Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

PubWeight™: 1.31‹?› | Rank: Top 10%

🔗 View Article (PMC 508193)

Published in J Clin Invest on July 15, 1997

Authors

F M LaFerla1, J C Troncoso, D K Strickland, C H Kawas, G Jay

Author Affiliations

1: Department of Virology, Jerome H. Holland Laboratory, Rockville, Maryland 20855, USA.

Articles citing this

Intraneuronal Abeta42 accumulation in human brain. Am J Pathol (2000) 3.83

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol (2004) 2.15

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest (2004) 2.13

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79

A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol (2006) 1.66

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis (2009) 1.60

Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 1.41

Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease. Biochim Biophys Acta (2010) 1.24

Potential mechanisms contributing to sulfatide depletion at the earliest clinically recognizable stage of Alzheimer's disease: a tale of shotgun lipidomics. J Neurochem (2007) 1.18

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. PLoS One (2010) 1.17

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem (2009) 1.16

Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proc Natl Acad Sci U S A (2002) 1.11

Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PLoS One (2009) 1.10

Aβ internalization by neurons and glia. Int J Alzheimers Dis (2011) 0.99

Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system. Brain Struct Funct (2009) 0.97

LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease. Front Physiol (2012) 0.96

Endocytic pathways mediating oligomeric Abeta42 neurotoxicity. Mol Neurodegener (2010) 0.92

Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23. ACS Chem Neurosci (2010) 0.92

Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease. Mol Neurobiol (2007) 0.92

Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins. Int J Alzheimers Dis (2010) 0.89

Fleshing out the amyloid cascade hypothesis: the molecular biology of Alzheimer's disease. Dialogues Clin Neurosci (2000) 0.87

Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiol Aging (2014) 0.87

HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons. PLoS One (2010) 0.85

Allopregnanolone and neurogenesis in the nigrostriatal tract. Front Cell Neurosci (2014) 0.83

Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: ramifications for the Alzheimer's drug discovery. Mol Pharm (2012) 0.82

Calcium and neurogenesis in Alzheimer's disease. Front Neurosci (2010) 0.82

Caenorhabditis elegans as a model organism to study APP function. Exp Brain Res (2011) 0.82

Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease. Curr Alzheimer Res (2012) 0.82

TDP-43: a new player on the AD field? Exp Neurol (2012) 0.80

TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity. Brain Res (2008) 0.80

Cellular cofactors for amyloid beta-peptide-induced cell stress. Moving from cell culture to in vivo. Am J Pathol (1999) 0.78

Functional Roles of the Interaction of APP and Lipoprotein Receptors. Front Mol Neurosci (2017) 0.75

Articles cited by this

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol (1992) 34.17

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science (1993) 33.32

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology (1991) 23.01

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07

A receptor-mediated pathway for cholesterol homeostasis. Science (1986) 19.28

Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A (1993) 15.04

Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol (1991) 14.25

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science (1988) 13.54

Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol (1995) 9.35

Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature (1992) 7.16

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature (1992) 7.02

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol (1990) 6.79

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron (1994) 6.41

Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science (1992) 5.22

Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem (1994) 4.98

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A (1993) 4.86

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem (1992) 4.66

The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis. J Neuropathol Exp Neurol (1996) 4.39

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res (1991) 4.31

Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature (1994) 4.28

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron (1993) 3.92

Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest (1994) 3.58

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest (1985) 3.49

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science (1989) 3.47

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA. J Histochem Cytochem (1993) 3.41

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc Natl Acad Sci U S A (1989) 3.26

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem (1990) 3.25

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta (1987) 2.90

Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron (1996) 2.89

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature (1989) 2.75

Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem (1982) 2.71

Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science (1996) 2.69

Isoform-specific binding of apolipoprotein E to beta-amyloid. J Biol Chem (1994) 2.66

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci U S A (1993) 2.62

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci U S A (1993) 2.57

Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci U S A (1994) 2.52

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem (1992) 2.40

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell (1995) 2.37

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J Biol Chem (1992) 2.27

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp Neurol (1994) 2.25

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A (1992) 2.23

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci (1996) 2.14

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet (1995) 2.03

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein. Proc Natl Acad Sci U S A (1992) 1.85

Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport (1994) 1.81

Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid. Biochem Biophys Res Commun (1993) 1.80

The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J Neuropathol Exp Neurol (1993) 1.79

Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP). J Histochem Cytochem (1994) 1.72

First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins. J Biol Chem (1987) 1.60

Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain. Neuron (1995) 1.56

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. J Clin Invest (1994) 1.54

A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport (1995) 1.53

Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet (1995) 1.51

Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol (1995) 1.49

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proc Natl Acad Sci U S A (1993) 1.42

Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease. Proc Natl Acad Sci U S A (1989) 1.40

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol (1995) 1.40

Apolipoprotein E genotype and Alzheimer's disease. Lancet (1993) 1.30

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J Biol Chem (1994) 1.30

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem (1995) 1.27

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. J Neuropathol Exp Neurol (1994) 1.22

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease. Am J Pathol (1992) 1.20

Synapse loss in the temporal lobe in Alzheimer's disease. Ann Neurol (1993) 1.16

Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation. Neuroscience (1995) 1.12

Immunological localization of glycoprotein 330, low density lipoprotein receptor related protein and 39 kDa receptor associated protein in embryonic mouse tissues. In Vivo (1995) 1.10

Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Exp Neurol (1994) 1.09

Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Nature (1990) 1.07

Characterization of monoclonal antibodies against human apolipoprotein E. J Clin Invest (1981) 1.06

Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex. Am J Pathol (1994) 1.05

Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease. Neurobiol Aging (1994) 1.03

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett (1996) 1.03

Neuronal lipofuscin accumulation in ageing and alzheimer dementia: a pathogenic mechanism? Br J Psychiatry (1982) 0.94

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest (1996) 0.92

On the metabolism of apolipoprotein E and the Alzheimer diseases. Exp Neurol (1995) 0.83

Apolipoprotein E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor. Neurosci Lett (1994) 0.78

Articles by these authors

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci U S A (1979) 6.93

HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (1991) 5.34

LRP: a multifunctional scavenger and signaling receptor. J Clin Invest (2001) 5.31

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest (2000) 5.07

Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell (1979) 4.30

The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science (1987) 4.01

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron (1993) 3.92

Identification of the SV40 agnogene product: a DNA binding protein. Nature (1981) 3.80

p53 transformation-related protein: detection by monoclonal antibody in mouse and human cells. Proc Natl Acad Sci U S A (1981) 3.72

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet (1994) 3.67

In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella. J Cell Biol (1994) 3.19

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. J Biol Chem (1991) 3.17

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. Nature (1988) 3.07

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol (2000) 2.78

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat Genet (1999) 2.53

Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA. Proc Natl Acad Sci U S A (1980) 2.45

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol (1997) 2.43

Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology (2004) 2.42

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem (1992) 2.40

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell (1995) 2.37

The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life. Neurology (2009) 2.33

Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. Science (1985) 2.23

Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene. Science (1985) 2.22

The mammalian low-density lipoprotein receptor family. Annu Rev Nutr (1999) 2.21

Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. J Biol Chem (2000) 2.18

Secretion of a transplantation-related antigen. Cell (1983) 2.12

A nonpolymorphic class I gene in the murine major histocompatibility complex. Cell (1984) 2.12

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest (2000) 2.11

Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice. Science (1989) 2.08

The released interleukin 2 receptor binds interleukin 2 efficiently. J Immunol (1986) 2.08

A transgenic mouse model for human neurofibromatosis. Science (1987) 2.05

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet (1995) 2.03

Gene expression: chemical synthesis of E. coli ribosome binding sites and their use in directing the expression of mammalian proteins in bacteria. Nucleic Acids Res (1982) 2.01

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem (2000) 2.00

Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice. Nature (1989) 1.98

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol Cell Biol (1990) 1.91

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. J Biol Chem (1992) 1.89

Prevalence of dementia after age 90: results from the 90+ study. Neurology (2008) 1.88

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proc Natl Acad Sci U S A (1992) 1.88

Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem (1996) 1.85

Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Arch Pathol Lab Med (2001) 1.82

Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet (1995) 1.80

Tissue-specific expression of an unusual H-2 (class I)-related gene. Proc Natl Acad Sci U S A (1982) 1.76

Identification of a transformation-specific protein induced by a Rous sarcoma virus. Cell (1978) 1.74

A common transformation-related protein in murine sarcomas and leukemias. Cold Spring Harb Symp Quant Biol (1980) 1.74

Dementia in hippocampal sclerosis resembles frontotemporal dementia more than Alzheimer disease. Neurology (2004) 1.74

Apolipoprotein E genotype and rate of decline in probable Alzheimer's disease. Arch Neurol (1996) 1.74

Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP). J Histochem Cytochem (1994) 1.72

The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism. J Biol Chem (2001) 1.72

Discrete regions of simian virus 40 large T antigen are required for nonspecific and viral origin-specific DNA binding. J Virol (1982) 1.71

Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Nature (1995) 1.71

Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest. Ann Thorac Surg (1999) 1.65

The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A (2000) 1.65

Human error in medicine: promise and pitfalls, part 2. Ann Emerg Med (2000) 1.61

Role of the major histocompatibility complex class I antigens in tumor growth and metastasis. Annu Rev Immunol (1988) 1.60

Simian virus 40-specific ribosome-binding proteins induced by a nondefective adenovirus 2-simian virus 40 hybrid. J Virol (1977) 1.59

Detection of a secreted form of the murine H-2 class I antigen with an antibody against its predicted carboxyl terminus. Proc Natl Acad Sci U S A (1984) 1.58

Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas. J Biol Chem (2000) 1.57

New chimeric splice junction in adenovirus type 2-simian virus 40 hybrid viral mRNA. J Virol (1980) 1.53

Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection. Ann Thorac Surg (2001) 1.50

A transcriptional enhancer and an interferon-responsive sequence in major histocompatibility complex class I genes. Mol Cell Biol (1986) 1.50

Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging. Neurobiol Aging (1996) 1.49

Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus-transformed fibroblasts. J Virol (1979) 1.48

Three classes of mouse H-2 messenger RNA distinguished by analysis of cDNA clones. Nature (1982) 1.48

No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology (2008) 1.45

Regulated expression of a murine class I gene in transgenic mice. Mol Cell Biol (1986) 1.44

Developmental activation of the H-2K gene is correlated with an increase in DNA methylation. Cell (1983) 1.44

Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sci U S A (1986) 1.43

Simian virus 40 tumor antigen: isolation of the origin-specific DNA-binding domain. J Virol (1983) 1.42

Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein. J Biol Chem (1998) 1.42

Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. J Biol Chem (1995) 1.41

Modulation of the tumorigenicity of human adenovirus-12-transformed cells by interferon. Cell (1985) 1.41

Expression of the complete human T-cell leukemia virus type I pX coding sequence as a functional protein in Escherichia coli. Proc Natl Acad Sci U S A (1986) 1.41

Enhanced venous thrombus resolution in plasminogen activator inhibitor type-2 deficient mice. J Thromb Haemost (2014) 1.41

The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin. J Cell Biol (1990) 1.40

Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65. J Neurosci (2001) 1.40

Combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for metastatic testicular teratoma: long-term follow-up. Eur J Cancer (1991) 1.39

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. J Biol Chem (1992) 1.38

Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene. J Exp Med (1997) 1.38

Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. J Thromb Haemost (2005) 1.35

The early region of human papovavirus JC induces dysmyelination in transgenic mice. Cell (1986) 1.35

Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice. J Exp Med (1988) 1.34

Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis. J Clin Invest (1996) 1.33

Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene. Virology (1989) 1.32

Construction of a general vector for efficient expression of mammalian proteins in bacteria: use of a synthetic ribosome binding site. Proc Natl Acad Sci U S A (1981) 1.31

Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor in vitro. A process facilitated by cell-surface proteoglycans. J Biol Chem (1993) 1.31

Molecular mechanism for the capture and excision of the transforming gene of avian sarcoma virus as suggested by analysis of recombinant clones. J Virol (1980) 1.31

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J Biol Chem (1994) 1.30

p53 transformation-related protein: detection of an associated phosphotransferase activity. Proc Natl Acad Sci U S A (1981) 1.30

Subcellular localization of the simian virus 40 agnoprotein. J Virol (1983) 1.29

Late effects of treatment in survivors of childhood acute myeloid leukemia. J Clin Oncol (2000) 1.28

Functional insertion of an Alu type 2 (B2 SINE) repetitive sequence in murine class I genes. Science (1984) 1.28

Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology (2004) 1.28

Expression of major histocompatibility complex class I antigens as a strategy for the potentiation of immune recognition of tumor cells. Proc Natl Acad Sci U S A (1986) 1.24

Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann Neurol (1995) 1.23

Comparison of class I (H-2) gene sequences. Derivation of unique probes for members of this multigene family. J Biol Chem (1983) 1.23

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons. J Neurochem (1999) 1.23

Neuropathology of preclinical and clinical late-onset Alzheimer's disease. Ann Neurol (1998) 1.23