Published in Microb Drug Resist on January 01, 1996
Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2001) 12.65
Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol (2009) 10.42
Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Clin Microbiol Rev (1997) 6.98
Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs. Microbiol Mol Biol Rev (1998) 4.70
Pathogenesis of methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis (2008) 3.88
Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2011) 3.60
Local variants of Staphylococcal cassette chromosome mec in sporadic methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococci: evidence of horizontal gene transfer? Antimicrob Agents Chemother (2004) 2.12
Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia. J Infect Dis (2015) 2.08
Mobile genetic elements of Staphylococcus aureus. Cell Mol Life Sci (2010) 1.95
Genetic organization of the mecA region in methicillin-susceptible and methicillin-resistant strains of Staphylococcus sciuri. J Bacteriol (1998) 1.94
Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power. Curr Opin Microbiol (2007) 1.93
Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent. Microbiol Mol Biol Rev (2002) 1.91
Coagulase-negative staphylococci. Clin Microbiol Rev (2014) 1.85
Recruitment of the mecA gene homologue of Staphylococcus sciuri into a resistance determinant and expression of the resistant phenotype in Staphylococcus aureus. J Bacteriol (2001) 1.80
Guidelines for reporting novel mecA gene homologues. Antimicrob Agents Chemother (2012) 1.54
Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother (1998) 1.43
Molecular characterization of Staphylococcus sciuri strains isolated from humans. J Clin Microbiol (2000) 1.34
In vitro activities of RWJ-54428 (MC-02,479) against multiresistant gram-positive bacteria. Antimicrob Agents Chemother (2001) 1.34
Development of methicillin resistance in clinical isolates of Staphylococcus sciuri by transcriptional activation of the mecA homologue native to s. J Bacteriol (2003) 1.32
In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2008) 1.21
Endocarditis due to Staphylococcus sciuri. Eur J Clin Microbiol Infect Dis (1998) 1.18
The gene encoding the low-affinity penicillin-binding protein 3r in Enterococcus hirae S185R is borne on a plasmid carrying other antibiotic resistance determinants. Antimicrob Agents Chemother (1998) 1.17
Carriage of methicillin-resistant Staphylococci and their SCCmec types in a long-term-care facility. J Clin Microbiol (2008) 1.15
Determination of the chromosomal relationship between mecA and gyrA in methicillin-resistant coagulase-negative staphylococci. Antimicrob Agents Chemother (1998) 1.13
Detection of mecC-positive Staphylococcus aureus (CC130-MRSA-XI) in diseased European hedgehogs (Erinaceus europaeus) in Sweden. PLoS One (2013) 1.06
Rapid microarray-based identification of different mecA alleles in Staphylococci. Antimicrob Agents Chemother (2012) 1.03
Is methicillin-resistant Staphylococcus aureus an emerging community pathogen? A review of the literature. Can J Infect Dis (2000) 0.99
Penicillin-binding proteins and cell wall composition in beta-lactam-sensitive and -resistant strains of Staphylococcus sciuri. J Bacteriol (2007) 0.98
Molecular epidemiology of methicillin-resistant Staphylococcus hominis (MRSHo): low clonality and reservoirs of SCCmec structural elements. PLoS One (2011) 0.97
A novel hybrid SCCmec-mecC region in Staphylococcus sciuri. J Antimicrob Chemother (2013) 0.97
Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. Antimicrob Agents Chemother (2008) 0.95
Partial nucleotide sequencing of the mecA genes of Staphylococcus aureus isolates from cats and dogs. J Clin Microbiol (2006) 0.90
Combinations of cefoxitin plus other β-lactams are synergistic in vitro against community associated methicillin-resistant Staphylococcus aureus. Eur J Clin Microbiol Infect Dis (2013) 0.88
Genomic Basis for Methicillin Resistance in Staphylococcus aureus. Infect Chemother (2013) 0.88
Livestock-associated Staphylococcus aureus: the United States experience. PLoS Pathog (2015) 0.88
High-level (beta)-lactam resistance and cell wall synthesis catalyzed by the mecA homologue of Staphylococcus sciuri introduced into Staphylococcus aureus. J Bacteriol (2005) 0.85
Phage typing, PCR amplification for mecA gene, and antibiotic resistance patterns as epidemiologic markers in nosocomial outbreaks of methicillin resistant Staphylococcus aureus. Saudi J Biol Sci (2009) 0.82
The pls gene found in methicillin-resistant Staphylococcus aureus strains is common in clinical isolates of Staphylococcus sciuri. J Clin Microbiol (2005) 0.81
Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. Antimicrob Agents Chemother (2010) 0.81
The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens. Mol Ecol (2015) 0.79
Antibiotics trigger initiation of SCCmec transfer by inducing SOS responses. Nucleic Acids Res (2017) 0.75
Resistance mechanisms. Ann Transl Med (2016) 0.75
Plasmid-related quinolone resistance determinants in epidemic Vibrio parahaemolyticus, uropathogenic Escherichia coli, and marine bacteria from an aquaculture area in Chile. Microb Ecol (2014) 0.75
[MRSA/MRSE-VISA/GISA/VRSA-PRP-VRE: current gram positive problem bacteria and mechanism of resistance, prevalence and clinical consequences]. Wien Med Wochenschr (2003) 0.75
Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J Bacteriol (1984) 14.64
Multiple antibiotic resistance in a bacterium with suppressed autolytic system. Nature (1970) 9.07
The evolution of pandemic clones of methicillin-resistant Staphylococcus aureus: identification of two ancestral genetic backgrounds and the associated mec elements. Microb Drug Resist (2001) 7.78
Expression of methicillin resistance in heterogeneous strains of Staphylococcus aureus. Antimicrob Agents Chemother (1986) 7.71
The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection. N Engl J Med (1999) 7.64
Penicillin-binding proteins of multiply antibiotic-resistant South African strains of Streptococcus pneumoniae. Antimicrob Agents Chemother (1980) 6.96
Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network. J Clin Microbiol (2001) 6.66
Choline-containing teichoic acid as a structural component of pneumococcal cell wall and its role in sensitivity to lysis by an autolytic enzyme. J Biol Chem (1970) 6.06
Biological consequences of the replacement of choline by ethanolamine in the cell wall of Pneumococcus: chanin formation, loss of transformability, and loss of autolysis. Proc Natl Acad Sci U S A (1968) 5.92
Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1989) 5.65
On the nature of the pneumococcal activator substance. Proc Natl Acad Sci U S A (1966) 5.54
Choline in the cell wall of a bacterium: novel type of polymer-linked choline in Pneumococcus. Science (1967) 5.51
The evolution of methicillin resistance in Staphylococcus aureus: similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones. Proc Natl Acad Sci U S A (2001) 5.45
The mechanism of the irreversible antimicrobial effects of penicillins: how the beta-lactam antibiotics kill and lyse bacteria. Annu Rev Microbiol (1979) 5.33
Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother (1980) 5.12
Cellular metabolism in genetic transformation of pneumococci: requirement for protein synthesis during induction of competence. J Bacteriol (1970) 4.99
Peptidoglycan composition of a highly methicillin-resistant Staphylococcus aureus strain. The role of penicillin binding protein 2A. J Biol Chem (1992) 4.92
Involvement of multiple genetic determinants in high-level methicillin resistance in Staphylococcus aureus. J Bacteriol (1989) 4.91
Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis. Proc Natl Acad Sci U S A (1975) 4.85
Penicillin-binding proteins of penicillin-susceptible and intrinsically resistant Neisseria gonorrhoeae. Antimicrob Agents Chemother (1980) 4.80
Spread and maintenance of a dominant methicillin-resistant Staphylococcus aureus (MRSA) clone during an outbreak of MRSA disease in a Spanish hospital. J Clin Microbiol (1994) 4.68
Intercontinental spread of a multidrug-resistant methicillin-resistant Staphylococcus aureus clone. J Clin Microbiol (1998) 4.58
Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus. J Bacteriol (1997) 4.52
Molecular typing of methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis: comparison of results obtained in a multilaboratory effort using identical protocols and MRSA strains. Microb Drug Resist (2000) 4.24
Multiple mechanisms of methicillin resistance and improved methods for detection in clinical isolates of Staphylococcus aureus. Antimicrob Agents Chemother (1991) 4.22
The rate of killing of Escherichia coli by beta-lactam antibiotics is strictly proportional to the rate of bacterial growth. J Gen Microbiol (1986) 4.09
Molecular epidemiology of methicillin-resistant Staphylococcus aureus in 12 New York hospitals. MRSA Collaborative Study Group. J Infect Dis (1998) 3.94
Evidence for the introduction of a multiresistant clone of serotype 6B Streptococcus pneumoniae from Spain to Iceland in the late 1980s. J Infect Dis (1993) 3.94
Methicillin-resistant Staphylococcus aureus disease in a Portuguese hospital: characterization of clonal types by a combination of DNA typing methods. Eur J Clin Microbiol Infect Dis (1994) 3.87
CD14 is a pattern recognition receptor. Immunity (1994) 3.79
Model for the mechanism controlling the expression of competent state in Pneumococcus cultures. J Bacteriol (1966) 3.77
Lipoteichoic acid: a specific inhibitor of autolysin activity in Pneumococcus. Proc Natl Acad Sci U S A (1975) 3.76
The induction of meningeal inflammation by components of the pneumococcal cell wall. J Infect Dis (1985) 3.66
Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase: molecular cloning and DNA sequencing. J Bacteriol (1996) 3.58
Geographic distribution of penicillin-resistant clones of Streptococcus pneumoniae: characterization by penicillin-binding protein profile, surface protein A typing, and multilocus enzyme analysis. Clin Infect Dis (1992) 3.52
Reassessment of the number of auxiliary genes essential for expression of high-level methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother (1994) 3.50
Evidence for the geographic spread of a methicillin-resistant Staphylococcus aureus clone between Portugal and Spain. J Clin Microbiol (1995) 3.45
Detection of an archaic clone of Staphylococcus aureus with low-level resistance to methicillin in a pediatric hospital in Portugal and in international samples: relics of a formerly widely disseminated strain? J Clin Microbiol (1999) 3.45
Conversion of a homogeneously methicillin-resistant strain of Staphylococcus aureus to heterogeneous resistance by Tn551-mediated insertional inactivation. Eur J Clin Microbiol (1986) 3.44
Illustration of a common framework for relating multiple typing methods by application to macrolide-resistant Streptococcus pyogenes. J Clin Microbiol (2006) 3.36
Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin. J Clin Invest (1985) 3.35
Pneumococcal Forssman antigen. A choline-containing lipoteichoic acid. J Biol Chem (1973) 3.31
Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus. Antimicrob Agents Chemother (1981) 3.29
Geographic spread of epidemic multiresistant Staphylococcus aureus clone in Brazil. J Clin Microbiol (1995) 3.24
Extremely high incidence of antibiotic resistance in clinical isolates of Streptococcus pneumoniae in Hungary. J Infect Dis (1991) 3.18
Tolerant response of Streptococcus sanguis to beta-lactams and other cell wall inhibitors. Antimicrob Agents Chemother (1977) 3.17
Use of integrational plasmid vectors to demonstrate the polycistronic nature of a transcriptional unit (spoIIA) required for sporulation of Bacillus subtilis. J Gen Microbiol (1984) 3.15
A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization. Proc Natl Acad Sci U S A (1995) 3.12
Insertional inactivation of the mec gene in a transposon mutant of a methicillin-resistant clinical isolate of Staphylococcus aureus. Antimicrob Agents Chemother (1990) 3.09
Inhibition of bacterial wall lysins by lipoteichoic acids and related compounds. Biochem Biophys Res Commun (1975) 3.01
Serotyping Streptococcus pneumoniae by multiplex PCR. J Clin Microbiol (2003) 3.00
The role of autolysins in cell death. Ann N Y Acad Sci (1974) 2.99
Natural history of colonization with vancomycin-resistant Enterococcus faecium. Infect Control Hosp Epidemiol (1995) 2.97
Isolation and characterization of a Tn551-autolysis mutant of Staphylococcus aureus. J Bacteriol (1992) 2.92
Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes. Infect Immun (1994) 2.92
Inactivated pbp4 in highly glycopeptide-resistant laboratory mutants of Staphylococcus aureus. J Biol Chem (1999) 2.89
An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci. Proc Natl Acad Sci U S A (2001) 2.85
Control of the competent state in Pneumococcus by a hormone-like cell product: an example for a new type of regulatory mechanism in bacteria. Nature (1965) 2.84
High interlaboratory reproducibility of DNA sequence-based typing of bacteria in a multicenter study. J Clin Microbiol (2006) 2.80
Alteration of Escherichia coli murein during amino acid starvation. J Bacteriol (1980) 2.78
Evolution of a vancomycin-intermediate Staphylococcus aureus strain in vivo: multiple changes in the antibiotic resistance phenotypes of a single lineage of methicillin-resistant S. aureus under the impact of antibiotics administered for chemotherapy. J Clin Microbiol (2003) 2.74
Penicillin-binding proteins of penicillin-susceptible and -resistant pneumococci: immunological relatedness of altered proteins and changes in peptides carrying the beta-lactam binding site. Antimicrob Agents Chemother (1986) 2.72
Two international methicillin-resistant Staphylococcus aureus clones endemic in a university hospital in Patras, Greece. J Clin Microbiol (2003) 2.68
Evaluation of the bactericidal activity of beta-lactam antibiotics on slowly growing bacteria cultured in the chemostat. Antimicrob Agents Chemother (1986) 2.68
Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates causing respiratory disease in the United States. Microb Drug Resist (1998) 2.62
Frequent recovery of a single clonal type of multidrug-resistant Staphylococcus aureus from patients in two hospitals in Taiwan and China. J Clin Microbiol (2003) 2.55
Purification of the pneumococcal N-acetylmuramyl-L-alanine amidase to biochemical homogeneity. J Biol Chem (1976) 2.52
Abnormal autolytic enzyme in a pneumococus with altered teichoic acid composition. Proc Natl Acad Sci U S A (1971) 2.51
Specific recognition of choline residues in the cell wall teichoic acid by the N-acetylmuramyl-L-alanine amidase of Pneumococcus. J Biol Chem (1975) 2.50
Structure of the peptide network of pneumococcal peptidoglycan. J Biol Chem (1987) 2.45
Suppression of autolysis and cell wall turnover in heterogeneous Tn551 mutants of a methicillin-resistant Staphylococcus aureus strain. J Bacteriol (1991) 2.42
Beta-lactam-specific resistant mutants of Staphylococcus aureus. Antimicrob Agents Chemother (1986) 2.41
Activation of the alternative complement pathway by pneumococcal cell wall teichoic acid. J Immunol (1978) 2.40
An autoradiographic study of genetic transformation. Proc Natl Acad Sci U S A (1968) 2.36
Antibiotic resistance as a stress response: complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin. Microb Drug Resist (1999) 2.35
Specificity of DNA uptake in genetic transformation of gonococci. Biochem Biophys Res Commun (1979) 2.34
The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis. J Infect Dis (1985) 2.34
Capsular transformation of a multidrug-resistant Streptococcus pneumoniae in vivo. J Infect Dis (1998) 2.33
Antibiotic tolerance among clinical isolates of bacteria. Rev Infect Dis (1985) 2.32
Transmission of multidrug-resistant serotype 23F Streptococcus pneumoniae in group day care: evidence suggesting capsular transformation of the resistant strain in vivo. J Infect Dis (1995) 2.31
Secretion of lipids induced by inhibition of peptidoglycan synthesis in streptococci. J Bacteriol (1977) 2.31
From penicillin-binding proteins to the lysis and death of bacteria: a 1979 view. Rev Infect Dis (1980) 2.31
Gradual alterations in cell wall structure and metabolism in vancomycin-resistant mutants of Staphylococcus aureus. J Bacteriol (1999) 2.29
In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother (1980) 2.29
Triggering of autolytic cell wall degradation in Escherichia coli by beta-lactam antibiotics. Antimicrob Agents Chemother (1979) 2.26
Suppression of lytic effect of beta lactams on Escherichia coli and other bacteria. Proc Natl Acad Sci U S A (1976) 2.22
Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureus. J Bacteriol (2003) 2.21
The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae. J Biol Chem (2000) 2.19
A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci. Proc Natl Acad Sci U S A (1990) 2.18