Published in Toxicology on March 28, 1997
The formation and biological significance of N7-guanine adducts. Mutat Res (2009) 1.21
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Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen. Environ Health Perspect (1998) 0.90
Theoretical investigation of substrate specificity for cytochromes P450 IA2, P450 IID6 and P450 IIIA4. J Comput Aided Mol Des (2000) 0.85
Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer. Oncol Lett (2016) 0.78
Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male fischer 344 rats and of human livers. Toxicol Sci (2011) 0.77
A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species. Biochem J (1965) 2.47
Carbenoxolone in the treatment of duodenal ulcer. Practitioner (1967) 1.95
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes. Biochem J (1965) 1.76
Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats. Fundam Appl Toxicol (1997) 1.49
The effects of some terpenoids and other dietary anutrients on hepatic drug-metabolizing enzymes. Biochem J (1969) 1.37
A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program. Mutagenesis (1990) 1.37
Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins. Biochem Pharmacol (1987) 1.22
The absorption and excretion of carbenoxolone in man. J Pharm Pharmacol (1970) 1.22
Quantitative and qualitative aspects of the plasma protein binding of carbenoxolone, an ulcer-healing drug. Ann N Y Acad Sci (1973) 1.21
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment. Br J Ind Med (1991) 1.16
A retrospective evaluation of COMPACT predictions of the outcome of NTP rodent carcinogenicity testing. Environ Health Perspect (1995) 1.15
Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver. Biochem J (1971) 1.11
The stimulation of hydroxylation by carcinogenic and non-carcinogenic compounds. Biochem Pharmacol (1966) 1.09
Activation mechanisms to chemical toxicity. Arch Toxicol (1987) 1.05
COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP. Environ Health Perspect (1996) 1.02
Pharmacology of mucus. Br Med Bull (1978) 1.01
The metabolism of [2-14C] indole in the rat. Biochem J (1966) 1.00
Mechanisms of chemical toxicity--a unifying hypothesis. Regul Toxicol Pharmacol (1982) 0.97
An adenomatous polyp case-control study to assess occupational risk factors following a workplace colorectal cancer cluster. Am J Epidemiol (1991) 0.97
Single-dose pharmacokinetics of perhexiline administered orally to humans. J Chromatogr (1984) 0.95
The mechanism of action of phenformin in starved rats. Biochem Pharmacol (1983) 0.95
Interaction of a series of nitriles with the alcohol-inducible isoform of P450: computer analysis of structure-activity relationships. Xenobiotica (1994) 0.93
In vitro enhancement of hepatic microsomal biphenyl 2-hydroxylation by carcinogens. Nature (1974) 0.92
Effects of preincubation invitro with 3, 4-benzopyrene and phenobarbital on the drug-metabolism systems present in the microsomal and soluble fractions of the avocado pear (Persea americana). Biochem Soc Trans (1975) 0.91
Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis. Drug Metab Rev (1993) 0.91
The induction of hepatic microsomal enzymes by safrole. Biochem J (1970) 0.91
Organic nitrate reductase: reassessment of its subcellular localization and tissue distribution and its relationship to the glutathione transferases. Int J Biochem (1989) 0.91
Hepatic microsomal drug metabolism in the pregnant rat. Xenobiotica (1982) 0.90
Molecular dimensions of the substrate binding site of cytochrome P-448. Biochem Pharmacol (1986) 0.90
Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen. Environ Health Perspect (1998) 0.90
Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates. J Pharm Pharmacol (1975) 0.90
The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab Rev (1990) 0.90
The fate of ( 14 C)carbenoxolone in patients with gastric ulcer. Clin Sci (1972) 0.90
A study of the possible metabolism of trichlorofluoromethane. Biochem J (1972) 0.89
Effects of pregnancy on the metabolism of drugs in the rat and rabbit. Biochem Pharmacol (1973) 0.89
An association of upper respiratory cancer with exposure to diethyl sulfate. J Occup Med (1979) 0.89
Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450. Xenobiotica (1987) 0.88
Computer modelling in predicting carcinogenicity. Eur J Cancer Prev (1993) 0.87
A comparison of the metabolism of HEOD (dieldrin) in the CF1 mouse with that in the CFE rat. Food Cosmet Toxicol (1972) 0.87
Effect of protein/energy nutrition on rat plasma corticosteroids and liver microsomal hydroxylase activity. Nutr Metab (1975) 0.87
Proceedings: Interaction of carbenoxolone sodium with other drigs bound to plasma proteins. Br J Pharmacol (1975) 0.86
The cytochromes P-448--a unique family of enzymes involved in chemical toxicity and carcinogenesis. Biochem Pharmacol (1987) 0.86
The absorption of carbenoxolone administered orally as a positioned-release capsule. Gut (1970) 0.85
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes. Biochem J (1976) 0.85
Metabolism of toxic substances. Br Med Bull (1969) 0.85
Eric Boyland--a pioneer in cancer biochemistry. Xenobiotica (1987) 0.84
Further studies on the pharmacokinetics of perhexiline maleate in humans. Xenobiotica (1986) 0.84
Aromatization of shikimic acid in the rat and the role of gastrointestinal micro-organisms. Biochem Soc Trans (1976) 0.84
Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl. Biochem J (1979) 0.84
Determination of leukemogenic benzene exposure concentrations: refined analyses of the Pliofilm cohort. Risk Anal (1996) 0.84
The effects of chronic drug administration on hepatic enzyme induction and folate metabolism. Br J Clin Pharmacol (1978) 0.84
The effects of development on the activity of drug-metabolizing enzymes in the liver of the rat. Biochem J (1970) 0.83
Molecular modelling of cytochrome CYP1A1: a putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4-acetylaminofluorene. Toxicol Lett (1994) 0.83
Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme-substrate and enzyme-inhibitor interactions. Toxicol In Vitro (2003) 0.83
Studies on the cytochrome P-450 of avocado (Persea [corrected] americana) mesocarp microsomal fraction. Xenobiotica (1990) 0.82
Nitrosamine carcinogenesis: rodent assays, quantitative structure-activity relationships, and human risk assessment. Drug Metab Rev (1997) 0.82
The effects of carbon disulphide on rat liver microsomal mixed-function oxidases, in vivo and in vitro. Biochem J (1980) 0.82
Effect of natural and synthetic glucocorticoids on rat hepatic microsomal drug metabolism. J Steroid Biochem (1976) 0.82
Safrole: its metabolism, carcinogenicity and interactions with cytochrome P-450. Food Cosmet Toxicol (1981) 0.82
Stereoselective pharmacokinetics of perhexiline. Xenobiotica (1986) 0.82
The use of computers in the safety evaluation of drugs and other chemicals. Eur J Drug Metab Pharmacokinet (1995) 0.81
Metabolism of endrin in the rat. J Agric Food Chem (1971) 0.81
Industrial solvents: some factors affecting their passage into and through the skin. Ann Occup Hyg (1981) 0.81
Structural requirements for substrates of cytochromes P-450 and P-448. Chem Biol Interact (1987) 0.81
Metabolic abnormalities of tryptophan and nicotinic acid in patients with rheumatoid arthritis. Rheumatol Rehabil (1978) 0.81
Drug metabolism, cytochrome P450 spin state, and phospholipid changes during pregnancy in the rat. Biochem Pharmacol (1981) 0.81
The metabolism of cyclohexanecarboxylate in the rat. Biochem J (1977) 0.81
Isoprene cancer risk and the time pattern of dose administration. Toxicology (1996) 0.81
The effect of dietary cadmium on zinc, copper and iron levels in the bone of rats. Toxicol Lett (1980) 0.80
A comparison of the protective effects of N-acetyl-cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity. Toxicology (1983) 0.80
Long-term studies on chemically induced liver enlargement in the rat. I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytoluene. Toxicology (1977) 0.80
Proceedings: The effects of ulcerogenic and ulcer-healing drugs on gastric mucus. Gut (1975) 0.80
Human carcinogens: an evaluation study via the COMPACT and HazardExpert procedures. Hum Exp Toxicol (2002) 0.80
Proceedings: The effect of mucosal damage on gastric glycoprotein synthesis in the rat. Br J Pharmacol (1974) 0.80
Subchronic feeding study of four white mineral oils in dogs and rats. Drug Chem Toxicol (1995) 0.80
Studies on the nature of the in vitro enhancement of biphenyl 2-hydroxylation provoked by some chemical carcinogens. Biochem Pharmacol (1976) 0.80
The mutagenic and cell transforming properties of shikimic acid and some of its bacterial and mammalian metabolites. Toxicol Lett (1984) 0.80
Experimental atherosclerosis in the Wistar rat [proceedings]. Br J Pharmacol (1978) 0.79
Prediction of chemical carcinogenicity from molecular and electronic structures: a comparison of MINDO/3 and CNDO/2 molecular orbital methods. Toxicol Lett (1989) 0.79
The metabolism of cyclohexanecarboxylic acid in the isolated perfused rat liver. Xenobiotica (1977) 0.79
The effects of sodium carbenoxolone on the stability of cellular membranes. Scand J Gastroenterol Suppl (1980) 0.79
The biochemical pharmacology of mucus. Adv Exp Med Biol (1977) 0.79
Serum "prealbumin" as an index of liver function in human hepatobiliary disease. Clin Chim Acta (1981) 0.79
Activation of benzo(a)pyrene and 2-acetamidofluorene to mutagens by microsomal preparations from different animal species: role of cytochrome P-450 and P-448. Xenobiotica (1981) 0.79
Induction of the drug-metabolizing enzymes. Basic Life Sci (1975) 0.79
The role of nutrition in toxicology. Annu Rev Nutr (1981) 0.79
The effect of carbenoxolone on the subcellular distribution of ( 3 H) aldosterone in rat kidney. Biochem J (1972) 0.79
Glycylprolyl-p-nitroanilidase in hepatobiliary disease. Clin Chim Acta (1981) 0.79
A retrospective study of the molecular toxicology of benoxaprofen. Toxicology (1990) 0.79
The protective effects of L-ascorbic acid and DL-alpha-tocopherol on cultured rat embryos treated with xanthine/xanthine oxidase. Mutat Res (1989) 0.79
Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes. Toxicology (1998) 0.79
Drug interaction. R Soc Health J (1972) 0.78
Drug metabolism in the ferret: effects of age, sex and strain. Gen Pharmacol (1977) 0.78
Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Possible implications in its hepatotoxicity. Biochem Pharmacol (1991) 0.78
Inhibition of cytochrome P-448 mixed function oxidase activity following administration of 9-hydroxyellipticine to rats. Chem Biol Interact (1980) 0.78
The influence of some hepatic enzyme inducers and inhibitors on extrahepatic drug metabolism. Drug Metab Dispos (1974) 0.78
Anaerobic dechlorination of trichlorofluoromethane by liver microsomal preparations in vitro. Biochem Soc Trans (1975) 0.78
Molecular modeling of enzymes and receptors involved in carcinogenesis: QSARs and compact-3D. Drug Metab Rev (1994) 0.78