Published in Proc Natl Acad Sci U S A on December 24, 1996
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J (1999) 4.68
DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J Exp Med (2002) 2.48
Regulation of p53 activity in nuclear bodies by a specific PML isoform. EMBO J (2000) 2.38
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J (2007) 2.07
Retracted High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J Clin Invest (2007) 1.34
Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer. J Biol Chem (2012) 1.26
Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Mol Cell Biol (2001) 1.21
Expression of C-terminal deleted p53 isoforms in neuroblastoma. Nucleic Acids Res (2006) 1.12
Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts. Am J Pathol (2005) 1.05
p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance. Front Oncol (2012) 1.04
Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells. EMBO J (2000) 1.01
Mortalin-based cytoplasmic sequestration of p53 in a nonmammalian cancer model. Am J Pathol (2006) 0.98
Role of p53 in Cell Death and Human Cancers. Cancers (Basel) (2011) 0.95
Immortalization of epithelial progenitor cells mediated by resveratrol. Oncogene (2007) 0.92
The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies. Biophys J (2008) 0.90
Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity. Mech Ageing Dev (2007) 0.89
Reversible aggregation plays a crucial role on the folding landscape of p53 core domain. Biophys J (2004) 0.88
Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activity. Oncotarget (2015) 0.86
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. Cell Death Dis (2014) 0.86
p53 Aggregates penetrate cells and induce the co-aggregation of intracellular p53. PLoS One (2013) 0.86
The DNA binding and accumulation of p53 from breast cancer cell lines and the link with serine 15 phosphorylation. Cancer Biol Ther (2012) 0.78
A monoclonal antibody against p53 cross-reacts with processing bodies. PLoS One (2012) 0.77
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60
Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53
p53: puzzle and paradigm. Genes Dev (1996) 13.16
Clinical implications of the p53 tumor-suppressor gene. N Engl J Med (1993) 7.29
Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev (1991) 6.30
Regulation of the specific DNA binding function of p53. Cell (1992) 6.16
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev (1993) 6.02
Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature (1992) 4.36
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci U S A (1994) 3.76
Monoclonal antibody analysis of p53 expression in normal and transformed cells. J Virol (1986) 3.72
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37
Structure of the NF-kappa B p50 homodimer bound to DNA. Nature (1995) 3.33
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci U S A (1992) 3.27
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway. Mol Cell Biol (1994) 3.05
The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J (1992) 2.97
Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci U S A (1995) 2.56
Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. Cancer Res (1993) 2.18
Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport. Nature (1991) 1.99
Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet (1995) 1.80
Regulation of transcription factor localization: fine-tuning of gene expression. Trends Biochem Sci (1996) 1.76
Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus. Oncogene (1996) 1.75
Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet (1992) 1.69
Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol Cell Biol (1996) 1.61
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proc Natl Acad Sci U S A (1995) 1.52
Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas. J Natl Cancer Inst (1994) 1.35
p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma. Am J Pathol (1995) 1.32
Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma. Int J Cancer (1993) 1.27
Expression of p53 in premalignant and malignant squamous epithelium. Oncogene (1991) 1.26
The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. Am J Pathol (1996) 1.15
Expression of p53 protein in malignant melanoma: clinicopathological and prognostic implications. Br J Dermatol (1995) 0.90
Identification of proteins in DNA-protein complexes after blotting of EMSA gels. Biotechniques (1995) 0.85
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J (1999) 4.68
Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem (2000) 4.11
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins. Cell Death Differ (2009) 1.93
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ (2011) 1.76
Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol Cell Biol (1996) 1.61
Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett (2001) 1.61
p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis. Cell Death Differ (2010) 1.60
Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Res (1999) 1.38
[Eradication of hepatitis C virus after 3 months of interferon treatment in a patient with chronic hepatitis C]. Gastroenterol Clin Biol (2000) 1.38
Oncogenes induce and activate endogenous p73 protein. J Biol Chem (2000) 1.34
Inhibition of matrix metalloproteinase 9 activation by a specific monoclonal antibody. Hybridoma (1993) 1.27
Axon guidance at the midline choice point. Dev Dyn (2001) 1.19
Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. Cell Growth Differ (1998) 1.17
Use of fluorescein hydrazide and fluorescein thiosemicarbazide reagents for the fluorometric determination of protein carbonyl groups and for the detection of oxidized protein on polyacrylamide gels. Anal Biochem (1987) 1.16
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding. Cell Death Differ (2009) 1.12
Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. Cell Death Differ (2007) 1.09
Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation. J Biol Chem (1999) 1.06
Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo. Oncogene (2006) 1.05
Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors. Cell Death Dis (2011) 1.05
Poor prognosis of p53 gene mutation and nuclear overexpression of p53 protein in inflammatory breast carcinoma. J Natl Cancer Inst (1993) 1.01
Two-factor reprogramming of somatic cells to pluripotent stem cells reveals partial functional redundancy of Sox2 and Klf4. Cell Death Differ (2012) 0.98
The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria. Cell Death Differ (2005) 0.97
Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase. Gut (2004) 0.96
Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis (1997) 0.95
Low levels of cell cycle inhibitor p27kip1 combined with high levels of Ki-67 predict shortened disease-free survival in T1 and T2 invasive breast carcinomas. Int J Oncol (2001) 0.93
Construction of deletion mutants of the Escherichia coli UvrA protein and their purification from inclusion bodies. J Biol Chem (1991) 0.92
Plasma assay of gelatinase B: tissue inhibitor of metalloproteinase complexes in cancer. Cancer (1995) 0.91
ΔNp63 regulates select routes of reprogramming via multiple mechanisms. Cell Death Differ (2013) 0.89
Loss of p53 function in uterine papillary serous carcinoma. Hum Pathol (1998) 0.88
Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats. Jpn J Cancer Res (1994) 0.88
Cancer cachexia decreases specific force and accelerates fatigue in limb muscle. Biochem Biophys Res Commun (2013) 0.85
DeltaNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation. Cell Death Differ (2004) 0.85
p73 is dispensable for commitment to neural stem cell fate, but is essential for neural stem cell maintenance and for blocking premature differentiation. Cell Death Differ (2012) 0.83
Conformation-dependent antibody response to Pseudomonas aeruginosa outer membrane proteins induced by immunization in humans. FEMS Immunol Med Microbiol (2000) 0.83
Deregulated expression of DeltaNp73alpha causes early embryonic lethality. Cell Death Differ (2006) 0.83
Corrigendum: Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Nature (2015) 0.81
Extraction of type IV collagenase/gelatinase from plasma membranes of human pancreatic cancer cells. Matrix Suppl (1992) 0.80
Effect of high or low frequency electroacupuncture on the cellular activity of catecholaminergic neurons in the brain stem. Acupunct Electrother Res (2000) 0.79
Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines. Int J Oncol (2000) 0.78
Facial cold receptors and the survival reflex "diving bradycardia" in man. Jpn J Physiol (1990) 0.78
Clinical experience of e-PTFE membrane implant surgery for refractory glaucoma. Br J Ophthalmol (2003) 0.78
Excision repair of adozelesin-N3 adenine adduct by 3-methyladenine-DNA glycosylases and UvrABC nuclease. Mol Cells (2001) 0.77
The topodynamics of incision of UV-irradiated covalently closed DNA by the Escherichia coli Uvr(A)BC endonuclease. J Biol Chem (1996) 0.77
The benzoxathiolone LYR-71 down-regulates interferon-gamma-inducible pro-inflammatory genes by uncoupling tyrosine phosphorylation of STAT-1 in macrophages. Br J Pharmacol (2009) 0.77
Axon guidance at the midline of the developing CNS. Anat Rec (2000) 0.77
Effect of unilateral pulmonary vagotomy on respiratory control in man. Respiration (1990) 0.77
Rb function is required for E1A-induced S-phase checkpoint activation. Cell Death Differ (2008) 0.77
New cell surface marker of the rat floor plate and notochord. Dev Dyn (1998) 0.77
Extraction of type-IV collagenase/gelatinase from plasma membranes of human cancer cells. Int J Cancer (1990) 0.77
p73 - constitutively open for business. Cell Death Differ (2013) 0.76
Promotion potential of tamoxifen on hepatocarcinogenesis in female SD or F344 rats initiated with diethylnitrosamine. Cancer Lett (1996) 0.76
Potential preventive effects of Chelidonium majis L. (Papaveraceae) herb extract on glandular stomach tumor development in rats treated with N-methyl-N'-nitro-N nitrosoguanidine (MNNG) and hypertonic sodium chloride. Cancer Lett (1997) 0.76
Effect of DNA topology on plasmid DNA repair in vivo. FEBS Lett (2000) 0.76
Protein carbonyl formation in blood plasma by cephalosporins. Arch Biochem Biophys (1997) 0.76
Calcium ionophore-induced degradation of neurofilament and cell death in MSN neuroblastoma cells. Neurochem Res (1998) 0.76
Post-initiation treatment of Indole-3-carbinol did not suppress N-methyl-N-nitrosourea induced mammary carcinogenesis in rats. Cancer Lett (2001) 0.76
Cardiac responses to hypoxia and hypercapnia in spinal man. Eur Heart J (1990) 0.76
Chemopreventive effect of 2-(allylthio)pyrazine (2-AP) on rat colon carcinogenesis induced by azoxymethane (AOM). Cancer Lett (2001) 0.75
A study for watermark methods appropriate to medical images. J Digit Imaging (2001) 0.75
Ventilatory responses to chemosensory stimuli in quadriplegic subjects. Eur Respir J (1990) 0.75
Estimation of peripheral chemoreceptor contribution to exercise hyperpnea in man. Jpn J Physiol (1988) 0.75
Clostridium perfringens septicemia with massive hemolysis in a patient with Hodgkin's lymphoma. Am J Emerg Med (1997) 0.75
Optimization of a nanotip on a surface for the ultrafast probing of propagating surface plasmons. Opt Express (2016) 0.75
Esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents. Bioorg Med Chem Lett (2001) 0.75
Contribution of chemical and non-chemical drives to breath-holding determined by visual analog scale (VAS). Jpn J Physiol (1990) 0.75
Paralysis of respiratory muscles and hypoxic ventilatory chemoreflex. Biomed Biochim Acta (1989) 0.75
Dynamic profile of cardiovascular activity in relation to augmented ventilation and humoral agents during hypercapnic hypoxia. Jpn J Physiol (1991) 0.75
Colloidal gold-labeled insulin complex. Characterization and binding to adipocytes. Histochemistry (1986) 0.75
Dependence of biphasic heart rate response to sustained hypoxia on magnitude of ventilation in man. Jpn J Physiol (1992) 0.75
Double minutes in the papillary thyroid cancer cell line PTC-1113A. Cancer Genet Cytogenet (1996) 0.75
Ventilatory and cardiovascular responses to hypoxic and hyperoxic static handgrip exercise in man. Respir Physiol (1990) 0.75
[Progression of a hepatic hemangioma under progestins]. Gastroenterol Clin Biol (2001) 0.75
Effect of verapamil on ventilatory and circulatory responses to hypoxia and hypercapnia in normal subjects. Jpn J Physiol (1992) 0.75
Nuclear overexpression of p53 protein does not correlate with gene mutation in primary peritoneal carcinoma. Hum Pathol (1997) 0.75