The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group.

PubWeight™: 9.34‹?› | Rank: Top 0.1%

🔗 View Article (PMID 9174558)

Published in Lancet on May 31, 1997

Associated clinical trials:

Optimal Delay Time to Initiate Anticoagulation After Ischemic Stroke in Atrial Fibrillation (START) | NCT03021928

Articles citing this

(truncated to the top 100)

Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ (2002) 20.22

Clinical trials in head injury. J Neurotrauma (2002) 4.34

Size and quality of randomised controlled trials in head injury: review of published studies. BMJ (2000) 3.51

Impact of functional status at six months on long term survival in patients with ischaemic stroke: prospective cohort studies. BMJ (2008) 2.43

Cardiovascular manifestations of hypereosinophilic syndromes. Immunol Allergy Clin North Am (2007) 2.17

The importance of clinical trial data sharing: toward more open science. Circ Cardiovasc Qual Outcomes (2012) 2.16

Controversies in neurology: asymptomatic carotid stenosis--intervention or just stick to medical therapy. The argument for carotid endarterectomy. J Neural Transm (Vienna) (2011) 2.01

Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial. Lancet Neurol (2013) 1.93

Anticoagulation after cardioembolic stroke: to bridge or not to bridge? Arch Neurol (2008) 1.79

Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials. Lancet Neurol (2013) 1.62

Strategies to improve retention in randomised trials. Cochrane Database Syst Rev (2013) 1.58

Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials. Lancet (2016) 1.56

Treating the acute stroke patient as an emergency: current practices and future opportunities. Int J Clin Pract (2006) 1.55

Acute ischaemic stroke. BMJ (2000) 1.52

Description and evaluation of an acute stroke unit. CMAJ (2002) 1.49

Aspirin for acute stroke of unknown etiology in resource-limited settings: a decision analysis. Neurology (2014) 1.47

Cell adhesion molecules and ischemic stroke. Neurol Res (2008) 1.43

A better future in stroke? Lancet (1997) 1.39

Stroke rates: 1980-2000: the Minnesota Stroke Survey. Am J Epidemiol (2009) 1.31

Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 1.31

The International Stroke Trial database. Trials (2011) 1.28

Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia. J Neurol (2005) 1.23

PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480]. BMC Cardiovasc Disord (2005) 1.22

Out-of-hospital fluid in severe sepsis: effect on early resuscitation in the emergency department. Prehosp Emerg Care (2010) 1.16

Ischemic stroke in the elderly: an overview of evidence. Nat Rev Neurol (2010) 1.15

Why antiplatelet treatment in spontaneous internal carotid dissection? J Neural Transm (Vienna) (2012) 1.07

Multifunctional actions of approved and candidate stroke drugs. Neurotherapeutics (2009) 1.03

Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase. J Neurol Neurosurg Psychiatry (2007) 1.03

Thrombosis and antithrombotic therapy in women. Arterioscler Thromb Vasc Biol (2009) 1.03

Fatigue after stroke: baseline predictors and influence on survival. Analysis of data from UK patients recruited in the International Stroke Trial. PLoS One (2011) 1.01

Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. BMC Cardiovasc Disord (2003) 1.01

Current and future concepts in stroke prevention. CMAJ (2004) 0.99

Management of ischaemic stroke in the acute setting: review of the current status. Cardiovasc J Afr (2013) 0.97

Hemorrhagic transformation in patients with acute ischaemic stroke and an indication for anticoagulation. Eur J Neurol (2013) 0.96

Tissue-type plasminogen activator as a therapeutic target in stroke. Expert Opin Ther Targets (2008) 0.95

A cluster-randomized trial to improve stroke care in hospitals. Neurology (2010) 0.95

Recent Advances. Neurology. BMJ (1999) 0.93

Management dilemmas in acute pulmonary embolism. Thorax (2013) 0.93

[Prevention of stroke]. Wien Med Wochenschr (2003) 0.92

Suppressive effect of aspirin on aberrant crypt foci in patients with colorectal cancer. Gut (2003) 0.89

MR perfusion imaging in acute ischemic stroke. Neuroimaging Clin N Am (2011) 0.89

Two simple questions to assess neurologic outcomes at 3 months after out-of-hospital cardiac arrest: experience from the public access defibrillation trial. Resuscitation (2010) 0.88

Heparin and aspirin in stroke. Lancet (2001) 0.88

Antithrombotic medication for cardioembolic stroke prevention. Stroke Res Treat (2011) 0.87

Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: study protocol for a randomized controlled trial. Trials (2012) 0.87

Thrombolysis ImPlementation in Stroke (TIPS): evaluating the effectiveness of a strategy to increase the adoption of best evidence practice--protocol for a cluster randomised controlled trial in acute stroke care. Implement Sci (2014) 0.86

Evidence based cardiology: Prevention of ischaemic stroke. BMJ (1999) 0.86

Trends in Ambulatory Prescribing of Antiplatelet Therapy among US Ischemic Stroke Patients: 2000-2007. Adv Pharmacol Sci (2012) 0.86

Antiplatelets versus anticoagulants for the treatment of cervical artery dissection: Bayesian meta-analysis. PLoS One (2013) 0.86

Hemorrhagic transformation of childhood arterial ischemic stroke. Stroke (2011) 0.86

Effects of preoperative aspirin on cardiocerebral and renal complications in non-emergent cardiac surgery patients: a sub-group and cohort study. PLoS One (2012) 0.86

Risk-assessment algorithm and recommendations for venous thromboembolism prophylaxis in medical patients. Vasc Health Risk Manag (2007) 0.86

Evaluating drug treatments for Parkinson's disease: how good are the trials? BMJ (2002) 0.86

Antiplatelet agents for stroke prevention. Neurotherapeutics (2011) 0.85

Study for determination of the optimal cessation period of therapy with anti-platelet agents prior to invasive endoscopic procedures. J Gastroenterol (2005) 0.84

Where will the next generation of stroke treatments come from? PLoS Med (2010) 0.84

Evidence from clinical trials: can we do better? NeuroRx (2004) 0.83

Aspirin: pharmacology and clinical applications. Thrombosis (2011) 0.83

Is there an ideal way to initiate antiplatelet therapy with aspirin? A crossover study on healthy volunteers evaluating different dosing schemes with whole blood aggregometry. BMC Res Notes (2011) 0.82

Using 'dead or dependent' as an outcome measure in clinical trials in Parkinson's disease. J Neurol Neurosurg Psychiatry (2014) 0.82

Acute ischemic stroke in a pediatric patient. West J Emerg Med (2008) 0.81

Conformational and functional effects induced by D- and L-amino acid epimerization on a single gene encoded peptide from the skin secretion of Hypsiboas punctatus. PLoS One (2013) 0.81

Next-generation antithrombotics in ischemic stroke: preclinical perspective on 'bleeding-free antithrombosis'. J Cereb Blood Flow Metab (2012) 0.81

Risk Factors for DVT/PE in Patients with Stroke and Intracranial Hemorrhage. Open Neurol J (2014) 0.81

Imaging of acute stroke prior to treatment: current practice and evolving techniques. Br J Radiol (2014) 0.81

Low-molecular-weight heparin or dual antiplatelet therapy is more effective than aspirin alone in preventing early neurological deterioration and improving the 6-month outcome in ischemic stroke patients. J Clin Neurol (2015) 0.81

Neuropathic pain as a process: reversal of chronification in an animal model. J Pain Res (2011) 0.81

Thrombo-prophylaxis in acutely ill medical and critically ill patients. Indian J Crit Care Med (2014) 0.81

Drug treatment of acute ischemic stroke. Am J Cardiovasc Drugs (2013) 0.80

Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388). Int J Stroke (2015) 0.79

Antithrombotic agents' use in patients with atrial fibrillation and acute cerebral ischemia. J Neurol (2006) 0.79

Detection of paroxysmal atrial fibrillation or flutter in patients with acute ischemic stroke or transient ischemic attack by Holter monitoring. Indian Heart J (2014) 0.79

The Use of NeuroAiD (MLC601) in Postischemic Stroke Patients. Rehabil Res Pract (2012) 0.79

Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case study. J Thromb Thrombolysis (2012) 0.79

Secondary stroke prevention: challenges and solutions. Vasc Health Risk Manag (2015) 0.79

Interpretation of IST and CAST stroke trials. International Stroke Trial. Chinese Acute Stroke Trial. Lancet (1997) 0.78

Current treatments in neurology: stroke. J Neurol (2005) 0.78

Acute treatment for ischemic stroke in 2004. Emerg Radiol (2004) 0.78

Aspirin resistance and other aspirin-related concerns. Neurol Sci (2015) 0.78

Efficacy versus safety: the dilemma of using novel platelet inhibitors for the treatment of patients with ischemic stroke and coronary artery disease. Ther Clin Risk Manag (2014) 0.77

Induced hypertensive therapy in an acute ischemic stroke patient with early neurological deterioration. J Clin Neurol (2007) 0.77

Stroke, dementia, and drug delivery. Br J Clin Pharmacol (2004) 0.77

Plasminogen activators and ischemic stroke: conditions for acute delivery. Semin Thromb Hemost (2013) 0.77

Acute stroke: we have the treatments and we have the evidence--we need to use them. Crit Care (2007) 0.77

Silent New Brain Lesions: Innocent Bystander or Guilty Party? J Stroke (2015) 0.77

Statistical analysis plan for the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial. Int J Stroke (2014) 0.77

Stroke management. BMJ Clin Evid (2011) 0.77

Mechanism of heparin acceleration of tissue inhibitor of metalloproteases-1 (TIMP-1) degradation by the human neutrophil elastase. PLoS One (2011) 0.77

Efficacy of anti-coagulant treatment with argatroban on cardioembolic stroke. J Neurol (2007) 0.77

Clinical use of aspirin in treatment and prevention of cardiovascular disease. Thrombosis (2011) 0.77

The five ps of acute ischemic stroke treatment: parenchyma, pipes, perfusion, penumbra, and prevention of complications. Ochsner J (2003) 0.76

Rapid weather changes are associated with increased ischemic stroke risk: a case-crossover study. Eur J Epidemiol (2015) 0.76

Management of anticoagulant-related intracranial hemorrhage: an evidence-based review. Crit Care (2014) 0.76

Pre-Hospital Glyceryl Trinitrate: Potential for Use in Intracerebral Hemorrhage. J Neurol Disord (2013) 0.76

Anticoagulant therapy for ischemic stroke: A review of literature. J Res Med Sci (2012) 0.76

Basic characteristics of hospital stroke services in Eastern Hungary. Eur J Epidemiol (1999) 0.76

Treatment of acute ischemic stroke: beyond thrombolysis and supportive care. Neurotherapeutics (2011) 0.76

Antiplatelet therapy in secondary stroke prevention--state of the art. J Cell Mol Med (2010) 0.76

An update on prevention of venous thromboembolism in hospitalized acutely ill medical patients. Thromb J (2006) 0.76

Antiplatelet drug resistance is associated with early neurological deterioration in acute minor ischemic stroke in the Chinese population. J Neurol (2016) 0.76