PubRank

G P Pfeifer

Author PubWeight™ 95.74‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 2000 5.50
2 Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 1996 5.17
3 X-chromosome inactivation and cell memory. Trends Genet 1992 3.76
4 Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. Carcinogenesis 2001 2.66
5 Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function. Curr Biol 2000 2.46
6 Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. J Natl Cancer Inst 2000 2.27
7 Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer. Science 1994 2.21
8 Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. Cancer Res 2001 2.18
9 In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol Cell Biol 1995 1.93
10 Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells. J Biol Chem 2001 1.80
11 The tumor suppressor RASSF1A in human carcinogenesis: an update. Histol Histopathol 2005 1.76
12 Cytosine methylation determines hot spots of DNA damage in the human P53 gene. Proc Natl Acad Sci U S A 1997 1.69
13 Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers. Oncogene 1995 1.57
14 Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers. Oncogene 1998 1.38
15 Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis. Histol Histopathol 2003 1.38
16 The DNA damage spectrum produced by simulated sunlight. J Mol Biol 2000 1.31
17 In vivo protein-DNA interactions at the c-jun promoter: preformed complexes mediate the UV response. Mol Cell Biol 1993 1.29
18 DNA repair domains within a human gene: selective repair of sequences near the transcription initiation site. EMBO J 1996 1.25
19 Ligation-mediated PCR improves the sensitivity of methylation analysis by restriction enzymes and detection of specific DNA strand breaks. Nucleic Acids Res 1990 1.24
20 Isolation and characterization of DNA cytosine 5-methyltransferase from human placenta. Biochim Biophys Acta 1983 1.20
21 Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas. Int J Cancer 2001 1.20
22 Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases. Cancer Res 1997 1.19
23 Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers. Cancer Res 2001 1.18
24 Extension product capture improves genomic sequencing and DNase I footprinting by ligation-mediated PCR. Nucleic Acids Res 1992 1.17
25 The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas. Oncogene 2001 1.17
26 The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer. Oncogene 1993 1.15
27 Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors. Carcinogenesis 2000 1.15
28 Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer. Oncogene 1992 1.11
29 UV light as a footprinting agent: modulation of UV-induced DNA damage by transcription factors bound at the promoters of three human genes. J Mol Biol 1995 1.11
30 UV damage and repair mechanisms in mammalian cells. Bioessays 1996 1.08
31 PCR-aided DNaseI footprinting of single copy gene sequences in permeabilized cells. Nucleic Acids Res 1990 1.08
32 Inhibition of transcription factor binding by ultraviolet-induced pyrimidine dimers. Biochemistry 1996 1.05
33 Constitutive protection of E2F recognition sequences in the human thymidine kinase promoter during cell cycle progression. J Biol Chem 1997 1.03
34 Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine residues in solar UV mutagenesis. J Mol Biol 2001 1.01
35 Frequent epigenetic inactivation of cystatin M in breast carcinoma. Oncogene 2006 0.99
36 Sequence-specific and domain-specific DNA repair in xeroderma pigmentosum and Cockayne syndrome cells. J Biol Chem 1997 0.99
37 In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation. Oncogene 1997 0.98
38 Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene. Mol Cell Biol 1998 0.98
39 Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo. J Mol Biol 1998 0.98
40 Lack of gene- and strand-specific DNA repair in RNA polymerase III-transcribed human tRNA genes. Mol Cell Biol 1997 0.95
41 Cell cycle-independent removal of UV-induced pyrimidine dimers from the promoter and the transcription initiation domain of the human CDC2 gene. Nucleic Acids Res 2000 0.95
42 Involvement of 5-methylcytosine in sunlight-induced mutagenesis. J Mol Biol 1999 0.95
43 The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells. Oncogene 2012 0.94
44 DNA methyltransferase polypeptides in mouse and human cells. Biochim Biophys Acta 1986 0.94
45 Frequent promoter methylation of tumor-related genes in sporadic and men2-associated pheochromocytomas. Exp Clin Endocrinol Diabetes 2005 0.92
46 Processing of UV damage in vitro by FEN-1 proteins as part of an alternative DNA excision repair pathway. Biochemistry 1999 0.92
47 Quantitation and mapping of aflatoxin B1-induced DNA damage in genomic DNA using aflatoxin B1-8,9-epoxide and microsomal activation systems. Mutat Res 1999 0.91
48 UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin. Cancer Res 2001 0.91
49 In vivo structure of two divergent promoters at the human PCNA locus. Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1. J Biol Chem 1999 0.91
50 The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts. Oncogene 1998 0.91
51 RASSF1A interacts with and activates the mitotic kinase Aurora-A. Oncogene 2008 0.90
52 Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy. Oncogene 2010 0.90
53 Preferential binding of DNA methyltransferase and increased de novo methylation of deoxyinosine containing DNA. FEBS Lett 1986 0.89
54 In vivo protein-DNA interactions at the c-jun promoter in quiescent and serum-stimulated fibroblasts. J Cell Biochem 1995 0.89
55 Intracellular distribution of DNA methyltransferase during the cell cycle. FEBS Lett 1988 0.88
56 Purification and characterization of mammalian DNA methyltransferases by use of monoclonal antibodies. J Biol Chem 1985 0.88
57 The transcription-repair coupling factor CSA is required for efficient repair only during the elongation stages of RNA polymerase II transcription. Mutat Res 1998 0.87
58 Genomic structure and mutation screening of the E2F4 gene in human tumors. Int J Cancer 2000 0.87
59 Use of UvrABC nuclease to quantify benzo[a]pyrene diol epoxide-DNA adduct formation at methylated versus unmethylated CpG sites in the p53 gene. Carcinogenesis 1999 0.86
60 Impaired enzymatic methylation of BPDE-modified DNA. Carcinogenesis 1984 0.85
61 A high-resolution analysis of chromatin structure along p53 sequences. Mol Carcinog 1996 0.85
62 TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database. Mutagenesis 2001 0.85
63 Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR. Carcinogenesis 2001 0.85
64 Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. Biochemistry 1994 0.84
65 Involvement of DNA damage and repair in mutational spectra. Mutat Res 2000 0.82
66 Proliferation-associated expression of DNA methyltransferase in human embryonic lung cells. Virchows Arch B Cell Pathol Incl Mol Pathol 1989 0.82
67 Synthesis and characterization of poly[d(G-z5C)]. B-Z transition and inhibition of DNA methylase. Biochemistry 1985 0.81
68 Structure of mouse DNA (cytosine-5-)-methyltransferase. Eur J Biochem 1988 0.81
69 Preparation of monoclonal antibodies against DNA-cytosine-5-methyltransferase from human placenta. Eur J Cell Biol 1984 0.80
70 Improved in vivo dimethyl sulfate footprinting using AlkA protein: DNA-protein interactions at the mouse H19 gene promoter in primary embryo fibroblasts. Anal Biochem 2000 0.78
71 Isolation and characterization of proteins that stimulate the activity of mammalian DNA methyltransferase. Biochim Biophys Acta 1988 0.78
72 Cloning and characterization of the human RNA polymerase I subunit hRPA40. Biochim Biophys Acta 1998 0.77
73 Variable DNA methylation changes during differentiation of human melanoma cells. Exp Cell Res 1988 0.77
74 A new verdict for an old convict. Nat Genet 2001 0.77
75 Mouse DNA-cytosine-5-methyltransferase: sequence specificity of the methylation reaction and electron microscopy of enzyme-DNA complexes. EMBO J 1985 0.76
76 Mapping of UV photoproducts along the human P53 gene. Ann N Y Acad Sci 1994 0.76
77 Fluorescence-based directed termination PCR: direct mutation characterization without sequencing. Nucleic Acids Res 2001 0.75
78 Characterization of DNA methylating enzymes by use of monoclonal antibodies. Prog Clin Biol Res 1985 0.75
79 Mapping of DNA alkylation sites induced by aziridinylbenzoquinones in human cells by ligation-mediated polymerase chain reaction. Cancer Res 1994 0.75
80 Smoking causes cancer! Curr Biol 1997 0.75
81 Variations of DNA-(cytosine-5-)-methyltransferase activities after administration of N-hydroxy-N-aminofluorene to Sprague-Dawley rats. Cancer Lett 1988 0.75
82 Immunocytochemical staining of different cell types in vaginal smears by monoclonal anti-DNA methylase antibodies. Diagn Cytopathol 1988 0.75