Published in Infect Immun on December 01, 1996
A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells. EMBO J (1998) 4.53
Detection of intimins alpha, beta, gamma, and delta, four intimin derivatives expressed by attaching and effacing microbial pathogens. J Clin Microbiol (1998) 3.50
Locus of enterocyte effacement from Citrobacter rodentium: sequence analysis and evidence for horizontal transfer among attaching and effacing pathogens. Infect Immun (2001) 2.68
Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease. Infect Immun (1999) 2.50
Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun (2004) 2.32
Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium. Infect Immun (2003) 2.17
Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev (1998) 1.88
Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection. Infect Immun (2002) 1.73
IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol (2008) 1.66
Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis. Infect Immun (2001) 1.60
Identification of enterohemorrhagic Escherichia coli O26:H- genes required for intestinal colonization in calves. Infect Immun (2005) 1.52
Role of EspB in experimental human enteropathogenic Escherichia coli infection. Infect Immun (2000) 1.47
Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium. Infect Immun (2001) 1.34
Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine. Cell Host Microbe (2012) 1.29
Effect of prior experimental human enteropathogenic Escherichia coli infection on illness following homologous and heterologous rechallenge. Infect Immun (1998) 1.23
Role of periplasmic chaperones and BamA (YaeT/Omp85) in folding and secretion of intimin from enteropathogenic Escherichia coli strains. J Bacteriol (2009) 1.14
Enteropathogenic Escherichia coli infection induces expression of the early growth response factor by activating mitogen-activated protein kinase cascades in epithelial cells. Infect Immun (2001) 1.11
The microbiome and regulation of mucosal immunity. Immunology (2014) 1.10
Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice. Infect Immun (2009) 1.08
Expression of intimin gamma from enterohemorrhagic Escherichia coli in Citrobacter rodentium. Infect Immun (2000) 1.04
Identification of immunodominant regions within the C-terminal cell binding domain of intimin alpha and intimin beta from enteropathogenic Escherichia coli. Infect Immun (1998) 1.03
Gamma interferon produced by antigen-specific CD4+ T cells regulates the mucosal immune responses to Citrobacter rodentium infection. Infect Immun (2010) 1.03
In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections. Cold Spring Harb Perspect Med (2013) 0.99
Involvement of T helper type 17 and regulatory T cell activity in Citrobacter rodentium invasion and inflammatory damage. Clin Exp Immunol (2009) 0.99
CesD2 of enteropathogenic Escherichia coli is a second chaperone for the type III secretion translocator protein EspD. Infect Immun (2003) 0.99
Mouse model of enteropathogenic Escherichia coli infection. Infect Immun (2005) 0.99
Protection against hemorrhagic colitis in an animal model by oral immunization with isogeneic rabbit enteropathogenic Escherichia coli attenuated by truncating intimin. Infect Immun (2005) 0.97
Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism. Microbiology (2007) 0.95
In vitro evolution of an archetypal enteropathogenic Escherichia coli strain. J Bacteriol (2013) 0.92
Gamma interferon influences intestinal epithelial hyperplasia caused by Lawsonia intracellularis infection in mice. Infect Immun (2000) 0.92
Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1. Infect Immun (2009) 0.92
Allele- and tir-independent functions of intimin in diverse animal infection models. Front Microbiol (2012) 0.91
Strain-dependent cellular immune responses in cattle following Escherichia coli O157:H7 colonization. Infect Immun (2014) 0.88
Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells. Pediatr Res (2009) 0.88
RegR virulence regulon of rabbit-specific enteropathogenic Escherichia coli strain E22. Infect Immun (2013) 0.81
The immune responses to bacterial antigens encountered in vivo at mucosal surfaces. Philos Trans R Soc Lond B Biol Sci (2000) 0.78
Immunization of mice with Lactobacillus casei expressing a beta-intimin fragment reduces intestinal colonization by Citrobacter rodentium. Clin Vaccine Immunol (2011) 0.78
Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions. Am J Physiol Cell Physiol (2014) 0.76
IL-4 Protects the Mitochondria Against TNFα and IFNγ Induced Insult During Clearance of Infection with Citrobacter rodentium and Escherichia coli. Sci Rep (2015) 0.75
Protection of rabbits against enteropathogenic Escherichia coli (EPEC) using an intimin null mutant. BMC Vet Res (2006) 0.75
Citrobacter rodentium mouse model of bacterial infection. Nat Protoc (2016) 0.75
Tpl2 promotes innate cell recruitment and effector T cell differentiation to limit Citrobacter rodentium burden and dissemination. Infect Immun (2017) 0.75
Immunogenic Domains and Secondary Structure of Escherichia coli Recombinant Secreted Protein Escherichia coli-Secreted Protein B. Front Immunol (2017) 0.75
Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol (1987) 58.68
Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect Immun (1991) 15.39
A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc Natl Acad Sci U S A (1990) 14.22
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc Natl Acad Sci U S A (1995) 12.79
Escherichia coli that cause diarrhea: enterotoxigenic, enteropathogenic, enteroinvasive, enterohemorrhagic, and enteroadherent. J Infect Dis (1987) 12.26
Escherichia coli strains that cause diarrhoea but do not produce heat-labile or heat-stable enterotoxins and are non-invasive. Lancet (1978) 10.29
The diarrheal response of humans to some classic serotypes of enteropathogenic Escherichia coli is dependent on a plasmid encoding an enteroadhesiveness factor. J Infect Dis (1985) 9.18
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat (1974) 8.05
Pathogenesis of escherichia coli gastroenteritis in man--another mechanism. N Engl J Med (1980) 8.01
Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc Natl Acad Sci U S A (1995) 6.59
Cloning and characterization of the eae gene of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol (1992) 6.09
The eae gene of enteropathogenic Escherichia coli encodes a 94-kilodalton membrane protein, the expression of which is influenced by the EAF plasmid. Infect Immun (1991) 5.75
A second chromosomal gene necessary for intimate attachment of enteropathogenic Escherichia coli to epithelial cells. J Bacteriol (1993) 5.02
Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection. J Clin Invest (1993) 4.53
The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model. J Clin Invest (1993) 4.11
Attaching and effacing locus of a Citrobacter freundii biotype that causes transmissible murine colonic hyperplasia. Infect Immun (1993) 3.34
Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells. Proc Natl Acad Sci U S A (1995) 3.24
Sharing of virulence-associated properties at the phenotypic and genetic levels between enteropathogenic Escherichia coli and Hafnia alvei. J Med Microbiol (1992) 3.03
The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia. Infect Immun (1993) 3.03
Characterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei. Infect Immun (1994) 2.85
The role of the eaeA gene in diarrhea and neurological complications in a gnotobiotic piglet model of enterohemorrhagic Escherichia coli infection. Infect Immun (1995) 2.69
Transmissible murine colonic hyperplasia. Vet Pathol (1978) 2.11
The etiology of transmissible murine colonic hyperplasia. Lab Anim Sci (1976) 1.98
Genetic and biochemical characterization of Citrobacter rodentium sp. nov. J Clin Microbiol (1995) 1.81
Molecular characterization of a carboxy-terminal eukaryotic-cell-binding domain of intimin from enteropathogenic Escherichia coli. Infect Immun (1995) 1.75
Host specificity of enteropathogenic Escherichia coli from rabbits: lack of correlation between adherence in vitro and pathogenicity for laboratory animals. Infect Immun (1994) 1.03
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature (2001) 15.44
Genome sequence of Yersinia pestis, the causative agent of plague. Nature (2001) 14.36
Nipah virus: a recently emergent deadly paramyxovirus. Science (2000) 9.39
The transposon Tn1 as a probe for studying ColE1 structure and function. Mol Gen Genet (1977) 8.71
Plasmid-mediated adhesion in enteropathogenic Escherichia coli. J Pediatr Gastroenterol Nutr (1983) 6.59
Enteropathogenic and enterohaemorrhagic Escherichia coli: more subversive elements. Mol Microbiol (1998) 6.12
Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia. Emerg Infect Dis (2001) 5.65
A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells. EMBO J (1998) 4.53
Phylogeny of the defined murine microbiota: altered Schaedler flora. Appl Environ Microbiol (1999) 3.76
Analysis of sequences transposed by complementation of two classes of transposition-deficient mutants of Tn3. J Bacteriol (1978) 3.69
Identification and characterization of TnphoA mutants of Salmonella that are unable to pass through a polarized MDCK epithelial cell monolayer. Mol Microbiol (1988) 3.59
The role of a stress-response protein in Salmonella typhimurium virulence. Mol Microbiol (1991) 3.52
Detection of intimins alpha, beta, gamma, and delta, four intimin derivatives expressed by attaching and effacing microbial pathogens. J Clin Microbiol (1998) 3.50
Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice. Infect Immun (1988) 3.44
IgA production without mu or delta chain expression in developing B cells. Nat Immunol (2001) 3.26
Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect Immun (1997) 3.21
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. Proc Natl Acad Sci U S A (1989) 3.13
Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. J Exp Med (2000) 3.12
Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo. Infect Immun (1989) 3.00
Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases. Clin Microbiol Rev (2001) 2.97
Characterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei. Infect Immun (1994) 2.85
Serologic evidence for the presence in Pteropus bats of a paramyxovirus related to equine morbillivirus. Emerg Infect Dis (1996) 2.83
URINARY EXCRETION OF THIAMIN IN CLINICAL CASES AND THE VALUE OF SUCH ANALYSES IN THE DIAGNOSIS OF THIAMIN DEFICIENCY. J Clin Invest (1940) 2.77
Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia. Microbes Infect (2001) 2.71
Salmonella: immune responses and vaccines. Vet J (2001) 2.68
Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants. Proc Natl Acad Sci U S A (1995) 2.63
Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease. Infect Immun (1999) 2.50
Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans. Infect Immun (1997) 2.44
Construction of genetically defined double aro mutants of Salmonella typhi. Vaccine (1991) 2.42
Role of intimin and bundle-forming pili in enteropathogenic Escherichia coli adhesion to pediatric intestinal tissue in vitro. Infect Immun (1998) 2.41
Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine. Biotechnology (N Y) (1992) 2.38
Screening for enteropathogenic Escherichia coli in infants with diarrhea by the fluorescent-actin staining test. Infect Immun (1991) 2.35
A lethal role for lipid A in Salmonella infections. Mol Microbiol (1998) 2.30
Expression of a cloned Staphylococcus aureus alpha-hemolysin determinant in Bacillus subtilis and Staphylococcus aureus. Infect Immun (1983) 2.28
Bacterial copper- and zinc-cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis. Mol Microbiol (1997) 2.23
Genetic analysis of K88-mediated adhesion of enterotoxigenic Escherichia coli. Nature (1981) 2.21
Polypeptides expressed in Escherichia coli K-12 minicells by transposition elements Tn1 and Tn3. J Bacteriol (1979) 2.17
Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect Immun (1996) 2.14
Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium. Infect Immun (1999) 2.14
Comparison of the Escherichia coli K-12 genome with sampled genomes of a Klebsiella pneumoniae and three salmonella enterica serovars, Typhimurium, Typhi and Paratyphi. Nucleic Acids Res (2000) 2.07
Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model. Microb Pathog (1992) 2.04
Cloning, expression, and mapping of the Staphylococcus aureus alpha-hemolysin determinant in Escherichia coli K-12. Infect Immun (1983) 2.03
Cytolethal distending toxin sequence and activity in the enterohepatic pathogen Helicobacter hepaticus. Infect Immun (2000) 1.99
Concentrations of interleukin 6 and tumour necrosis factor in serum and stools of children with Shigella dysenteriae 1 infection. Gut (1993) 1.98
Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity. J Exp Med (1998) 1.98
Syndrome of intractable diarrhoea with persistent villous atrophy in early childhood: a clinicopathological survey of 47 cases. J Pediatr Gastroenterol Nutr (1998) 1.97
Bacterial infection promotes colon tumorigenesis in Apc(Min/+) mice. J Infect Dis (2001) 1.96
Binding of intimin from enteropathogenic Escherichia coli to Tir and to host cells. Mol Microbiol (1999) 1.95
Salmonella typhimurium aroA mutants as carriers of the Escherichia coli heat-labile enterotoxin B subunit to the murine secretory and systemic immune systems. Microb Pathog (1987) 1.93
Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon. Gut (1986) 1.93
Expression of a gene for glucan-binding protein from Streptococcus mutans in Escherichia coli. J Gen Microbiol (1985) 1.93
Salmonella enterica serovar Typhi possesses a unique repertoire of fimbrial gene sequences. Infect Immun (2001) 1.83
An attenuated aroA Salmonella typhimurium vaccine elicits humoral and cellular immunity to cloned beta-galactosidase in mice. J Infect Dis (1987) 1.81
Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice. Proc Natl Acad Sci U S A (2009) 1.81
Role of chronic hepatitis in development of thalassaemic liver disease. Arch Dis Child (1976) 1.80
Roles for Fis and YafK in biofilm formation by enteroaggregative Escherichia coli. Mol Microbiol (2001) 1.80
Ultrastructural study of adhesion of enterotoxigenic Escherichia coli to erythrocytes and human intestinal epithelial cells. Infect Immun (1984) 1.79
Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression. Infect Immun (1994) 1.79
Adhesion of enteroaggregative Escherichia coli to pediatric intestinal mucosa in vitro. Infect Immun (1996) 1.78
Serology of typhoid fever in an area of endemicity and its relevance to diagnosis. J Clin Microbiol (2001) 1.75
Molecular characterization of a carboxy-terminal eukaryotic-cell-binding domain of intimin from enteropathogenic Escherichia coli. Infect Immun (1995) 1.75
Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins. Immunol Today (1999) 1.74
Role of ompR-dependent genes in Salmonella typhimurium virulence: mutants deficient in both ompC and ompF are attenuated in vivo. Infect Immun (1991) 1.74
Ultrastructural study of adherence to and penetration of cultured cells by two invasive Escherichia coli strains isolated from infants with enteritis. Infect Immun (1984) 1.73
Role of bacterial intimin in colonic hyperplasia and inflammation. Science (1999) 1.71
Adhesion of enterotoxigenic Escherichia coli to human small intestinal enterocytes. Infect Immun (1985) 1.71
Response to autoimmune enteropathy to cyclosporin A therapy. Gut (1991) 1.71
Interleukin-12 is required for control of the growth of attenuated aromatic-compound-dependent salmonellae in BALB/c mice: role of gamma interferon and macrophage activation. Infect Immun (1998) 1.69
The involvement of tumor necrosis factor in immunity to Salmonella infection. J Immunol (1991) 1.68
Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp. J Med Microbiol (2000) 1.68
Identification and characterization of a protective immunodominant B cell epitope of pertactin (P.69) from Bordetella pertussis. Eur J Immunol (1991) 1.67
Cytolethal distending toxin in avian and human isolates of Helicobacter pullorum. J Infect Dis (2000) 1.67
Igh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens. Infect Immun (2000) 1.67
Molecular characterization of the surface layer proteins from Clostridium difficile. Mol Microbiol (2001) 1.65
Construction and characterization of a Yersinia enterocolitica O:8 high-temperature requirement (htrA) isogenic mutant. Infect Immun (1996) 1.64
The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins. J Biol Chem (1996) 1.64
Inability of an isogenic urease-negative mutant stain of Helicobacter mustelae to colonize the ferret stomach. Infect Immun (1995) 1.63
Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers. Infect Immun (2000) 1.63
Down regulation of intimin expression during attaching and effacing enteropathogenic Escherichia coli adhesion. Infect Immun (1997) 1.63
Growth of Clostridium difficile and production of toxins A and B in complex and defined media. J Med Microbiol (1986) 1.62
Spontaneous inflammatory bowel disease in multiple mutant mouse lines: association with colonization by Helicobacter hepaticus. Helicobacter (1998) 1.61
Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein. Infect Immun (2000) 1.60
Loperamide: studies on its mechanism of action. Gut (1981) 1.60
Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis. Infect Immun (2001) 1.60
Lethal familial protracted diarrhoea. Arch Dis Child (1981) 1.59