Published in Microvasc Res on May 01, 1996
Guidelines for the welfare and use of animals in cancer research. Br J Cancer (2010) 6.97
Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage (1997) 4.13
Evidence for striatal dopamine release during a video game. Nature (1998) 3.28
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res (1997) 2.96
The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations. Br J Cancer (2005) 2.85
The colour centre in the cerebral cortex of man. Nature (1989) 2.69
Positron emission tomography compartmental models. J Cereb Blood Flow Metab (2001) 2.28
Clearing-factor lipase in adipose tissue. Distinction of different states of the enzyme and the possible role of the fat cell in the maintenance of tissue activity. Biochem J (1969) 1.57
An assessment of 31P MRS as a method of measuring pH in rat tumours. NMR Biomed (1993) 1.45
Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation. Eur J Cancer (2000) 1.44
Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease. Neurosci Lett (1995) 1.44
Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Arch Gen Psychiatry (1998) 1.42
Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats. J Neurochem (1979) 1.33
Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res (2001) 1.32
Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials. Br J Radiol (2003) 1.27
Parametric image reconstruction using spectral analysis of PET projection data. Phys Med Biol (1998) 1.26
Cortical dysfunction in non-demented Parkinson's disease patients: a combined (31)P-MRS and (18)FDG-PET study. Brain (2000) 1.17
Combination of dynamic and integral methods for generating reproducible functional CBF images. J Cereb Blood Flow Metab (1990) 1.14
Changes in central opioid receptor binding in relation to inflammation and pain in patients with rheumatoid arthritis. Br J Rheumatol (1994) 1.12
Multiresolution analysis of emission tomography images in the wavelet domain. J Cereb Blood Flow Metab (1999) 1.12
Kinetic modeling of hyperpolarized (13)C pyruvate metabolism in tumors using a measured arterial input function. Magn Reson Med (2012) 1.09
Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsy. Neurology (2001) 1.04
Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy. Br J Cancer (2001) 1.03
Measurement of tumor oxygenation: in vivo comparison of a luminescence fiber-optic sensor and a polarographic electrode in the p22 tumor. Radiat Res (2001) 1.02
The irreversible disposal rate of free fatty acids in the plasma of fed and starved rats. Biochem J (1973) 1.02
The use of ketamine plus diazepam anaesthesia to increase the radiosensitivity of a C3H mouse mammary adenocarcinoma in hyperbaric oxygen. Br J Radiol (1984) 1.01
In vivo distribution of opioid receptors in man in relation to the cortical projections of the medial and lateral pain systems measured with positron emission tomography. Neurosci Lett (1991) 1.01
Chromosome 14 linked familial Alzheimer's disease. A clinico-pathological study of a single pedigree. Brain (1995) 0.99
Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide. Br J Cancer (2000) 0.99
Limitations of the reporter green fluorescent protein under simulated tumor conditions. Cancer Res (2001) 0.99
Are block copolymer worms more effective Pickering emulsifiers than block copolymer spheres? Soft Matter (2014) 0.99
An automatic algorithm for the segmentation and morphological analysis of microvessels in immunostained histological tumour sections. J Microsc (2010) 0.98
Adaptive-optimal design in PET occupancy studies. Clin Pharmacol Ther (2010) 0.96
The energy metabolism of RIF-1 tumours following hydralazine. Radiother Oncol (1990) 0.96
Modeling dynamic PET-SPECT studies in the wavelet domain. J Cereb Blood Flow Metab (2000) 0.94
Characterisation of tumour blood flow using a 'tissue-isolated' preparation. Br J Cancer (1994) 0.93
Regional blood-brain glucose transfer in the rat: a novel double-membrane kinetic analysis. J Cereb Blood Flow Metab (1986) 0.93
Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid. Cancer Gene Ther (2000) 0.93
Relationships between extraction and metabolism of glucose, blood flow, and tissue blood volume in regions of rat brain. J Cereb Blood Flow Metab (1983) 0.93
Non-linear regression techniques in data analysis. Med Inform (Lond) (1985) 0.91
The binding of L-tryptophan to serum albumins in the presence of non-esterified fatty acids. Biochem J (1975) 0.91
Effects of a single exposure to carbon disulphide on the rate of urea production and on plasma free fatty acid and glucose concentrations in the rat. Br J Ind Med (1975) 0.91
Horseradish peroxidase-mediated gene therapy: choice of prodrugs in oxic and anoxic tumor conditions. Mol Cancer Ther (2001) 0.90
In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis. Ann Neurol (1998) 0.90
Measuring the velocity of fluorescently labelled red blood cells with a keyhole tracking algorithm. J Microsc (2008) 0.90
Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using [11C] diprenorphine and positron emission tomography. J Cereb Blood Flow Metab (1999) 0.89
Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem (1989) 0.88
Extraction of 5-fluorouracil by tumor and liver: a noninvasive positron emission tomography study of patients with gastrointestinal cancer. Cancer Res (2001) 0.88
Benzodiazepine site pharmacokinetic/pharmacodynamic quantification in man: direct measurement of drug occupancy and effects on the human brain in vivo. Neuropharmacology (1996) 0.88
The effects of hyperoxic and hypercarbic gases on tumour blood flow. Br J Cancer (1999) 0.88
The combined measurement of blood flow and metabolism in RIF-1 tumours in vivo. A study using H2 flow and 31P NMR spectroscopy. NMR Biomed (1990) 0.88
Analysis of dynamic radioligand displacement or "activation" studies. J Cereb Blood Flow Metab (1997) 0.87
Modification of tumor blood flow: current status and future directions. Semin Radiat Oncol (1998) 0.87
Sites of action of morphine in the brain. Lancet (1991) 0.87
The effect of the nitric oxide donor glyceryl trinitrate on global and regional cerebral blood flow in man. J Neurol Sci (2000) 0.87
The effects of diet, lipolysis and limb ischaemia on the distribution of plasma tryptophan in the rat. Biochem J (1975) 0.86
Anatomical mapping of glucose transporter protein and pyruvate dehydrogenase in rat brain: an immunogold study. Brain Res (1989) 0.86
11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. Neurology (1997) 0.85
Resistance to flow through tissue-isolated transplanted rat tumours located in two different sites. Br J Cancer (1993) 0.85
The effect of the nitric oxide synthase inhibitor L-NMMA on basal CBF and vasoneuronal coupling in man: a PET study. J Cereb Blood Flow Metab (1999) 0.85
Nitric oxide in biological fluids: analysis of nitrite and nitrate by high-performance ion chromatography. J Chromatogr A (1995) 0.85
Semi-automated software for the three-dimensional delineation of complex vascular networks. J Microsc (2003) 0.84
Separating Parkinson's disease from normality. Discriminant function analysis of fluorodopa F 18 positron emission tomography data. Arch Neurol (1994) 0.84
An interpretation of the intravenous glucose tolerance test in the light of recent findings on the kinetics of glucose and insulin in man. Clin Sci Mol Med (1978) 0.84
Unexpectedly high affinity of a novel histamine H(3) receptor antagonist, GSK239512, in vivo in human brain, determined using PET. Br J Pharmacol (2014) 0.83
Characterization of Na+,K+-ATPase in cultured and separated neuronal and glial cells from rat cerebellum. J Neurochem (1984) 0.83
Radiation-induced modification of blood flow distribution in a rat fibrosarcoma. Int J Radiat Biol (1991) 0.83
A method for the simultaneous estimation of regional rates of glucose influx and phosphorylation in rat brain using radiolabeled 2-deoxyglucose. Brain Res (1981) 0.83
Evaluation of [11C]GB67, a novel radioligand for imaging myocardial alpha 1-adrenoceptors with positron emission tomography. Eur J Nucl Med (2000) 0.83
Regional changes in brain glucose utilization in rats given a pyrethroid insecticide. Brain Res (1980) 0.83
Inhibition, by 2-oxo acids that accumulate in maple-syrup-urine disease, of lactate, pyruvate, and 3-hydroxybutyrate transport across the blood-brain barrier. J Neurochem (1982) 0.83
A general method to correct PET data for tissue metabolites using a dual-scan approach. J Nucl Med (2000) 0.83
11C-diprenorphine binding in Huntington's disease: a comparison of region of interest analysis with statistical parametric mapping. J Cereb Blood Flow Metab (1997) 0.82
Oxic and anoxic enhancement of radiation-mediated toxicity by horseradish peroxidase/indole-3-acetic acid gene therapy. Int J Radiat Biol (2002) 0.82
In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer. Cancer Gene Ther (2010) 0.81
Central benzodiazepine receptors in malformations of cortical development: A quantitative study. Brain (2001) 0.80
GABA-benzodiazepine receptor function in alcohol dependence: a combined 11C-flumazenil PET and pharmacodynamic study. Psychopharmacology (Berl) (2005) 0.80
Central benzodiazepine/gamma-aminobutyric acid A receptors in idiopathic generalized epilepsy: an [11C]flumazenil positron emission tomography study. Epilepsia (1997) 0.80
Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat. Nucl Med Biol (1997) 0.80
Quantitation of [11C]diprenorphine cerebral kinetics in man acquired by PET using presaturation, pulse-chase and tracer-only protocols. J Neurosci Methods (1994) 0.80
Regional hippocampal [11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. Brain (1997) 0.79
The calculation of errors and the choice of sampling times in the determination of irreversible disposal rates in vivo by isotope experiments. Biochem J (1975) 0.79
Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: a feasibility study. Cancer Chemother Pharmacol (1998) 0.79
The turnover of blood glucose and plasma free fatty acids in the rat after acute carbon disulphide intoxication. Biochem Pharmacol (1977) 0.79
Gene delivery to hypoxic cells in vitro. Br J Cancer (2000) 0.79
A study of the kinetic behaviour of glucose based on simultaneous estimates of influx and phosphorylation in brain regions of rats in different physiological states. Brain Res (1981) 0.79
Estimation of the kinetic parameters of undirectional transport across the blood-brain barrier. J Neurochem (1979) 0.79
The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification. Br J Cancer (2005) 0.78
On-line measurement of exhaled [11C]CO2 during PET. J Nucl Med (2000) 0.78
Effect of endothelin-1 and sarafotoxin S6c on blood flow in a rat tumor. J Cardiovasc Pharmacol (1995) 0.78
The effect of cobalt on the uptake of plasma iron by the liver. Biochem J (1976) 0.78
Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI. Methods (2011) 0.78
Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol. Br J Cancer (2004) 0.78
Investigation of the opioid system in absence seizures with positron emission tomography. J Neurol Neurosurg Psychiatry (1993) 0.78
Tumour blood flow modification by endothelin-related peptides in the rat HSN fibrosarcoma. Br J Cancer Suppl (1996) 0.78
Studies on the relationship between cerebral glucose transport and phosphorylation using 2-deoxyglucose. J Cereb Blood Flow Metab (1986) 0.78
Tracer 2-deoxyglucose kinetics in brain regions of rats given kainic acid. J Cereb Blood Flow Metab (1988) 0.78
Vascular response of tumour and normal tissues to endothelin-1 following antagonism of ET(A) and ET(B) receptors in anaesthetised rats. Int J Cancer (1997) 0.77
Normal values for left ventricular volumes obtained using gated PET. G Ital Cardiol (1998) 0.77