H Kaneto

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 2001 1.81
2 Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma. Oncogene 2000 1.76
3 The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells. Diabetes 1996 1.72
4 Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Invest 1997 1.64
5 Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun 2003 1.27
6 Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect. J Pharmacobiodyn 1987 1.18
7 Increased stress protein ORP150 autoantibody production in Type 1 diabetic patients. Diabet Med 2006 1.13
8 Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription. Biochem Biophys Res Commun 1996 1.11
9 Location of an inducible nitric oxide synthase mRNA in the normal kidney. Kidney Int 1994 1.03
10 Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes. Diabetologia 2004 1.00
11 Further evidence for the implication of a kappa-opioid receptor mechanism in the production of psychological stress-induced analgesia. Jpn J Pharmacol 1990 1.00
12 Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in diabetes. J Biol Chem 1997 0.96
13 TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase. Free Radic Biol Med 1997 0.94
14 Evaluation of gut motility in type II diabetes by the radiopaque marker method. J Gastroenterol Hepatol 2000 0.93
15 Pharmacologic studies on analgesics. VII. Significance of the calcium ion in morphine analgesia. J Pharmacol Exp Ther 1966 0.91
16 Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas. Mol Cell Biol 1999 0.88
17 Involvement of glycation and oxidative stress in diabetic macroangiopathy. Diabetes 1996 0.88
18 Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes. Osteoarthritis Cartilage 2004 0.88
19 Glycation and inactivation of sorbitol dehydrogenase in normal and diabetic rats. Biochem J 1996 0.86
20 The contribution of fructose and nitric oxide to oxidative stress in hamster islet tumor (HIT) cells through the inactivation of glutathione peroxidase. Electrophoresis 2000 0.84
21 Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells. J Clin Invest 1997 0.84
22 Transforming growth factor β1 T868C gene polymorphism is associated with cerebral infarction in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 2011 0.83
23 Infrequent widespread microsatellite instability in hepatocellular carcinomas. Int J Oncol 2000 0.83
24 Antibodies to BSA conjugates of morphine derivatives: strict dependency of the immunological specificity on the hapten structure. Jpn J Pharmacol 1974 0.83
25 Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells. Diabetologia 1999 0.83
26 A non-opioid mechanism in the inhibitory effect of ginseng saponins on electrically evoked contractions of guinea-pig ileum and mouse vas deferens. J Pharmacobiodyn 1988 0.82
27 Dramatic recovery of counter-regulatory hormone response to hypoglycaemia after intensive insulin therapy in poorly controlled Type I diabetes mellitus. Diabetologia 1998 0.82
28 Important role of adrenergic function in the development of analgesic tolerance to morphine in mice. Jpn J Pharmacol 1986 0.82
29 Effects of footshock-, psychological- and forced swimming-stress on the learning and memory processes: involvement of opioidergic pathways. Jpn J Pharmacol 1995 0.81
30 Identification of oxidative stress-regulated genes in rat aortic smooth muscle cells by suppression subtractive hybridization. FEBS Lett 1999 0.81
31 Behavioral and pharmacological studies on gluten exorphin A5, a newly isolated bioactive food protein fragment, in mice. Jpn J Pharmacol 2000 0.80
32 Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. Jpn J Pharmacol 1994 0.80
33 Role of protein kinase C in cisplatin nephrotoxicity. Int J Urol 1999 0.80
34 Mutation of the Pax6 gene causes impaired glucose-stimulated insulin secretion. Diabetologia 2004 0.79
35 Facilitation of memory retrieval by pretest morphine mediated by mu but not delta and kappa opioid receptors. Psychopharmacology (Berl) 1990 0.79
36 Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 2011 0.78
37 Involvement of different mechanisms, opioid and non-opioid forms, in the analgesia induced by footshock (FS) and immobilized-water immersion (IW) stress. Jpn J Pharmacol 1983 0.78
38 Blockade of the development of analgesic tolerance to morphine by concurrent treatment with opioid- but not non-opioid-mediated stress in mice. Jpn J Pharmacol 1988 0.78
39 beta-cell adaptation to hyperglycemia. Diabetes 2001 0.78
40 Differentiation of alcohol and barbital physical dependence. Yakubutsu Seishin Kodo 1986 0.78
41 Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive avoidance response in mice: comparison with acetylcholinesterase inhibitors. Psychopharmacology (Berl) 1993 0.78
42 Glycation of metal-containing proteins such as Cu,Zn-superoxide dismutase, ceruloplasmin, and ferritin: possible implication for DNA damage in vivo. Contrib Nephrol 1995 0.78
43 Characterization of protein kinase C expression in human kidney. Tohoku J Exp Med 1996 0.78
44 Association of soluble CD40 ligand with carotid atherosclerosis in Japanese type 1 diabetic patients. Diabetologia 2006 0.78
45 The morphine 3-glucuronide directed antibody: its immunological specificity and possible use for radioimmunoassay of morphine in urine. Jpn J Pharmacol 1974 0.78
46 Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants. Jpn J Pharmacol 1993 0.78
47 Participation of GABAergic systems in the production of antinociception by various stresses in mice. Jpn J Pharmacol 1992 0.77
48 The effect of ginseng extract on locomotor sensitization and conditioned place preference induced by methamphetamine and cocaine in mice. Pharmacol Biochem Behav 1996 0.77
49 State dependent and/or direct memory retrieval by morphine in mice. Psychopharmacology (Berl) 1990 0.77
50 Single dose tolerance to the analgesic effect of clonidine and cross-tolerance between morphine and clonidine. Jpn J Pharmacol 1985 0.77
51 Antinociceptive effect of dihydroetorphine and its tolerance/dependence liability in mice. Biol Pharm Bull 1993 0.77
52 Role of adrenal glucocorticoids in the blockade of the development of analgesic tolerance to morphine by footshock stress exposure in mice. Jpn J Pharmacol 1989 0.77
53 Differential roles of the adrenal gland in the suppression of morphine antinociceptive tolerance development by alpha- and beta-adrenergic blockers. Jpn J Pharmacol 1991 0.77
54 High prevalence of glucose intolerance in Japanese patients with peripheral arterial disease. Diabetes Res Clin Pract 2010 0.77
55 Effect of straight chain fatty acids on seizures induced by picrotoxin and pentylenetetrazole in mice. J Pharmacobiodyn 1990 0.77
56 Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis. Biochem Biophys Res Commun 2009 0.77
57 FS stress induces long-lasting memory facilitation: involvement of cholinergic pathways. Pharmacol Biochem Behav 1996 0.77
58 Participation of an alpha 2-mediated mechanism in the production of forced swimming-stress induced analgesia in mice. J Pharmacobiodyn 1991 0.77
59 Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits. J Biochem 1996 0.77
60 Morphine dependence with or without tolerance in formalin-treated mice: further evidence for the dissociation. Jpn J Pharmacol 1994 0.77
61 Effects of Tyr-MIF-1 on stress-induced analgesia and the blockade of development of morphine tolerance by stress in mice. Jpn J Pharmacol 1999 0.77
62 Role of vasopressin in the blockade of the development of morphine tolerance by footshock and psychological stress. Arch Int Pharmacodyn Ther 1991 0.76
63 Regeneration of beta cells in the native pancreata after syngeneic and allogeneic pancreas transplantations in spontaneously type 2 diabetic Torii rats. Transplant Proc 2008 0.76
64 The role of the catecholaminergic mechanism in foot shock (FS) stress- and immobilized-water immersion (IW) stress-induced analgesia in mice. Jpn J Pharmacol 1984 0.76
65 A potent mu-opioid receptor agonist, dihydroetorphine, fails to produce the conditioned place preference in mice. Jpn J Pharmacol 1996 0.76
66 Evidence for the dissociation of morphine analgesia, tolerance and dependence. J Pharm Pharmacol 1985 0.76
67 The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo. J Pharmacobiodyn 1991 0.76
68 Morphine analgesia without development of tolerance in reserpinized mice. Jpn J Pharmacol 1986 0.76
69 Role of leukocyte adhesion molecules in monocyte/ macrophage infiltration in weanling rats with unilateral ureteral obstruction. Int J Urol 2000 0.76
70 Facilitation of memory retrieval by pre-test morphine and its state dependency in the step-through type passive avoidance learning test in mice. Jpn J Pharmacol 1990 0.75
71 [Study of a new endogenous inhibitor of enkephalin-degrading enzymes; pharmacological function and metabolism of spinorphin]. Masui 1993 0.75
72 Antiamnesic action of cromakalim, a potassium channel opener, in mice treated with hypoxia- and cerebral ischemia-type stress stimuli. Cell Mol Neurobiol 1998 0.75
73 [Marked improvement of "severe acute pancreatitis" with continuous administration of protease inhibitor: nafamostat mesilate (Futhan) via intraarterial infusion in a case]. Nihon Shokakibyo Gakkai Zasshi 1996 0.75
74 Modulation of morphine action by lauric acid. Biol Pharm Bull 1993 0.75
75 A scoring system for abstinence syndrome in morphine dependent mice and application to evaluate morphine type dependence liability of drugs. Jpn J Pharmacol 1973 0.75
76 [Determination of the development of psychotic dependence to drugs in small animals. 4. Selective drinking of barbital and ethanol solutions by mice]. Yakubutsu Seishin Kodo 1982 0.75
77 Antinociceptive effect of dihydroetorphine following various routes of administration: a comparative study with morphine. Biol Pharm Bull 1996 0.75
78 [Studies on the barbital-type physical dependence liability of mequitazine in mice and rats (author's transl)]. J Toxicol Sci 1981 0.75
79 [Stereo-morphometric study on the muscular architecture of normal ureteral wall at the ureteropelvic junction]. Nihon Hinyokika Gakkai Zasshi 1988 0.75
80 Characteristics of peripheral arterial disease in Japanese type 2 diabetic patients. Diabetologia 2006 0.75
81 Studies on physical dependence inducible by hours exposure of mice to morphine. Jpn J Pharmacol 1972 0.75
82 Amino acids and peptides. IX. Synthetic studies on leu-enkephalin analogues containing a ureylene bond. Chem Pharm Bull (Tokyo) 1988 0.75
83 Changes of brain calcium content in normal and morphinized mice after the administration of morphine. Jpn J Pharmacol 1967 0.75
84 Amino acids and peptides. XXII. Preparation and antinociceptive effect of [D-Ala2]Leu-enkephalin-poly(ethylene glycol) hybrid. Biol Pharm Bull 1994 0.75
85 [Studies on tolerance to and dependence on SS Bron solution-W: effect of major constituents on the action of dihydrocodeine in mice]. Arukoru Kenkyuto Yakubutsu Ison 1986 0.75
86 [Pharmacological studies on analgesics. 8. Significance of calcium in the mechanism of morphine analgesia. (2)]. Nihon Yakurigaku Zasshi 1966 0.75
87 Dependency on the brain function of arginine vasopressin system of the development to and recovery from analgesic tolerance to morphine. Brain Res 1992 0.75
88 Amino acids and peptides. XXIII. Leu-enkephalin analogs containing a fluorinated amino acid at position 2, 4 or 5. Chem Pharm Bull (Tokyo) 1994 0.75
89 Insulin resistance and endothelial dysfunction in type 2 diabetic patients with non-alcoholic steatohepatitis. Diabet Med 2009 0.75
90 Further studies on the determinant role of brain level of pentobarbital for the development of acute hypnotic tolerance. J Pharmacobiodyn 1981 0.75
91 Improvement of psoriatic arthritis by pioglitazone treatment in a type 2 diabetic patient. Diabetes Res Clin Pract 2010 0.75
92 Proceedings: Concomitant changes of synaptosomal Mg++-Ca++-ATPase activity with rise and fall of morphine tolerance and dependence. Jpn J Pharmacol 1974 0.75
93 [Usefulness of CT-guided RFA for hepatocellular carcinoma]. Gan To Kagaku Ryoho 2001 0.75
94 [Tolerance and physical dependence producing liability of doxepin]. Nihon Yakurigaku Zasshi 1972 0.75
95 Oxidative stress caused by glycation of Cu,Zn-superoxide dismutase and its effects on intracellular components. Nephrol Dial Transplant 1996 0.75
96 Proceedings: Radioimmunoassay of urinary metabolites of morphine. Jpn J Pharmacol 1974 0.75
97 Drug metabolizing function of isolated perfused liver. Jpn J Pharmacol 1975 0.75
98 Selectivity for opioid receptor subtypes of enkephalin analogues in isolated smooth muscle and in the analgesic effect in mice. J Pharmacobiodyn 1989 0.75
99 [Determination of mental dependence liability of drugs using small animals. 3. Selective drinking behavior of mice caused by dependence-liable drugs]. Nihon Yakurigaku Zasshi 1983 0.75
100 Further evidence for the participation of an alpha 2-adrenoceptor mediated mechanism in the production of forced swimming-stress induced analgesia in mice. J Pharmacobiodyn 1991 0.75
101 Synaptic plasticity: stairway to memory. Jpn J Pharmacol 1995 0.75
102 Morphine specific seizure induced in poly-D-lysine pretreated mice and some evidence suggesting the presence of a novel site for the morphine effect. Jpn J Pharmacol 1973 0.75
103 Urinary excretion patterns of morphine in humans followed by an radioimmunoassay method. Jpn J Pharmacol 1975 0.75
104 Reverse tolerance to the swimming time prolonging effect of d-amphetamine in mice. Jpn J Pharmacol 1986 0.75
105 [Experimental models for studying the avoidance response in mice and the anti-amnesic effect of prolyl endopeptidase inhibitors]. Nihon Yakurigaku Zasshi 1987 0.75
106 Sandwich enzyme-immunoassay of human urinary trypsin inhibitor (urinastatin) and urinastatin-like immunoreactive substance in mouse urine. Scand J Clin Lab Invest 1990 0.75
107 Determining the origin of hematuria by immunocytochemical staining of erythrocytes in urine for Tamm-Horsfall protein. J Urol 1996 0.75
108 [Determination of the development of psychotic dependence to drugs in small animals. 2. Selective drinking of morphine and cocaine solutions and its reinforcement in mice]. Yakubutsu Seishin Kodo 1981 0.75
109 Distinctive implication of emotional factors in various types of stress-induced analgesia. Jpn J Pharmacol 1988 0.75
110 Footshock- and psychological-stress prevent the development of tolerance to spinal but not supraspinal morphine. Jpn J Pharmacol 1991 0.75
111 Brain level of pentobarbital is the primary determinant for the development of hypnotic of hypnotic tolerance in mice. J Pharmacobiodyn 1980 0.75
112 [Fine needle aspiration biopsy of metastatic lesions and regional lymph-nodes in genitourinary cancer]. Nihon Hinyokika Gakkai Zasshi 1984 0.75
113 Distinctive effect of ginseng saponins on development of morphine tolerance in guinea-pig ileum and mouse vas deferens. J Pharmacobiodyn 1988 0.75
114 [A case of "phantom-robber"]. Zasshi Tokyo Ika Daigaku 1967 0.75
115 [Prostatic cancer with cystic degeneration: a case report]. Hinyokika Kiyo 1991 0.75
116 Development of physical dependence on morphine not accompanied with tolerance formation. J Pharmacobiodyn 1992 0.75
117 Ischemia induces a reduction in the content of ulinastatin-like substance in the murine hippocampus. Neurochem Res 1998 0.75
118 Chronic unilateral ureteral obstruction represented as renin-dependent hypertension. Nephron 2000 0.75
119 [A case of inflammatory fibrosarcoma of the retroperitoneum]. Nihon Shokakibyo Gakkai Zasshi 2001 0.75
120 [Acute tolerance to continuous subcutaneous infusion of morphine]. Nihon Yakurigaku Zasshi 1970 0.75
121 Lack of the development of morphine tolerance in experimental amnesia: role of arginine vasopressin. Brain Res 1993 0.75
122 Demonstration of a human urinary trypsin inhibitor (urinastatin)-like substance in the murine brain. Brain Res 1993 0.75
123 [Tolerance to and dependence on opioids in isolated longitudinal muscle of guinea pig ileum. Validity of the muscle preparation as a receptor model for opioids (author's transl)]. Nihon Yakurigaku Zasshi 1980 0.75
124 Cross reverse tolerance between amphetamine, cocaine and morphine. J Pharmacobiodyn 1987 0.75
125 Characterization of G proteins in obstructed kidneys. Int J Urol 1996 0.75
126 [Preparation of cerebral ischemia-induced amnesic model in mice and ameliorative effect of several compounds on the model]. Nihon Yakurigaku Zasshi 1989 0.75
127 Blockade by ginseng extract of the development of reverse tolerance to the ambulation-accelerating effect of methamphetamine in mice. Jpn J Pharmacol 1992 0.75
128 Protein synthesis in mouse brain during development of acute morphine tolerance. Jpn J Pharmacol 1975 0.75
129 Effect of morphine on the liberation of acetylcholine from the mouse cerebral cortical slices in relation to the calcium concentration in the medium. Jpn J Pharmacol 1967 0.75
130 Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice. Jpn J Pharmacol 1995 0.75
131 [Radioimmunoassay of drugs capable of inducing dependency]. Nihon Yakurigaku Zasshi 1975 0.75
132 [Studies on the physical dependence liability to guanabenz]. Nihon Yakurigaku Zasshi 1982 0.75
133 Release of substance P by intrathecal KK-3, a newly synthesized Leu-enkephalin derivative. Pharmacol Biochem Behav 1989 0.75
134 Dual action mechanisms of KK-3, a newly synthesized leu-enkephalin derivative, in the production of spinal analgesic effects. Jpn J Pharmacol 1990 0.75
135 [Quantitative gas chromatographic studies on the determination of ethyl alcohol in blood and the estimation of variations in ethyl alcohol in preserved or putrefied blood]. Zasshi Tokyo Ika Daigaku 1968 0.75
136 Comparative studies on the inhibitory effect of morphine, pentobarbital and ethanol on the electrically evoked contractions of isolated mouse vas deferens. J Pharmacobiodyn 1989 0.75
137 Comparative studies on morphine- and stress-induced analgesia and the development of tolerance to the effects: implication of protein synthesis mechanism in the process. Jpn J Pharmacol 1985 0.75
138 Amino acids and peptides. XIX. Preparation of enkephalin-poly(ethylene glycol) hybrid and evaluation of its analgesic activity. Chem Pharm Bull (Tokyo) 1993 0.75
139 [A study on hemorrhage during and after operation of TURP (transurethral prostatic resection)--effect of morphine or buprenorphine for suppression of postoperative hemorrhage by epidural infusion]. Hinyokika Kiyo 1986 0.75
140 Characterization of socio-psychological stress-induced antinociception in the formalin test in mice. Jpn J Pharmacol 1999 0.75
141 [Screening procedure for barbital type physical dependence liability of psychotropic drugs in mice]. Nihon Yakurigaku Zasshi 1973 0.75
142 Attempts to classify dependence-liable drugs by using a simple drug-discrimination test in mice. Gen Pharmacol 1998 0.75
143 Implication of ATP-sensitive K+ channels in various stress-induced analgesia (SIA) in mice. Jpn J Pharmacol 1996 0.75
144 Timing of cycloheximide administration and inhibition of the development of analgesic tolerance to morphine. Life Sci 1983 0.75
145 A simple quantitative method for the evaluation of physical dependence liability of morphine in mice. Jpn J Pharmacol 1971 0.75
146 Participation of liver function in the acute tolerance to pentobarbital induced after short-term infusion. Jpn J Pharmacol 1971 0.75
147 Adrenergic function and the development of analgesic tolerance to morphine. Jpn J Pharmacol 1989 0.75
148 Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mice. Jpn J Pharmacol 1993 0.75
149 Implication of endogenous opioid mechanism in the production of the antinociceptive effect induced by psychological stress in mice. Jpn J Pharmacol 1987 0.75
150 Blockade of the development of analgesic tolerance to morphine by psychological stress through benzodiazepine receptor mediated mechanism. Jpn J Pharmacol 1989 0.75
151 Amino acids and peptides. XXIV. Preparation and antinociceptive effect of [D-Ala2,(N-Me)Phe4]enkephalin analog-poly(ethylene glycol) hybrids. Chem Pharm Bull (Tokyo) 1994 0.75
152 Radioimmunoassay of methionine enkephalin and interference by brain factor of immunoreactivity and opiate receptor binding activity. Jpn J Pharmacol 1979 0.75
153 Anti-stress effect of ginseng on the inhibition of the development of morphine tolerance in stressed mice. Jpn J Pharmacol 1992 0.75
154 Physical dependence produced by dihydroetorphine in mice. Biol Pharm Bull 1994 0.75
155 Changes of lipid peroxidation in mouse brain crude synaptosomal preparations in relation to the development and disappearance of tolerance to ethanol. Subst Alcohol Actions Misuse 1983 0.75
156 Diversity of underlying mechanisms in the production of analgesic and pentobarbital-hypnosis prolonging effects of various analgesic drugs and stresses. Jpn J Pharmacol 1985 0.75
157 [Case of unusual strangulation]. Zasshi Tokyo Ika Daigaku 1965 0.75
158 [Anti-amnesic effect of prolyl endopeptidase inhibitors in mice]. Nihon Yakurigaku Zasshi 1987 0.75
159 [Acquisition of a lever press behavior by mice in a water reinforcement situation]. Yakubutsu Seishin Kodo 1984 0.75
160 Role of spinal kappa opioid receptors in the blockade of the development of antinociceptive tolerance to morphine. Eur J Pharmacol 1991 0.75
161 A new toxic neoanisatin derivative from the pericarps of Illicium majus. Chem Pharm Bull (Tokyo) 1990 0.75
162 Involvement of different receptor subtypes for the production of in vitro and in vivo effects in a series of synthetic enkephalin analogues. J Pharmacobiodyn 1985 0.75
163 Trends in physiological role of opioids in psychoneuroendocrine-immune network. Nihon Shinkei Seishin Yakurigaku Zasshi 1994 0.75
164 [Assessment of anxiolytics (6)--A novel method in mice using psychological stress]. Nihon Shinkei Seishin Yakurigaku Zasshi 1995 0.75