Published in Genes Dev on January 01, 2013
IgH chain class switch recombination: mechanism and regulation. J Immunol (2014) 2.27
Human apurinic/apyrimidinic endonuclease 1. Antioxid Redox Signal (2013) 1.34
Noncoding RNA transcription targets AID to divergently transcribed loci in B cells. Nature (2014) 1.16
New paradigms for functional HIV-specific nonneutralizing antibodies. Curr Opin HIV AIDS (2013) 1.09
DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum. Microbiol Mol Biol Rev (2014) 0.96
Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences. PLoS Biol (2014) 0.95
Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J Exp Med (2015) 0.92
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiol Spectr (2015) 0.90
Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. Nat Commun (2015) 0.90
Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations. Cell Cycle (2013) 0.88
E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells. Genes Dev (2013) 0.88
miR-182 is largely dispensable for adaptive immunity: lack of correlation between expression and function. J Immunol (2015) 0.84
Overlapping hotspots in CDRs are critical sites for V region diversification. Proc Natl Acad Sci U S A (2015) 0.84
MicroRNA 155 control of p53 activity is context dependent and mediated by Aicda and Socs1. Mol Cell Biol (2015) 0.80
Progression from IgD+ IgM+ to isotype-switched B cells is site specific during coronavirus-induced encephalomyelitis. J Virol (2014) 0.80
Theory and strategy for Pneumococcal vaccines in the elderly. Hum Vaccin Immunother (2016) 0.80
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution. Nat Commun (2015) 0.80
Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA. EMBO J (2016) 0.80
Waldenström macroglobulinemia: clinical and immunological aspects, natural history, cell of origin, and emerging mouse models. ISRN Hematol (2013) 0.79
Emerging concepts of epigenetic dysregulation in hematological malignancies. Nat Immunol (2016) 0.79
Control of Transposon-Mediated Directed Mutation by the Escherichia coli Phosphoenolpyruvate:Sugar Phosphotransferase System. J Mol Microbiol Biotechnol (2015) 0.78
RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome. Adv Immunol (2015) 0.78
An Epigenetics-Inspired DNA-Based Data Storage System. Angew Chem Int Ed Engl (2016) 0.77
Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal-center interactions. Proc Natl Acad Sci U S A (2014) 0.77
Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes. Nucleic Acids Res (2015) 0.77
A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination. Cell Rep (2016) 0.77
Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry. Cell (2017) 0.76
Understanding the multiple biological aspects leading to myeloma. Haematologica (2014) 0.76
CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis. Brain Behav Immun (2016) 0.76
Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease. Immunology (2015) 0.76
You break it, you fix it: functions for AID downstream of deamination. Nat Immunol (2013) 0.75
Hodgkin Lymphoma Cells Have a Specific Long Noncoding RNA Expression Pattern. Am J Pathol (2016) 0.75
Transgenic mouse model of IgM(+) lymphoproliferative disease mimicking Waldenström macroglobulinemia. Blood Cancer J (2016) 0.75
Activation-induced cytidine deaminase in B cells of hepatits C virus-related cryoglobulinaemic vasculitis. Clin Exp Immunol (2015) 0.75
Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression. Mol Immunol (2016) 0.75
RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations. J Mol Biol (2017) 0.75
Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells. J Exp Med (2017) 0.75
DNA repair and systemic lupus erythematosus. DNA Repair (Amst) (2017) 0.75
Biochemical regulatory features of AID remain conserved from lamprey to humans. Mol Cell Biol (2017) 0.75
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell (1993) 11.76
Germinal centers. Annu Rev Immunol (1994) 10.85
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci U S A (1982) 10.50
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell (2000) 9.99
Intraclonal generation of antibody mutants in germinal centres. Nature (1991) 7.39
Antigen receptor tail clue. Nature (1989) 7.32
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature (2002) 7.12
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem (1999) 6.67
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol (2002) 6.55
Germinal centers. Annu Rev Immunol (2012) 6.26
Translocations among antibody genes in human cancer. Science (1983) 6.20
Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol (2008) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Cell (2004) 5.84
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74
Variability in the lambda light chain sequences of mouse antibody. Nature (1970) 5.71
Germinal-center organization and cellular dynamics. Immunity (2007) 5.62
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49
Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03
Chromosome territories. Cold Spring Harb Perspect Biol (2010) 5.00
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature (2002) 4.89
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A (2003) 4.89
Imaging of germinal center selection events during affinity maturation. Science (2006) 4.86
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol (2003) 4.81
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Organization of immunoglobulin heavy chain genes and allelic deletion model. Proc Natl Acad Sci U S A (1978) 3.95
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
Spatial proximity of translocation-prone gene loci in human lymphomas. Nat Genet (2003) 3.91
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
In vivo imaging of germinal centres reveals a dynamic open structure. Nature (2007) 3.83
Myc dynamically and preferentially relocates to a transcription factory occupied by Igh. PLoS Biol (2007) 3.82
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell (1982) 3.72
Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. Proc Natl Acad Sci U S A (1980) 3.70
AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat Immunol (2003) 3.69
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65
Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat Immunol (2001) 3.60
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol (2003) 3.58
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. Mol Biol Evol (2004) 3.57
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci U S A (2003) 3.45
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity (1996) 3.39
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J Exp Med (1984) 3.36
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A (1996) 3.34
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity (1998) 3.27
AID mediates hypermutation by deaminating single stranded DNA. J Exp Med (2003) 3.24
DNA sequences at immunoglobulin switch region recombination sites. Nucleic Acids Res (1993) 3.18
Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity (2007) 3.07
Shutdown of class switch recombination by deletion of a switch region control element. Science (1993) 2.99
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene. J Exp Med (1990) 2.98
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92
B cell differentiation and isotype switching is related to division cycle number. J Exp Med (1996) 2.90
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Cell (1981) 2.84
AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79
Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol Cell (2005) 2.68
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature (2012) 2.44
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing. Nature (1980) 2.41
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell (2008) 2.39
The influence of transcriptional orientation on endogenous switch region function. Nat Immunol (2003) 2.38
The complexity of signaling pathways activated by the BCR. Curr Opin Immunol (1997) 2.25
Mechanisms of human DNA repair: an update. Toxicology (2003) 2.24
Circular DNA is excised by immunoglobulin class switch recombination. Cell (1990) 2.22
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors. Proc Natl Acad Sci U S A (1982) 2.16
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci U S A (2005) 2.13
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med (1998) 2.00
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A (2006) 1.95
RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res (1995) 1.93
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice. J Exp Med (2006) 1.92
Visualizing B cell capture of cognate antigen from follicular dendritic cells. J Exp Med (2009) 1.91
Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase. J Biol Chem (2004) 1.90
Early events in B cell activation. Annu Rev Immunol (2010) 1.86
Balancing AID and DNA repair during somatic hypermutation. Trends Immunol (2009) 1.86
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med (2010) 1.85
Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. J Exp Med (2005) 1.84
S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J (1994) 1.84
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol (2012) 1.83
A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon. EMBO J (1993) 1.82
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J Exp Med (2000) 1.82
Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med (2008) 1.80
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med (2005) 1.80
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat Rev Immunol (2012) 1.80
Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med (2008) 1.78
miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J Exp Med (2008) 1.77
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol Cell Biol (2007) 1.71
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med (2007) 1.70
Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells. J Cell Biol (1978) 1.66
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. Int Immunol (2009) 1.62
Switch transcripts in immunoglobulin class switching. Science (1995) 1.62
Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol (2010) 1.62
Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes. J Exp Med (1985) 1.59
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Nature (2006) 3.31
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
AID in somatic hypermutation and class switch recombination. Curr Opin Immunol (2006) 2.48
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A (2009) 1.50
Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Mol Cell Biol (2005) 1.50
Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol (2009) 1.24
The Saccharomyces cerevisiae 60 S ribosome biogenesis factor Tif6p is regulated by Hrr25p-mediated phosphorylation. J Biol Chem (2008) 0.95
Functional differences between kindlin-1 and kindlin-2 in keratinocytes. J Cell Sci (2012) 0.90
E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells. Genes Dev (2013) 0.88
Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity. Transcription (2013) 0.79
Recombinant retroviral production and infection of B cells. J Vis Exp (2011) 0.75