. J Biomol NMR (2011) 0.80
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74
Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (2013) 8.81
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol (2008) 6.23
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature (2004) 5.85
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab (2007) 4.51
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem (2005) 4.30
The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci Transl Med (2011) 4.24
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care (2009) 3.69
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci U S A (2010) 3.23
A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med (2002) 3.22
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci Transl Med (2011) 3.20
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science (2008) 3.17
Obesity-related derangements in metabolic regulation. Annu Rev Biochem (2006) 3.14
Continuous electroencephalographic monitoring in critically ill patients: indications, limitations, and strategies. Crit Care Med (2013) 2.79
Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes (2009) 2.68
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63
An R2 statistic for fixed effects in the linear mixed model. Stat Med (2008) 2.53
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care (2003) 2.49
Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling. Annu Rev Pharmacol Toxicol (2006) 2.48
Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology. Free Radic Biol Med (2007) 2.47
Dissecting the in vivo metabolic potential of two human gut acetogens. J Biol Chem (2010) 2.42
Nitric oxide represses the Arabidopsis floral transition. Science (2004) 2.41
Extracellular thiols and thiol/disulfide redox in metabolism. Annu Rev Nutr (2004) 2.41
Redox compartmentalization in eukaryotic cells. Biochim Biophys Acta (2008) 2.35
Effects of home access and availability of alcohol on young adolescents' alcohol use. Addiction (2007) 2.35
Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circ Cardiovasc Genet (2010) 2.34
Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality. Crit Care Med (2009) 2.31
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem (2009) 2.28
Prospective evaluation of pain and analgesic use following major elective intracranial surgery. J Neurosurg (2007) 2.26
Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery. Obesity (Silver Spring) (2008) 2.23
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. Mol Syst Biol (2009) 2.21
PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem (2003) 2.20
Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif. J Biol Chem (2003) 2.14
Incidence of ventricular shunt placement for hydrocephalus with clipping versus coiling for ruptured and unruptured cerebral aneurysms in the Nationwide Inpatient Sample database: 2002 to 2007. World Neurosurg (2011) 2.12
Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1. Toxicol Sci (2004) 2.12
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab (2012) 2.11
Deformable M-Reps for 3D Medical Image Segmentation. Int J Comput Vis (2003) 2.10
Acute lung injury in critical neurological illness. Crit Care Med (2012) 2.09
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci U S A (2002) 2.04
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem (2006) 2.03
Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease. Atherosclerosis (2005) 2.02
Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. Circulation (2009) 2.01
Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab (2010) 2.00
Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2008) 1.99
apLCMS--adaptive processing of high-resolution LC/MS data. Bioinformatics (2009) 1.98
A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management. Clin Infect Dis (2003) 1.93
Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu Rev Nutr (2003) 1.93
Adaptive trial designs: a review of barriers and opportunities. Trials (2012) 1.91
Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state. Circulation (2005) 1.90
Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring) (2011) 1.90
Nutritional metabolomics: progress in addressing complexity in diet and health. Annu Rev Nutr (2012) 1.89
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A (2005) 1.88
Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J (2007) 1.86
Oxidation of glutathione and cysteine in human plasma associated with smoking. Free Radic Biol Med (2003) 1.82
Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling. Biochem J (2005) 1.78
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A (2009) 1.77
Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem (2006) 1.74
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J Biol Chem (2007) 1.73
Oxidative stress markers are associated with persistent atrial fibrillation. Clin Chem (2007) 1.72
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell (2003) 1.71
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Computing Confidence Bounds for Power and Sample Size of the General Linear Univariate Model. Am Stat (1995) 1.69
Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development. Clin Endocrinol (Oxf) (2008) 1.67
Diurnal variation in glutathione and cysteine redox states in human plasma. Am J Clin Nutr (2007) 1.66
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab (2012) 1.66
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem (2005) 1.65
Efficacy of intravenous patient-controlled analgesia after supratentorial intracranial surgery: a prospective randomized controlled trial. Clinical article. J Neurosurg (2009) 1.64
Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality. J Clin Endocrinol Metab (2014) 1.64
Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function. Circulation (2012) 1.64
Properties of internal pilots with the univariate approach to repeated measures. Stat Med (2003) 1.63
Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age. Am J Clin Nutr (2007) 1.62
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. J Biol Chem (2007) 1.62
The role of plasma aminothiols in the prediction of coronary microvascular dysfunction and plaque vulnerability. Atherosclerosis (2011) 1.62
Real longitudinal data analysis for real people: building a good enough mixed model. Stat Med (2010) 1.61