Published in Antimicrob Agents Chemother on May 01, 1997
Microscopic-observation drug-susceptibility assay for the diagnosis of TB. N Engl J Med (2006) 8.39
Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay. J Clin Microbiol (1998) 7.84
Rapid, efficient detection and drug susceptibility testing of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures. The Tuberculosis Working Group in Peru. J Clin Microbiol (2000) 5.01
Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2002) 4.10
Microscopic observation drug susceptibility assay, a rapid, reliable diagnostic test for multidrug-resistant tuberculosis suitable for use in resource-poor settings. J Clin Microbiol (2004) 3.27
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob Agents Chemother (2007) 2.80
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) (2009) 2.58
A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen. PLoS One (2009) 2.15
Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: rapid, simple, and inexpensive method. Antimicrob Agents Chemother (2003) 1.93
In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis. Antimicrob Agents Chemother (2005) 1.81
A dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosis. PLoS One (2013) 1.71
Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing. Antimicrob Agents Chemother (2005) 1.61
Search for new drugs for treatment of tuberculosis. Antimicrob Agents Chemother (2001) 1.56
Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil. Antimicrob Agents Chemother (2004) 1.53
Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis. Antimicrob Agents Chemother (1998) 1.53
Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter. Antimicrob Agents Chemother (2003) 1.46
Evaluation of microscopic observation drug susceptibility assay for detection of multidrug-resistant Mycobacterium tuberculosis. J Clin Microbiol (2007) 1.45
Role of porins for uptake of antibiotics by Mycobacterium smegmatis. Antimicrob Agents Chemother (2008) 1.44
Multiple applications of Alamar Blue as an indicator of metabolic function and cellular health in cell viability bioassays. Sensors (Basel) (2012) 1.43
Slow polymerization of Mycobacterium tuberculosis FtsZ. J Bacteriol (2000) 1.42
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. PLoS One (2007) 1.41
Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua. J Nat Prod (2009) 1.36
Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases. J Nat Prod (2004) 1.36
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob Agents Chemother (2001) 1.34
Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis. Antimicrob Agents Chemother (2006) 1.33
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One (2013) 1.31
Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus. J Org Chem (2007) 1.29
Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. J Med Chem (2010) 1.29
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. J Med Chem (2006) 1.28
Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1. J Am Chem Soc (2003) 1.27
New target for inhibition of bacterial RNA polymerase: 'switch region'. Curr Opin Microbiol (2011) 1.26
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases. J Nat Prod (2006) 1.25
Broth microdilution susceptibility testing for Leptospira spp. Antimicrob Agents Chemother (2004) 1.24
Antimycobacterial activities of 2,4-diamino-5-deazapteridine derivatives and effects on mycobacterial dihydrofolate reductase. Antimicrob Agents Chemother (2000) 1.24
High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) (2011) 1.23
Dolabellane-type diterpenoids with antiprotozoan activity from a southwestern Caribbean gorgonian octocoral of the genus Eunicea. J Nat Prod (2010) 1.22
Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence. J Antimicrob Chemother (2011) 1.20
Use of receiver operating characteristic curves to assess the performance of a microdilution assay for determination of drug susceptibility of clinical isolates of Mycobacterium tuberculosis. Eur J Clin Microbiol Infect Dis (2003) 1.19
Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett (2008) 1.15
Counter-current chromatography based analysis of synergy in an anti-tuberculosis ethnobotanical. J Chromatogr A (2007) 1.14
Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2014) 1.12
Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria. Pharm Biol (2009) 1.12
Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2013) 1.12
Clofazimine analogs with efficacy against experimental tuberculosis and reduced potential for accumulation. Antimicrob Agents Chemother (2011) 1.10
Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery. Chem Biol (2013) 1.10
Mycobacterium leprae is naturally resistant to PA-824. Antimicrob Agents Chemother (2006) 1.09
Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin. BMC Microbiol (2009) 1.09
Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases. Am J Respir Crit Care Med (2012) 1.08
Making the most of Papua New Guinea's biodiversity: Establishment of an integrated set of programs that link botanical survey with pharmacological assessment in "The Land of the Unexpected" Pharm Biol (2009) 1.08
Tuberculosis in the developing world: recent advances in diagnosis with special consideration of extensively drug-resistant tuberculosis. Curr Opin Infect Dis (2008) 1.07
Inter- and intra-assay reproducibility of microplate Alamar blue assay results for isoniazid, rifampicin, ethambutol, streptomycin, ciprofloxacin, and capreomycin drug susceptibility testing of Mycobacterium tuberculosis. J Clin Microbiol (2008) 1.07
Indoleamides are active against drug-resistant Mycobacterium tuberculosis. Nat Commun (2013) 1.03
Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli. J Bacteriol (1999) 1.03
Novel paradigms for drug discovery: computational multitarget screening. Trends Pharmacol Sci (2008) 1.03
Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds. Bioorg Med Chem (2012) 1.03
Computational models for in-vitro anti-tubercular activity of molecules based on high-throughput chemical biology screening datasets. BMC Pharmacol (2012) 1.03
The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo. Antimicrob Agents Chemother (2014) 1.02
Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. J Med Chem (2007) 1.02
Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis. J Med Chem (2012) 1.02
Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling. Proc Natl Acad Sci U S A (2014) 1.01
The tuberculosis epidemic. Scientific challenges and opportunities. Public Health Rep (1998) 1.01
Antimycobacterial susceptibility testing methods for natural products research. Braz J Microbiol (2010) 1.01
Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba. J Clin Microbiol (2005) 1.01
Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models. PLoS One (2013) 1.01
N-Aroyl-3,5-bis(benzylidene)-4-piperidones: a novel class of antimycobacterial agents. Bioorg Med Chem (2008) 1.00
Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery. Pharm Res (2013) 0.99
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents. Tuberculosis (Edinb) (2011) 0.98
A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. PLoS One (2012) 0.98
In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis. Antimicrob Agents Chemother (2006) 0.97
New anti-tuberculosis agents amongst known drugs. Tuberculosis (Edinb) (2009) 0.97
Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice. Antimicrob Agents Chemother (2013) 0.97
Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Bioorg Med Chem (2009) 0.97
Synthesis and evaluation of new fluorinated anti-tubercular compounds. Iran J Pharm Res (2014) 0.95
Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia. J Nat Prod (2010) 0.95
Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs. Antimicrob Agents Chemother (2002) 0.94
Combining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosis. Pharm Res (2012) 0.94
Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis. Antimicrob Agents Chemother (2011) 0.93
Importance of porins for biocide efficacy against Mycobacterium smegmatis. Appl Environ Microbiol (2011) 0.91
Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible. Antimicrob Agents Chemother (2006) 0.91
Evaluation of fluoromycobacteriophages for detecting drug resistance in Mycobacterium tuberculosis. J Clin Microbiol (2011) 0.91
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg Med Chem (2007) 0.90
Anti-TB polyynes from the roots of Angelica sinensis. Phytother Res (2008) 0.90
Pyrido[1,2-a]benzimidazole-based agents active against tuberculosis (TB), multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB. ChemMedChem (2011) 0.90
Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity. Bioorg Med Chem (2009) 0.89
SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents. J Med Chem (2013) 0.89
In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide. J Antimicrob Chemother (2008) 0.89
Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer. Infect Agent Cancer (2012) 0.89
Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis. J Nat Prod (2008) 0.88
In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis. Antimicrob Agents Chemother (2014) 0.87
Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum. Planta Med (2005) 0.87
Chemical transformation and biological studies of marine sesquiterpene (S)-(+)-curcuphenol and its analogs. Biochim Biophys Acta (2007) 0.86
Drug discovery targeting cell division proteins, microtubules and FtsZ. Bioorg Med Chem (2014) 0.86
Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives. ChemMedChem (2011) 0.86
Synthetic lethality reveals mechanisms of Mycobacterium tuberculosis resistance to β-lactams. MBio (2014) 0.85
Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters. Eur J Med Chem (2010) 0.85
Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic. BMC Complement Altern Med (2014) 0.85
Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo. Antimicrob Agents Chemother (2008) 0.85
Biological evaluation of plants of Laos used in the treatment of tuberculosis in Lao traditional medicine. Pharm Biol (2009) 0.85
Carbamidocyclophanes F and G with Anti-Mycobacterium tuberculosis Activity from the Cultured Freshwater Cyanobacterium Nostoc sp. Tetrahedron Lett (2014) 0.85
Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. Eur J Med Chem (2013) 0.85
A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay. J Immunol Methods (1994) 5.34
Evaluation of a novel colorimetric broth microdilution method for antifungal susceptibility testing of yeast isolates. J Clin Microbiol (1994) 5.33
Colorimetric method for determining MICs of antimicrobial agents for Mycobacterium tuberculosis. J Clin Microbiol (1995) 3.60
Qualitative and quantitative drug-susceptibility tests in mycobacteriology. Am Rev Respir Dis (1988) 3.11
Use of a colorimetric system for yeast susceptibility testing. J Clin Microbiol (1995) 2.54
A rapid method for screening antimicrobial agents for activities against a strain of Mycobacterium tuberculosis expressing firefly luciferase. Antimicrob Agents Chemother (1993) 2.39
Ability of commercial and reference antimicrobial susceptibility testing methods to detect vancomycin resistance in enterococci. J Clin Microbiol (1995) 2.38
Evaluation of Alamar colorimetric MIC method for antimicrobial susceptibility testing of gram-negative bacteria. J Clin Microbiol (1994) 2.31
Rapid broth macrodilution method for determination of MICs for Mycobacterium avium isolates. J Clin Microbiol (1993) 2.25
Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery. Antimicrob Agents Chemother (1996) 1.94
Rapid susceptibility testing of Mycobacterium tuberculosis by bioluminescence assay of mycobacterial ATP. Antimicrob Agents Chemother (1988) 1.76
Detection of vancomycin resistance in enterococci by the Alamar MIC system. J Clin Microbiol (1995) 1.65
Reliability of two novel methods, Alamar and E test, for detection of methicillin-resistant Staphylococcus aureus. J Clin Microbiol (1993) 1.48
Rapid assay for mycobacterial growth and antibiotic susceptibility using gel microdrop encapsulation. J Clin Microbiol (1995) 1.48
High-throughput screen for detecting antimycobacterial agents. Antimicrob Agents Chemother (1995) 1.46
Stability of antimycobacterial drugs in susceptibility testing. Antimicrob Agents Chemother (1992) 1.43
Use of Mono Mac 6 human monocytic cell line and J774 murine macrophage cell line in parallel antimycobacterial drug studies. Antimicrob Agents Chemother (1996) 1.39
Quantification of mitogen induced human lymphocyte proliferation: comparison of alamarBlue assay to 3H-thymidine incorporation assay. J Clin Lab Anal (1995) 1.38
Identification of a genomic fragment of Mycobacterium tuberculosis responsible for in vivo growth advantage. Infect Agents Dis (1993) 1.34
L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae. J Immunol (1991) 2.15
Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages. Infect Immun (1987) 1.81
Leprosy. Clin Microbiol Rev (1988) 1.74
Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis. Antimicrob Agents Chemother (1998) 1.53
Rapid and simple MTT method for rifampicin and isoniazid susceptibility testing of Mycobacterium tuberculosis. Int J Tuberc Lung Dis (2002) 1.42
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob Agents Chemother (2001) 1.34
Ethnobotany/ethnopharmacology and mass bioprospecting: issues on intellectual property and benefit-sharing. J Ethnopharmacol (2005) 1.31
Antimycobacterial cycloartanes from Borrichia frutescens. J Nat Prod (1996) 1.30
Rapid in vitro metabolic screen for antileprosy compounds. Antimicrob Agents Chemother (1987) 1.28
Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents. J Med Chem (2001) 1.25
Antimycobacterial plant terpenoids. Planta Med (2001) 1.19
Use of receiver operating characteristic curves to assess the performance of a microdilution assay for determination of drug susceptibility of clinical isolates of Mycobacterium tuberculosis. Eur J Clin Microbiol Infect Dis (2003) 1.19
Chemotherapy of leprosy. Annu Rev Pharmacol Toxicol (1988) 1.11
Clinical trial of clarithromycin for lepromatous leprosy. Antimicrob Agents Chemother (1994) 1.07
Minocycline in lepromatous leprosy. Int J Lepr Other Mycobact Dis (1995) 1.05
Inhibition of phenolic glycolipid-I synthesis in extracellular Mycobacterium leprae as an indicator of antimicrobial activity. Int J Lepr Other Mycobact Dis (1988) 0.98
Effect of noncoliforms on coliform detection in potable groundwater: improved recovery with an anaerobic membrane filter technique. Appl Environ Microbiol (1984) 0.97
Antimycobacterial ergosterol-5,8-endoperoxide from Ajuga remota. Planta Med (1999) 0.97
Antimycobacterial activity of substituted isosteres of pyridine- and pyrazinecarboxylic acids. J Med Chem (1998) 0.95
Effects of activated macrophages on Mycobacterium leprae. Infect Immun (1991) 0.94
Clinical trial of sparfloxacin for lepromatous leprosy. Antimicrob Agents Chemother (1994) 0.92
Antimycobacterial activities of dehydrocostus lactone and its oxidation products. J Nat Prod (1998) 0.91
Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens. J Nat Prod (2001) 0.90
Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine. Antimicrob Agents Chemother (1999) 0.89
Antimycobacterial evaluation of germacranolides. Phytochemistry (1998) 0.89
Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis. Phytomedicine (2006) 0.88
Development of an extraction method for mycobacterial metabolome analysis. J Pharm Biomed Anal (2005) 0.86
Antimycobacterial activity of (E)-phytol and derivatives: a preliminary structure-activity study. Planta Med (1998) 0.85
Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis. Pharm Biol (2012) 0.85
An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development. Pharm Biol (2011) 0.84
Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa. Planta Med (1999) 0.83
Oleanane triterpenes from Junellia tridens. J Nat Prod (2000) 0.82
Assessment of antimycobacterial activity of a series of mainly marine derived natural products. Planta Med (2000) 0.82
Antimycobacterial triterpenes from Melia volkensii. J Nat Prod (1999) 0.82
Diterpenes from Solidago rugosa. Phytochemistry (1995) 0.82
Syntheses and evaluation of benzodiazaborine compounds against M. tuberculosis H37Rv in vitro. Bioorg Med Chem Lett (1998) 0.82
Antimycobacterial flavones from Haplopappus sonorensis. Fitoterapia (2003) 0.82
Susceptibility of Mycobacterium kansasii to ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid. Antimicrob Agents Chemother (1993) 0.82
Comparative in vitro antimicrobial activity of Chinese medicinal herbs. J Ethnopharmacol (1986) 0.81
Agelasine F from a Philippine Agelas sp. sponge exhibits in vitro antituberculosis activity. Planta Med (2000) 0.81
Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity. Evid Based Complement Alternat Med (2011) 0.81
Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile. Phytomedicine (1999) 0.80
Mycobacterial plasmids: screening and possible relationship to antibiotic resistance in Mycobacterium avium/Mycobacterium intracellulare. Microbiol Immunol (1986) 0.80
A new antitubercular mulinane diterpenoid from Azorella madreporica Clos. J Nat Prod (1998) 0.79
(+)-Totarol from Chamaecyparis nootkatensis and activity against Mycobacterium tuberculosis. Fitoterapia (2001) 0.79
Antimycobacterial crude plant extracts from South, Central, and North America. Phytomedicine (1998) 0.79
Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities. Phytother Res (2001) 0.78
Evaluation of a modified antimycobacterial susceptibility test using Middlebrook 7H10 agar containing 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride. J Microbiol Methods (2006) 0.78
Antimycobacterial activity of substituted isosteres of pyridine- and pyrazinecarboxylic acids. 2. J Med Chem (2001) 0.77
Antitubercular activity of triterpenoids from Lippia turbinata. J Nat Prod (2001) 0.76
Synthesis and evaluation of rifabutin analogs against Mycobacterium avium and H(37)Rv, MDR and NRP Mycobacterium tuberculosis. Bioorg Med Chem (2008) 0.75
NMR and molecular mechanics study of pyrethrins I and II. J Agric Food Chem (1999) 0.75
Induction of pyruvate decarboxylase in Candida utilis. Mycopathologia (1983) 0.75
Antimycobacterial matricaria esters and lactones from Astereae species. Planta Med (1998) 0.75