Published in J Exp Med on July 21, 1997
Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest (2004) 1.87
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. Physiol Rev (2013) 1.60
Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis. J Clin Invest (2001) 0.99
Neuroendocrine-immune interactions in rheumatoid arthritis: mechanisms of glucocorticoid resistance. Neuroimmunomodulation (2008) 0.92
Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids. Crit Care (2004) 0.91
Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss. Ann Rheum Dis (2009) 0.90
DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins. J Am Soc Nephrol (2007) 0.87
Glucocorticoid availability in colonic inflammation of rat. Dig Dis Sci (2007) 0.83
Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas. Br J Cancer (2005) 0.82
Hepatic inflammation induced by high-fructose diet is associated with altered 11βHSD1 expression in the liver of Wistar rats. Eur J Nutr (2014) 0.80
Activated glucocorticoid and eicosanoid pathways in endometriosis. Fertil Steril (2012) 0.78
Regulation of 11β-hydroxysteroid dehydrogenase type 1 and 7α-hydroxylase CYP7B1 during social stress. PLoS One (2014) 0.76
Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia. Proc Natl Acad Sci U S A (2014) 0.75
Evidence for glucocorticoid-mediated hypertension after uninephrectomy. Physiol Rep (2013) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science (1995) 11.16
Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest (1988) 5.22
The PPARalpha-leukotriene B4 pathway to inflammation control. Nature (1996) 5.14
Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science (1995) 4.85
Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science (1986) 4.25
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science (1987) 3.45
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science (1988) 2.93
Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice. J Exp Med (1988) 2.92
Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med (1996) 2.50
The glomerular mesangial cell: an expanding role for a specialized pericyte. FASEB J (1987) 2.26
Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J (1995) 1.84
Neutral proteinase activity produced in vitro by cells of the glomerular mesangium. Kidney Int (1983) 1.81
The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis. J Immunol (1987) 1.80
Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity. J Immunol (1987) 1.74
Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J Immunol (1987) 1.73
Synergistic stimulation of fibroblast prostaglandin production by recombinant interleukin 1 and tumor necrosis factor. J Immunol (1987) 1.73
Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol (1994) 1.67
Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase. J Biol Chem (1989) 1.54
Novel and enhanced IL-1 gene expression in autoimmune mice with lupus. J Immunol (1988) 1.37
CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: respective roles of interleukin-1, interleukin-2, interferon-gamma and accessory cells. Eur J Immunol (1993) 1.36
Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells. J Clin Invest (1993) 1.28
Phospholipases and phospholipid turnover in Escherichia coli spheroplasts. Biochim Biophys Acta (1972) 1.19
Glucocorticoids suppress group II phospholipase A2 production by blocking mRNA synthesis and post-transcriptional expression. J Biol Chem (1990) 1.15
Interleukin 1 and tumor necrosis factor synergistically stimulate prostaglandin synthesis and phospholipase A2 release from rat renal mesangial cells. Biochem Biophys Res Commun (1989) 1.13
Prostaglandin E2 production is synergistically increased in cultured human glomerular mesangial cells by combinations of IL-1 and tumor necrosis factor-alpha 1. J Immunol (1989) 1.11
Mesangial cell turnover: effect of heparin and peptide growth factors. Lab Invest (1991) 1.11
Group II phospholipase A2 mRNA synthesis is stimulated by two distinct mechanisms in rat vascular smooth muscle cells. FEBS Lett (1990) 1.08
Glomerular interleukin 1 production is dependent on macrophage infiltration in anti-GBM glomerulonephritis. Kidney Int (1991) 1.04
Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene. Lancet (1996) 1.01
Enhanced expression of group II phospholipase A2 gene in the tissues of endotoxin shock rats and its suppression by glucocorticoid. FEBS Lett (1990) 1.01
Glomerular tumor necrosis factor and interleukin 1 during acute aminonucleoside nephrosis. An immunohistochemical study. Lab Invest (1991) 1.01
Production of interleukin 1 in glomerular cell cultures from patients with rapidly progressive crescentic glomerulonephritis. Am J Nephrol (1988) 1.00
Interleukin-1 beta, tumor necrosis factor and forskolin stimulate the synthesis and secretion of group II phospholipase A2 in rat mesangial cells. Biochem Biophys Res Commun (1991) 1.00
Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology (1989) 1.00
Interleukin-1 alpha stimulates prostaglandin biosynthesis in serum-activated mesangial cells by induction of a non-pancreatic (type II) phospholipase A2. J Biol Chem (1991) 0.96
Tumor necrosis factor-alpha-induced apoptosis in hepatocytes in long-term culture. Am J Pathol (1996) 0.96
Pharmacokinetics and pharmacodynamics of three different prednisolone prodrugs: effect on circulating lymphocyte subsets and function. J Immunol (1984) 0.95
Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta. J Clin Endocrinol Metab (1995) 0.95
The interaction of cytokines in regulating oestradiol 17 beta-hydroxysteroid dehydrogenase activity in MCF-7 cells. J Steroid Biochem Mol Biol (1994) 0.93
Kinetics and dynamics of prednisolone. Endocr Rev (1987) 0.88
Glucocorticoid deficiency increases phospholipase A2 activity in rats. J Clin Invest (1993) 0.88
Haemodialysis activates phospholipase A2 enzyme. Nephrol Dial Transplant (1996) 0.85
Expression of 11 beta-hydroxysteroid dehydrogenase using recombinant vaccinia virus. Mol Endocrinol (1990) 0.85
Point mutations abolish 11 beta-hydroxysteroid dehydrogenase type II activity in three families with the congenital syndrome of apparent mineralocorticoid excess. Mol Cell Endocrinol (1996) 0.84
Inhibitory effect of glycyrrhetinic acid derivatives on lipoxygenase and prostaglandin synthetase. Chem Pharm Bull (Tokyo) (1986) 0.83
Cell-specific regulation of type II phospholipase A2 expression in rat mesangial cells. J Clin Invest (1993) 0.83
Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones. Proc Natl Acad Sci U S A (1994) 0.80
Kinetic studies on rat liver 11 beta-hydroxysteroid dehydrogenase. Biochim Biophys Acta (1991) 0.78
Liver cirrhosis induces renal and liver phospholipase A2 activity in rats. J Clin Invest (1996) 0.78
Altered glomerular steady-state levels of tumour necrosis factor-alpha mRNA during nephrotic and sclerotic phases of puromycin aminonucleoside nephrosis in rats. Clin Sci (Lond) (1993) 0.77
The human 11 beta-hydroxysteroid dehydrogenase type II enzyme: comparisons with other species and localization to the distal nephron. J Steroid Biochem Mol Biol (1995) 0.77
Effect of drugs on gene expression in mammalian cells: a highly efficient procedure to test large numbers of samples. Nucleic Acids Res (1993) 0.76
11 beta-Hydroxysteroid dehydrogenase accounts for low prednisolone/prednisone ratios in the kidney. Endocrinology (1994) 0.76
Furosemide inhibits 11 beta-hydroxysteroid dehydrogenase in vitro and in vivo. Endocrinology (1995) 0.76
Risk of infectious complications in patients taking glucocorticosteroids. Rev Infect Dis (1990) 2.42
BOLD-MRI for the assessment of renal oxygenation in humans: acute effect of nephrotoxic xenobiotics. Kidney Int (2006) 2.05
A novel expression assay to study transcriptional activators. Gene (1990) 1.96
Selective enhancement of gene transfer by steroid-mediated gene delivery. Nat Biotechnol (2001) 1.63
Molecular basis of human salt sensitivity: the role of the 11beta-hydroxysteroid dehydrogenase type 2. J Clin Endocrinol Metab (1999) 1.59
Impact of ketoconazole on the metabolism of prednisolone. Clin Pharmacol Ther (1989) 1.46
The role of the 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension. J Hypertens (2000) 1.43
McLeod syndrome: a neurohaematological disorder. Vox Sang (2007) 1.27
The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane. J Biol Chem (1999) 1.26
A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis. Mol Cell Biol (1997) 1.21
Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid. Toxicon (1987) 1.20
In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice. Hypertension (2001) 1.19
Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene. Oncogene (1994) 1.17
Measuring frequency noise and intrinsic linewidth of a room-temperature DFB quantum cascade laser. Opt Express (2011) 1.14
Adrenalectomy decreases lipocortin-I messenger ribonucleic acid and tissue protein content in rats. Endocrinology (1992) 1.13
Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma. Clin Chem (1979) 1.13
Prophylactic hemodialysis after radiocontrast media in patients with renal insufficiency is potentially harmful. Am J Med (2001) 1.08
Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease. Kidney Int (2001) 1.07
PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule. Curr Top Med Chem (2007) 1.06
Saturated-absorption cavity ring-down spectroscopy. Phys Rev Lett (2010) 1.04
Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans. J Pharmacol Exp Ther (1987) 1.03
Synthesis and evaluation of tricyclic dipyrido diazepinone derivatives as inhibitors of secretory phospholipase A2 with anti-inflammatory activity. Curr Top Med Chem (2007) 1.02
The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2. J Biol Chem (2001) 1.02
Thigh muscle mass and function in patients treated with glucocorticoids. Eur J Clin Invest (1985) 1.01
Pharmacokinetics of carumonam in patients with renal insufficiency. Antimicrob Agents Chemother (1986) 1.01
Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction. Transplantation (1982) 1.00
Inhibition of 11beta-hydroxysteroid dehydrogenase by bile acids in rats with cirrhosis. Hepatology (1999) 0.99
Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis. J Clin Invest (2001) 0.99
Interaction of plant lipids with 14 kDa phospholipase A2 enzymes. Biochem J (1996) 0.98
Regulation of hematopoiesis by microvascular endothelium. Leuk Lymphoma (1997) 0.98
Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils. Biochim Biophys Acta (1989) 0.97
Observing the intrinsic linewidth of a quantum-cascade laser: beyond the Schawlow-Townes limit. Phys Rev Lett (2010) 0.97
Fleroxacin clinical pharmacokinetics. Clin Pharmacokinet (1992) 0.96
Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet (1990) 0.96
Hyaluronidase inhibitors: a biological and therapeutic perspective. Curr Med Chem (2009) 0.96
Evidence that prednisone-induced myopathy is reversed by physical training. J Clin Endocrinol Metab (1985) 0.96
Pharmacokinetics and pharmacodynamics of three different prednisolone prodrugs: effect on circulating lymphocyte subsets and function. J Immunol (1984) 0.95
Procoagulant activity of Calotropis gigantea latex associated with fibrin(ogen)olytic activity. Toxicon (2005) 0.95
The anti-snake venom properties of Tamarindus indica (leguminosae) seed extract. Phytother Res (2006) 0.94
Prednisolone clearance at steady state in dogs. J Pharmacol Exp Ther (1980) 0.94
Trough levels and concentration time curves of cyclosporine in patients undergoing renal transplantation. Clin Pharmacol Ther (1988) 0.94
Pharmacokinetics of 3 prednisolone prodrugs. Evidence of therapeutic inequivalence in renal transplant patients with rejection. Transplantation (1985) 0.92
Expression of human recombinant lipocortin I in a wheat-germ cell-free system and Xenopus oocytes. Lipocortin is not secreted. Biochem J (1991) 0.92
The dose-dependent systemic availability of prednisone: one reason for the reduced biological effect of alternate-day prednisone. Br J Clin Pharmacol (1986) 0.92
Pharmacokinetics of intravenous cefetamet and oral cefetamet pivoxil in patients with renal insufficiency. Antimicrob Agents Chemother (1989) 0.91
Epithelial sodium channel (ENaC) subunit mRNA and protein expression in rats with puromycin aminonucleoside-induced nephrotic syndrome. Clin Sci (Lond) (2003) 0.90
Altered skeletal muscle ultrastructure in renal transplant patients on prednisone. Kidney Int (1986) 0.90
Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans. J Clin Endocrinol Metab (1994) 0.90
[Hydatid cysts of the brain. Diagnostic and therapeutic problems apropos of 100 cases]. Neurochirurgie (1977) 0.89
Lamb-dip-locked quantum cascade laser for comb-referenced IR absolute frequency measurements. Opt Express (2008) 0.89
Annexin I modulates cell functions by controlling intracellular calcium release. FASEB J (1999) 0.89
Coadministration of theophylline enhances diuretic response to furosemide in infants during extracorporeal membrane oxygenation: a randomized controlled pilot study. J Pediatr (1998) 0.88
Urinary 6 beta-hydroxyprednisolone excretion indicates enhanced prednisolone catabolism. J Lab Clin Med (1983) 0.88
Presence of lipocortins I and IV, but not II and VI, in human platelets. FEBS Lett (1993) 0.88
Glucocorticoid deficiency increases phospholipase A2 activity in rats. J Clin Invest (1993) 0.88
Study of acute renal ischemia in the rat using magnetic resonance imaging and spectroscopy. Magn Reson Med (1989) 0.88
The use of dynamic posturography to detect neurosensorial disorder in IDDM without clinical neuropathy. J Diabetes Complications (1999) 0.87
Stimulation of SV40 DNA replication by the human c-myc enhancer. FEBS Lett (1992) 0.87
Anticoagulant effect of Naja naja venom 5'nucleotidase: demonstration through the use of novel specific inhibitor, vanillic acid. Toxicon (2006) 0.87
Topical application of serine proteases from Wrightia tinctoria R. Br. (Apocyanaceae) latex augments healing of experimentally induced excision wound in mice. J Ethnopharmacol (2013) 0.87
Pharmacokinetics and metabolism of intravenous and oral fleroxacin in subjects with normal and impaired renal function and in patients on continuous ambulatory peritoneal dialysis. Antimicrob Agents Chemother (1989) 0.87
Chemistry and structural evaluation of different phospholipase A2 inhibitors in arachidonic acid pathway mediated inflammation and snake venom toxicity. Curr Top Med Chem (2007) 0.87
Purification and characterization of a 34-kDa, heat stable glycoprotein from Synadenium grantii latex: action on human fibrinogen and fibrin clot. Biochimie (2006) 0.86
Hyaluronidase and protease activities from Indian snake venoms: neutralization by Mimosa pudica root extract. Fitoterapia (2004) 0.86
Prednisolone clearance at steady state in man. J Clin Endocrinol Metab (1982) 0.86
Differential effect of impaired renal function on the kinetics of clavulanic acid and amoxicillin. Antimicrob Agents Chemother (1986) 0.85
Haemodialysis activates phospholipase A2 enzyme. Nephrol Dial Transplant (1996) 0.85
Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone. J Clin Endocrinol Metab (1981) 0.85
MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity. FEBS Lett (2000) 0.85
Sirolimus-associated eyelid edema in kidney transplant recipients. Transplantation (2001) 0.85
Acute cyclosporine-induced nephrotoxicity in renal transplant recipients: the role of the transplanted kidney. J Am Soc Nephrol (1996) 0.85
Thrombin like activity of Asclepias curassavica L. latex: action of cysteine proteases. J Ethnopharmacol (2009) 0.84
Altered body fat distribution in patients with glucocorticoid treatment and in patients on long-term dialysis. Am J Clin Nutr (1986) 0.84
Altered plasma protein-binding of prednisolone in patients with the nephrotic syndrome. Am J Kidney Dis (1984) 0.84