Published in Proc Natl Acad Sci U S A on March 22, 2004
The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature (2005) 2.50
Long single alpha-helical tail domains bridge the gap between structure and function of myosin VI. Nat Struct Mol Biol (2008) 1.88
The power stroke of myosin VI and the basis of reverse directionality. Proc Natl Acad Sci U S A (2006) 1.72
How are the cellular functions of myosin VI regulated within the cell? Biochem Biophys Res Commun (2007) 1.58
Myosin VI walks "wiggly" on actin with large and variable tilting. Mol Cell (2007) 1.54
Formation of salt bridges mediates internal dimerization of myosin VI medial tail domain. Structure (2010) 1.53
Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach. Mol Cell (2009) 1.42
Structure of the light chain-binding domain of myosin V. Proc Natl Acad Sci U S A (2005) 1.33
The unique insert at the end of the myosin VI motor is the sole determinant of directionality. Proc Natl Acad Sci U S A (2007) 1.30
Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis. Nat Rev Mol Cell Biol (2010) 1.27
Cargo-binding makes a wild-type single-headed myosin-VI move processively. Biophys J (2006) 1.27
Unconstrained steps of myosin VI appear longest among known molecular motors. Biophys J (2004) 1.24
Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport. Proc Natl Acad Sci U S A (2011) 1.23
Precise positioning of myosin VI on endocytic vesicles in vivo. PLoS Biol (2007) 1.17
Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI. Biophys J (2011) 1.00
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Head of myosin IX binds calmodulin and moves processively toward the plus-end of actin filaments. J Biol Chem (2010) 0.91
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Flexible light-chain and helical structure of F-actin explain the movement and step size of myosin-VI. Biophys J (2006) 0.88
Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection. Traffic (2012) 0.85
Myosin VI deafness mutation prevents the initiation of processive runs on actin. Proc Natl Acad Sci U S A (2015) 0.84
Calcium can mobilize and activate myosin-VI. Proc Natl Acad Sci U S A (2016) 0.84
Actin filament dynamics in the actomyosin VI complex is regulated allosterically by calcium-calmodulin light chain. J Mol Biol (2011) 0.82
Reverse conformational changes of the light chain-binding domain of myosin V and VI processive motor heads during and after hydrolysis of ATP by small-angle X-ray solution scattering. J Mol Biol (2009) 0.79
Structure of androcam supports specialized interactions with myosin VI. Proc Natl Acad Sci U S A (2012) 0.78
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Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications. EMBO J (2003) 1.40
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Calcium functionally uncouples the heads of myosin VI. J Biol Chem (2003) 1.18
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Relative affinity constants by electrospray ionization and Fourier transform ion cyclotron resonance mass spectrometry: calmodulin binding to peptide analogs of myosin light chain kinase. Biophys J (2003) 0.84
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Structural identification of a bacterial quorum-sensing signal containing boron. Nature (2002) 8.11
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol (2004) 7.38
PTC124 targets genetic disorders caused by nonsense mutations. Nature (2007) 6.67
High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A (2005) 6.52
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res (2004) 4.04
The mechanism of myosin VI translocation and its load-induced anchoring. Cell (2004) 3.85
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol (2006) 3.78
A structural state of the myosin V motor without bound nucleotide. Nature (2003) 3.63
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J (2002) 3.53
Three myosin V structures delineate essential features of chemo-mechanical transduction. EMBO J (2004) 3.21
Role of the lever arm in the processive stepping of myosin V. Proc Natl Acad Sci U S A (2002) 2.86
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice. J Cell Biol (2002) 2.76
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The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature (2005) 2.50
A model of myosin V processivity. J Biol Chem (2004) 2.49
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat Med (2008) 2.49
Myostatin activation in patients with advanced heart failure and after mechanical unloading. Eur J Heart Fail (2010) 2.40
A force-dependent state controls the coordination of processive myosin V. Proc Natl Acad Sci U S A (2005) 2.39
Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin. J Biol Chem (2004) 2.31
2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol (2010) 2.30
Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat. Hum Gene Ther (2008) 2.27
A transgenic mouse for in vivo detection of endogenous labeled mRNA. Nat Methods (2011) 2.27
The structure of the rigor complex and its implications for the power stroke. Philos Trans R Soc Lond B Biol Sci (2004) 2.17
Haemoglobin Noah Mehmet Oeztuerk (alpha(2) delta(2)143 (H21)His-->Tyr: A novel delta-chain variant in the 2,3-DPG binding site. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 2.05
Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). J Clin Invest (2003) 1.93
Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Curr Biol (2004) 1.89
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. Hum Mol Genet (2004) 1.85
Neovasculogenic therapy to augment perfusion and preserve viability in ischemic cardiomyopathy. Ann Thorac Surg (2006) 1.82
Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clustering. Mol Cell (2006) 1.80
A flexible domain is essential for the large step size and processivity of myosin VI. Mol Cell (2005) 1.78
What can myosin VI do in cells? Curr Opin Cell Biol (2006) 1.77
Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol Biol Evol (2010) 1.77
Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008. Virol J (2010) 1.76
Characterization of therapeutic antibodies and related products. Anal Chem (2012) 1.75
Outbreak of acute respiratory disease in China caused by B2 species of adenovirus type 11. J Clin Microbiol (2008) 1.67
A tale of two oxidation states: bacterial colonization of arsenic-rich environments. PLoS Genet (2007) 1.59
Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formerly S.bovis). Carcinogenesis (2004) 1.58
The structural basis for the large powerstroke of myosin VI. Cell (2007) 1.56
Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins. Curr Pharm Biotechnol (2008) 1.53
The motor mechanism of myosin V: insights for muscle contraction. Philos Trans R Soc Lond B Biol Sci (2004) 1.53
Mechanism of microtubule stabilization by doublecortin. Mol Cell (2004) 1.52
Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain. Structure (2009) 1.50
Gene clusters involved in anaerobic benzoate degradation of Geobacter metallireducens. Mol Microbiol (2005) 1.50
How myosin VI coordinates its heads during processive movement. EMBO J (2007) 1.49
Biosimilar, biobetter, and next generation antibody characterization by mass spectrometry. Anal Chem (2012) 1.49
Kinetic characterization of the weak binding states of myosin V. Biochemistry (2002) 1.46
All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol (2003) 1.46
Myosin IIb is unconventionally conventional. J Biol Chem (2003) 1.45
Myosin VI rewrites the rules for myosin motors. Cell (2010) 1.43
Interhead distance measurements in myosin VI via SHRImP support a simplified hand-over-hand model. Biophys J (2005) 1.43
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proc Natl Acad Sci U S A (2011) 1.42
Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach. Mol Cell (2009) 1.42
Magnesium regulates ADP dissociation from myosin V. J Biol Chem (2004) 1.42
Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry (2004) 1.40
Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats. J Appl Physiol (1985) (2004) 1.40
Template-free 13-protofilament microtubule-MAP assembly visualized at 8 A resolution. J Cell Biol (2010) 1.38
A strategy for improving the room-temperature luminescence properties of Ru(II) complexes with tridentate ligands. J Am Chem Soc (2002) 1.38
Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol. Genome Res (2008) 1.36
The brown algal kelp Laminaria digitata features distinct bromoperoxidase and iodoperoxidase activities. J Biol Chem (2003) 1.35
A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. Biochem J (2002) 1.34
Cargo binding induces dimerization of myosin VI. Proc Natl Acad Sci U S A (2009) 1.34
The unique insert at the end of the myosin VI motor is the sole determinant of directionality. Proc Natl Acad Sci U S A (2007) 1.30
Patterning, prestress, and peeling dynamics of myocytes. Biophys J (2004) 1.29
Functional role of loop 2 in myosin V. Biochemistry (2004) 1.29
Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretory compartment delivering Plasmodium falciparum proteins to the surface of its host cell. Mol Cell Proteomics (2005) 1.29
Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell (2009) 1.28
Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse. PLoS One (2012) 1.26
Dynamic behavior in diplatinum metalloreceptors. Inorg Chem (2002) 1.26
Metabolic diversity among main microorganisms inside an arsenic-rich ecosystem revealed by meta- and proteo-genomics. ISME J (2011) 1.24
Age-related differences in lower-limb muscle cross-sectional area and torque production in boys with Duchenne muscular dystrophy. Arch Phys Med Rehabil (2010) 1.24
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J (2007) 1.24
Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy. EMBO Rep (2010) 1.23
Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport. Proc Natl Acad Sci U S A (2011) 1.23
Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm. Proc Natl Acad Sci U S A (2009) 1.23
Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy. Radiology (2013) 1.22
Genetic evidence of paleolithic colonization and neolithic expansion of modern humans on the tibetan plateau. Mol Biol Evol (2013) 1.22
Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils. PLoS One (2010) 1.21
Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy. J Thorac Cardiovasc Surg (2005) 1.20
Adhesion-contractile balance in myocyte differentiation. J Cell Sci (2004) 1.20
Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A (2008) 1.20
Calcium functionally uncouples the heads of myosin VI. J Biol Chem (2003) 1.18