Published in Cell on February 07, 1997
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest (1999) 7.69
Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J (1998) 6.65
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med (1999) 6.27
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J (1998) 5.05
The many roles of FAS receptor signaling in the immune system. Immunity (2009) 4.67
NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol (2001) 4.55
Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L. EMBO J (1997) 4.53
Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med (1998) 4.51
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev (1999) 4.39
Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell (1997) 4.39
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med (1998) 4.08
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev (1998) 3.92
Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature (2011) 3.86
The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J (2001) 3.85
Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med (1998) 3.72
Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat Immunol (2009) 3.63
CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol (1997) 3.52
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev (1999) 3.25
PARP is important for genomic stability but dispensable in apoptosis. Genes Dev (1997) 3.20
To kill a tumor cell: the potential of proapoptotic receptor agonists. J Clin Invest (2008) 3.05
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J (1998) 3.03
Gene-for-gene disease resistance without the hypersensitive response in Arabidopsis dnd1 mutant. Proc Natl Acad Sci U S A (1998) 3.02
Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J Cell Biol (1998) 2.96
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A (2003) 2.91
Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells. J Exp Med (1997) 2.90
The inflammatory response to cell death. Annu Rev Pathol (2008) 2.85
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J (1998) 2.84
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. J Cell Biol (1997) 2.84
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J (1998) 2.82
Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med (1999) 2.81
Caspase activation is required for T cell proliferation. J Exp Med (1999) 2.74
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev (2010) 2.64
Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest (1998) 2.60
Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J (1998) 2.56
Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci U S A (2000) 2.49
Proteases for cell suicide: functions and regulation of caspases. Microbiol Mol Biol Rev (2000) 2.48
CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J (1998) 2.44
Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood (2006) 2.42
Life and death by death receptors. FASEB J (2009) 2.39
Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice. J Exp Med (1998) 2.39
Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest (2007) 2.34
The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. J Exp Med (1997) 2.33
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest (1999) 2.32
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev (2002) 2.31
Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol (2002) 2.30
Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol (1999) 2.25
Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol (2000) 2.25
Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs. J Exp Med (1999) 2.13
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat Immunol (2008) 2.12
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol (2004) 2.11
Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J Exp Med (1998) 2.11
Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys J (2005) 2.09
Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Res (2009) 2.09
Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med (2004) 2.09
The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J (2000) 2.08
Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol (2001) 2.08
The costimulatory role of TIM molecules. Immunol Rev (2009) 2.07
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L). Proc Natl Acad Sci U S A (1999) 1.99
Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway. J Exp Med (1999) 1.99
Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J Cell Biol (2000) 1.98
Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway. PLoS Biol (2012) 1.96
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol (1998) 1.88
Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling. J Immunol (1999) 1.88
Caspase-independent cell killing by Fas-associated protein with death domain. J Cell Biol (1998) 1.87
Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest (1998) 1.86
Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis. Infect Immun (1997) 1.85
T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest (2000) 1.85
Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol (2000) 1.83
Analysis of apoptosis during hair follicle regression (catagen) Am J Pathol (1997) 1.82
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med (1997) 1.80
The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis. Br J Cancer (1998) 1.75
Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J Cell Biol (1998) 1.75
E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk. J Cell Biol (1998) 1.75
Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia. Ann Rheum Dis (1999) 1.75
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med (1998) 1.74
Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. Am J Hum Genet (1999) 1.74
CD95, BIM and T cell homeostasis. Nat Rev Immunol (2009) 1.73
Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. EMBO J (1999) 1.73
Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J Exp Med (2004) 1.73
Chemotherapeutic approaches for targeting cell death pathways. Oncologist (2006) 1.70
Expression of Fas ligand in liver metastases of human colonic adenocarcinomas. Proc Natl Acad Sci U S A (1997) 1.68
Necrotic death pathway in Fas receptor signaling. J Cell Biol (2000) 1.68
Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Mol Cell Biol (2002) 1.67
HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism. J Exp Med (1998) 1.66
Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc Natl Acad Sci U S A (2001) 1.66
Detection of programmed cell death using fluorescence energy transfer. Nucleic Acids Res (1998) 1.65
Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes Dev (2003) 1.63
Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cells. J Virol (1999) 1.61
Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci U S A (2006) 1.59
Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway. Mol Cell Biol (1998) 1.59
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J (1999) 1.59
The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations. J Clin Invest (1999) 1.58
Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases. Am J Pathol (1997) 1.58
Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity. Trends Immunol (2004) 1.56
Activation of caspase 3 during Legionella pneumophila-induced apoptosis. Infect Immun (1999) 1.55
Adenoviral-mediated gene transfer in lymphocytes. Proc Natl Acad Sci U S A (1998) 1.51
Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells. J Virol (2000) 1.50
Apoptosis: telling cells their time is up. Curr Biol (1996) 1.13