Published in Biochemistry on March 04, 1997
Processing of topoisomerase I cleavable complexes into DNA damage by transcription. Nucleic Acids Res (1997) 1.63
Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analog. Appl Environ Microbiol (2009) 1.12
The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136. Nucleic Acids Res (2005) 1.02
Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev (2010) 1.00
A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors. Cancer Chemother Pharmacol (2009) 0.95
Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer. J Antimicrob Chemother (2009) 0.88
Characterization of Interstrand DNA-DNA Cross-Links Derived from Abasic Sites Using Bacteriophage ϕ29 DNA Polymerase. Biochemistry (2015) 0.84
The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother (2011) 0.84
Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent. Invest New Drugs (2004) 0.83
From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl (2016) 0.82
DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents. ACS Med Chem Lett (2010) 0.79
Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates. J Antimicrob Chemother (2012) 0.79
Identification of the dioxygenase-generated intermediate formed during biosynthesis of the dihydropyrrole moiety common to anthramycin and sibiromycin. Bioorg Med Chem (2014) 0.77
Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes. PLoS One (2014) 0.75
Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments. PLoS One (2016) 0.75
DNA sequence-selective C8-linked pyrrolobenzodiazepine-heterocyclic polyamide conjugates show anti-tubercular-specific activities. J Antibiot (Tokyo) (2016) 0.75
Role of the conserved AAUAAA sequence: four AAUAAA point mutants prevent messenger RNA 3' end formation. Science (1984) 7.35
Sequence of the OXA2 beta-lactamase: comparison with other penicillin-reactive enzymes. FEBS Lett (1985) 3.69
Comparison of non-mydriatic retinal photography with ophthalmoscopy in 2159 patients: mobile retinal camera study. BMJ (1990) 3.65
Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells. Mol Cell Biol (2000) 3.57
Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance. Lancet Oncol (2001) 2.98
Inhibition of human telomerase by a G-quadruplex-interactive compound. J Med Chem (1997) 2.66
The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro. Mol Cell Biol (1986) 2.62
Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure. Eur J Cancer (2009) 2.52
Sequence and location of the poly C tract in aphtho- and cardiovirus RNA. Nucleic Acids Res (1979) 1.95
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards. Nucleic Acids Res (1986) 1.72
Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae. Mol Cell Biol (2000) 1.71
Products of in vitro cleavage and polyadenylation of simian virus 40 late pre-mRNAs. Mol Cell Biol (1987) 1.61
Obstetric complications in DSM-III schizophrenics and their siblings. Lancet (1990) 1.59
bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res (1993) 1.59
DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents. Cancer Res (1986) 1.57
Rectal mucosal plasma cells in inflammatory bowel disease. Gut (1983) 1.56
Genome amplification and gene expression in the ciliate macronucleus. Biochem Genet (1972) 1.53
Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties. Biochemistry (1992) 1.52
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours. Curr Biol (1999) 1.52
Body mass index, waist circumference, waist-hip ratio, and glucose intolerance in Chinese and Europid adults in Newcastle, UK. J Epidemiol Community Health (1997) 1.51
Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies. J Mol Biol (1997) 1.48
Energetics of DNA intercalation reactions. Biochemistry (2000) 1.39
Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines. Cancer Res (1991) 1.36
Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy. Biochem Pharmacol (2008) 1.35
Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase. Nucleic Acids Res (1991) 1.34
Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay. Clin Cancer Res (1999) 1.28
Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding. EMBO J (1990) 1.26
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem (2001) 1.24
Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy. Cancer Res (2000) 1.18
Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine. Biochemistry (1993) 1.17
Small intestinal plasma cells in coeliac disease. Gut (1984) 1.16
alpha-DNA-V. Parallel annealing, handedness and conformation of the duplex of the unnatural alpha-hexadeoxyribonucleotide alpha-[d(CpApTpGpCpG)] with its beta-complement beta-[d(GpTpApCpGpC)] deduced from high field 1H-NMR. Nucleic Acids Res (1987) 1.16
Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards. Nucleic Acids Res (1987) 1.16
Mechanism of DNA strand breakage by piperidine at sites of N7-alkylguanines. Biochim Biophys Acta (1986) 1.13
Production of renomedullary prostaglandins by renomedullary interstitial cells grown in tissue culture. Circ Res (1972) 1.12
The penetration of amoxycillin/clavulanic acid into peritoneal fluid. J Antimicrob Chemother (1983) 1.12
Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide. J Med Chem (1995) 1.12
High esophageal stricture: a complication of "inlet patch" mucosa. Gastroenterology (1988) 1.11
Behaviors associated with Neisseria gonorrhoeae and Chlamydia trachomatis: cervical infection among young women attending adolescent clinics. Clin Pediatr (Phila) (2000) 1.11
An investigation into the ability of elderly patients continuing to take prescribed drugs after discharge from hospital and recommendations concerning improving the situation. Gerontology (1978) 1.11
Interaction of berenil with the EcoRI dodecamer d(CGCGAATTCGCG)2 in solution studied by NMR. Biochemistry (1991) 1.10
DNA repair capacity and cisplatin sensitivity of human testis tumour cells. Int J Cancer (1997) 1.10
The cytotoxicity, DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil and 4-[bis(2-chloroethyl)amino] benzoic acid. Biochem Pharmacol (1992) 1.10
DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin. Nucleic Acids Res (1995) 1.08
R-body-producing bacteria. Microbiol Rev (1989) 1.08
Alkaline phosphatase in normal infants. Arch Dis Child (1971) 1.07
Excision repair of nitrogen mustard-DNA adducts in Saccharomyces cerevisiae. Nucleic Acids Res (1999) 1.06
Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy. Br J Cancer (2007) 1.06
Renomedullary interstitial cell tumor (formerly fibroma of renal medulla). Hum Pathol (1972) 1.05
Pharmacokinetics of enrofloxacin and danofloxacin in plasma, inflammatory exudate, and bronchial secretions of calves following subcutaneous administration. Antimicrob Agents Chemother (1999) 1.05
Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis-[amminedichloro(2-methylpyridine)] platinum(II) (AMD473). Anticancer Drug Des (1998) 1.04
Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones. J Med Chem (1998) 1.03
DNA damage by anticancer agents and its repair: mapping in cells at the subgene level with quantitative polymerase chain reaction. Anal Biochem (1994) 1.02
Challenges with fats and fatty acid methods. J Anim Sci (2003) 1.02
The therapeutic potential of ribozymes. Blood (1998) 1.02
DNA tetraplex-binding drugs: structure-selective targeting is critical for antitumour telomerase inhibition. Mini Rev Med Chem (2001) 1.01
Measurement of drug-induced DNA interstrand crosslinking using the single-cell gel electrophoresis (comet) assay. Methods Mol Med (1999) 1.01
DNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells. Nucleic Acids Res (1994) 1.01
Intersyngenic variations in the esterases of axenic stocks of Paramecium aurelia. Biochem Genet (1971) 1.01
Binocular vision, age and symptoms. Ophthalmic Physiol Opt (1989) 1.00
Crystal structure of an oligonucleotide duplex containing G.G base pairs: influence of mispairing on DNA backbone conformation. Proc Natl Acad Sci U S A (1993) 1.00
Renomedullary antihypertensive function in accelerated (malignant) hypertension. Observations on renomedullary interstitial cells. J Clin Invest (1972) 1.00
Parsing free energies of drug-DNA interactions. Methods Enzymol (2000) 0.99
Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA). Nucleic Acids Res (1995) 0.99
Application of two microsatellite sequences in wheat storage proteins as molecular markers. Theor Appl Genet (1995) 0.98
Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives. J Med Chem (1992) 0.98
Thermodynamic, kinetic, and conformational properties of a parallel intermolecular DNA triplex containing 5' and 3' junctions. Biochemistry (1998) 0.97
RNA homologies between protozoa. J Protozool (1967) 0.97
Thermodynamics of nucleic acids and their interactions with ligands. Q Rev Biophys (2000) 0.97
Evaluation of N-ras oncogene anti-sense, sense and nonsense sequence methylphosphonate oligonucleotide analogues. Anticancer Drug Des (1988) 0.96
A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonuclease BamHI. Nucleic Acids Res (1993) 0.96
In vitro isoflavone supplementation reduces hydrogen peroxide-induced DNA damage in sperm. Teratog Carcinog Mutagen (2002) 0.96
Hydration and solution structure of d(CGCAAATTTGCG)2 and its complex with propamidine from NMR and molecular modelling. Biochim Biophys Acta (1997) 0.96
Conformational properties of the G.G mismatch in d(CGCGAATTGGCG)2 determined by NMR. Biochemistry (1992) 0.96
Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity. Mol Pharmacol (1992) 0.96
Angina bullosa haemorrhagica: clinical and laboratory features in 30 patients. Oral Surg Oral Med Oral Pathol (1987) 0.95
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds. Chem Res Toxicol (1992) 0.95
Influence of soybean oil in high fiber diets fed to nonlactating cows on ruminal unsaturated fatty acids and nutrient digestibility. J Dairy Sci (1998) 0.94
Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines. J Med Chem (1999) 0.94
Duodenal bulb plasma cells in duodenitis and duodenal ulceration. Gut (1985) 0.93
A molecular anchor for stabilizing triple-helical DNA. Proc Natl Acad Sci U S A (1995) 0.93
Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate. Cancer Res (1992) 0.93
Calcium phosphate coatings obtained by Nd:YAG laser cladding: physicochemical and biologic properties. J Biomed Mater Res A (2003) 0.92
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase. J Med Chem (1998) 0.92
Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones. Front Biosci (2000) 0.92
GC-rich regions in genomes as targets for DNA alkylation. Carcinogenesis (1988) 0.92
Effects of differential supplementation of fatty acids during the peripartum and breeding periods of Holstein cows: I. Uterine and metabolic responses, reproduction, and lactation. J Dairy Sci (2011) 0.92
Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material. Br J Cancer (2001) 0.91
Structural and dynamic aspects of binding of a prototype lexitropsin to the decadeoxyribonucleotide d(CGCAATTGCG)2 deduced from high-resolution 1H NMR Studies. Biochemistry (1988) 0.91
Mutations in VAPB are not associated with sporadic ALS. Neurology (2007) 0.91
Fat in lactation rations: review. J Dairy Sci (1980) 0.91
Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking. J Med Chem (1994) 0.90
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: evidence for two forms of tomaymycin bound to DNA. Biochemistry (1986) 0.90
Effects of bis(6-mercaptopurine-9-beta-D-ribofuranoside)-5',5"-phosphate and its butyryl derivative on mouse leukaemia L1210 and a 6-mercaptopurine-resistant subline in culture. Biochem Pharmacol (1982) 0.90
The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor. Int J Radiat Oncol Biol Phys (1986) 0.90