Intermolecular tuning of calmodulin by target peptides and proteins: differential effects on Ca2+ binding and implications for kinase activation.

PubWeight™: 1.63‹?› | Rank: Top 4%

🔗 View Article (PMC 2144748)

Published in Protein Sci on April 01, 1997

Authors

O B Peersen1, T S Madsen, J J Falke

Author Affiliations

1: Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215, USA.

Articles citing this

Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death. Am J Hum Genet (2012) 1.89

Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity. Biochemistry (2007) 1.42

Experimentally exploring the conformational space sampled by domain reorientation in calmodulin. Proc Natl Acad Sci U S A (2004) 1.39

C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state. Biochemistry (2002) 1.39

The unique insert in myosin VI is a structural calcium-calmodulin binding site. Proc Natl Acad Sci U S A (2004) 1.38

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels. J Gen Physiol (2013) 1.30

Ca(2+)/calmodulin-dependent protein kinases. Cell Mol Life Sci (2008) 1.30

An allosteric model of calmodulin explains differential activation of PP2B and CaMKII. Proc Natl Acad Sci U S A (2008) 1.18

Conformational changes of calmodulin upon Ca2+ binding studied with a microfluidic mixer. Proc Natl Acad Sci U S A (2008) 1.13

Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons. Proc Natl Acad Sci U S A (2005) 1.12

Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA. Biochemistry (2008) 1.10

Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity. EMBO J (2009) 1.09

Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach. J Gen Physiol (2014) 1.07

Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. J Biol Chem (2008) 1.06

Acidic/IQ motif regulator of calmodulin. J Biol Chem (2007) 1.05

The kinetic cycle of cardiac troponin C: calcium binding and dissociation at site II trigger slow conformational rearrangements. Protein Sci (1998) 1.04

Computing phenomenologic Adair-Klotz constants from microscopic MWC parameters. BMC Syst Biol (2009) 0.99

Enhancement by Mg2+ of domain specificity in Ca2+-dependent interactions of calmodulin with target sequences. Protein Sci (2000) 0.98

Structural basis for calmodulin as a dynamic calcium sensor. Structure (2012) 0.97

Solution structure of S100A1 bound to the CapZ peptide (TRTK12). J Mol Biol (2009) 0.97

Solvent-induced differentiation of protein backbone hydrogen bonds in calmodulin. Protein Sci (2007) 0.97

Differential calcium signaling by cone specific guanylate cyclase-activating proteins from the zebrafish retina. PLoS One (2011) 0.94

Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin. J Biol Chem (2009) 0.92

Post-tetanic increase in the fast-releasing synaptic vesicle pool at the expense of the slowly releasing pool. J Gen Physiol (2010) 0.91

Intrinsically disordered PEP-19 confers unique dynamic properties to apo and calcium calmodulin. Biochemistry (2010) 0.91

A calcium-relay mechanism in vertebrate phototransduction. ACS Chem Neurosci (2013) 0.90

A simulation study on the activation of cardiac CaMKII delta-isoform and its regulation by phosphatases. Biophys J (2008) 0.89

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach. BMC Syst Biol (2008) 0.88

The multidrug transporter LmrP protein mediates selective calcium efflux. J Biol Chem (2012) 0.88

Neurogranin alters the structure and calcium binding properties of calmodulin. J Biol Chem (2014) 0.87

Energetics of calmodulin domain interactions with the calmodulin binding domain of CaMKII. Proteins (2009) 0.86

Recognition of β-calcineurin by the domains of calmodulin: thermodynamic and structural evidence for distinct roles. Proteins (2010) 0.86

The delicate bistability of CaMKII. Biophys J (2013) 0.84

Calmodulin transduces Ca2+ oscillations into differential regulation of its target proteins. ACS Chem Neurosci (2013) 0.83

Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions. PLoS Comput Biol (2015) 0.82

CaMKII activation and dynamics are independent of the holoenzyme structure: an infinite subunit holoenzyme approximation. Phys Biol (2012) 0.82

Thermodynamic linkage between calmodulin domains binding calcium and contiguous sites in the C-terminal tail of Ca(V)1.2. Biophys Chem (2011) 0.82

Ca(2+) sensor proteins in dendritic spines: a race for Ca(2+). Front Mol Neurosci (2012) 0.81

Distinct mechanisms of calmodulin binding and regulation of adenylyl cyclases 1 and 8. Biochemistry (2012) 0.81

Conserved properties of individual Ca2+-binding sites in calmodulin. Proc Natl Acad Sci U S A (2016) 0.81

Conformational and metal-binding properties of androcam, a testis-specific, calmodulin-related protein from Drosophila. Protein Sci (1999) 0.80

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release. J Biol Chem (2015) 0.80

Comparing the calcium binding abilities of two soybean calmodulins: towards understanding the divergent nature of plant calmodulins. Plant Cell (2013) 0.79

Prediction of volatile anesthetic binding sites in proteins. Biophys J (2006) 0.79

A transcriptional reporter of intracellular Ca(2+) in Drosophila. Nat Neurosci (2015) 0.79

Calcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1). Biophys Chem (2014) 0.77

Conformational heterogeneity of the calmodulin binding interface. Nat Commun (2016) 0.77

Combining modelling and experimental approaches to explain how calcium signatures are decoded by calmodulin-binding transcription activators (CAMTAs) to produce specific gene expression responses. New Phytol (2015) 0.76

Opposing Intermolecular Tuning of Ca(2+) Affinity for Calmodulin by Neurogranin and CaMKII Peptides. Biophys J (2017) 0.75

Structural preference for changes in the direction of the Ca2+-induced transition: a study of the regulatory domain of skeletal troponin-C. Biophys J (2003) 0.75

Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin. Proteins (2015) 0.75

PEP-19 modulates calcium binding to calmodulin by electrostatic steering. Nat Commun (2016) 0.75

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module. Biochemistry (2016) 0.75

Articles cited by this

Calcium signaling. Cell (1995) 8.87

A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids. Science (1990) 6.60

Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. Science (1992) 4.89

Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science (1995) 4.25

Helix propensities of the amino acids measured in alanine-based peptides without helix-stabilizing side-chain interactions. Protein Sci (1994) 3.94

Calmodulin. Adv Protein Chem (1982) 3.89

Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Science (1993) 3.75

Calcium-induced conformational transition revealed by the solution structure of apo calmodulin. Nat Struct Biol (1995) 3.75

Solution structure of calcium-free calmodulin. Nat Struct Biol (1995) 3.36

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc Natl Acad Sci U S A (1979) 3.33

The mechanism of alpha-helix formation by peptides. Annu Rev Biophys Biomol Struct (1992) 3.22

The multifunctional calcium/calmodulin-dependent protein kinase: from form to function. Annu Rev Physiol (1995) 3.18

Binding of diffusible molecules by macromolecules: rapid measurement by rate of dialysis. J Biol Chem (1969) 3.15

Calcium binding and conformational response in EF-hand proteins. Trends Biochem Sci (1996) 3.13

Calcium binding to calmodulin and its globular domains. J Biol Chem (1991) 2.79

Bacterial expression and characterization of proteins derived from the chicken calmodulin cDNA and a calmodulin processed gene. J Biol Chem (1985) 2.20

Calcium-induced structural changes and domain autonomy in calmodulin. Nat Struct Biol (1995) 2.09

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I. Cell (1996) 2.09

Dual calcium ion regulation of calcineurin by calmodulin and calcineurin B. Biochemistry (1994) 2.02

Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase. Proc Natl Acad Sci U S A (1985) 2.00

Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase. Biochemistry (1986) 1.94

Calmodulin-binding domains: just two faced or multi-faceted? Trends Biochem Sci (1995) 1.81

Target recognition by calmodulin: dissecting the kinetics and affinity of interaction using short peptide sequences. Protein Sci (1996) 1.73

Synaptic vesicle biogenesis, docking, and fusion: a molecular description. Physiol Rev (1996) 1.65

Ca2+ binding and conformational change in two series of point mutations to the individual Ca(2+)-binding sites of calmodulin. J Biol Chem (1992) 1.64

Regulatory and structural motifs of chicken gizzard myosin light chain kinase. Proc Natl Acad Sci U S A (1990) 1.62

Effects of myosin light chain kinase and peptides on Ca2+ exchange with the N- and C-terminal Ca2+ binding sites of calmodulin. J Biol Chem (1996) 1.60

Test reactions for a stopped-flow apparatus. Reduction of 2,6-dichlorophenolindophenol and potassium ferricyanide by L-ascorbic acid. Anal Biochem (1978) 1.59

Ca(2+)-regulated dynamic compartmentalization of calmodulin in living smooth muscle cells. J Biol Chem (1995) 1.44

The interaction of calmodulin with amphiphilic peptides. J Biol Chem (1985) 1.43

Regulation of calmodulin-binding myosins. Trends Cell Biol (1995) 1.42

Recognition and characterization of calmodulin-binding sequences in peptides and proteins. Methods Enzymol (1987) 1.39

Structure of a recombinant calmodulin from Drosophila melanogaster refined at 2.2-A resolution. J Biol Chem (1991) 1.38

The gamma-subunit of skeletal muscle phosphorylase kinase contains two noncontiguous domains that act in concert to bind calmodulin. J Biol Chem (1989) 1.36

Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. J Biol Chem (1993) 1.35

The calmodulin binding domain of the plasma membrane Ca2+ pump interacts both with calmodulin and with another part of the pump. J Biol Chem (1989) 1.28

Calcium binding to complexes of calmodulin and calmodulin binding proteins. Biochemistry (1985) 1.27

Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. Science (1988) 1.23

Kinetics of calcium dissociation from calmodulin and its tryptic fragments. A stopped-flow fluorescence study using Quin 2 reveals a two-domain structure. Eur J Biochem (1985) 1.23

Calcium-binding proteins. 1: EF-hands. Protein Profile (1994) 1.22

Molecular mechanisms of action of calmodulin. Recent Prog Horm Res (1988) 1.20

Mutational analysis of the autoinhibitory domain of calmodulin kinase II. J Biol Chem (1994) 1.20

Stopped-flow studies of calcium dissociation from calcium-binding-site mutants of Drosophila melanogaster calmodulin. Eur J Biochem (1992) 1.16

Calcium/calmodulin inhibition of basic-helix-loop-helix transcription factor domains. Nature (1994) 1.15

Interaction of calmodulin with the calmodulin binding domain of the plasma membrane Ca2+ pump. Biochemistry (1990) 1.11

Different mechanisms for Ca2+ dissociation from complexes of calmodulin with nitric oxide synthase or myosin light chain kinase. J Biol Chem (1996) 1.11

Determination of calcium-binding constants by flow dialysis. Anal Biochem (1994) 1.06

Second messenger signaling in olfactory transduction. J Neurobiol (1996) 1.05

Controlled proteolysis of the purified Ca2+-ATPase of the erythrocyte membrane. A correlation between the structure and the function of the enzyme. J Biol Chem (1984) 1.05

Is the binding of magnesium (II) to calmodulin significant? An investigation by magnesium-25 nuclear magnetic resonance. Biochemistry (1987) 1.04

Interactions of myogenic bHLH transcription factors with calcium-binding calmodulin and S100a (alpha alpha) proteins. Biochemistry (1995) 1.03

A molecular mechanism for autoinhibition of myosin light chain kinases. J Biol Chem (1993) 1.03

Calmodulin and calmodulin-binding proteins in the nucleus. Cell Calcium (1994) 1.03

Kinetic tuning of the EF-hand calcium binding motif: the gateway residue independently adjusts (i) barrier height and (ii) equilibrium. Biochemistry (1996) 0.99

A series of point mutations reveal interactions between the calcium-binding sites of calmodulin. Protein Sci (1992) 0.99

Binding of calcium by calmodulin: influence of the calmodulin binding domain of the plasma membrane calcium pump. Biochemistry (1992) 0.96

Identification of basic residues involved in activation and calmodulin binding of rabbit smooth muscle myosin light chain kinase. J Biol Chem (1992) 0.94

Fluorescence studies of the interaction of calmodulin with myosin light chain kinase. J Biol Chem (1981) 0.94

Structure and sequence of the Drosophila melanogaster calmodulin gene. J Mol Biol (1987) 0.94

Investigating the high affinity and low sequence specificity of calmodulin binding to its targets. J Mol Biol (1994) 0.93

Model for the interaction of amphiphilic helices with troponin C and calmodulin. Proteins (1990) 0.92

Releasing the calcium trigger. Nat Struct Biol (1995) 0.92

X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants. Nat Struct Biol (1995) 0.87

Tuning the equilibrium ion affinity and selectivity of the EF-hand calcium binding motif: substitutions at the gateway position. Biochemistry (1996) 0.86

The calmodulin-binding domain of the inducible (macrophage) nitric oxide synthase. Eur J Biochem (1995) 0.85

Calcium release from calmodulin and its C-terminal or N-terminal halves in the presence of the calmodulin antagonists phenoxybenzamine and melittin measured by stopped-flow fluorescence with Quin 2 and intrinsic tyrosine. Inhibition of calmodulin-dependent protein kinase of cardiac sarcoplasmic reticulum. Eur J Biochem (1986) 0.84

Intrasteric regulation of myosin light chain kinase. J Biol Chem (1995) 0.82

Role of the N-terminal region of the skeletal muscle myosin light chain kinase target sequence in its interaction with calmodulin. Protein Sci (1995) 0.82

Interaction of calmodulin with skeletal muscle myosin light chain kinase. Biochemistry (1981) 0.82

Modulation of the stability of rabbit skeletal muscle myosin light chain kinase through the calmodulin-binding domain. J Biol Chem (1990) 0.80

Interaction between calmodulin and target proteins. Adv Exp Med Biol (1989) 0.77

Calcium regulation of Drosophila development. Adv Second Messenger Phosphoprotein Res (1995) 0.77

Articles by these authors

The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci (1996) 4.20

Global flexibility in a sensory receptor: a site-directed cross-linking approach. Science (1987) 3.40

Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping. J Mol Biol (1992) 2.98

Molecular mechanism of transmembrane signaling by the aspartate receptor: a model. Proc Natl Acad Sci U S A (1996) 2.74

Cysteine and disulfide scanning reveals two amphiphilic helices in the linker region of the aspartate chemoreceptor. Biochemistry (1998) 2.23

Transmembrane signaling by the aspartate receptor: engineered disulfides reveal static regions of the subunit interface. Biochemistry (1995) 2.12

Lock on/off disulfides identify the transmembrane signaling helix of the aspartate receptor. J Biol Chem (1995) 1.99

Evidence that both ligand binding and covalent adaptation drive a two-state equilibrium in the aspartate receptor signaling complex. J Gen Physiol (2001) 1.95

Purification of proteins using polyhistidine affinity tags. Methods Enzymol (2000) 1.87

Use of 19F NMR to probe protein structure and conformational changes. Annu Rev Biophys Biomol Struct (1996) 1.83

Attractant regulation of the aspartate receptor-kinase complex: limited cooperative interactions between receptors and effects of the receptor modification state. Biochemistry (2000) 1.70

Activation of the phosphosignaling protein CheY. II. Analysis of activated mutants by 19F NMR and protein engineering. J Biol Chem (1993) 1.68

Structure and dynamics of Escherichia coli chemosensory receptors. Engineered sulfhydryl studies. Biophys J (1992) 1.65

The aspartate receptor cytoplasmic domain: in situ chemical analysis of structure, mechanism and dynamics. Structure (1999) 1.59

Cysteine and disulfide scanning reveals a regulatory alpha-helix in the cytoplasmic domain of the aspartate receptor. J Biol Chem (1997) 1.59

Ca2+-signaling cycle of a membrane-docking C2 domain. Biochemistry (1997) 1.51

Signaling domain of the aspartate receptor is a helical hairpin with a localized kinase docking surface: cysteine and disulfide scanning studies. Biochemistry (1999) 1.47

Effects of protein stabilizing agents on thermal backbone motions: a disulfide trapping study. Biochemistry (1996) 1.45

Attractant- and disulfide-induced conformational changes in the ligand binding domain of the chemotaxis aspartate receptor: a 19F NMR study. Biochemistry (1994) 1.40

Detection of a conserved alpha-helix in the kinase-docking region of the aspartate receptor by cysteine and disulfide scanning. J Biol Chem (1998) 1.35

C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity. Biochemistry (2001) 1.33

Large amplitude twisting motions of an interdomain hinge: a disulfide trapping study of the galactose-glucose binding protein. Biochemistry (1995) 1.28

19F NMR studies of the D-galactose chemosensory receptor. 1. Sugar binding yields a global structural change. Biochemistry (1991) 1.24

Open conformation of a substrate-binding cleft: 19F NMR studies of cleft angle in the D-galactose chemosensory receptor. Biochemistry (1991) 1.23

Novel ion specificity of a carboxylate cluster Mg(II) binding site: strong charge selectivity and weak size selectivity. Biochemistry (1993) 1.15

Location of the membrane-docking face on the Ca2+-activated C2 domain of cytosolic phospholipase A2. Biochemistry (1998) 1.15

Calcium(II) site specificity: effect of size and charge on metal ion binding to an EF-hand-like site. Biochemistry (1990) 1.13

Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2. J Biol Chem (1998) 1.11

Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering. J Biol Chem (1993) 1.09

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience (2010) 1.07

The kinetic cycle of cardiac troponin C: calcium binding and dissociation at site II trigger slow conformational rearrangements. Protein Sci (1998) 1.04

19F NMR studies of the D-galactose chemosensory receptor. 2. Ca(II) binding yields a local structural change. Biochemistry (1991) 1.02

Kinetic tuning of the EF-hand calcium binding motif: the gateway residue independently adjusts (i) barrier height and (ii) equilibrium. Biochemistry (1996) 0.99

Identification of a site critical for kinase regulation on the central processing unit (CPU) helix of the aspartate receptor. Biochemistry (1999) 0.98

Molecular mechanisms of band 3 inhibitors. 1. Transport site inhibitors. Biochemistry (1986) 0.98

Molecular tuning of an EF-hand-like calcium binding loop. Contributions of the coordinating side chain at loop position 3. J Gen Physiol (1997) 0.94

The kinetic equation for the chloride transport cycle of band 3. A 35Cl and 37Cl NMR study. J Biol Chem (1985) 0.93

Chloride binding to the anion transport binding sites of band 3. A 35Cl NMR study. J Biol Chem (1984) 0.92

Kinetic control of Ca(II) signaling: tuning the ion dissociation rates of EF-hand Ca(II) binding sites. Proc Natl Acad Sci U S A (1993) 0.89

The minimal structure containing the band 3 anion transport site. A 35Cl NMR study. J Biol Chem (1985) 0.88

Optimizing the metal binding parameters of an EF-hand-like calcium chelation loop: coordinating side chains play a more important tuning role than chelation loop flexibility. Biochemistry (1997) 0.88

Molecular mechanisms of band 3 inhibitors. 2. Channel blockers. Biochemistry (1986) 0.86

Tuning the equilibrium ion affinity and selectivity of the EF-hand calcium binding motif: substitutions at the gateway position. Biochemistry (1996) 0.86

Direct observation of the transmembrane recruitment of band 3 transport sites by competitive inhibitors. A 35Cl NMR study. J Biol Chem (1984) 0.84

Molecular mechanisms of band 3 inhibitors. 3. Translocation inhibitors. Biochemistry (1986) 0.80

Halide binding by the purified halorhodopsin chromoprotein. II. New chloride-binding sites revealed by 35Cl NMR. J Biol Chem (1984) 0.78

A proton NMR study of the mechanism of the erythrocyte glucose transporter. Proc Natl Acad Sci U S A (1986) 0.77

Evidence that anion transport by band 3 proceeds via a ping-pong mechanism involving a single transport site. A 35 Cl NMR study. J Biol Chem (1985) 0.77

Ion Channels within Ion Transport Proteins: Evidence in the Band 3 System. Biophys J (1984) 0.75