Published in Curr Opin Immunol on June 01, 1997
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med (2002) 3.24
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor. Immunity (2010) 2.75
The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med (1998) 1.88
Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol Cell Biol (2000) 1.81
SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J Exp Med (1998) 1.78
Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity (2000) 1.74
The tipping points in the initiation of B cell signalling: how small changes make big differences. Nat Rev Immunol (2010) 1.68
Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway. J Virol (2000) 1.68
Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell (2003) 1.66
Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med (2008) 1.63
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A (1999) 1.57
Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta (2009) 1.55
Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes Dev (2000) 1.48
Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses. J Exp Med (1998) 1.47
Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J Exp Med (2003) 1.44
A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med (2000) 1.42
Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. J Exp Med (1998) 1.41
Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. J Biol Chem (2009) 1.38
Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. J Exp Med (1999) 1.38
Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med (2002) 1.36
Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes. J Exp Med (2000) 1.35
Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med (2000) 1.34
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. J Exp Med (2002) 1.30
Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving phosphatidylinositol-3 kinase activation. J Virol (2001) 1.27
Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase. Mol Cell Biol (2006) 1.26
Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. J Exp Med (2003) 1.25
SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors. Mol Cell Biol (1999) 1.22
Regulation of AID, the B-cell genome mutator. Genes Dev (2013) 1.21
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J (2002) 1.21
The cytoskeleton coordinates the early events of B-cell activation. Cold Spring Harb Perspect Biol (2011) 1.17
Paired immunoglobulin-like receptor (PIR)-A is involved in activating mast cells through its association with Fc receptor gamma chain. J Exp Med (1998) 1.16
Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development. J Virol (2003) 1.14
The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc Natl Acad Sci U S A (2000) 1.14
Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk. EMBO J (1998) 1.13
Epstein-Barr virus latent membrane protein 2A regulates c-Jun protein through extracellular signal-regulated kinase. J Virol (2002) 1.13
Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. Immunity (1999) 1.10
The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction. Proc Natl Acad Sci U S A (2000) 1.08
Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells. J Immunol (2010) 1.06
Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding. J Exp Med (2000) 1.05
Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk. J Exp Med (2003) 1.05
Association of SWAP-70 with the B cell antigen receptor complex. Proc Natl Acad Sci U S A (2000) 1.04
NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms. Blood (2008) 1.04
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med (1998) 1.02
Augmentation of antigen receptor-mediated responses by histamine H1 receptor signaling. J Exp Med (1999) 1.01
B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. J Exp Med (2001) 1.00
Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation. J Exp Med (1998) 0.99
Detection of kinase translocation using microfluidic electroporative flow cytometry. Anal Chem (2007) 0.94
Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med (2002) 0.93
Virus-induced maturation and activation of autoreactive memory B cells. J Exp Med (2000) 0.90
Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. J Exp Med (2001) 0.89
Intrinsic differences in the initiation of B cell receptor signaling favor responses of human IgG(+) memory B cells over IgM(+) naive B cells. J Immunol (2012) 0.89
Spatial coupling of JNK activation to the B cell antigen receptor by tyrosine-phosphorylated ezrin. J Immunol (2013) 0.89
A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells. J Exp Med (2004) 0.88
Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells. Proc Natl Acad Sci U S A (2000) 0.88
Fcgamma receptor cross-linking stimulates cell proliferation of macrophages via the ERK pathway. J Biol Chem (2009) 0.88
Models of signal transduction through the B-cell antigen receptor. Immunology (2003) 0.87
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A (2000) 0.87
Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). Clin Exp Immunol (2001) 0.85
Diverse phosphorylation patterns of B cell receptor-associated signaling in naïve and memory human B cells revealed by phosphoflow, a powerful technique to study signaling at the single cell level. Front Cell Infect Microbiol (2012) 0.85
New insights into the DT40 B cell receptor cluster using a proteomic proximity labeling assay. J Biol Chem (2014) 0.84
Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization. PLoS One (2015) 0.81
B cell receptor accessory molecules in the channel catfish, Ictalurus punctatus. Dev Comp Immunol (2008) 0.81
No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory. Cell Res (2014) 0.81
B-cell receptor: from resting state to activate. Immunology (2012) 0.80
Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. J Exp Med (2005) 0.80
IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation. J Immunol (2013) 0.79
Outer membrane protein A (OmpA) of Shigella flexneri 2a induces TLR2-mediated activation of B cells: involvement of protein tyrosine kinase, ERK and NF-κB. PLoS One (2014) 0.78
Rheumatoid factors induce signaling from B cells, leading to Epstein-Barr virus and B-cell activation. J Virol (2004) 0.78
Understanding the initiation of B cell signaling through live cell imaging. Methods Enzymol (2012) 0.77
Dengue Virus Directly Stimulates Polyclonal B Cell Activation. PLoS One (2015) 0.76
Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair. Neurotherapeutics (2016) 0.75
The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 downregulation. Blood (2016) 0.75
Antigen receptor signalling in apoptosis-resistant mutants of WEHI 231 cells. Immunology (2000) 0.75
Roles of Zinc Signaling in the Immune System. J Immunol Res (2016) 0.75
MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteins. Oncotarget (2017) 0.75
Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins. Elife (2017) 0.75