Peroxisome proliferator-activated receptors: structures and function.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 8993548)

Published in Ann N Y Acad Sci on December 27, 1996

Authors

J D Tugwood1, T C Aldridge, K G Lambe, N Macdonald, N J Woodyatt

Author Affiliations

1: Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom.

Articles citing this

Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)? Environ Health Perspect (2001) 1.85

IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1. Proc Natl Acad Sci U S A (2001) 1.26

A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants. Environ Health Perspect (2009) 1.13

PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males. BMC Med Genet (2007) 0.99

Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. Comp Hepatol (2003) 0.97

Orphan nuclear receptors as targets for drug development. Pharm Res (2010) 0.97

The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene. Biochem J (2000) 0.91

Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies. Environ Health Perspect (2008) 0.90

Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Mutat Res (2011) 0.87

Molecular basis of non-responsiveness to peroxisome proliferators: the guinea-pig PPARalpha is functional and mediates peroxisome proliferator-induced hypolipidaemia. Biochem J (1998) 0.82

Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha. Toxicology (2009) 0.82

Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial. Evid Based Complement Alternat Med (2014) 0.81

Cross-species gene expression analysis of species specific differences in the preclinical assessment of pharmaceutical compounds. PLoS One (2014) 0.77

Interaction of oestrogen and peroxisome proliferator-activated receptors with apolipoprotein(a) gene enhancers. Biochem J (2002) 0.77

Interaction of oxazaphosphorines with multidrug resistance-associated protein 4 (MRP4). AAPS J (2010) 0.75

Articles by these authors

HIV transmission, travel, and Thailand. BMJ (1992) 2.36

PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem Biophys Res Commun (1993) 1.79

National assessment of prevalent diagnosed HIV infections. Commun Dis Public Health (2000) 1.69

Lymphogranuloma venereum in the United Kingdom. Sex Transm Infect (2005) 1.40

Nucleotide sequences of H1 histone genes from Xenopus laevis. A recently diverged pair of H1 genes and an unusual H1 pseudogene. Nucleic Acids Res (1983) 1.32

Comparative efficacies of erythromycin-sulfisoxazole and cefaclor in acute otitis media: a double blind randomized trial. Pediatr Infect Dis J (1987) 1.29

Acrylamide: review of toxicity data and dose-response analyses for cancer and noncancer effects. Crit Rev Toxicol (2006) 1.17

Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha). Carcinogenesis (1998) 1.13

Emerging canine angiostrongylosis in northern England: five fatal cases. Vet Rec (2009) 1.09

Organization and expression of cloned histone gene clusters from Xenopus laevis and X. borealis. Nucleic Acids Res (1982) 1.07

Risky sexual behaviour in context: qualitative results from an investigation into risk factors for seroconversion among gay men who test for HIV. Sex Transm Infect (2008) 1.04

Severe respiratory syncytial virus infection among otherwise healthy prematurely born infants: What are we trying to prevent? Paediatr Child Health (1998) 1.04

PPAR alpha and the regulation of cell division and apoptosis. Toxicology (2002) 1.00

Sexually transmitted diseases among teenagers in England and Wales. Commun Dis Rep CDR Rev (1997) 0.99

An outbreak of hepatitis A among young men associated with having sex in public venues. Commun Dis Public Health (2001) 0.98

Differential activation by xenoestrogens of ER alpha and ER beta when linked to different response elements. J Endocrinol (1998) 0.98

Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha. Toxicol Lett (2000) 0.95

Infection control in cystic fibrosis: practical recommendations for the hospital, clinic, and social settings. Am J Infect Control (2000) 0.94

Individual Xenopus histone genes are replication-independent in oocytes and replication-dependent in Xenopus or mouse somatic cells. Nucleic Acids Res (1985) 0.93

The role of palliative care in the home in medical education: report from a national consensus Conference. J Palliat Med (2001) 0.91

An interprofessional palliative care oncology rehabilitation program: effects on function and predictors of program completion. Curr Oncol (2013) 0.90

Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha. Mutat Res (2000) 0.90

Chlamydia infection in street youth: Need for more aggressive screening programs. Can J Infect Dis (1996) 0.88

A prospective evaluation of an interdisciplinary nutrition-rehabilitation program for patients with advanced cancer. Curr Oncol (2013) 0.87

The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs. Carcinogenesis (1999) 0.87

Species differences in response to diethylhexylphthalate: suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression. Arch Toxicol (2000) 0.86

Statement on euthanasia and physician-assisted suicide. J Palliat Care (1994) 0.84

Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor alpha or the peroxisome proliferator nafenopin. Eur J Biochem (2000) 0.84

Diagnosis of lymphogranuloma venereum from biopsy samples. Gut (2006) 0.83

Suppression of apoptosis and induction of DNA synthesis in vitro by the phthalate plasticizers monoethylhexylphthalate (MEHP) and diisononylphthalate (DINP): a comparison of rat and human hepatocytes in vitro. Arch Toxicol (1999) 0.81

Numbers of adults with diagnosed HIV infection 1996-2005--adjusted totals and extrapolations for England, Wales and Northern Ireland. Commun Dis Public Health (2002) 0.81

HIV in gay and bisexual men in the United Kingdom: 25 years of public health surveillance. Epidemiol Infect (2007) 0.81

Effects of endocrine disrupting compounds on the pathology and oestrogen receptor alpha and beta distribution in the uterus and cervix of ewe lambs. Domest Anim Endocrinol (2003) 0.80

Reduced susceptibility to penicillin among pneumococci causing invasive infection in children - Canada, 1991 to 1998. Can J Infect Dis (2001) 0.80

Application of genomics to the definition of the molecular basis for toxicity. Toxicol Lett (2001) 0.80

Peroxisome proliferator-activated receptor (PPAR) alpha-regulated growth responses and their importance to hepatocarcinogenesis. Toxicol Lett (1998) 0.80

Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter. Toxicol Lett (1999) 0.79

Healing and survivorship: what makes a difference? Curr Oncol (2008) 0.79

Induction of DNA replication by peroxisome proliferators is independent of both tumour necrosis factor (alpha) priming and EGF-receptor tyrosine kinase activity. J Cell Sci (1999) 0.78

Relationship between antenatal group B streptococcal vaginal colonization and premature labour. Paediatr Child Health (1999) 0.78

Bacterial colonization of human milk. South Med J (1981) 0.77

Knowledge and Attitudes of Physicians about Lipids. Can Fam Physician (1990) 0.77

Analysis of antibiotic use and misuse in children hospitalized with RSV infection. Paediatr Child Health (1999) 0.76

Familial spontaneous rupture of the colon: report of two cases. Dis Colon Rectum (1970) 0.76

Peroxisome proliferator-activated receptor-alpha and the pleiotropic responses to peroxisome proliferators. Arch Toxicol Suppl (1998) 0.76

Outbreak of Q fever in workers at a meat processing plant in Scotland, July 2006. Euro Surveill (2006) 0.76

Sudden death in a young asthmatic. Br Med J (1969) 0.75

Acellular versus whole-cell pertussis vaccines. Can J Infect Dis (1992) 0.75

Death in 12-24-Year-Old Youth in Nova Scotia: High Risk of Preventable Deaths for Males, Socially Deprived and Rural Populations-A Report from the NSYOUTHS Program. Int J Pediatr (2010) 0.75

World TB Day, March 24, 2000 - Forging new partnerships to stop TB. Paediatr Child Health (2000) 0.75

Sexually transmitted diseases and HIV infection among homosexual men. BMJ (1993) 0.75

Regulated analgesics and pain control. CMAJ (1996) 0.75

Amino acid residues in both the DNA-binding and ligand-binding domains influence transcriptional activity of the human peroxisome proliferator-activated receptor alpha. Biochem Biophys Res Commun (1997) 0.75

Increased high risk sexual behaviour in homosexual men. There is no evidence for a decreased incidence of HIV infection. BMJ (2000) 0.75

Canada and the WHO Cancer Pain Relief Program. J Palliat Care (1986) 0.75

Continuous subcutaneous infusion of narcotics using a portable disposable pump. J Palliat Care (1985) 0.75

Experimental Study of Two-frequency Dielectrophoresis Effects on a Linear Electrode Array. Conf Proc IEEE Eng Med Biol Soc (2005) 0.75

Spontaneous rupture of the oesophagus. Br J Surg (1968) 0.75

Controversies in palliative care. J Palliat Care (1988) 0.75

Neonatal intracranial hemorrhage and complicating hydrocephalus. J Clin Ultrasound (1984) 0.75

Oestradiol is a potent mitogen and modulator of GnRH signalling in alphaT3-1 cells: are these effects causally related? J Endocrinol (2000) 0.75

Origins of war. Lancet (1970) 0.75

War prevention and the doctor. Lancet (1970) 0.75

Ovarian cancer screening was feasible but did not decrease incidence of index cancer or mortality. West J Med (2000) 0.75

Neurosonographic identification of ventricular asymmetry in premature infants. Clin Radiol (1984) 0.75

Platelet MAO activity in depression. Compr Psychiatry (1983) 0.75

Delineating peroxisome proliferator action to improve human risk assessment. Prog Clin Biol Res (1994) 0.75

Nursing care study - depression: an unhappy ending. Nurs Mirror (1982) 0.75

Rainfall Singularities. Science (1961) 0.75

PPAR alpha-mediated responses in the rodent liver: a holistic biochemical view. Curr Protein Pept Sci (2000) 0.75