Published in Nature on March 13, 1997
IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc Natl Acad Sci U S A (2007) 2.27
Molecular basis of NF-κB signaling. Annu Rev Biophys (2013) 2.03
Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci U S A (2000) 2.03
Structural interactions of fibroblast growth factor receptor with its ligands. Proc Natl Acad Sci U S A (2000) 1.76
Protein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces. Nat Commun (2014) 1.59
Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide. Biochem J (2004) 1.57
Extracting function from a beta-trefoil folding motif. Proc Natl Acad Sci U S A (2008) 1.34
Structural insights into the assembly and activation of IL-1β with its receptors. Nat Immunol (2010) 1.32
Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes. Structure (2009) 1.24
Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Sci Signal (2012) 1.20
Expression of secreted cytokine and chemokine inhibitors by ectromelia virus. J Virol (2000) 1.20
Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein. Proc Natl Acad Sci U S A (2008) 1.13
Biomolecular dynamics: order-disorder transitions and energy landscapes. Rep Prog Phys (2012) 1.12
Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci U S A (2013) 1.09
Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy. Br J Pharmacol (2009) 1.08
Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex. Proc Natl Acad Sci U S A (1999) 1.07
Structure of the activating IL-1 receptor signaling complex. Nat Struct Mol Biol (2012) 1.06
Engineering encodable lanthanide-binding tags into loop regions of proteins. J Am Chem Soc (2011) 1.02
TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB. J Biol Chem (2009) 1.00
Subversion of cytokine networks by virally encoded decoy receptors. Immunol Rev (2012) 0.98
Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein. Proc Natl Acad Sci U S A (2001) 0.96
XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases. MAbs (2011) 0.90
Type I IL-1 receptor (IL-1RI) as potential new therapeutic target for bronchial asthma. Mediators Inflamm (2010) 0.87
Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18. J Biol Chem (2009) 0.85
Folding circular permutants of IL-1β: route selection driven by functional frustration. PLoS One (2012) 0.84
Preclinical efficacy and safety of an anti-IL-1β vaccine for the treatment of type 2 diabetes. Mol Ther Methods Clin Dev (2014) 0.84
Design of a superior cytokine antagonist for topical ophthalmic use. Proc Natl Acad Sci U S A (2013) 0.84
Cytosolic domain of the type I interleukin-1 receptor spontaneously recruits signaling molecules to activate a proinflammatory gene. J Clin Invest (1997) 0.84
Understanding the folding-function tradeoff in proteins. PLoS One (2013) 0.83
Targeting interleukin 18 with interleukin 18 binding protein. Ann Rheum Dis (2000) 0.83
The structural basis for receptor recognition of human interleukin-18. Nat Commun (2014) 0.83
Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses. Protein Sci (2014) 0.81
Oligomerization reduces heparin affinity but enhances receptor binding of fibroblast growth factor 2. Biochem J (2000) 0.81
Allosteric switching of agonist/antagonist activity by a single point mutation in the interluekin-1 receptor antagonist, IL-1Ra. J Mol Biol (2013) 0.81
Arabidopsis genes, AtNPR1, AtTGA2 and AtPR-5, confer partial resistance to soybean cyst nematode (Heterodera glycines) when overexpressed in transgenic soybean roots. BMC Plant Biol (2014) 0.80
Benzylpenicillin differentially conjugates to IFN-gamma, TNF-alpha, IL-1beta, IL-4 and IL-13 but selectively reduces IFN-gamma activity. Clin Exp Immunol (2003) 0.80
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β. MAbs (2015) 0.79
Accessory to inflammation. Nat Immunol (2010) 0.79
Altered backbone and side-chain interactions result in route heterogeneity during the folding of interleukin-1β (IL-1β). Biophys J (2013) 0.79
IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats. Dig Dis Sci (2012) 0.78
Lutropins appear to contact two independent sites in the extracellular domain of their receptors. Biochem J (1998) 0.78
Identification of potential small molecule allosteric modulator sites on IL-1R1 ectodomain using accelerated conformational sampling method. PLoS One (2015) 0.78
Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1. PLoS One (2016) 0.78
Structural differences between the putative carbohydrate-recognition domains of human IL-1 alpha, IL-1 beta and IL-1 receptor antagonist obtained by in silico modeling. Glycoconj J (2007) 0.78
Comparative analysis of receptor binding by chicken and human interleukin-1β. J Mol Model (2010) 0.77
Muscle IL1β Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization. J Neurosci (2016) 0.76
Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity. Sci Rep (2016) 0.75
Preparation of Soluble Proteins from Escherichia coli. Curr Protoc Protein Sci (2014) 0.75
Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain. PLoS One (2016) 0.75
Nipah virus: a recently emergent deadly paramyxovirus. Science (2000) 9.39
Bronchiolitis-associated hospitalizations among US children, 1980-1996. JAMA (1999) 8.07
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol (2000) 7.78
Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies. J Infect Dis (1985) 5.91
Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group. Clin Infect Dis (2000) 4.82
Beyond viruses: clinical profiles and etiologies associated with encephalitis. Clin Infect Dis (2006) 3.59
Enterovirus 71 infections and neurologic disease--United States, 1977-1991. J Infect Dis (1994) 3.31
Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community. J Gen Virol (1998) 3.06
Temporal and geographic patterns of isolates of nonpolio enterovirus in the United States, 1970-1983. J Infect Dis (1986) 3.01
Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation (2009) 2.85
A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest (1989) 2.71
Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol (2001) 2.70
Bronchiolitis-associated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 1979-1997. J Infect Dis (2000) 2.68
Molecular characterization of Nipah virus, a newly emergent paramyxovirus. Virology (2000) 2.63
Case-control study of risk factors for human infection with a new zoonotic paramyxovirus, Nipah virus, during a 1998-1999 outbreak of severe encephalitis in Malaysia. J Infect Dis (2000) 2.57
Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions. Proc Natl Acad Sci U S A (1991) 2.55
Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J Infect Dis (1996) 2.55
Respiratory syncytial virus pneumonia among the elderly: an assessment of disease burden. J Infect Dis (1999) 2.44
Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. J Infect Dis (1990) 2.41
Detection of Norwalk virus antibodies and antigen with a biotin-avidin immunoassay. J Clin Microbiol (1985) 2.28
Concurrent circulation of antigenically distinct strains of respiratory syncytial virus during community outbreaks. J Infect Dis (1986) 2.26
CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein. Nat Immunol (2001) 2.21
Genetic diversity of the attachment protein of subgroup B respiratory syncytial viruses. J Virol (1991) 2.14
Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America. J Infect Dis (2000) 2.13
A cohort study of health care workers to assess nosocomial transmissibility of Nipah virus, Malaysia, 1999. J Infect Dis (2001) 2.02
Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc Natl Acad Sci U S A (1991) 1.97
Myocardial iron loading in patients with thalassemia major on deferoxamine chelation. J Cardiovasc Magn Reson (2006) 1.97
Adenoviruses from patients with AIDS: a plethora of serotypes and a description of five new serotypes of subgenus D (types 43-47). J Infect Dis (1988) 1.87
Microneutralization test for respiratory syncytial virus based on an enzyme immunoassay. J Clin Microbiol (1985) 1.84
Occupational risk of human parvovirus B19 infection for school and day-care personnel during an outbreak of erythema infectiosum. JAMA (1990) 1.79
Tissue Doppler echocardiography in patients with thalassaemia detects early myocardial dysfunction related to myocardial iron overload. Eur Heart J (2003) 1.79
Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J Biol Chem (1991) 1.78
Bronchiolitis-associated hospitalizations among American Indian and Alaska Native children. Pediatr Infect Dis J (2000) 1.75
Analyses of homologous rotavirus infection in the mouse model. Virology (1995) 1.75
Simultaneous detection and identification of human parainfluenza viruses 1, 2, and 3 from clinical samples by multiplex PCR. J Clin Microbiol (1998) 1.71
Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice. J Virol (1999) 1.71
Antibody-mediated enhancement of respiratory syncytial virus infection in two monocyte/macrophage cell lines. J Infect Dis (1989) 1.70
Pediatric hospitalizations for croup (laryngotracheobronchitis): biennial increases associated with human parainfluenza virus 1 epidemics. J Infect Dis (1997) 1.69
Human rabies in the United States, 1960 to 1979: epidemiology, diagnosis, and prevention. Ann Intern Med (1984) 1.68
Evaluation of monoclonal antibody-based capture enzyme immunoassays for detection of specific antibodies to measles virus. J Clin Microbiol (1991) 1.68
Rotavirus as a cause of diarrheal morbidity and mortality in the United States. J Infect Dis (1988) 1.65
Postexposure trial of a human diploid cell strain rabies vaccine. J Infect Dis (1980) 1.58
Management and outcomes of pregnancies complicated by human B19 parvovirus infection: a prospective study. Am J Obstet Gynecol (1990) 1.58
Molecular characterization of a nosocomial outbreak of human respiratory syncytial virus on an adult leukemia/lymphoma ward. J Infect Dis (1999) 1.57
Diagnosis of measles with an IgM capture EIA: the optimal timing of specimen collection after rash onset. J Infect Dis (1997) 1.56
National surveillance of Kawasaki disease. Pediatrics (1980) 1.53
Kawasaki syndrome: description of two outbreaks in the United States. N Engl J Med (1981) 1.52
Detection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay. J Clin Microbiol (1986) 1.51
Human parainfluenza virus-associated hospitalizations among children less than five years of age in the United States. Pediatr Infect Dis J (2001) 1.51
Human-to-human transmission of rabies virus by corneal transplant. N Engl J Med (1979) 1.50
Chronic parvovirus infection in a presumably immunologically healthy woman. Clin Infect Dis (1992) 1.45
Human parvovirus B19-induced epidemic acute red cell aplasia in patients with hereditary hemolytic anemia. Blood (1986) 1.42
Norwalk virus antigen and antibody response in an adult volunteer study. J Clin Microbiol (1987) 1.39
Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse. J Virol (2000) 1.39
Identification of epitopes on respiratory syncytial virus proteins by competitive binding immunoassay. J Clin Microbiol (1986) 1.33
Diarrheal deaths in American children. Are they preventable? JAMA (1988) 1.31
A large outbreak of epidemic keratoconjunctivitis: problems in controlling nosocomial spread. J Infect Dis (1989) 1.28
A British abattoir survey of tumours in cattle, sheep and pigs. Vet Rec (1969) 1.28
Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor. J Biol Chem (1995) 1.28
Feline leukemia-virus infection of kittens: mortality associated with atrophy of the thymus and lymphoid depletion. J Natl Cancer Inst (1971) 1.25
Analysis of respiratory syncytial virus genetic variability with amplified cDNAs. J Clin Microbiol (1993) 1.25
Risk factors for Nipah virus infection among abattoir workers in Singapore. J Infect Dis (2000) 1.23
Comparison of monoclonal time-resolved fluoroimmunoassay with monoclonal capture-biotinylated detector enzyme immunoassay for adenovirus antigen detection. J Clin Microbiol (1987) 1.22
Antigenic and genomic diversity within group A respiratory syncytial virus. J Infect Dis (1991) 1.22
Pharyngoconjunctival fever caused by adenovirus type 4: report of a swimming pool-related outbreak with recovery of virus from pool water. J Infect Dis (1979) 1.21
National surveillance for respiratory syncytial virus, United States, 1985-1990. J Infect Dis (1994) 1.21
Waterborne gastroenteritis due to the Norwalk agent: clinical and epidemiologic investigation. Am J Public Health (1982) 1.20
The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease). J Infect Dis (1986) 1.20
Multiple primer pairs for polymerase chain reaction (PCR) amplification of human parvovirus B19 DNA. J Virol Methods (1993) 1.19
Tumours of the female genitalia in cattle, sheep and pigs found in a British abattoir survey. J Comp Pathol (1969) 1.18
Meniscal injuries: detection using MR imaging. Radiology (1986) 1.18
Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I. J Biol Chem (1990) 1.17
Parainfluenza virus infection among adults hospitalized for lower respiratory tract infection. Clin Infect Dis (1999) 1.16
Comparison of monoclonal antibody time-resolved fluoroimmunoassay with monoclonal antibody capture-biotinylated detector enzyme immunoassay for respiratory syncytial virus and parainfluenza virus antigen detection. J Clin Microbiol (1989) 1.16
Echovirus 30 infection and aseptic meningitis in parents of children attending a child care center. J Infect Dis (1994) 1.15
Antigenic and genetic diversity among the attachment proteins of group A respiratory syncytial viruses that have caused repeat infections in children. J Infect Dis (1998) 1.14
Vitamin A therapy for children with respiratory syncytial virus infection: a multicenter trial in the United States. Pediatr Infect Dis J (1996) 1.13
Monoclonal antibody-based capture enzyme immunoassays for specific serum immunoglobulin G (IgG), IgA, and IgM antibodies to respiratory syncytial virus. J Clin Microbiol (1990) 1.13
Respiratory syncytial virus infection and G and/or SH protein expression contribute to substance P, which mediates inflammation and enhanced pulmonary disease in BALB/c mice. J Virol (2000) 1.12
Serum immunoglobulin A response to Norwalk virus infection. J Clin Microbiol (1989) 1.11
Clinical patterns and seasonal trends in respiratory syncytial virus hospitalizations in São Paulo, Brazil. Rev Inst Med Trop Sao Paulo (2001) 1.11
Active surveillance for respiratory virus infections in adults who have undergone bone marrow and peripheral blood stem cell transplantation. Bone Marrow Transplant (2003) 1.10
Nosocomial transmission of respiratory syncytial virus in immunocompromised adults. J Clin Microbiol (1991) 1.09
Development and evaluation of an IgM capture enzyme immunoassay for diagnosis of recent Norwalk virus infection. J Virol Methods (1989) 1.08
Treatment of respiratory syncytial virus infection with vitamin A: a randomized, placebo-controlled trial in Santiago, Chile. Pediatr Infect Dis J (1996) 1.08
Nonclassic measles infections in an immune population exposed to measles during a college bus trip. J Med Virol (1998) 1.08
Genetic diversity of human parvovirus B19: sequence analysis of the VP1/VP2 gene from multiple isolates. J Gen Virol (1996) 1.06
Group-specific serum antibody responses in children with primary and recurrent respiratory syncytial virus infections. J Infect Dis (1991) 1.06
Human parvovirus B19 infection during pregnancy. J Infect Dis (1987) 1.06
Antigenic analysis of current wild type and vaccine strains of measles virus. J Infect Dis (1994) 1.05
Serum immunoglobulin G antibody subclass response to respiratory syncytial virus F and G glycoproteins after first, second, and third infections. J Clin Microbiol (1989) 1.04
Lymphosarcoma (leukemia) in cattle, sheep and pigs in Great Britain. Cancer (1968) 1.03
Canopy and environmental control of root dynamics in a long-term study of Concord grape. New Phytol (2005) 1.03
Differentiation of respiratory syncytial virus subgroups with cDNA probes in a nucleic acid hybridization assay. J Clin Microbiol (1990) 1.02
Risk of adverse outcomes of pregnancy after human parvovirus B19 infection. J Infect Dis (1988) 1.01
Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta. J Biol Chem (1995) 1.01
Use of mixture models in determining laboratory criterion for identification of seropositive individuals: application to parvovirus B19 serology. J Virol Methods (1990) 1.01