Published in Proc Natl Acad Sci U S A on July 22, 1997
Contribution of nonneutralizing vaccine-elicited antibody activities to improved protective efficacy in rhesus macaques immunized with Tat/Env compared with multigenic vaccines. J Immunol (2009) 1.93
Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains. J Virol (1998) 1.52
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Tat as one key to HIV-induced immune pathogenesis and Tat (correction of Pat) toxoid as an important component of a vaccine. Proc Natl Acad Sci U S A (1999) 1.32
Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway. J Virol (2000) 1.27
Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART. PLoS One (2010) 1.13
Effect of p38 mitogen-activated protein kinase on the replication of encephalomyocarditis virus. J Virol (2003) 1.09
Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge. Proc Natl Acad Sci U S A (1999) 1.08
Outcome of simian-human immunodeficiency virus strain 89.6p challenge following vaccination of rhesus macaques with human immunodeficiency virus Tat protein. J Virol (2002) 1.03
Inhibition of Epstein-Barr virus (EBV) reactivation by short interfering RNAs targeting p38 mitogen-activated protein kinase or c-myc in EBV-positive epithelial cells. J Virol (2004) 0.94
HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1. J Gene Med (2006) 0.93
The presence of anti-Tat antibodies in HIV-infected individuals is associated with containment of CD4+ T-cell decay and viral load, and with delay of disease progression: results of a 3-year cohort study. Retrovirology (2014) 0.92
HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: results of a randomized phase II exploratory clinical trial. Retrovirology (2015) 0.89
Activation of transcription of the human cytomegalovirus early UL4 promoter by the Ets transcription factor binding element. J Virol (2000) 0.88
R5 variants of human immunodeficiency virus type 1 preferentially infect CD62L- CD4+ T cells and are potentially resistant to nucleoside reverse transcriptase inhibitors. J Virol (2006) 0.86
HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms. J Virol (2014) 0.85
The HIV-1 Tat protein induces the activation of CD8+ T cells and affects in vivo the magnitude and kinetics of antiviral responses. PLoS One (2013) 0.85
HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells. Elife (2015) 0.84
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem (2013) 0.84
T-Cell Signaling in HIV-1 Infection. Open Virol J (2013) 0.83
Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication. Proc Natl Acad Sci U S A (2000) 0.83
HIV-1 Tat B-cell epitope vaccination was ineffectual in preventing viral rebound after ART cessation: HIV rebound with current ART appears to be due to infection with new endogenous founder virus and not to resurgence of pre-existing Tat-dependent viremia. Hum Vaccin Immunother (2012) 0.81
HIV-Tat immunization induces cross-clade neutralizing antibodies and CD4(+) T cell increases in antiretroviral-treated South African volunteers: a randomized phase II clinical trial. Retrovirology (2016) 0.76
The two sides of Tat. Elife (2016) 0.75
Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort. BMC Infect Dis (2016) 0.75
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (1995) 34.97
Viral dynamics in human immunodeficiency virus type 1 infection. Nature (1995) 28.54
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell (1990) 17.60
Cellular uptake of the tat protein from human immunodeficiency virus. Cell (1988) 10.19
VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol (1990) 7.62
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature (1996) 6.75
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature (1997) 6.53
Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science (1993) 5.40
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (1995) 4.95
Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell (1992) 4.50
JNK is involved in signal integration during costimulation of T lymphocytes. Cell (1994) 4.36
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science (1995) 3.46
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma. Nature (1994) 3.05
Blocked Ras activation in anergic CD4+ T cells. Science (1996) 2.64
Bioassay for trans-activation using purified human immunodeficiency virus tat-encoded protein: trans-activation requires mRNA synthesis. Proc Natl Acad Sci U S A (1989) 2.51
Chemokines and HIV-1 second receptors. Confluence of two fields generates optimism in AIDS research. Nat Med (1996) 2.44
Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med (1995) 2.28
Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. J Virol (1992) 1.97
Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science (1997) 1.97
The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc Natl Acad Sci U S A (1993) 1.93
Human immunodeficiency viruses regulated by alternative trans-activators: genetic evidence for a novel non-transcriptional function of Tat in virion infectivity. EMBO J (1994) 1.78
Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human immunodeficiency virus type 1 transactivation protein, tat. J Cell Biol (1990) 1.57
Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation. J Virol (1995) 1.51
HIV-1 Tat protein as a potential AIDS vaccine. Nat Med (1996) 1.29
Viral latency in HIV disease. Cell (1995) 1.23
Expression of CD25 defines peripheral blood mononuclear cells with productive versus latent HIV infection. J Immunol (1995) 1.15
Effect of antibody to HIV-1 Tat protein on viral replication in vitro and progression of HIV-1 disease in vivo. J Acquir Immune Defic Syndr Hum Retrovirol (1995) 1.07
T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles. Crit Rev Immunol (1995) 1.07
T-cell dynamics of immunodeficiency. Nat Med (1995) 1.06
Expression of Fas/APO-1 during the progression of astrocytomas. Cancer Res (1995) 0.94
Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science (1992) 24.32
Penicillin-binding proteins and cell shape in E. coli. Nature (1975) 10.20
A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci U S A (1974) 8.74
Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell (1984) 6.53
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res (2000) 6.42
Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization. Nucleic Acids Res (1993) 5.82
Isolation and characterization of acid phosphatase mutants in Saccharomyces cerevisiae. J Bacteriol (1973) 5.24
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett (1990) 5.14
Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction. Surgery (1988) 5.03
Animal cell cycle. Annu Rev Biochem (1978) 4.80
DNA synthesis inhibition and the induction of protein X in Escherichia coli. J Mol Biol (1976) 4.65
Studies on protein folding, unfolding and fluctuations by computer simulation. I. The effect of specific amino acid sequence represented by specific inter-unit interactions. Int J Pept Protein Res (1975) 4.49
Membrane transport proteins. Proteins that appear to be parts of membrane transport systems are being isolated and characterized. Science (1968) 4.23
Electron transfer by domain movement in cytochrome bc1. Nature (1998) 4.08
Cytidine triphosphate synthetase of Escherichia coli B. I. Purification and kinetics. J Biol Chem (1967) 4.01
Transport changes rapidly initiated by serum addition to "contact inhibited" 3T3 cells. Proc Natl Acad Sci U S A (1969) 3.98
Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst (1997) 3.92
Changes of membrane proteins and their relation to deoxyribonucleic acid synthesis and cell division of Escherichia coli. J Biol Chem (1970) 3.76
Multiple pathways of putrescine biosynthesis in Escherichia coli. J Biol Chem (1966) 3.74
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet (2001) 3.65
Ethical consideration of incidental findings on adult brain MRI in research. Neurology (2004) 3.56
Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids. Transplant Proc (1987) 3.55
Inhibition of an early event in the cell division cycle of Escherichia coli by FL1060, an amidinopenicillanic acid. J Bacteriol (1975) 3.49
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science (1995) 3.46
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A (2000) 3.44
Model for regulation of Escherichia coli DNA repair functions. Proc Natl Acad Sci U S A (1975) 3.32
Mutations in the gene encoding gap junction protein beta-3 associated with autosomal dominant hearing impairment. Nat Genet (1998) 3.24
Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res (1991) 3.24
Renal transplantation in baboons under FK 506. Surgery (1989) 3.17
Alterations of the PPP2R1B gene in human lung and colon cancer. Science (1998) 3.14
Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. Cancer Res (1992) 3.12
Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc Natl Acad Sci U S A (1980) 3.12
Orthotopic liver transplantation in dogs receiving FK-506. Transplant Proc (1987) 3.11
Transport of amino acids by confluent and nonconfluent 3T3 and polyoma virus-transformed 3T3 cells growing on glass cover slips. J Biol Chem (1969) 3.05
A binding site for sulfate and its relation to sulfate transport into Salmonella typhimurium. J Biol Chem (1966) 3.04
Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood (2001) 3.00
Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science (1986) 2.89
Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci U S A (1993) 2.85
Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells. Cell (1979) 2.84
Gene therapy progress and prospects: nonviral vectors. Gene Ther (2002) 2.79
A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem Biophys Res Commun (1991) 2.72
Isolation and characterization of recessive, constitutive mutations for repressible acid phosphatase synthesis in Saccharomyces cerevisiae. J Bacteriol (1975) 2.71
Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J Virol (2001) 2.69
Purification and properties of a sulfate-binding protein from Salmonella typhimurium. J Biol Chem (1966) 2.69
Toxicity of ALS-linked SOD1 mutants. Science (2000) 2.69
Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting. Int J Tuberc Lung Dis (2009) 2.68
Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther (2001) 2.67
Conditional mutations involving septum formation in Escherichia coli. J Bacteriol (1967) 2.64
Evidence for a relationship between deoxyribonucleic acid metabolism and septum formation in Escherichia coli. J Bacteriol (1968) 2.54
Thymidine and thymine incorporation into deoxyribonucleic acid: inhibition and repression by uridine of thymidine phosphorylase of Escherichia coli. J Bacteriol (1967) 2.41
Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci U S A (1993) 2.35
Synthesis of labile, serum-dependent protein in early G1 controls animal cell growth. Proc Natl Acad Sci U S A (1979) 2.28
Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Mol Cell Biol (1998) 2.28
Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene (1993) 2.25
Sequence of enzyme synthesis and gene replication during the cell cycle of Bacillus subtilis. Proc Natl Acad Sci U S A (1965) 2.18
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18
Four of eleven loci required for transient complementation of human cytomegalovirus DNA replication cooperate to activate expression of replication genes. J Virol (1996) 2.17
Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol (1998) 2.14
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol (2001) 2.14
Relativistic jet activity from the tidal disruption of a star by a massive black hole. Nature (2011) 2.12
Location of sulfate-binding protein in Salmonella typhimurium. J Bacteriol (1968) 2.11
Enzymatic completion of mammalian lagging-strand DNA replication. Proc Natl Acad Sci U S A (1994) 2.11
The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim Biophys Acta (1995) 2.10
Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission. Emerg Infect Dis (2000) 2.08
Proteomic analysis of nucleoporin interacting proteins. J Biol Chem (2001) 2.06
Regulation of sulfate transport in Salmonella typhimurium. J Bacteriol (1966) 2.06
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog (1998) 2.06
A permeable animal cell preparation for studying macromolecular synthesis. DNA synthesis and the role of deoxyribonucleotides in S phase initiation. Biochemistry (1978) 2.05
Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains. J Neurosci (2004) 2.03
Transmembrane pH gradient and membrane potential in Clostridium acetobutylicum during growth under acetogenic and solventogenic conditions. Appl Environ Microbiol (1985) 2.02
Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim Biophys Acta (1991) 2.01
Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol Cell Biol (1994) 2.00
Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene (2007) 1.95
Changes in the synthesis of actin and other cell proteins after stimulation of serum-arrested cells. Proc Natl Acad Sci U S A (1979) 1.95
Crystal structure of an activated response regulator bound to its target. Nat Struct Biol (2001) 1.95
Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc Natl Acad Sci U S A (2000) 1.94
Restriction point control of cell growth by a labile protein: evidence for increased stability in transformed cells. Proc Natl Acad Sci U S A (1982) 1.93
Evidence for a sulfate-binding site external to the cell membrane of Salmonella typhimurium. Biochim Biophys Acta (1965) 1.93
Genetics of sulfate transport by Salmonella typhimurium. J Bacteriol (1971) 1.92
Cell-free activity of a sulfate binding site involved in active transport. Proc Natl Acad Sci U S A (1966) 1.92
A cytoplasmic RNA vector derived from nontransmissible Sendai virus with efficient gene transfer and expression. J Virol (2000) 1.92
Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides. Mol Biol Cell (1999) 1.91
Deoxyribonucleic acid synthesis during the division cycle of Escherichia coli: a comparison of strains B-r, K-12, 15, and 15T- under conditions of slow growth. J Bacteriol (1974) 1.90
New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy. FEBS Lett (1994) 1.90
A biosynthetic ornithine decarboxylase in Escherichia coli. Biochem Biophys Res Commun (1965) 1.87
Control of thymidine kinase mRNA during the cell cycle. Mol Cell Biol (1987) 1.86
Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol (2000) 1.86
Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther (1997) 1.86
Benchmark data and power calculations for evaluating disease outbreak detection methods. MMWR Morb Mortal Wkly Rep (2004) 1.86
Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc Natl Acad Sci U S A (1982) 1.86
Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis. Proc Natl Acad Sci U S A (1998) 1.86
Differential display using one-base anchored oligo-dT primers. Nucleic Acids Res (1994) 1.85
Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice. Clin Exp Immunol (2006) 1.84
Gene therapy progress and prospects: non-viral gene therapy by systemic delivery. Gene Ther (2006) 1.84
Patterns of protein synthesis and tolerance of anoxia in root tips of maize seedlings acclimated to a low-oxygen environment, and identification of proteins by mass spectrometry. Plant Physiol (2000) 1.82
Cyclin E, a potential prognostic marker for breast cancer. Cancer Res (1994) 1.82
Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest (2000) 1.82
Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease. Ann Neurol (2000) 1.82
The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Hum Gene Ther (1999) 1.81
Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res (2000) 1.80