Published in J Virol on February 01, 1997
Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2. J Virol (1998) 4.71
Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro. J Virol (1997) 2.32
Role for highly regulated rep gene expression in adeno-associated virus vector production. J Virol (1997) 2.19
Characterization of adeno-associated virus genomes isolated from human tissues. J Virol (2005) 1.72
Structure of adeno-associated virus vector DNA following transduction of the skeletal muscle. J Virol (1999) 1.44
Host cell DNA repair pathways in adeno-associated viral genome processing. J Virol (2006) 1.43
Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination. J Virol (2000) 1.37
Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. J Virol (2006) 1.36
Novel transcriptional regulatory signals in the adeno-associated virus terminal repeat A/D junction element. J Virol (2000) 1.32
Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success--a personal perspective. Hum Gene Ther (2015) 1.27
AAV's anatomy: roadmap for optimizing vectors for translational success. Curr Gene Ther (2010) 1.27
Viral-mediated gene therapy for the muscular dystrophies: successes, limitations and recent advances. Biochim Biophys Acta (2006) 1.25
Consequences of DNA-dependent protein kinase catalytic subunit deficiency on recombinant adeno-associated virus genome circularization and heterodimerization in muscle tissue. J Virol (2003) 1.16
Trans-splicing adeno-associated viral vector-mediated gene therapy is limited by the accumulation of spliced mRNA but not by dual vector coinfection efficiency. Hum Gene Ther (2004) 1.16
Identification of cellular proteins that interact with the adeno-associated virus rep protein. J Virol (2008) 1.12
Infectious molecular clones of adeno-associated virus isolated directly from human tissues. J Virol (2008) 1.11
Biology of adeno-associated viral vectors in the central nervous system. Front Mol Neurosci (2014) 1.04
A helper-dependent capsid-modified adenovirus vector expressing adeno-associated virus rep78 mediates site-specific integration of a 27-kilobase transgene cassette. J Virol (2006) 0.97
A cis-acting element that directs circular adeno-associated virus replication and packaging. J Virol (2002) 0.96
Self-complementary AAV mediates gene targeting and enhances endonuclease delivery for double-strand break repair. Gene Ther (2010) 0.95
Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes. J Virol (1999) 0.95
Definition of herpes simplex virus type 1 helper activities for adeno-associated virus early replication events. PLoS Pathog (2009) 0.89
Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system. PLoS One (2008) 0.88
Transfer of the full-length dystrophin-coding sequence into muscle cells by a dual high-capacity hybrid viral vector with site-specific integration ability. J Virol (2005) 0.88
Rescue of the adeno-associated virus genome from a plasmid vector: evidence for rescue by replication. J Virol (2003) 0.87
Replication competent helper functions for recombinant AAV vector generation. Gene Ther (2002) 0.87
Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release. J Virol (2012) 0.87
Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics. Cell Mol Neurobiol (2016) 0.86
Charge-to-alanine mutagenesis of the adeno-associated virus type 2 Rep78/68 proteins yields temperature-sensitive and magnesium-dependent variants. J Virol (1999) 0.86
Creating a novel origin of replication through modulating DNA-protein interfaces. PLoS One (2010) 0.84
Arsenic trioxide stabilizes accumulations of adeno-associated virus virions at the perinuclear region, increasing transduction in vitro and in vivo. J Virol (2013) 0.84
Adeno-associated virus (AAV) Rep protein enhances the generation of a recombinant mini-adenovirus (Ad) utilizing an Ad/AAV hybrid virus. J Virol (2000) 0.82
Adeno-associated Virus as a Mammalian DNA Vector. Microbiol Spectr (2015) 0.82
Adeno-associated virus inverted terminal repeats stimulate gene editing. Gene Ther (2014) 0.81
Promyelocytic leukemia protein is a cell-intrinsic factor inhibiting parvovirus DNA replication. J Virol (2013) 0.81
The Adeno-Associated Virus Genome Packaging Puzzle. J Mol Genet Med (2015) 0.80
Formation of AAV single stranded DNA genome from a circular plasmid in Saccharomyces cerevisiae. PLoS One (2011) 0.80
AAV: An Overview of Unanswered Questions. Hum Gene Ther (2017) 0.77
Establishment of a novel cell line for the enhanced production of recombinant adeno-associated virus vectors for gene therapy. Hum Gene Ther (2014) 0.76
The persistence of alien genomes. Proc Natl Acad Sci U S A (2000) 0.75
Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. Sci Rep (2016) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol (1967) 106.91
Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A (1990) 7.06
Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J Virol (1989) 6.69
Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J (1991) 6.13
The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity. Cell (1990) 5.98
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Proc Natl Acad Sci U S A (1982) 5.73
Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV. Cell (1983) 5.27
Integration of the adeno-associated virus genome into cellular DNA in latently infected human Detroit 6 cells. J Virol (1980) 5.09
A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells. J Virol (1996) 4.83
Adeno-associated virus general transduction vectors: analysis of proviral structures. J Virol (1988) 4.64
Concatemers of alternating plus and minus strands are intermediates in adenovirus-associated virus DNA synthesis. Proc Natl Acad Sci U S A (1976) 4.62
A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol (1987) 4.57
Transcriptional elements as components of eukaryotic origins of DNA replication. Cell (1988) 4.43
Palindromic base sequences and replication of eukaryote chromosome ends. Nature (1974) 4.33
Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells. Proc Natl Acad Sci U S A (1984) 3.92
Factors that bind to adeno-associated virus terminal repeats. J Virol (1989) 3.56
Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics (1991) 3.47
Replication of adeno-associated virus in synchronized cells without the addition of a helper virus. J Virol (1987) 3.44
In vitro resolution of covalently joined AAV chromosome ends. Cell (1990) 3.24
Latent infection of KB cells with adeno-associated virus type 2. J Virol (1986) 2.88
Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization. J Virol (1992) 2.84
The recombination signals for adeno-associated virus site-specific integration. Proc Natl Acad Sci U S A (1996) 2.74
Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein. J Virol (1993) 2.69
Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genome. J Virol (1990) 2.62
Replication of adeno-associated virus DNA. Complementation of naturally occurring rep- mutants by a wild-type genome or an ori- mutant and correction of terminal palindrome deletions. J Mol Biol (1984) 2.51
Organization of adeno-associated virus DNA in latently infected Detroit 6 cells. Virology (1989) 2.43
DNA amplification of adeno-associated virus as a response to cellular genotoxic stress. Cancer Res (1988) 2.39
A human parvovirus, adeno-associated virus, as a eucaryotic vector: transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase. Mol Cell Biol (1984) 2.36
Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats. J Virol (1996) 2.32
The cryptic life style of adeno-associated virus. Bioessays (1995) 2.27
Recombinant junctions formed by site-specific integration of adeno-associated virus into an episome. J Virol (1995) 2.02
Adeno-associated virus: integration at a specific chromosomal locus. Curr Opin Genet Dev (1993) 1.87
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector. Proc Natl Acad Sci U S A (1992) 1.82
Replication of adeno-associated virus in cells irradiated with UV light at 254 nm. J Virol (1989) 1.67
In vitro rescue of an integrated hybrid adeno-associated virus/simian virus 40 genome. J Mol Biol (1991) 1.61
In vitro replication of adeno-associated virus DNA. Proc Natl Acad Sci U S A (1992) 1.60
Transcription factors and the control of DNA replication. Curr Opin Cell Biol (1992) 1.30
In vitro excision of adeno-associated virus DNA from recombinant plasmids: isolation of an enzyme fraction from HeLa cells that cleaves DNA at poly(G) sequences. Mol Cell Biol (1988) 1.26
Rescue and replication signals of the adeno-associated virus 2 genome. J Mol Biol (1995) 1.17
Intermediates of adeno-associated virus DNA replication in vitro. J Virol (1994) 1.04
Origin of adeno-associated virus DNA replication is a target of carcinogen-inducible DNA amplification. J Virol (1991) 1.03
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
TM4: a free, open-source system for microarray data management and analysis. Biotechniques (2003) 38.02
Comparative genomics of the eukaryotes. Science (2000) 26.62
Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast (1998) 23.00
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy (2008) 12.35
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science (1997) 11.89
Stromal gene signatures in large-B-cell lymphomas. N Engl J Med (2008) 11.34
Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet (1999) 11.10
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet (1997) 10.71
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med (2013) 8.89
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol (1998) 8.45
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (1999) 8.23
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther (1999) 7.96
Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding. J Virol (1990) 7.85
Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol (1998) 7.76
Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature (1990) 7.32
Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A (1990) 7.06
IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity (2001) 6.56
Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol (1996) 6.43
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol (1996) 6.22
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Proc Natl Acad Sci U S A (1982) 5.73
Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease. Neurology (2006) 5.67
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet (1994) 5.49
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A (1997) 5.32
Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV. Cell (1983) 5.27
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat Med (1999) 5.26
Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science (1999) 5.22
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates. J Virol (1995) 5.01
Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo. Gene Ther (2003) 4.92
A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol (1987) 4.57
Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. Cell (1999) 4.57
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell (2000) 4.53
Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A (1998) 4.35
Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther (2001) 4.35
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res (1997) 4.32
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3. EMBO J (2001) 4.23
A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell (1998) 4.21
Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients. Antimicrob Agents Chemother (2011) 4.21
Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial. Gut (2007) 4.21
Dominance is the major genetic basis of heterosis in rice as revealed by QTL analysis using molecular markers. Genetics (1995) 4.18
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science (1997) 4.03
Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest (1997) 4.00
Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test-retest reproducibility. Skeletal Radiol (2003) 3.93
Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo. Gene Ther (2003) 3.85
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J Virol (2000) 3.84
Prophylactic atenolol reduces postoperative myocardial ischemia. McSPI Research Group. Anesthesiology (1998) 3.79
The synaptic SNARE complex is a parallel four-stranded helical bundle. Nat Struct Biol (1998) 3.74
Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol (2000) 3.73
Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Science (1995) 3.62
Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways. Plant Cell (2001) 3.60
Evidence for a partially folded intermediate in alpha-synuclein fibril formation. J Biol Chem (2001) 3.60
Reliability and validity of the CMT neuropathy score as a measure of disability. Neurology (2005) 3.44
A piston model for transmembrane signaling of the aspartate receptor. Science (1999) 3.42
LifeLines: using visualization to enhance navigation and analysis of patient records. Proc AMIA Symp (1998) 3.35
Tenofovir is superior to entecavir for achieving complete viral suppression in HBeAg-positive chronic hepatitis B patients with high HBV DNA. Aliment Pharmacol Ther (2014) 3.32
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32
Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism. J Virol (2000) 3.27
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
In vitro resolution of covalently joined AAV chromosome ends. Cell (1990) 3.24
Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron (2001) 3.20
Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res (1997) 3.17
Plasmodium malariae infection in an asymptomatic 74-year-old Greek woman with splenomegaly. N Engl J Med (1998) 3.13
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. J Biol Chem (2001) 3.13
Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity. J Virol (1991) 3.09
Is guided self-help as effective as face-to-face psychotherapy for depression and anxiety disorders? A systematic review and meta-analysis of comparative outcome studies. Psychol Med (2010) 3.08
Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1. Science (2000) 3.07
Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res (1996) 3.03
Coping skills training for youth with diabetes mellitus has long-lasting effects on metabolic control and quality of life. J Pediatr (2000) 3.02
Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging (2005) 3.00
The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis. Plant Cell (1997) 3.00
Artificial 'spin ice' in a geometrically frustrated lattice of nanoscale ferromagnetic islands. Nature (2006) 2.96
Positioning of the mitotic spindle by a cortical-microtubule capture mechanism. Science (2000) 2.92
Identification of trait-improving quantitative trait loci alleles from a wild rice relative, Oryza rufipogon. Genetics (1998) 2.91
The completeness, validity, and timeliness of AIDS surveillance data. Ann Epidemiol (2001) 2.89
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem (2001) 2.89
Adeno-associated virus vector carrying human minidystrophin genes effectively ameliorates muscular dystrophy in mdx mouse model. Proc Natl Acad Sci U S A (2000) 2.83
Apoptosis and cancer: mutations within caspase genes. J Med Genet (2009) 2.80
Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen. J Biol Chem (1995) 2.80
The effects of poverty on child health and development. Annu Rev Public Health (1997) 2.78
16S rRNA gene-based detection of tetrachloroethene-dechlorinating Desulfuromonas and Dehalococcoides species. Appl Environ Microbiol (2000) 2.75
NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif. Cell (1998) 2.73
Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science (1996) 2.71
Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content. Circulation (2001) 2.71
High-performance high-TC superconducting wires. Science (2006) 2.69
Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein. J Virol (1993) 2.69
Interaction of the sigma factor and the nusA gene protein of E. coli with RNA polymerase in the initiation-termination cycle of transcription. Cell (1981) 2.57
The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr Biol (1998) 2.57
Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum (2006) 2.57
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol (2001) 2.56
DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae. Mutat Res (2001) 2.50
Drought- and salt-tolerant plants result from overexpression of the AVP1 H+-pump. Proc Natl Acad Sci U S A (2001) 2.50
Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients. J Am Coll Cardiol (1997) 2.49
High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum (2002) 2.45
Adolescents' attitudes to general practice in north London. Br J Gen Pract (1997) 2.45
Molecular evolution and mosaic structure of alpha, beta, and gamma intimins of pathogenic Escherichia coli. Mol Biol Evol (1999) 2.44